iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093957

Ensembl Protein ID

ENSPSIP00000015397.1

UniProt Accession

K7G536; K7G536_PELSI

Genbank Protein ID

ENSPSIP00000015397

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGCU01093915

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000013620.1	ENSPSIT00000015469.1	ENSPSIP00000015397.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.20e-62	210.3	325	854
UBD/Alpha-Helix/UBA	1.20e-21	76.2	723	761

Active Site

Position(s)	Description	Evidence
334	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
817	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 325  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQSAPSDPTQDFSTQVAKLGHGLlsgeyskpasgdgeqqpeqnQKGVQDGIA 412
           7******************************.99999999********************66666666666665544433355555*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             ++++  +++F++ +++++kcl+
   Q: 413  PRMFKSLVGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSENPNEVFRFLVEEKLKCLT 472
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +k                             +++cLe++ ++e++++   ++++  ++k+ a k+
   Q: 473  TGKVKYTQRVDYIMQLPVPMDAALNKDelleyeerkhqaeeekqplpelvrakvPFSSCLEAYGAPEQVDD---FWSTALQAKSMALKT 558
           *********************98877799****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s    +                                          
   Q: 559  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISALQGTglqpgeeempdiapplvtpdepkgslgfygnedddsfcsphf 646
           *******************997.*******************87776788888888888888888888888888888777777777777 PP
   S: 268  ...............................................................................peekqke... 274
                                                                                          +     +   
   Q: 647  ssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwimshmddpdfanplvlpgssgpgstivcpdppsedS-----Vati 730
           77777777777777777777777777777777766666666666666666666666666666666666666666555550.....0555 PP
   S: 275  ..................................................................kkkYeLiavvvHsG.slssGHYv 296
                                                                             + kY+L+a v+H+G s+ +GHYv
   Q: 731  vsmgfsrdqamkalratsnsleravdwifshiddldaeaamdisegrsaaesisesipvgpkvrdgPGKYQLFAFVSHMGtSTMCGHYV 819
           555555555555666666666667777777777777777777777777778888888888888888*********************** PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 820  CHIKK-DGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 854
           *****.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +ed ++ +v+MGF+r++a +aLra++n+le+Av++++++
   Q: 723  SEDSVATIVSMGFSRDQAMKALRATSNSLERAVDWIFSH 761
           699**********************************97 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MAELSEALLS VLPTIRVPKA GDRVHKEECA FSFDTPESDG GLYICMNTFL GFGKQYVEKY 60
YGKTGHRVYL HLKRTRKLKE EDSSSSAGDP PRKKPTRLAI GIEGGFDIPE EKFEYDDDVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTAACGGTA GCGCCACCTC TCTGCTTTTG CTCCTGGGTG AAACTGGATT GGCTGCCTAG 60
CCTCTGACAA CACACGTTTG TGATTGGTCA GGGTGGGGCT GTGGGCGGTG CCGCAGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pss:102452638

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.19	0.00e+00	660.00
IUUC-Aml-002104	Ailuropoda melanoleuca	89.78	0.00e+00	1533.00
IUUC-Atr-002580	Amborella trichopoda	46.26	0.00e+00	750.00
IUUC-Apl-003774	Anas platyrhynchos	94.86	0.00e+00	1600.00
IUUC-Aca-005368	Anolis carolinensis	90.20	0.00e+00	1590.00
IUUC-Aly-005727	Arabidopsis lyrata	47.15	0.00e+00	751.00
IUUC-Ath-006974	Arabidopsis thaliana	47.26	0.00e+00	753.00
IUUC-Ago-007890	Ashbya gossypii	27.64	1.00e-77	284.00
IUUC-Acl-008057	Aspergillus clavatus	34.47	3.00e-126	445.00
IUUC-Afl-008547	Aspergillus flavus	36.02	6.00e-117	414.00
IUUC-Afu-008805	Aspergillus fumigatus	34.65	5.00e-118	418.00
IUUC-Ani-009441	Aspergillus nidulans	32.80	1.00e-99	357.00
IUUC-Ang-009720	Aspergillus niger	34.15	2.00e-119	423.00
IUUC-Aor-010111	Aspergillus oryzae	33.88	4.00e-127	448.00
IUUC-Ate-010531	Aspergillus terreus	31.94	8.00e-106	377.00
IUUC-Ame-011893	Astyanax mexicanus	64.17	0.00e+00	991.00
IUUC-Bgr-012183	Blumeria graminis	34.14	6.00e-124	438.00
IUUC-Bta-013179	Bos taurus	89.99	0.00e+00	1537.00
IUUC-Bci-013858	Botrytis cinerea	34.07	5.00e-130	458.00
IUUC-Bdi-014904	Brachypodium distachyon	47.09	0.00e+00	724.00
IUUC-Bol-015296	Brassica oleracea	47.69	0.00e+00	759.00
IUUC-Bra-017939	Brassica rapa	47.79	0.00e+00	766.00
IUUC-Cel-018625	Caenorhabditis elegans	34.85	4.00e-133	468.00
IUUC-Cja-019063	Callithrix jacchus	88.38	0.00e+00	1507.00
IUUC-Cfa-020976	Canis familiaris	87.40	0.00e+00	1483.00
IUUC-Cpo-022265	Cavia porcellus	87.18	0.00e+00	1476.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.22	4.00e-118	418.00
IUUC-Csa-024177	Chlorocebus sabaeus	86.84	0.00e+00	1354.00
IUUC-Cho-024702	Choloepus hoffmanni	84.79	0.00e+00	945.00
IUUC-Cin-025411	Ciona intestinalis	50.71	0.00e+00	842.00
IUUC-Csv-026347	Ciona savignyi	45.77	0.00e+00	790.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.69	2.00e-116	412.00
IUUC-Cne-026831	Cryptococcus neoformans	35.29	3.00e-130	458.00
IUUC-Dre-027982	Danio rerio	66.51	0.00e+00	1101.00
IUUC-Dno-029034	Dasypus novemcinctus	89.99	0.00e+00	1547.00
IUUC-Dor-030479	Dipodomys ordii	88.13	0.00e+00	677.00
IUUC-Dse-031467	Dothistroma septosporum	36.05	6.00e-133	468.00
IUUC-Dme-032075	Drosophila melanogaster	49.31	0.00e+00	813.00
IUUC-Ete-032865	Echinops telfairi	80.81	0.00e+00	1370.00
IUUC-Eca-034059	Equus caballus	90.05	0.00e+00	1547.00
IUUC-Eeu-035304	Erinaceus europaeus	85.16	0.00e+00	1408.00
IUUC-Fca-035515	Felis catus	89.75	0.00e+00	1538.00
IUUC-Fal-037271	Ficedula albicollis	92.00	0.00e+00	1506.00
IUUC-Fox-037745	Fusarium oxysporum	35.31	3.00e-130	458.00
IUUC-Fso-038158	Fusarium solani	35.39	9.00e-129	454.00
IUUC-Gmo-039071	Gadus morhua	64.29	0.00e+00	1078.00
IUUC-Ggr-040098	Gaeumannomyces graminis	32.60	3.00e-118	419.00
IUUC-Gga-040635	Gallus gallus	95.45	0.00e+00	1688.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.45	0.00e+00	1093.00
IUUC-Gma-043614	Glycine max	46.62	0.00e+00	726.00
IUUC-Ggo-044602	Gorilla gorilla	89.87	0.00e+00	1537.00
IUUC-Hsa-045959	Homo sapiens	89.87	0.00e+00	1537.00
IUUC-Hvu-047563	Hordeum vulgare	47.66	9.00e-173	600.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	89.18	0.00e+00	1536.00
IUUC-Kpa-049156	Komagataella pastoris	33.06	1.00e-113	403.00
IUUC-Lch-049648	Latimeria chalumnae	81.07	0.00e+00	1385.00
IUUC-Lpe-051523	Leersia perrieri	46.43	0.00e+00	728.00
IUUC-Lma-053216	Leptosphaeria maculans	34.32	2.00e-115	410.00
IUUC-Laf-054327	Loxodonta africana	89.28	0.00e+00	1529.00
IUUC-Mcc-055443	Macaca mulatta	89.99	0.00e+00	1540.00
IUUC-Meu-056298	Macropus eugenii	89.79	0.00e+00	1022.00
IUUC-Mor-057106	Magnaporthe oryzae	36.11	2.00e-132	466.00
IUUC-Mpo-057589	Magnaporthe poae	33.76	2.00e-122	433.00
IUUC-Mtr-058680	Medicago truncatula	47.44	0.00e+00	737.00
IUUC-Mla-058903	Melampsora laricipopulina	32.08	1.00e-119	423.00
IUUC-Mga-059669	Meleagris gallopavo	94.55	0.00e+00	1598.00
IUUC-Mvi-060476	Microbotryum violaceum	34.89	1.00e-124	440.00
IUUC-Mmr-060575	Microcebus murinus	89.63	0.00e+00	1539.00
IUUC-Mdo-062183	Monodelphis domestica	88.34	0.00e+00	1477.00
IUUC-Mmu-063592	Mus musculus	90.22	0.00e+00	1543.00
IUUC-Mac-065634	Musa acuminata	43.18	0.00e+00	697.00
IUUC-Mpu-066082	Mustela putorius furo	86.93	0.00e+00	1476.00
IUUC-Mlu-067345	Myotis lucifugus	87.79	0.00e+00	1513.00
IUUC-Nfi-068558	Neosartorya fischeri	35.30	1.00e-126	447.00
IUUC-Ncr-068960	Neurospora crassa	34.45	6.00e-115	408.00
IUUC-Nle-070173	Nomascus leucogenys	87.16	0.00e+00	1474.00
IUUC-Opr-070556	Ochotona princeps	89.52	0.00e+00	1546.00
IUUC-Ont-071502	Oreochromis niloticus	64.42	0.00e+00	1085.00
IUUC-Ocu-074861	Oryctolagus cuniculus	87.04	0.00e+00	1490.00
IUUC-Oba-075109	Oryza barthii	46.84	0.00e+00	735.00
IUUC-Obr-076292	Oryza brachyantha	47.78	0.00e+00	730.00
IUUC-Ogl-077065	Oryza glaberrima	48.13	0.00e+00	765.00
IUUC-Ogu-078776	Oryza glumaepatula	47.07	0.00e+00	746.00
IUUC-Oin-080048	Oryza indica	47.90	0.00e+00	758.00
IUUC-Olo-080711	Oryza longistaminata	45.50	0.00e+00	679.00
IUUC-Ome-081506	Oryza meridionalis	46.57	0.00e+00	691.00
IUUC-Oni-082320	Oryza nivara	46.28	0.00e+00	733.00
IUUC-Opu-083801	Oryza punctata	46.96	0.00e+00	725.00
IUUC-Oru-085139	Oryza rufipogon	46.16	0.00e+00	734.00
IUUC-Osa-085713	Oryza sativa	48.25	0.00e+00	768.00
IUUC-Ola-086951	Oryzias latipes	64.88	0.00e+00	1077.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.13	0.00e+00	627.00
IUUC-Oga-088625	Otolemur garnettii	89.18	0.00e+00	1526.00
IUUC-Oar-089995	Ovis aries	87.68	0.00e+00	1511.00
IUUC-Ptr-090640	Pan troglodytes	87.87	0.00e+00	1531.00
IUUC-Pan-091974	Papio anubis	89.08	0.00e+00	1522.00
IUUC-Pma-094242	Petromyzon marinus	71.92	3.00e-170	590.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.52	7.00e-109	387.00
IUUC-Ppa-095901	Physcomitrella patens	48.91	0.00e+00	800.00
IUUC-Pfo-097148	Poecilia formosa	65.66	0.00e+00	1090.00
IUUC-Pab-098068	Pongo abelii	83.29	0.00e+00	1370.00
IUUC-Pop-098943	Populus trichocarpa	46.62	0.00e+00	732.00
IUUC-Pca-100738	Procavia capensis	91.21	0.00e+00	1089.00
IUUC-Pva-102154	Pteropus vampyrus	89.02	0.00e+00	1513.00
IUUC-Pgr-103343	Puccinia graminis	34.40	2.00e-107	383.00
IUUC-Ptt-103928	Puccinia triticina	30.23	1.00e-105	377.00
IUUC-Pte-104306	Pyrenophora teres	32.03	5.00e-105	375.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.64	2.00e-108	386.00
IUUC-Rno-105801	Rattus norvegicus	90.11	0.00e+00	1543.00
IUUC-Sce-106304	Saccharomyces cerevisiae	27.83	2.00e-74	273.00
IUUC-Sha-107635	Sarcophilus harrisii	87.75	0.00e+00	1481.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.55	2.00e-105	376.00
IUUC-Spo-108144	Schizosaccharomyces pombe	31.67	2.00e-111	396.00
IUUC-Smo-108848	Selaginella moellendorffii	48.18	0.00e+00	761.00
IUUC-Sit-110728	Setaria italica	47.09	0.00e+00	772.00
IUUC-Sly-111523	Solanum lycopersicum	47.97	0.00e+00	789.00
IUUC-Sbi-114419	Sorghum bicolor	47.31	0.00e+00	759.00
IUUC-Sre-115225	Sporisorium reilianum	34.54	9.00e-126	444.00
IUUC-Ssc-115686	Sus scrofa	88.47	0.00e+00	1525.00
IUUC-Tgu-117346	Taeniopygia guttata	94.76	0.00e+00	1650.00
IUUC-Tru-118350	Takifugu rubripes	64.55	0.00e+00	1110.00
IUUC-Tni-120658	Tetraodon nigroviridis	66.09	0.00e+00	1099.00
IUUC-Tca-121585	Theobroma cacao	48.08	0.00e+00	751.00
IUUC-Tre-122043	Trichoderma reesei	34.34	9.00e-121	427.00
IUUC-Tvi-122303	Trichoderma virens	34.34	3.00e-124	439.00
IUUC-Tae-125686	Triticum aestivum	46.96	0.00e+00	741.00
IUUC-Tur-126732	Triticum urartu	44.48	0.00e+00	696.00
IUUC-Tme-126909	Tuber melanosporum	34.64	1.00e-118	420.00
IUUC-Tbe-127261	Tupaia belangeri	85.07	0.00e+00	984.00
IUUC-Uma-129599	Ustilago maydis	34.09	8.00e-132	464.00
IUUC-Vda-129688	Verticillium dahliae	33.72	9.00e-121	427.00
IUUC-Vvi-131116	Vitis vinifera	47.56	0.00e+00	722.00
IUUC-Xtr-131953	Xenopus tropicalis	79.28	0.00e+00	1373.00
IUUC-Xma-133837	Xiphophorus maculatus	65.77	0.00e+00	1092.00
IUUC-Yli-134510	Yarrowia lipolytica	34.75	2.00e-128	452.00
IUUC-Zma-135786	Zea mays	46.85	0.00e+00	724.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence