iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053775

UUCD1 version

UUC-LoA-00219

Ensembl Protein ID

ENSLAFP00000005161.3

UniProt Accession

G3SXM1; G3SXM1_LOXAF

Protein Name

Uncharacterized protein

Gene Name

RFWD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000006150.3	ENSLAFT00000006152.3	ENSLAFP00000005161.3
ENSLAFG00000006150.3	ENSLAFT00000026772.1	ENSLAFP00000025591.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-23	81.3	470	499
E3 activity/RING/RING	2.60e-06	28.2	136	174

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tdsvtclaf..sd.tllvsGsdDgtikvWD 29
           +++++c+++     +ll+s+ + gt+ +WD
   Q: 470  NSKISCISWssYHkNLLASSDYEGTVILWD 499
           689******9622599************** PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++++  + + CgH f+ +C+++          + rCP C+
   Q: 136  CPICFDMIEE-AYMTKCGHSFCYKCIHQS------LEDNNRCPKCN 174
           ********99.888***********9555......999999****6 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSGSRPAGSG SAGKSPGSSA ASSLTSASSS LSSSPSPPSV AASAAALVSG GAAQAAGSGG 60
LGGPVRPVLV AAAASGSGGG AVSVGPSRLS CAARPSPGVG GSSSSLGSGS RKRPLPTPLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCAGGTA GCCGCCCGGC CGGATCGGGC TCCGCTGGGA AGAGCCCTGG CTCCTCGGCG 60
GCCTCCTCGT TGACTTCCGC CTCCTCGTCC TTATCCTCTT CCCCGTCGCC CCCTTCCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00400--WD40

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000885	Aegilops tauschii	39.97	3.00e-125	442.00
IUUC-Aml-001265	Ailuropoda melanoleuca	98.70	0.00e+00	1237.00
IUUC-Atr-002460	Amborella trichopoda	38.85	5.00e-125	441.00
IUUC-Apl-003796	Anas platyrhynchos	97.42	0.00e+00	1151.00
IUUC-Aca-005078	Anolis carolinensis	96.76	0.00e+00	1196.00
IUUC-Aly-006014	Arabidopsis lyrata	39.81	2.00e-129	456.00
IUUC-Ath-007636	Arabidopsis thaliana	39.72	3.00e-129	455.00
IUUC-Ame-011176	Astyanax mexicanus	75.27	7.00e-70	258.00
IUUC-Bta-012595	Bos taurus	98.28	0.00e+00	1245.00
IUUC-Bdi-014152	Brachypodium distachyon	39.01	4.00e-128	451.00
IUUC-Bol-016380	Brassica oleracea	40.00	4.00e-130	458.00
IUUC-Bra-017690	Brassica rapa	38.87	9.00e-125	440.00
IUUC-Cja-018926	Callithrix jacchus	98.12	0.00e+00	1240.00
IUUC-Cfa-021088	Canis familiaris	98.28	0.00e+00	1249.00
IUUC-Cpo-022442	Cavia porcellus	97.31	0.00e+00	1213.00
IUUC-Cre-022579	Chlamydomonas reinhardtii	33.45	2.00e-33	135.00
IUUC-Csa-024119	Chlorocebus sabaeus	96.90	0.00e+00	1237.00
IUUC-Cho-024883	Choloepus hoffmanni	66.45	5.00e-105	375.00
IUUC-Cin-025375	Ciona intestinalis	55.59	0.00e+00	675.00
IUUC-Cme-027350	Cyanidioschyzon merolae	41.42	2.00e-78	286.00
IUUC-Dre-028453	Danio rerio	87.48	0.00e+00	1073.00
IUUC-Dno-029887	Dasypus novemcinctus	98.27	0.00e+00	1239.00
IUUC-Dor-031110	Dipodomys ordii	80.04	0.00e+00	915.00
IUUC-Ete-033016	Echinops telfairi	84.27	0.00e+00	1040.00
IUUC-Eca-034403	Equus caballus	98.61	0.00e+00	1155.00
IUUC-Eeu-034690	Erinaceus europaeus	83.48	0.00e+00	950.00
IUUC-Fca-036475	Felis catus	97.93	0.00e+00	1156.00
IUUC-Fal-037189	Ficedula albicollis	97.97	0.00e+00	1181.00
IUUC-Gmo-039245	Gadus morhua	86.32	0.00e+00	1053.00
IUUC-Gga-040806	Gallus gallus	97.73	0.00e+00	1228.00
IUUC-Gac-042177	Gasterosteus aculeatus	87.60	0.00e+00	1091.00
IUUC-Gma-044187	Glycine max	40.96	8.00e-127	447.00
IUUC-Ggo-044430	Gorilla gorilla	97.67	0.00e+00	926.00
IUUC-Hsa-045853	Homo sapiens	98.59	0.00e+00	1246.00
IUUC-Hvu-047750	Hordeum vulgare	38.52	1.00e-93	338.00
IUUC-Itr-048238	Ictidomys tridecemlineatus	99.17	1.00e-143	501.00
IUUC-Lch-050420	Latimeria chalumnae	91.83	0.00e+00	1141.00
IUUC-Lpe-051219	Leersia perrieri	38.82	3.00e-124	439.00
IUUC-Loc-052728	Lepisosteus oculatus	91.56	0.00e+00	1100.00
IUUC-Meu-056595	Macropus eugenii	76.53	5.00e-175	607.00
IUUC-Mtr-058555	Medicago truncatula	40.33	2.00e-133	469.00
IUUC-Mga-059646	Meleagris gallopavo	97.08	0.00e+00	1149.00
IUUC-Mmr-060990	Microcebus murinus	98.28	0.00e+00	1247.00
IUUC-Mdo-062287	Monodelphis domestica	98.22	0.00e+00	1234.00
IUUC-Mmu-064097	Mus musculus	97.97	0.00e+00	1246.00
IUUC-Mac-065240	Musa acuminata	41.26	3.00e-135	475.00
IUUC-Mpu-066612	Mustela putorius furo	97.94	0.00e+00	1159.00
IUUC-Mlu-067967	Myotis lucifugus	96.46	0.00e+00	1156.00
IUUC-Nle-069543	Nomascus leucogenys	98.28	0.00e+00	1244.00
IUUC-Opr-070366	Ochotona princeps	82.94	0.00e+00	709.00
IUUC-Ont-071522	Oreochromis niloticus	87.28	0.00e+00	1078.00
IUUC-Oan-073409	Ornithorhynchus anatinus	97.77	0.00e+00	1153.00
IUUC-Ocu-073756	Oryctolagus cuniculus	97.92	0.00e+00	1216.00
IUUC-Oba-075149	Oryza barthii	38.83	2.00e-126	447.00
IUUC-Obr-076563	Oryza brachyantha	39.35	3.00e-126	445.00
IUUC-Ogl-077701	Oryza glaberrima	38.83	9.00e-127	447.00
IUUC-Ogu-078383	Oryza glumaepatula	38.83	9.00e-127	447.00
IUUC-Oin-079965	Oryza indica	36.99	5.00e-113	401.00
IUUC-Olo-080639	Oryza longistaminata	38.61	3.00e-124	439.00
IUUC-Ome-081821	Oryza meridionalis	38.46	1.00e-114	407.00
IUUC-Oni-082622	Oryza nivara	38.83	9.00e-127	447.00
IUUC-Opu-083295	Oryza punctata	38.83	1.00e-126	447.00
IUUC-Oru-084661	Oryza rufipogon	38.83	9.00e-127	447.00
IUUC-Osa-085766	Oryza sativa	38.83	9.00e-127	447.00
IUUC-Ola-086727	Oryzias latipes	87.26	0.00e+00	1097.00
IUUC-Olu-087702	Ostreococcus lucimarinus	42.77	5.00e-68	250.00
IUUC-Oga-088215	Otolemur garnettii	96.56	0.00e+00	1223.00
IUUC-Oar-089880	Ovis aries	98.25	0.00e+00	1219.00
IUUC-Ptr-090597	Pan troglodytes	98.59	0.00e+00	1246.00
IUUC-Pan-091987	Papio anubis	98.28	0.00e+00	1244.00
IUUC-Psi-094033	Pelodiscus sinensis	97.27	0.00e+00	1154.00
IUUC-Pma-094587	Petromyzon marinus	69.84	0.00e+00	798.00
IUUC-Ppa-095256	Physcomitrella patens	39.67	2.00e-132	466.00
IUUC-Pfo-097388	Poecilia formosa	86.11	0.00e+00	1058.00
IUUC-Pab-098029	Pongo abelii	98.59	0.00e+00	1247.00
IUUC-Pop-099319	Populus trichocarpa	39.41	2.00e-130	459.00
IUUC-Pca-100846	Procavia capensis	91.37	0.00e+00	1142.00
IUUC-Ppe-101250	Prunus persica	38.31	6.00e-120	424.00
IUUC-Pva-102407	Pteropus vampyrus	97.81	0.00e+00	1233.00
IUUC-Rno-105312	Rattus norvegicus	97.97	0.00e+00	1243.00
IUUC-Sha-106514	Sarcophilus harrisii	98.39	0.00e+00	767.00
IUUC-Smo-109418	Selaginella moellendorffii	40.25	2.00e-129	456.00
IUUC-Sit-110248	Setaria italica	38.79	1.00e-127	450.00
IUUC-Sly-110964	Solanum lycopersicum	40.28	2.00e-130	459.00
IUUC-Stu-112882	Solanum tuberosum	40.59	9.00e-132	464.00
IUUC-Sar-113230	Sorex araneus	71.36	0.00e+00	794.00
IUUC-Sbi-113962	Sorghum bicolor	36.91	2.00e-122	433.00
IUUC-Ssc-115987	Sus scrofa	97.34	4.00e-178	617.00
IUUC-Tgu-116471	Taeniopygia guttata	97.73	0.00e+00	1228.00
IUUC-Tru-118231	Takifugu rubripes	86.95	0.00e+00	1044.00
IUUC-Tsy-119415	Tarsius syrichta	97.97	0.00e+00	1159.00
IUUC-Tni-120893	Tetraodon nigroviridis	86.59	0.00e+00	1055.00
IUUC-Tca-121703	Theobroma cacao	41.15	3.00e-129	455.00
IUUC-Tae-125317	Triticum aestivum	41.02	4.00e-133	468.00
IUUC-Tur-126557	Triticum urartu	40.66	4.00e-128	451.00
IUUC-Tbe-127253	Tupaia belangeri	71.29	0.00e+00	847.00
IUUC-Ttr-129100	Tursiops truncatus	96.62	0.00e+00	1128.00
IUUC-Vpa-130613	Vicugna pacos	92.39	0.00e+00	1089.00
IUUC-Vvi-130880	Vitis vinifera	41.17	3.00e-123	435.00
IUUC-Xtr-132033	Xenopus tropicalis	95.14	0.00e+00	1226.00
IUUC-Xma-133421	Xiphophorus maculatus	85.95	0.00e+00	1055.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence