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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063888
Ensembl Protein ID ENSMUSP00000004222.7
UniProt Accession Q61666; O08845; Q3TFY0; Q3UX35; Q62365; Q7TMW4; HIRA_MOUSE
Genbank Protein ID CAA63334.1; CAA68049.1; CAA53043.1; BAE22728.1; BAE40768.1; AAH52856.1
Protein Name Protein HIRA; TUP1-like enhancer of split protein 1
Genbank Nucleotide ID X92590; X99712; X75295; AK135928; AK168963; BC052856
Gene Name Hira; Tuple1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022702.15 ENSMUST00000120532.7 ENSMUSP00000112614.1
ENSMUSG00000022702.15 ENSMUST00000004222.13 ENSMUSP00000004222.7
ENSMUSG00000022702.15 ENSMUST00000153397.7 ENSMUSP00000117944.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.70e-20 71.5 69 98
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 69   HLACVNCVRWsNSgMYLASGGDDKLIMVWK 98
           8899******955699*************7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
 Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Protein Sequence
(Fasta)
MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ EDDEKDENIP 60
KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA TYIGPSTVFG SSGKLANVEQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063888|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCTGGTTCT GCATCGCCGG GCGGGATCTC AAGGCTTTGC CAGCCTGCTC ACACCGACCC 60
TCATCGGCGA CCACATCAGT GGCAGCGGAG TATCCCCGTC CTCCCCCCCC TGTCTACCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063888|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0043234--C:protein complex
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0031935--P:regulation of chromatin silencing
GO:0006351--P:transcription, DNA-templated
KEGG mmu:15260
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001039 Aegilops tauschii 40.05 3.00e-89 323.00
IUUC-Aml-001723 Ailuropoda melanoleuca 94.83 0.00e+00 1739.00
IUUC-Atr-003132 Amborella trichopoda 41.67 2.00e-88 321.00
IUUC-Apl-003197 Anas platyrhynchos 83.61 0.00e+00 1596.00
IUUC-Aca-004733 Anolis carolinensis 81.07 0.00e+00 1570.00
IUUC-Aly-005446 Arabidopsis lyrata 35.67 9.00e-83 301.00
IUUC-Ath-007627 Arabidopsis thaliana 36.60 2.00e-85 311.00
IUUC-Ago-007766 Ashbya gossypii 31.07 4.00e-59 223.00
IUUC-Acl-008104 Aspergillus clavatus 28.95 1.00e-63 238.00
IUUC-Afl-008591 Aspergillus flavus 29.83 7.00e-64 239.00
IUUC-Afu-008781 Aspergillus fumigatus 33.07 6.00e-58 219.00
IUUC-Ani-009272 Aspergillus nidulans 32.31 3.00e-53 203.00
IUUC-Ang-009655 Aspergillus niger 33.42 4.00e-65 243.00
IUUC-Aor-010119 Aspergillus oryzae 29.83 2.00e-64 241.00
IUUC-Ate-010530 Aspergillus terreus 26.80 2.00e-55 211.00
IUUC-Ame-011147 Astyanax mexicanus 85.00 6.00e-53 197.00
IUUC-Bgr-012237 Blumeria graminis 33.75 3.00e-63 237.00
IUUC-Bta-013320 Bos taurus 89.70 0.00e+00 1727.00
IUUC-Bci-013795 Botrytis cinerea 34.17 2.00e-68 254.00
IUUC-Bdi-014075 Brachypodium distachyon 42.86 1.00e-92 334.00
IUUC-Bol-016440 Brassica oleracea 32.22 2.00e-88 320.00
IUUC-Bra-016651 Brassica rapa 40.61 4.00e-87 316.00
IUUC-Cel-018692 Caenorhabditis elegans 38.10 7.00e-76 278.00
IUUC-Cja-018987 Callithrix jacchus 95.18 0.00e+00 1688.00
IUUC-Cfa-020132 Canis familiaris 93.81 0.00e+00 1736.00
IUUC-Cpo-021484 Cavia porcellus 96.26 0.00e+00 1804.00
IUUC-Cre-022846 Chlamydomonas reinhardtii 35.94 8.00e-62 232.00
IUUC-Csa-023081 Chlorocebus sabaeus 95.77 0.00e+00 1791.00
IUUC-Cin-025182 Ciona intestinalis 55.24 3.00e-156 546.00
IUUC-Csv-026154 Ciona savignyi 55.85 3.00e-152 533.00
IUUC-Cgl-026655 Colletotrichum gloeosporioides 31.12 3.00e-66 247.00
IUUC-Cne-026891 Cryptococcus neoformans 41.24 5.00e-83 302.00
IUUC-Cme-027349 Cyanidioschyzon merolae 29.00 3.00e-52 200.00
IUUC-Dre-027655 Danio rerio 69.27 0.00e+00 1345.00
IUUC-Dno-029557 Dasypus novemcinctus 82.89 0.00e+00 1081.00
IUUC-Dor-030687 Dipodomys ordii 82.03 0.00e+00 743.00
IUUC-Dse-031334 Dothistroma septosporum 30.53 1.00e-62 235.00
IUUC-Dme-031746 Drosophila melanogaster 55.51 3.00e-159 555.00
IUUC-Ete-032384 Echinops telfairi 88.05 0.00e+00 1613.00
IUUC-Eca-033430 Equus caballus 94.03 0.00e+00 1721.00
IUUC-Fca-036121 Felis catus 93.87 0.00e+00 1732.00
IUUC-Fal-036817 Ficedula albicollis 83.09 0.00e+00 1596.00
IUUC-Fox-037906 Fusarium oxysporum 34.62 2.00e-68 253.00
IUUC-Fso-038409 Fusarium solani 33.73 2.00e-67 251.00
IUUC-Gmo-039151 Gadus morhua 86.25 0.00e+00 703.00
IUUC-Ggr-040016 Gaeumannomyces graminis 35.04 2.00e-70 260.00
IUUC-Gga-040936 Gallus gallus 85.25 0.00e+00 1688.00
IUUC-Gac-041405 Gasterosteus aculeatus 62.77 0.00e+00 1192.00
IUUC-Gma-044252 Glycine max 36.82 1.00e-91 331.00
IUUC-Ggo-045430 Gorilla gorilla 95.28 0.00e+00 1781.00
IUUC-Hsa-046442 Homo sapiens 95.38 0.00e+00 1786.00
IUUC-Hvu-047587 Hordeum vulgare 36.90 1.00e-79 291.00
IUUC-Itr-048910 Ictidomys tridecemlineatus 99.67 3.00e-175 607.00
IUUC-Kpa-049145 Komagataella pastoris 30.88 3.00e-60 227.00
IUUC-Lch-050474 Latimeria chalumnae 75.26 0.00e+00 1415.00
IUUC-Lpe-051209 Leersia perrieri 35.03 1.00e-85 311.00
IUUC-Loc-052119 Lepisosteus oculatus 72.91 0.00e+00 1365.00
IUUC-Lma-053237 Leptosphaeria maculans 31.09 4.00e-68 253.00
IUUC-Laf-053718 Loxodonta africana 93.81 0.00e+00 1756.00
IUUC-Mcc-055621 Macaca mulatta 95.28 0.00e+00 1689.00
IUUC-Meu-055914 Macropus eugenii 77.25 0.00e+00 1426.00
IUUC-Mor-057090 Magnaporthe oryzae 32.94 7.00e-68 252.00
IUUC-Mpo-057364 Magnaporthe poae 32.59 1.00e-72 268.00
IUUC-Mtr-057744 Medicago truncatula 37.48 2.00e-91 330.00
IUUC-Mla-058914 Melampsora laricipopulina 41.40 2.00e-84 307.00
IUUC-Mga-060181 Meleagris gallopavo 83.15 0.00e+00 1624.00
IUUC-Mvi-060432 Microbotryum violaceum 37.78 7.00e-74 272.00
IUUC-Mmr-060871 Microcebus murinus 94.79 0.00e+00 1818.00
IUUC-Mdo-062301 Monodelphis domestica 84.64 0.00e+00 1611.00
IUUC-Mac-065137 Musa acuminata 38.84 1.00e-90 327.00
IUUC-Mpu-066732 Mustela putorius furo 94.73 0.00e+00 1776.00
IUUC-Mlu-067542 Myotis lucifugus 93.11 0.00e+00 1705.00
IUUC-Nfi-068396 Neosartorya fischeri 33.71 6.00e-58 219.00
IUUC-Ncr-068842 Neurospora crassa 32.46 1.00e-68 255.00
IUUC-Nle-070156 Nomascus leucogenys 96.07 0.00e+00 1798.00
IUUC-Opr-070808 Ochotona princeps 93.62 0.00e+00 1420.00
IUUC-Ont-072105 Oreochromis niloticus 68.18 0.00e+00 1320.00
IUUC-Ocu-074962 Oryctolagus cuniculus 95.42 0.00e+00 1769.00
IUUC-Oba-075178 Oryza barthii 35.93 2.00e-93 337.00
IUUC-Obr-076399 Oryza brachyantha 35.93 5.00e-94 339.00
IUUC-Ogu-078797 Oryza glumaepatula 35.93 2.00e-93 337.00
IUUC-Oin-080085 Oryza indica 34.52 2.00e-80 294.00
IUUC-Olo-081048 Oryza longistaminata 41.04 3.00e-66 247.00
IUUC-Ome-081324 Oryza meridionalis 35.75 8.00e-93 335.00
IUUC-Oni-082548 Oryza nivara 35.93 2.00e-93 337.00
IUUC-Opu-084008 Oryza punctata 42.09 4.00e-91 329.00
IUUC-Oru-084339 Oryza rufipogon 35.75 7.00e-93 335.00
IUUC-Osa-085782 Oryza sativa 35.75 7.00e-93 335.00
IUUC-Ola-087302 Oryzias latipes 72.26 0.00e+00 800.00
IUUC-Olu-087611 Ostreococcus lucimarinus 36.27 1.00e-89 324.00
IUUC-Oga-087935 Otolemur garnettii 94.54 0.00e+00 1734.00
IUUC-Oar-089229 Ovis aries 69.03 0.00e+00 1031.00
IUUC-Ptr-090715 Pan troglodytes 95.48 0.00e+00 1789.00
IUUC-Pan-092318 Papio anubis 95.63 0.00e+00 1761.00
IUUC-Psi-094053 Pelodiscus sinensis 83.04 0.00e+00 1605.00
IUUC-Pno-094985 Phaeosphaeria nodorum 32.60 7.00e-59 222.00
IUUC-Ppa-095819 Physcomitrella patens 36.28 4.00e-90 326.00
IUUC-Pfo-096857 Poecilia formosa 66.79 0.00e+00 1273.00
IUUC-Pab-098047 Pongo abelii 95.67 0.00e+00 1790.00
IUUC-Pop-099587 Populus trichocarpa 37.73 3.00e-90 327.00
IUUC-Pca-100558 Procavia capensis 92.71 0.00e+00 726.00
IUUC-Ppe-101261 Prunus persica 38.48 5.00e-92 332.00
IUUC-Pva-102683 Pteropus vampyrus 94.20 0.00e+00 1774.00
IUUC-Pgr-103660 Puccinia graminis 40.88 2.00e-77 284.00
IUUC-Ptt-103900 Puccinia triticina 41.83 2.00e-79 290.00
IUUC-Pte-104209 Pyrenophora teres 31.10 7.00e-66 246.00
IUUC-Pyt-104802 Pyrenophora triticirepentis 30.93 7.00e-66 246.00
IUUC-Rno-105566 Rattus norvegicus 99.01 0.00e+00 1864.00
IUUC-Sce-106291 Saccharomyces cerevisiae 32.59 2.00e-61 230.00
IUUC-Sha-107514 Sarcophilus harrisii 79.59 0.00e+00 1467.00
IUUC-Sja-107833 Schizosaccharomyces japonicus 35.57 1.00e-81 297.00
IUUC-Spo-108162 Schizosaccharomyces pombe 36.36 1.00e-77 284.00
IUUC-Smo-109533 Selaginella moellendorffii 37.58 1.00e-91 331.00
IUUC-Sit-110730 Setaria italica 36.23 4.00e-92 333.00
IUUC-Sly-111547 Solanum lycopersicum 38.15 1.00e-93 338.00
IUUC-Stu-112705 Solanum tuberosum 38.15 8.00e-94 338.00
IUUC-Sar-113222 Sorex araneus 88.41 0.00e+00 1527.00
IUUC-Sbi-114272 Sorghum bicolor 38.08 2.00e-94 340.00
IUUC-Sre-115061 Sporisorium reilianum 27.71 1.00e-91 331.00
IUUC-Ssc-116364 Sus scrofa 93.04 0.00e+00 1806.00
IUUC-Tgu-116645 Taeniopygia guttata 83.18 0.00e+00 1624.00
IUUC-Tru-117590 Takifugu rubripes 67.11 0.00e+00 1294.00
IUUC-Tsy-119212 Tarsius syrichta 89.97 0.00e+00 983.00
IUUC-Tni-119915 Tetraodon nigroviridis 66.90 0.00e+00 1267.00
IUUC-Tca-121765 Theobroma cacao 37.72 5.00e-91 329.00
IUUC-Tre-121887 Trichoderma reesei 29.15 3.00e-60 227.00
IUUC-Tvi-122262 Trichoderma virens 33.90 1.00e-60 228.00
IUUC-Tae-124148 Triticum aestivum 45.36 4.00e-39 156.00
IUUC-Tur-126483 Triticum urartu 43.37 3.00e-93 337.00
IUUC-Tme-127202 Tuber melanosporum 29.52 6.00e-57 216.00
IUUC-Tbe-127350 Tupaia belangeri 82.68 0.00e+00 641.00
IUUC-Ttr-129077 Tursiops truncatus 89.34 0.00e+00 1739.00
IUUC-Uma-129465 Ustilago maydis 35.40 8.00e-79 288.00
IUUC-Vda-129844 Verticillium dahliae 34.56 8.00e-67 249.00
IUUC-Vvi-131397 Vitis vinifera 37.20 3.00e-92 333.00
IUUC-Xtr-132057 Xenopus tropicalis 75.52 0.00e+00 1435.00
IUUC-Xma-134139 Xiphophorus maculatus 67.91 0.00e+00 798.00
IUUC-Yli-134424 Yarrowia lipolytica 31.48 9.00e-66 245.00
IUUC-Zma-135839 Zea mays 37.33 4.00e-92 332.00
Created Date 25-Jun-2017

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