iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053718

Ensembl Protein ID

ENSLAFP00000009251.3

UniProt Accession

G3T6S5; G3T6S5_LOXAF

Protein Name

Protein HIRA

Gene Name

HIRA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011054.3	ENSLAFT00000011056.3	ENSLAFP00000009251.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-20	72.0	69	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 69   HLACVNCVRWsNSgMYLASGGDDKLIMVWK 98
           8899******955699*************7 PP

Organism

Loxodonta africana

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

MKLLKPTWVN HNGKPIFSID IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ EDDEKDENIP 60
KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA TYIGPSTVFG SSGKLSNVEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGCTCC TGAAGCCGAC CTGGGTCAAC CACAATGGTG AGTATGTGTA GGGGTCGCAG 60
GAGGACAAGC CCGGAAGCGG GTCGGGGTCC ATAGTCAGGT CGGGGCCGCG CGCAGGCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0043234--C:protein complex
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001039	Aegilops tauschii	40.28	2.00e-89	324.00
IUUC-Aml-001723	Ailuropoda melanoleuca	95.22	0.00e+00	1749.00
IUUC-Atr-003132	Amborella trichopoda	41.92	1.00e-88	321.00
IUUC-Apl-003197	Anas platyrhynchos	85.17	0.00e+00	1626.00
IUUC-Aca-004733	Anolis carolinensis	83.02	0.00e+00	1585.00
IUUC-Aly-005446	Arabidopsis lyrata	40.77	2.00e-82	301.00
IUUC-Ath-007627	Arabidopsis thaliana	37.23	2.00e-85	310.00
IUUC-Ago-007766	Ashbya gossypii	31.07	5.00e-59	222.00
IUUC-Acl-008104	Aspergillus clavatus	29.71	8.00e-64	238.00
IUUC-Afl-008591	Aspergillus flavus	30.98	1.00e-65	244.00
IUUC-Afu-008781	Aspergillus fumigatus	33.99	3.00e-58	220.00
IUUC-Ani-009272	Aspergillus nidulans	28.57	7.00e-54	206.00
IUUC-Ang-009655	Aspergillus niger	33.42	5.00e-65	243.00
IUUC-Aor-010119	Aspergillus oryzae	30.98	4.00e-66	246.00
IUUC-Ate-010530	Aspergillus terreus	27.91	5.00e-57	216.00
IUUC-Ame-011147	Astyanax mexicanus	84.00	1.00e-52	197.00
IUUC-Bgr-012237	Blumeria graminis	33.83	7.00e-63	235.00
IUUC-Bta-013320	Bos taurus	90.10	0.00e+00	1745.00
IUUC-Bci-013795	Botrytis cinerea	29.89	4.00e-68	253.00
IUUC-Bdi-014075	Brachypodium distachyon	37.92	4.00e-92	332.00
IUUC-Bol-016440	Brassica oleracea	35.93	2.00e-89	323.00
IUUC-Bra-016651	Brassica rapa	37.66	4.00e-87	316.00
IUUC-Cel-018692	Caenorhabditis elegans	38.36	3.00e-76	280.00
IUUC-Cja-018987	Callithrix jacchus	95.18	0.00e+00	1680.00
IUUC-Cfa-020132	Canis familiaris	94.30	0.00e+00	1751.00
IUUC-Cpo-021484	Cavia porcellus	94.69	0.00e+00	1771.00
IUUC-Cre-022846	Chlamydomonas reinhardtii	35.68	2.00e-61	231.00
IUUC-Csa-023081	Chlorocebus sabaeus	95.67	0.00e+00	1780.00
IUUC-Cin-025182	Ciona intestinalis	56.06	4.00e-156	545.00
IUUC-Csv-026154	Ciona savignyi	55.35	7.00e-152	531.00
IUUC-Cgl-026655	Colletotrichum gloeosporioides	31.36	3.00e-66	247.00
IUUC-Cne-026891	Cryptococcus neoformans	41.35	6.00e-83	302.00
IUUC-Cme-027349	Cyanidioschyzon merolae	28.65	3.00e-52	200.00
IUUC-Dre-027655	Danio rerio	69.43	0.00e+00	1347.00
IUUC-Dno-029557	Dasypus novemcinctus	85.68	0.00e+00	1111.00
IUUC-Dor-030687	Dipodomys ordii	81.82	0.00e+00	740.00
IUUC-Dse-031334	Dothistroma septosporum	30.29	4.00e-62	233.00
IUUC-Dme-031746	Drosophila melanogaster	55.65	8.00e-159	554.00
IUUC-Ete-032384	Echinops telfairi	90.82	0.00e+00	1664.00
IUUC-Eca-033430	Equus caballus	95.12	0.00e+00	1740.00
IUUC-Fca-036121	Felis catus	94.66	0.00e+00	1753.00
IUUC-Fal-036817	Ficedula albicollis	85.25	0.00e+00	1626.00
IUUC-Fox-037906	Fusarium oxysporum	34.86	6.00e-69	255.00
IUUC-Fso-038409	Fusarium solani	33.73	1.00e-67	251.00
IUUC-Gmo-039151	Gadus morhua	85.71	0.00e+00	702.00
IUUC-Ggr-040016	Gaeumannomyces graminis	34.79	3.00e-70	260.00
IUUC-Gga-040936	Gallus gallus	85.74	0.00e+00	1705.00
IUUC-Gac-041405	Gasterosteus aculeatus	63.17	0.00e+00	1196.00
IUUC-Gma-044252	Glycine max	36.47	2.00e-89	324.00
IUUC-Ggo-045430	Gorilla gorilla	95.68	0.00e+00	1779.00
IUUC-Hsa-046442	Homo sapiens	95.58	0.00e+00	1779.00
IUUC-Hvu-047587	Hordeum vulgare	37.77	8.00e-80	291.00
IUUC-Itr-048910	Ictidomys tridecemlineatus	99.33	3.00e-175	607.00
IUUC-Kpa-049145	Komagataella pastoris	31.13	2.00e-60	227.00
IUUC-Lch-050474	Latimeria chalumnae	76.30	0.00e+00	1424.00
IUUC-Lpe-051209	Leersia perrieri	36.50	2.00e-85	310.00
IUUC-Loc-052119	Lepisosteus oculatus	73.44	0.00e+00	1380.00
IUUC-Lma-053237	Leptosphaeria maculans	33.07	3.00e-67	250.00
IUUC-Mcc-055621	Macaca mulatta	95.38	0.00e+00	1686.00
IUUC-Meu-055914	Macropus eugenii	78.10	0.00e+00	1453.00
IUUC-Mor-057090	Magnaporthe oryzae	33.97	1.00e-67	251.00
IUUC-Mpo-057364	Magnaporthe poae	31.71	2.00e-72	267.00
IUUC-Mtr-057744	Medicago truncatula	38.07	5.00e-91	329.00
IUUC-Mla-058914	Melampsora laricipopulina	41.67	9.00e-85	308.00
IUUC-Mga-060181	Meleagris gallopavo	83.74	0.00e+00	1643.00
IUUC-Mvi-060432	Microbotryum violaceum	37.78	7.00e-74	272.00
IUUC-Mmr-060871	Microcebus murinus	94.89	0.00e+00	1827.00
IUUC-Mdo-062301	Monodelphis domestica	86.68	0.00e+00	1627.00
IUUC-Mmu-063888	Mus musculus	93.71	0.00e+00	1747.00
IUUC-Mac-065137	Musa acuminata	39.40	5.00e-91	329.00
IUUC-Mpu-066732	Mustela putorius furo	94.83	0.00e+00	1782.00
IUUC-Mlu-067542	Myotis lucifugus	94.39	0.00e+00	1721.00
IUUC-Nfi-068396	Neosartorya fischeri	33.99	2.00e-58	221.00
IUUC-Ncr-068842	Neurospora crassa	32.46	2.00e-68	254.00
IUUC-Nle-070156	Nomascus leucogenys	95.38	0.00e+00	1788.00
IUUC-Opr-070808	Ochotona princeps	93.62	0.00e+00	1421.00
IUUC-Ont-072105	Oreochromis niloticus	67.83	0.00e+00	1317.00
IUUC-Ocu-074962	Oryctolagus cuniculus	95.02	0.00e+00	1769.00
IUUC-Oba-075178	Oryza barthii	42.35	4.00e-91	329.00
IUUC-Obr-076399	Oryza brachyantha	37.45	1.00e-91	331.00
IUUC-Ogu-078797	Oryza glumaepatula	42.35	4.00e-91	329.00
IUUC-Oin-080085	Oryza indica	40.80	7.00e-78	285.00
IUUC-Olo-081048	Oryza longistaminata	41.04	4.00e-66	246.00
IUUC-Ome-081324	Oryza meridionalis	42.35	5.00e-91	329.00
IUUC-Oni-082548	Oryza nivara	42.35	5.00e-91	329.00
IUUC-Opu-084008	Oryza punctata	42.35	4.00e-91	329.00
IUUC-Oru-084339	Oryza rufipogon	42.09	1.00e-90	327.00
IUUC-Osa-085782	Oryza sativa	42.09	1.00e-90	327.00
IUUC-Ola-087302	Oryzias latipes	67.65	0.00e+00	795.00
IUUC-Olu-087611	Ostreococcus lucimarinus	36.02	4.00e-90	325.00
IUUC-Oga-087935	Otolemur garnettii	94.25	0.00e+00	1721.00
IUUC-Oar-089229	Ovis aries	70.00	0.00e+00	1048.00
IUUC-Ptr-090715	Pan troglodytes	95.67	0.00e+00	1781.00
IUUC-Pan-092318	Papio anubis	95.53	0.00e+00	1750.00
IUUC-Psi-094053	Pelodiscus sinensis	83.72	0.00e+00	1630.00
IUUC-Pno-094985	Phaeosphaeria nodorum	32.60	8.00e-59	222.00
IUUC-Ppa-095819	Physcomitrella patens	39.55	8.00e-89	322.00
IUUC-Pfo-096857	Poecilia formosa	66.80	0.00e+00	1270.00
IUUC-Pab-098047	Pongo abelii	95.77	0.00e+00	1782.00
IUUC-Pop-099587	Populus trichocarpa	38.54	1.00e-91	331.00
IUUC-Pca-100558	Procavia capensis	98.59	0.00e+00	768.00
IUUC-Ppe-101261	Prunus persica	37.76	3.00e-91	330.00
IUUC-Pva-102683	Pteropus vampyrus	94.99	0.00e+00	1779.00
IUUC-Pgr-103660	Puccinia graminis	40.61	3.00e-77	283.00
IUUC-Ptt-103900	Puccinia triticina	41.55	5.00e-79	288.00
IUUC-Pte-104209	Pyrenophora teres	34.27	3.00e-65	243.00
IUUC-Pyt-104802	Pyrenophora triticirepentis	34.27	8.00e-65	242.00
IUUC-Rno-105566	Rattus norvegicus	93.31	0.00e+00	1769.00
IUUC-Sce-106291	Saccharomyces cerevisiae	32.35	3.00e-61	230.00
IUUC-Sha-107514	Sarcophilus harrisii	80.86	0.00e+00	1498.00
IUUC-Sja-107833	Schizosaccharomyces japonicus	35.37	3.00e-81	296.00
IUUC-Spo-108162	Schizosaccharomyces pombe	36.60	8.00e-78	285.00
IUUC-Smo-109533	Selaginella moellendorffii	37.04	8.00e-93	335.00
IUUC-Sit-109980	Setaria italica	38.32	1.00e-93	338.00
IUUC-Sly-111547	Solanum lycopersicum	38.15	8.00e-93	335.00
IUUC-Stu-112705	Solanum tuberosum	37.95	4.00e-93	336.00
IUUC-Sar-113222	Sorex araneus	89.02	0.00e+00	1530.00
IUUC-Sbi-114272	Sorghum bicolor	37.77	2.00e-93	337.00
IUUC-Sre-115061	Sporisorium reilianum	27.60	1.00e-91	331.00
IUUC-Ssc-116364	Sus scrofa	92.85	0.00e+00	1816.00
IUUC-Tgu-116645	Taeniopygia guttata	85.84	0.00e+00	1656.00
IUUC-Tru-117590	Takifugu rubripes	66.19	0.00e+00	1287.00
IUUC-Tsy-119212	Tarsius syrichta	89.27	0.00e+00	968.00
IUUC-Tni-119915	Tetraodon nigroviridis	66.37	0.00e+00	1269.00
IUUC-Tca-121765	Theobroma cacao	37.65	8.00e-91	328.00
IUUC-Tre-121887	Trichoderma reesei	33.90	1.00e-60	228.00
IUUC-Tvi-122262	Trichoderma virens	33.90	1.00e-60	228.00
IUUC-Tae-124148	Triticum aestivum	45.36	6.00e-39	155.00
IUUC-Tur-126483	Triticum urartu	38.97	1.00e-93	338.00
IUUC-Tme-127202	Tuber melanosporum	33.33	1.00e-56	215.00
IUUC-Tbe-127350	Tupaia belangeri	82.44	0.00e+00	637.00
IUUC-Ttr-129077	Tursiops truncatus	89.74	0.00e+00	1756.00
IUUC-Uma-129465	Ustilago maydis	35.85	3.00e-79	290.00
IUUC-Vda-129844	Verticillium dahliae	34.56	2.00e-66	248.00
IUUC-Vvi-131397	Vitis vinifera	37.85	4.00e-93	336.00
IUUC-Xtr-132057	Xenopus tropicalis	76.27	0.00e+00	1441.00
IUUC-Xma-134139	Xiphophorus maculatus	67.41	0.00e+00	791.00
IUUC-Yli-134424	Yarrowia lipolytica	31.48	1.00e-65	245.00
IUUC-Zma-135839	Zea mays	37.13	7.00e-92	332.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence