iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003306

Ensembl Protein ID

ENSAPLP00000002182.1

UniProt Accession

U3I4L1; U3I4L1_ANAPL

Genbank Protein ID

ENSAPLP00000002182

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

ADON01010251

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000002704.1	ENSAPLT00000002768.1	ENSAPLP00000002182.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	7.70e-92	308.0	14	350

Active Site

Position(s)	Description	Evidence
89	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
165	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 13   sdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCat 101
           sdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakqvi+N+Cat
   Q: 14   SDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQVINNACAT 91
           9*****************.****************.********************.........899********************* PP
   S: 102  yAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrl 190
           +A++svllnc ++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + + +++    +++afhfvsyv++ngrl
   Q: 92   QAIVSVLLNCAHQDIHLGETLSEFKEFSQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSSAK----EEDAFHFVSYVPVNGRL 176
           **************************************************************888776....89*************** PP
   S: 191  yeldglkpfPldlgkkketeelkdklkvv...........................raflerikllesdeirfnllaivadrrviktlr 252
           yeldgl++ P+dl   ++++++ ++++ v                               +    ++++eirfnl+aiv+dr++i+++r
   Q: 177  YELDGLREGPIDLVGACNQDDWISAVRPViekriqnkgfqvcwlfwkfqpekgtteV--SQLPSSYSEGEIRFNLMAIVSDRKMIYEQR 263
           ************************************************999886531..3334479999******************** PP
   S: 253  lnvlkid.........keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevref 332
           +  l+ +          +  ++l+ i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+      ++
   Q: 264  IAELQRQlaeeepmdtDQSSNMLSSIQSEVAKYQMLIEEENQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAK---EKQ 349
           977666567888888755678**********************************************************9942...233 PP
   S: 333  g 333
           +
   Q: 350  N 350
           3 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MEDSAGIFCF HNHSDPGVFT ELIKGFGCRG AQVEEIWSLE PENFEKLKPV HGLIFLFKWQ 60
PGEEPAGSVV QDSRLDTIFF AKQVINNACA TQAIVSVLLN CAHQDIHLGE TLSEFKEFSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGATT CAGCAGGAAT ATTCTGCTTC CATAACCATG TCCGATTTCT GAGCTGTTTG 60
AATGCAGACA GCAGTGTGAA AAGTCTTAAA GTGTCTACTC TGCACCTGAC AGCAGTGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	42.94	7.00e-76	276.00
IUUC-Aml-001866	Ailuropoda melanoleuca	85.96	3.00e-169	587.00
IUUC-Atr-002966	Amborella trichopoda	44.41	5.00e-75	274.00
IUUC-Aca-004763	Anolis carolinensis	87.02	3.00e-170	590.00
IUUC-Aly-005581	Arabidopsis lyrata	44.60	3.00e-70	258.00
IUUC-Ath-007283	Arabidopsis thaliana	44.32	3.00e-72	264.00
IUUC-Ago-007999	Ashbya gossypii	40.80	2.00e-30	125.00
IUUC-Acl-008231	Aspergillus clavatus	38.01	3.00e-44	171.00
IUUC-Afl-008557	Aspergillus flavus	34.02	5.00e-46	177.00
IUUC-Afu-008988	Aspergillus fumigatus	39.34	2.00e-45	175.00
IUUC-Ani-009420	Aspergillus nidulans	34.94	4.00e-46	177.00
IUUC-Ang-009859	Aspergillus niger	37.50	5.00e-41	160.00
IUUC-Aor-010145	Aspergillus oryzae	34.02	5.00e-46	177.00
IUUC-Ate-010347	Aspergillus terreus	38.46	6.00e-45	174.00
IUUC-Ame-010791	Astyanax mexicanus	82.12	5.00e-172	596.00
IUUC-Bgr-012298	Blumeria graminis	34.88	2.00e-41	162.00
IUUC-Bta-013251	Bos taurus	85.67	1.00e-167	581.00
IUUC-Bci-013786	Botrytis cinerea	34.82	2.00e-48	185.00
IUUC-Bdi-014132	Brachypodium distachyon	45.09	3.00e-73	268.00
IUUC-Bol-015611	Brassica oleracea	45.56	2.00e-75	275.00
IUUC-Bra-017769	Brassica rapa	45.43	3.00e-75	275.00
IUUC-Cel-018604	Caenorhabditis elegans	41.81	3.00e-74	271.00
IUUC-Cja-019768	Callithrix jacchus	86.30	2.00e-171	594.00
IUUC-Cfa-020207	Canis familiaris	85.96	3.00e-169	587.00
IUUC-Cpo-021925	Cavia porcellus	82.16	3.00e-161	560.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	42.23	1.00e-65	242.00
IUUC-Csa-023958	Chlorocebus sabaeus	85.09	5.00e-166	576.00
IUUC-Cho-024928	Choloepus hoffmanni	97.40	1.00e-41	163.00
IUUC-Cin-025771	Ciona intestinalis	48.30	4.00e-89	320.00
IUUC-Csv-026149	Ciona savignyi	51.72	7.00e-93	333.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	34.33	8.00e-46	176.00
IUUC-Cne-026955	Cryptococcus neoformans	33.90	4.00e-47	181.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.16	4.00e-43	167.00
IUUC-Dre-027409	Danio rerio	81.84	7.00e-170	589.00
IUUC-Dno-028921	Dasypus novemcinctus	85.38	6.00e-168	582.00
IUUC-Dse-031170	Dothistroma septosporum	34.44	1.00e-49	189.00
IUUC-Dme-031677	Drosophila melanogaster	55.46	2.00e-105	375.00
IUUC-Ete-032707	Echinops telfairi	60.17	6.00e-106	376.00
IUUC-Eca-033776	Equus caballus	87.34	6.00e-160	555.00
IUUC-Eeu-035305	Erinaceus europaeus	73.02	4.00e-75	274.00
IUUC-Fca-035846	Felis catus	87.13	5.00e-173	599.00
IUUC-Fal-037597	Ficedula albicollis	90.19	1.00e-157	548.00
IUUC-Fox-037670	Fusarium oxysporum	43.43	2.00e-45	175.00
IUUC-Fso-038243	Fusarium solani	43.43	8.00e-45	173.00
IUUC-Gmo-038499	Gadus morhua	77.19	4.00e-153	533.00
IUUC-Ggr-039975	Gaeumannomyces graminis	37.59	1.00e-40	159.00
IUUC-Gga-040904	Gallus gallus	89.30	0.00e+00	628.00
IUUC-Gac-042058	Gasterosteus aculeatus	81.29	1.00e-161	561.00
IUUC-Gma-043763	Glycine max	45.28	2.00e-76	278.00
IUUC-Ggo-044699	Gorilla gorilla	79.76	3.00e-151	527.00
IUUC-Hsa-046227	Homo sapiens	85.38	3.00e-168	583.00
IUUC-Hvu-047359	Hordeum vulgare	43.02	9.00e-75	273.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	86.53	8.00e-172	595.00
IUUC-Lch-049829	Latimeria chalumnae	83.92	4.00e-165	573.00
IUUC-Lpe-050899	Leersia perrieri	43.66	1.00e-68	252.00
IUUC-Loc-052264	Lepisosteus oculatus	82.80	6.00e-164	569.00
IUUC-Lma-053110	Leptosphaeria maculans	34.78	3.00e-39	155.00
IUUC-Laf-053639	Loxodonta africana	85.96	3.00e-169	587.00
IUUC-Mcc-055506	Macaca mulatta	85.09	6.00e-166	576.00
IUUC-Mor-057001	Magnaporthe oryzae	39.70	2.00e-45	176.00
IUUC-Mpo-057608	Magnaporthe poae	40.78	1.00e-30	125.00
IUUC-Mtr-057731	Medicago truncatula	43.98	2.00e-75	275.00
IUUC-Mla-059016	Melampsora laricipopulina	43.01	2.00e-41	161.00
IUUC-Mga-060178	Meleagris gallopavo	90.66	4.00e-173	599.00
IUUC-Mvi-060353	Microbotryum violaceum	35.54	8.00e-49	187.00
IUUC-Mmr-060738	Microcebus murinus	85.38	3.00e-168	583.00
IUUC-Mdo-062266	Monodelphis domestica	96.46	7.00e-113	399.00
IUUC-Mmu-063619	Mus musculus	83.92	7.00e-166	575.00
IUUC-Mac-065301	Musa acuminata	46.61	1.00e-79	289.00
IUUC-Mpu-066058	Mustela putorius furo	86.26	1.00e-169	588.00
IUUC-Mlu-067292	Myotis lucifugus	84.80	8.00e-166	575.00
IUUC-Nfi-068275	Neosartorya fischeri	34.88	5.00e-47	180.00
IUUC-Ncr-068713	Neurospora crassa	36.20	7.00e-51	193.00
IUUC-Nle-069013	Nomascus leucogenys	84.80	1.00e-165	575.00
IUUC-Opr-070628	Ochotona princeps	82.75	3.00e-162	564.00
IUUC-Ont-072688	Oreochromis niloticus	81.98	4.00e-162	563.00
IUUC-Oan-073004	Ornithorhynchus anatinus	86.13	7.00e-135	472.00
IUUC-Ocu-074303	Oryctolagus cuniculus	86.26	6.00e-170	590.00
IUUC-Oba-075002	Oryza barthii	44.35	3.00e-73	268.00
IUUC-Obr-076392	Oryza brachyantha	45.00	2.00e-70	258.00
IUUC-Ogl-077271	Oryza glaberrima	44.35	3.00e-73	268.00
IUUC-Ogu-078493	Oryza glumaepatula	44.35	3.00e-73	268.00
IUUC-Oin-080084	Oryza indica	44.35	3.00e-73	268.00
IUUC-Olo-080803	Oryza longistaminata	44.07	6.00e-73	267.00
IUUC-Ome-081146	Oryza meridionalis	43.50	7.00e-72	263.00
IUUC-Oni-082146	Oryza nivara	44.35	3.00e-73	268.00
IUUC-Opu-083633	Oryza punctata	44.54	3.00e-69	254.00
IUUC-Oru-084789	Oryza rufipogon	44.35	3.00e-73	268.00
IUUC-Osa-086196	Oryza sativa	44.35	3.00e-73	268.00
IUUC-Ola-087126	Oryzias latipes	82.16	6.00e-158	549.00
IUUC-Olu-087665	Ostreococcus lucimarinus	38.39	9.00e-61	226.00
IUUC-Oga-089140	Otolemur garnettii	86.55	1.00e-172	598.00
IUUC-Oar-090296	Ovis aries	85.96	2.00e-169	587.00
IUUC-Ptr-090566	Pan troglodytes	85.38	3.00e-168	583.00
IUUC-Pan-092052	Papio anubis	85.09	6.00e-166	576.00
IUUC-Psi-093723	Pelodiscus sinensis	88.92	1.00e-162	565.00
IUUC-Pma-094568	Petromyzon marinus	55.38	3.00e-101	361.00
IUUC-Pno-095120	Phaeosphaeria nodorum	35.13	4.00e-41	160.00
IUUC-Ppa-095761	Physcomitrella patens	43.72	1.00e-75	276.00
IUUC-Pfo-096210	Poecilia formosa	80.99	2.00e-161	561.00
IUUC-Pab-098463	Pongo abelii	85.38	3.00e-168	583.00
IUUC-Pop-099423	Populus trichocarpa	45.13	6.00e-76	277.00
IUUC-Pca-100108	Procavia capensis	83.88	9.00e-130	455.00
IUUC-Ppe-101176	Prunus persica	46.20	2.00e-75	275.00
IUUC-Pva-102629	Pteropus vampyrus	81.44	2.00e-132	464.00
IUUC-Pgr-103419	Puccinia graminis	37.14	1.00e-49	189.00
IUUC-Pte-104207	Pyrenophora teres	44.10	9.00e-30	122.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	35.69	6.00e-48	184.00
IUUC-Rno-105579	Rattus norvegicus	77.21	1.00e-151	528.00
IUUC-Sha-106894	Sarcophilus harrisii	84.87	2.00e-148	517.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	35.19	2.00e-51	195.00
IUUC-Spo-108371	Schizosaccharomyces pombe	38.34	2.00e-53	202.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	35.86	3.00e-42	165.00
IUUC-Smo-109396	Selaginella moellendorffii	47.13	1.00e-79	289.00
IUUC-Sit-110630	Setaria italica	45.95	2.00e-77	282.00
IUUC-Sly-110972	Solanum lycopersicum	45.43	8.00e-75	273.00
IUUC-Stu-112185	Solanum tuberosum	45.76	7.00e-80	290.00
IUUC-Sar-113294	Sorex araneus	79.30	3.00e-154	537.00
IUUC-Sbi-113951	Sorghum bicolor	46.24	6.00e-78	283.00
IUUC-Ssc-115501	Sus scrofa	87.08	1.00e-163	568.00
IUUC-Tgu-117152	Taeniopygia guttata	89.87	1.00e-157	548.00
IUUC-Tru-118388	Takifugu rubripes	80.99	9.00e-162	561.00
IUUC-Tsy-119109	Tarsius syrichta	85.67	1.00e-168	585.00
IUUC-Tni-120048	Tetraodon nigroviridis	80.99	3.00e-162	563.00
IUUC-Tca-121750	Theobroma cacao	46.54	1.00e-79	289.00
IUUC-Tre-122130	Trichoderma reesei	35.62	2.00e-47	182.00
IUUC-Tvi-122284	Trichoderma virens	35.83	3.00e-44	171.00
IUUC-Tae-124082	Triticum aestivum	43.55	4.00e-74	271.00
IUUC-Tur-126366	Triticum urartu	40.63	2.00e-61	229.00
IUUC-Tme-127187	Tuber melanosporum	37.15	9.00e-51	193.00
IUUC-Tbe-127619	Tupaia belangeri	79.37	6.00e-134	469.00
IUUC-Ttr-128867	Tursiops truncatus	85.77	2.00e-121	427.00
IUUC-Vda-129912	Verticillium dahliae	34.70	3.00e-45	174.00
IUUC-Vpa-130552	Vicugna pacos	93.36	1.00e-115	409.00
IUUC-Vvi-130881	Vitis vinifera	46.67	4.00e-76	277.00
IUUC-Xtr-131934	Xenopus tropicalis	77.65	6.00e-163	566.00
IUUC-Xma-133312	Xiphophorus maculatus	80.70	2.00e-160	557.00
IUUC-Yli-134487	Yarrowia lipolytica	35.55	7.00e-40	157.00
IUUC-Zma-135462	Zea mays	40.52	1.00e-64	239.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence