iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	3.70e-09	36.7	33	105

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekksg 75
           ++ + s++g++++l+v+ ++tV  L+++++++l++p e+ +L+ k++ L  + +L+++g+ dgs++ l+++++ 
   Q: 33   SLAIHSTTGTRYDLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSG-KLQEFGVGDGSKLTLVPTVEA 105
           6778999********88888*****************************999.*****************9875 PP

Organism

Rattus norvegicus

Functional Description
(View)

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (PubMed:24187134).

Protein Sequence
(Fasta)

MEPQPGGARS CRRGAPGGAC ELSTTAESAA PMSLAIHSTT GTRYDLSVPH DETVEGLRKR 60
LSQRLKVPKE RLALLHKDTR LSSGKLQEFG VGDGSKLTLV PTVEAGLMSQ ASRPEQSVMQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCAGGGG CCGCCCGGCC GGCCCCAGAC CGGCACGGCC ACCTCTCACC ACGACCCATA 60
CGCAGGTCGT CTGGAGCAGT GGTGACACAG GACCTACGGC ACCCGGTGAG TAGGGGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019900--F:kinase binding
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion

KEGG

rno:314623

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001211	Ailuropoda melanoleuca	80.82	2.00e-81	295.00
IUUC-Aca-004280	Anolis carolinensis	64.35	2.00e-43	169.00
IUUC-Aly-006539	Arabidopsis lyrata	34.09	7.00e-03	33.10
IUUC-Ath-006838	Arabidopsis thaliana	31.82	7.00e-03	33.50
IUUC-Ame-011299	Astyanax mexicanus	67.43	2.00e-62	233.00
IUUC-Bta-013082	Bos taurus	69.98	3.00e-149	521.00
IUUC-Bol-015166	Brassica oleracea	29.89	3.00e-03	35.80
IUUC-Bra-016943	Brassica rapa	30.00	2.00e-03	36.20
IUUC-Cel-018301	Caenorhabditis elegans	25.61	2.80e-02	32.30
IUUC-Cja-019102	Callithrix jacchus	80.27	2.00e-167	581.00
IUUC-Cfa-020096	Canis familiaris	79.17	7.00e-165	573.00
IUUC-Cpo-022290	Cavia porcellus	68.74	5.00e-147	513.00
IUUC-Csa-023581	Chlorocebus sabaeus	79.88	2.00e-163	568.00
IUUC-Cin-025582	Ciona intestinalis	40.00	9.00e-30	124.00
IUUC-Csv-025994	Ciona savignyi	38.42	5.00e-30	125.00
IUUC-Dre-027459	Danio rerio	67.54	2.00e-66	246.00
IUUC-Dor-030604	Dipodomys ordii	80.23	4.00e-139	487.00
IUUC-Dme-031978	Drosophila melanogaster	38.12	3.00e-23	104.00
IUUC-Eca-034126	Equus caballus	82.11	5.00e-74	270.00
IUUC-Fal-037190	Ficedula albicollis	72.25	2.00e-61	229.00
IUUC-Fso-038183	Fusarium solani	35.59	6.30e-01	30.80
IUUC-Gmo-039292	Gadus morhua	62.32	9.00e-60	223.00
IUUC-Gga-040242	Gallus gallus	57.90	1.00e-114	406.00
IUUC-Gac-042379	Gasterosteus aculeatus	61.43	2.00e-58	219.00
IUUC-Gma-043175	Glycine max	37.33	3.00e-06	43.10
IUUC-Ggo-045533	Gorilla gorilla	93.66	2.00e-80	292.00
IUUC-Hsa-045827	Homo sapiens	79.57	2.00e-160	558.00
IUUC-Itr-048112	Ictidomys tridecemlineatus	71.76	7.00e-125	440.00
IUUC-Lch-050469	Latimeria chalumnae	60.77	5.00e-131	461.00
IUUC-Loc-051781	Lepisosteus oculatus	61.93	1.00e-53	203.00
IUUC-Mcc-055441	Macaca mulatta	74.95	2.00e-131	462.00
IUUC-Meu-056379	Macropus eugenii	58.32	2.00e-110	392.00
IUUC-Mtr-057978	Medicago truncatula	31.17	5.00e-05	38.90
IUUC-Mdo-061920	Monodelphis domestica	85.53	9.00e-61	227.00
IUUC-Mmu-063828	Mus musculus	96.85	0.00e+00	692.00
IUUC-Mac-065611	Musa acuminata	32.43	7.00e-03	36.20
IUUC-Mpu-066091	Mustela putorius furo	79.09	8.00e-164	570.00
IUUC-Mlu-067919	Myotis lucifugus	92.39	1.00e-19	90.50
IUUC-Nle-069450	Nomascus leucogenys	67.64	4.00e-79	288.00
IUUC-Opr-070444	Ochotona princeps	65.62	2.00e-86	311.00
IUUC-Ont-071842	Oreochromis niloticus	62.38	2.00e-58	219.00
IUUC-Ola-087286	Oryzias latipes	58.37	5.00e-57	215.00
IUUC-Oga-088735	Otolemur garnettii	76.41	2.00e-161	562.00
IUUC-Oar-089367	Ovis aries	76.77	4.00e-87	315.00
IUUC-Pan-092335	Papio anubis	89.46	3.00e-175	607.00
IUUC-Psi-093850	Pelodiscus sinensis	38.51	2.00e-47	182.00
IUUC-Pfo-096547	Poecilia formosa	67.44	4.00e-59	222.00
IUUC-Pab-097811	Pongo abelii	76.51	1.00e-121	429.00
IUUC-Pop-099759	Populus trichocarpa	33.33	1.00e-04	37.70
IUUC-Pca-100261	Procavia capensis	75.59	5.00e-87	315.00
IUUC-Pva-102408	Pteropus vampyrus	78.50	1.00e-161	562.00
IUUC-Sly-110979	Solanum lycopersicum	32.05	2.00e-05	40.80
IUUC-Stu-112279	Solanum tuberosum	34.67	2.00e-05	40.80
IUUC-Ssc-115388	Sus scrofa	73.88	3.00e-118	418.00
IUUC-Tgu-116546	Taeniopygia guttata	55.46	2.00e-84	306.00
IUUC-Tru-118322	Takifugu rubripes	61.43	4.00e-58	219.00
IUUC-Tni-120877	Tetraodon nigroviridis	67.12	2.00e-61	230.00
IUUC-Ttr-128596	Tursiops truncatus	73.58	1.00e-126	446.00
IUUC-Xtr-132534	Xenopus tropicalis	53.52	2.00e-105	375.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence