iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072721

UUCD1 version

UUC-OrA-00031

Ensembl Protein ID

ENSOANP00000022911.2

UniProt Accession

F6PZY5; F6PZY5_ORNAN

Protein Name

Uncharacterized protein

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000014542.3	ENSOANT00000022915.3	ENSOANP00000022911.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.00e-82	275.5	3842	4173

Active Site

Position(s)	Description	Evidence
4142	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 3842 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaarstLHTNMFRFLGVLLGVAIRTGSPL 3928
           4566*********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledl..eevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeY 173
            l l+++++k+l g +l++ dl  ++vd++++  l++i++n+ +  e +++ l f+     +++++ +++  +++++++t e + eY
   Q: 3929 SLSLAEPVWKQLAGLNLTIADLseQKVDKDFIPGLMYIRDNEATAEEFEAMSLPFT-----VPSASGQDIQLSSKHTHITLESRAEY 4010
           **********************44469**************988888889999998.....788999999***************** PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefssee 260
           v+l ++yrl+e ++eqv+a+reG+ +v p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + iqwFw+v+e+fs++e
   Q: 4011 VRLAMNYRLHE-FDEQVAAVREGMARVAPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPTASLIQWFWDVMESFSNTE 4095
           ***********.**************************************************77.********************** PP
   S: 261  rkafLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           r+ fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4096 RSLFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4173
           ***************.8*************999988888***********************************99875 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

ILSGSLSPNE SFLRYLTLPQ DNELAIDLRQ TAVVIMAHLD RLATPCMPPQ CSSPKSHKGS 60
LQEVIGWGLI GWKYYANVIG PIQCEGLANL GVTQIACAEK RFLILSRNGR VYVQAYNSDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCTGTCTG GCTCTCTGAG TCCCAATGAA AGTTTTCTGA GGTACCTCAC TCTGCCCCAA 60
GACAATGAAT TAGCCATCGA CTTGCGACAG ACGGCAGTTG TGATTATGGC TCATTTAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR016186--C-type_lectin-like/link
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50255--CYTOCHROME_B5_2
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00173--Cyt-b5
PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM01117--Cyt-b5
SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	87.08	0.00e+00	3506.00
IUUC-Apl-003983	Anas platyrhynchos	87.75	0.00e+00	3511.00
IUUC-Aca-004300	Anolis carolinensis	93.16	0.00e+00	3502.00
IUUC-Ame-010621	Astyanax mexicanus	89.50	0.00e+00	3397.00
IUUC-Bta-013067	Bos taurus	86.28	0.00e+00	3457.00
IUUC-Bdi-014093	Brachypodium distachyon	32.99	4.00e-46	179.00
IUUC-Cja-019687	Callithrix jacchus	86.09	0.00e+00	3412.00
IUUC-Cfa-020672	Canis familiaris	86.80	0.00e+00	3493.00
IUUC-Cpo-021819	Cavia porcellus	83.96	0.00e+00	3316.00
IUUC-Csa-023817	Chlorocebus sabaeus	86.47	0.00e+00	3478.00
IUUC-Cho-024387	Choloepus hoffmanni	95.02	0.00e+00	761.00
IUUC-Cin-025709	Ciona intestinalis	57.51	0.00e+00	1420.00
IUUC-Csv-026336	Ciona savignyi	53.04	0.00e+00	1832.00
IUUC-Dre-027717	Danio rerio	86.55	0.00e+00	3367.00
IUUC-Dno-029296	Dasypus novemcinctus	86.85	0.00e+00	3489.00
IUUC-Dor-030979	Dipodomys ordii	94.72	0.00e+00	1058.00
IUUC-Dme-032171	Drosophila melanogaster	60.33	0.00e+00	1534.00
IUUC-Ete-032687	Echinops telfairi	90.03	0.00e+00	1557.00
IUUC-Eca-034046	Equus caballus	85.77	0.00e+00	3429.00
IUUC-Eeu-034859	Erinaceus europaeus	87.16	0.00e+00	1800.00
IUUC-Fca-036262	Felis catus	86.99	0.00e+00	3500.00
IUUC-Fal-037562	Ficedula albicollis	87.56	0.00e+00	3494.00
IUUC-Gmo-038739	Gadus morhua	90.43	0.00e+00	1028.00
IUUC-Gga-040359	Gallus gallus	92.89	0.00e+00	3508.00
IUUC-Gac-041879	Gasterosteus aculeatus	90.60	0.00e+00	1035.00
IUUC-Ggo-044692	Gorilla gorilla	86.37	0.00e+00	3467.00
IUUC-Hsa-045995	Homo sapiens	86.66	0.00e+00	3486.00
IUUC-Lch-049808	Latimeria chalumnae	69.07	0.00e+00	5050.00
IUUC-Loc-052685	Lepisosteus oculatus	85.14	0.00e+00	3449.00
IUUC-Laf-053372	Loxodonta africana	86.28	0.00e+00	3449.00
IUUC-Mcc-054693	Macaca mulatta	86.42	0.00e+00	3477.00
IUUC-Meu-056660	Macropus eugenii	96.31	0.00e+00	1923.00
IUUC-Mga-059371	Meleagris gallopavo	92.80	0.00e+00	3500.00
IUUC-Mmr-060787	Microcebus murinus	86.94	0.00e+00	3501.00
IUUC-Mdo-062518	Monodelphis domestica	86.43	0.00e+00	3291.00
IUUC-Mmu-063690	Mus musculus	86.37	0.00e+00	3448.00
IUUC-Mpu-066478	Mustela putorius furo	85.97	0.00e+00	3442.00
IUUC-Mlu-067596	Myotis lucifugus	81.45	0.00e+00	2138.00
IUUC-Nle-069445	Nomascus leucogenys	88.97	0.00e+00	879.00
IUUC-Opr-070990	Ochotona princeps	95.06	0.00e+00	2316.00
IUUC-Ont-072285	Oreochromis niloticus	87.88	0.00e+00	3396.00
IUUC-Ocu-074273	Oryctolagus cuniculus	86.66	0.00e+00	3477.00
IUUC-Ola-087346	Oryzias latipes	92.08	0.00e+00	1182.00
IUUC-Oga-088742	Otolemur garnettii	86.09	0.00e+00	3442.00
IUUC-Oar-090093	Ovis aries	86.28	0.00e+00	3467.00
IUUC-Ptr-091034	Pan troglodytes	78.62	0.00e+00	3083.00
IUUC-Pan-092783	Papio anubis	87.20	0.00e+00	3476.00
IUUC-Psi-094027	Pelodiscus sinensis	87.77	0.00e+00	3507.00
IUUC-Pfo-096208	Poecilia formosa	82.37	0.00e+00	2011.00
IUUC-Pva-103147	Pteropus vampyrus	88.79	0.00e+00	863.00
IUUC-Rno-105458	Rattus norvegicus	86.42	0.00e+00	3437.00
IUUC-Sha-106959	Sarcophilus harrisii	85.29	0.00e+00	3162.00
IUUC-Sly-110961	Solanum lycopersicum	36.07	5.00e-49	189.00
IUUC-Sar-113532	Sorex araneus	87.38	0.00e+00	1039.00
IUUC-Sbi-114352	Sorghum bicolor	32.14	2.00e-45	177.00
IUUC-Ssc-116304	Sus scrofa	94.44	0.00e+00	938.00
IUUC-Tgu-116789	Taeniopygia guttata	87.48	0.00e+00	3493.00
IUUC-Tru-118129	Takifugu rubripes	89.30	0.00e+00	3383.00
IUUC-Tsy-119302	Tarsius syrichta	84.35	0.00e+00	919.00
IUUC-Tni-120374	Tetraodon nigroviridis	86.77	0.00e+00	3376.00
IUUC-Tae-124157	Triticum aestivum	33.94	6.00e-46	179.00
IUUC-Tbe-128137	Tupaia belangeri	81.29	0.00e+00	1409.00
IUUC-Ttr-128273	Tursiops truncatus	83.85	0.00e+00	1946.00
IUUC-Vpa-130471	Vicugna pacos	76.41	0.00e+00	1335.00
IUUC-Xtr-132185	Xenopus tropicalis	86.35	0.00e+00	3393.00
IUUC-Xma-133233	Xiphophorus maculatus	87.33	0.00e+00	3378.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence