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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046456
Ensembl Protein ID ENSP00000454264.1
UniProt Accession Q9Y5A7; O95422; Q75MR9; Q8IX22; Q9BXR2; NUB1_HUMAN
Genbank Protein ID AAD42865.1; AAK21001.1; AAO14547.1; AAN01355.1; AAS02030.1; AAH46354.1; AAC82474.2
Protein Name NEDD8 ultimate buster 1; Negative regulator of ubiquitin-like proteins 1; Renal carcinoma antigen NY-REN-18
Genbank Nucleotide ID AF155099; AF300717; AF459743; AY129295; AC005486; BC046354; AF108083
Gene Name NUB1; NYREN18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000013374.15 ENST00000413040.6 ENSP00000398644.2
ENSG00000013374.15 ENST00000568733.5 ENSP00000454264.1
ENSG00000013374.15 ENST00000468404.5 ENSP00000420638.1
ENSG00000013374.15 ENST00000470316.5 ENSP00000420023.1
ENSG00000013374.15 ENST00000460712.1 ENSP00000420344.1
ENSG00000013374.15 ENST00000480714.1 ENSP00000419679.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 23649778
ULD/UDP/UBQ/UBQ_PIM UBQ_PIM 11585840; 26260793
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 2.00e-14 54.8 463 493
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 10   lveMGFdreealqaLraannnleaAveyLld 40
           l+ MG+++++a+q L aa++nl++A+  Ll+
   Q: 463  LKGMGYSTHAAQQVLHAASGNLDEALKILLS 493
           567**************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
 Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
Protein Sequence
(Fasta)
MKTNGGRCRI RALCWSRREW RGAGMAQKKY LQAKLTQFLR EDRIQLWKPP YTDENKKVGL 60
ALKDLAKQYS DRLECCENEV EKVIEEIRCK AIERGTGNDN YRTTGIATIE VFLPPRLKKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046456|UBD,UBA;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCCTCTTTC CAAGCGGCGG CGGCGGCGGC GGCGCGAAGG CGACAGCGGC GGCGGGGGCG 60
GGGCTGGCCT CACCCGGAAT GAAAACAAAC GGCGGCCGCT GCCGCATCCG GGCACTCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046456|UBD,UBA;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011990--TPR-like_helical_dom
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50030--UBA
Pfam

PF00627--UBA
SMART

SM00165--UBA
Gene Ontology

GO:0005634--C:nucleus
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0034341--P:response to interferon-gamma
GO:0034612--P:response to tumor necrosis factor
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:51667
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000706 Aegilops tauschii 24.91 1.00e-22 100.00
IUUC-Aml-002011 Ailuropoda melanoleuca 92.68 0.00e+00 1056.00
IUUC-Atr-002685 Amborella trichopoda 23.97 1.00e-27 117.00
IUUC-Apl-003818 Anas platyrhynchos 63.30 0.00e+00 654.00
IUUC-Aca-004439 Anolis carolinensis 63.58 0.00e+00 677.00
IUUC-Aly-005796 Arabidopsis lyrata 26.18 5.00e-32 132.00
IUUC-Ath-007419 Arabidopsis thaliana 25.71 3.00e-31 129.00
IUUC-Ani-009253 Aspergillus nidulans 24.73 2.70e-01 30.00
IUUC-Ame-011290 Astyanax mexicanus 45.11 6.00e-112 398.00
IUUC-Bta-013446 Bos taurus 86.83 0.00e+00 971.00
IUUC-Bdi-014400 Brachypodium distachyon 30.05 4.00e-25 109.00
IUUC-Bol-015407 Brassica oleracea 25.56 9.00e-26 111.00
IUUC-Bra-017386 Brassica rapa 24.93 4.00e-24 106.00
IUUC-Cja-018982 Callithrix jacchus 91.87 0.00e+00 984.00
IUUC-Cfa-020919 Canis familiaris 92.68 0.00e+00 1061.00
IUUC-Cpo-021709 Cavia porcellus 86.27 0.00e+00 1015.00
IUUC-Cre-023004 Chlamydomonas reinhardtii 25.89 8.00e-04 40.80
IUUC-Csa-023986 Chlorocebus sabaeus 96.24 0.00e+00 1119.00
IUUC-Cho-024391 Choloepus hoffmanni 96.51 1.00e-98 352.00
IUUC-Cin-025227 Ciona intestinalis 34.04 4.00e-75 275.00
IUUC-Csv-026213 Ciona savignyi 26.75 1.00e-11 63.20
IUUC-Dre-028258 Danio rerio 39.96 4.00e-92 332.00
IUUC-Dno-029732 Dasypus novemcinctus 91.06 0.00e+00 997.00
IUUC-Dor-030896 Dipodomys ordii 79.02 0.00e+00 872.00
IUUC-Dme-031789 Drosophila melanogaster 29.88 4.00e-45 176.00
IUUC-Ete-032810 Echinops telfairi 80.49 0.00e+00 872.00
IUUC-Eca-033649 Equus caballus 88.78 0.00e+00 1043.00
IUUC-Fca-035979 Felis catus 92.17 0.00e+00 1055.00
IUUC-Fal-036708 Ficedula albicollis 63.34 0.00e+00 664.00
IUUC-Gmo-039174 Gadus morhua 39.96 1.00e-79 291.00
IUUC-Gga-040165 Gallus gallus 64.16 0.00e+00 674.00
IUUC-Gac-042269 Gasterosteus aculeatus 40.22 5.00e-87 315.00
IUUC-Gma-043420 Glycine max 26.10 3.00e-23 103.00
IUUC-Ggo-045525 Gorilla gorilla 98.86 0.00e+00 1104.00
IUUC-Hvu-047099 Hordeum vulgare 30.05 8.00e-23 101.00
IUUC-Itr-048763 Ictidomys tridecemlineatus 89.29 0.00e+00 1007.00
IUUC-Lch-049579 Latimeria chalumnae 46.76 6.00e-128 451.00
IUUC-Lpe-051485 Leersia perrieri 28.77 1.00e-25 111.00
IUUC-Loc-051974 Lepisosteus oculatus 44.56 1.00e-116 413.00
IUUC-Laf-053661 Loxodonta africana 88.80 0.00e+00 1009.00
IUUC-Mcc-054599 Macaca mulatta 96.91 0.00e+00 1077.00
IUUC-Meu-055935 Macropus eugenii 77.56 0.00e+00 898.00
IUUC-Mtr-058497 Medicago truncatula 25.68 1.00e-24 108.00
IUUC-Mga-059711 Meleagris gallopavo 63.03 0.00e+00 660.00
IUUC-Mmr-061079 Microcebus murinus 90.30 0.00e+00 1040.00
IUUC-Mdo-062991 Monodelphis domestica 82.60 0.00e+00 898.00
IUUC-Mmu-064280 Mus musculus 85.51 0.00e+00 956.00
IUUC-Mac-064485 Musa acuminata 25.33 4.00e-30 126.00
IUUC-Mpu-066376 Mustela putorius furo 91.22 0.00e+00 1048.00
IUUC-Mlu-067808 Myotis lucifugus 89.76 0.00e+00 1069.00
IUUC-Nle-069384 Nomascus leucogenys 96.56 0.00e+00 1152.00
IUUC-Opr-071209 Ochotona princeps 83.99 1.00e-131 463.00
IUUC-Ont-071237 Oreochromis niloticus 42.80 1.00e-98 353.00
IUUC-Oan-073241 Ornithorhynchus anatinus 72.85 0.00e+00 810.00
IUUC-Ocu-074372 Oryctolagus cuniculus 89.43 0.00e+00 978.00
IUUC-Oba-075604 Oryza barthii 30.10 9.00e-27 115.00
IUUC-Obr-076272 Oryza brachyantha 30.19 8.00e-27 115.00
IUUC-Ogl-077860 Oryza glaberrima 30.10 9.00e-27 115.00
IUUC-Ogu-078907 Oryza glumaepatula 30.10 7.00e-27 115.00
IUUC-Oin-079073 Oryza indica 30.10 8.00e-27 115.00
IUUC-Olo-080884 Oryza longistaminata 30.10 9.00e-27 115.00
IUUC-Ome-081393 Oryza meridionalis 29.61 2.00e-26 114.00
IUUC-Oni-082606 Oryza nivara 30.10 7.00e-27 115.00
IUUC-Opu-083514 Oryza punctata 30.10 2.00e-26 114.00
IUUC-Oru-084709 Oryza rufipogon 30.58 2.00e-27 117.00
IUUC-Ola-086447 Oryzias latipes 43.02 1.00e-96 347.00
IUUC-Olu-087599 Ostreococcus lucimarinus 42.42 1.30e-02 34.30
IUUC-Oga-087931 Otolemur garnettii 92.36 0.00e+00 1024.00
IUUC-Oar-090452 Ovis aries 88.13 0.00e+00 1014.00
IUUC-Ptr-091538 Pan troglodytes 97.40 0.00e+00 1075.00
IUUC-Pan-092411 Papio anubis 96.79 0.00e+00 1096.00
IUUC-Psi-093867 Pelodiscus sinensis 61.59 1.00e-174 606.00
IUUC-Pma-094370 Petromyzon marinus 40.23 2.00e-97 349.00
IUUC-Ppa-096000 Physcomitrella patens 27.40 4.00e-34 139.00
IUUC-Pfo-097368 Poecilia formosa 42.76 1.00e-104 374.00
IUUC-Pab-097956 Pongo abelii 97.60 0.00e+00 1106.00
IUUC-Pop-099788 Populus trichocarpa 26.14 1.00e-27 117.00
IUUC-Pca-100209 Procavia capensis 79.65 2.00e-98 352.00
IUUC-Ppe-101943 Prunus persica 27.05 5.00e-19 89.40
IUUC-Pva-102894 Pteropus vampyrus 81.46 0.00e+00 905.00
IUUC-Rno-105948 Rattus norvegicus 87.15 0.00e+00 952.00
IUUC-Sha-106803 Sarcophilus harrisii 79.80 2.00e-119 422.00
IUUC-Smo-109087 Selaginella moellendorffii 27.73 1.00e-30 127.00
IUUC-Sit-110238 Setaria italica 32.35 6.00e-20 92.80
IUUC-Sly-111808 Solanum lycopersicum 26.21 1.00e-27 117.00
IUUC-Stu-112555 Solanum tuberosum 24.85 2.00e-25 110.00
IUUC-Sar-113510 Sorex araneus 77.59 5.00e-124 438.00
IUUC-Sbi-113830 Sorghum bicolor 31.02 6.00e-25 108.00
IUUC-Ssc-116283 Sus scrofa 88.21 0.00e+00 892.00
IUUC-Tgu-116651 Taeniopygia guttata 62.75 0.00e+00 658.00
IUUC-Tru-118492 Takifugu rubripes 42.68 5.00e-104 371.00
IUUC-Tsy-119635 Tarsius syrichta 83.74 0.00e+00 910.00
IUUC-Tni-120691 Tetraodon nigroviridis 42.76 8.00e-103 367.00
IUUC-Tca-121143 Theobroma cacao 23.08 1.00e-26 114.00
IUUC-Tae-123939 Triticum aestivum 24.91 6.00e-23 102.00
IUUC-Tbe-127414 Tupaia belangeri 85.37 0.00e+00 969.00
IUUC-Ttr-128330 Tursiops truncatus 82.81 0.00e+00 886.00
IUUC-Uma-129574 Ustilago maydis 23.66 5.30e-02 34.70
IUUC-Vpa-130210 Vicugna pacos 81.89 0.00e+00 796.00
IUUC-Vvi-131180 Vitis vinifera 23.20 4.00e-21 96.30
IUUC-Xtr-132695 Xenopus tropicalis 57.19 3.00e-171 595.00
IUUC-Xma-134255 Xiphophorus maculatus 42.76 4.00e-104 372.00
Created Date 25-Jun-2017

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