iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPPT	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/SKP1	SKP1	12169662; 12795696; 16983093

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/SKP1	2.00e-31	108.8	111	158

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/SKP1

   S: 1    ksLLdltcktVadmikgktpeeiRktFnienDftpeEeakvReEnqWA 48
           k+LLdltc+tVadmikgktpeeiR+tFni+nDftpeEe++vR+EnqWA
   Q: 111  KNLLDLTCQTVADMIKGKTPEEIRTTFNIKNDFTPEEEEEVRRENQWA 158
           79*********************************************9 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation.

Protein Sequence
(Fasta)

MSAKKIVLKS SDGESFEVEE AVALESQTIA HMVEDDCVDN GVPLPNVTSK ILAKVIEYCK 60
RHVEAAASKA EAVEGAATSD DDLKAWDADF MKIDQATLFE LILAANYLNI KNLLDLTCQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAATTTGAA ACAATTTCCT AATTTCCCTA AACTTGCGAC TTTTTAACAA TCGACCGACT 60
TATCAAAATT AGGGATTGTT TTATATATAA AGAGAGACGC ATCTCTTTAT TTCATTCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0927--Auxin signaling pathway
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0936--Ethylene signaling pathway
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016897--SKP1
IPR001232--SKP1-like
IPR011333--SKP1/BTB/POZ
IPR016072--Skp1_comp_dimer
IPR016073--Skp1_comp_POZ

Pfam

PF01466--Skp1
PF03931--Skp1_POZ

SMART

SM00512--Skp1

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0009524--C:phragmoplast
GO:0005886--C:plasma membrane
GO:0005819--C:spindle
GO:0009734--P:auxin-activated signaling pathway
GO:0007059--P:chromosome segregation
GO:0009873--P:ethylene-activated signaling pathway
GO:0000226--P:microtubule cytoskeleton organization
GO:0007275--P:multicellular organism development
GO:0045910--P:negative regulation of DNA recombination
GO:0016567--P:protein ubiquitination
GO:0046686--P:response to cadmium ion
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process

KEGG

ath:AT1G75950

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002858	Amborella trichopoda	77.07	8.00e-57	211.00
IUUC-Bgr-012280	Blumeria graminis	51.39	3.00e-34	136.00
IUUC-Bci-013888	Botrytis cinerea	53.15	5.00e-29	119.00
IUUC-Bol-015842	Brassica oleracea	93.12	2.00e-80	290.00
IUUC-Bra-016913	Brassica rapa	93.12	2.00e-80	290.00
IUUC-Cho-024854	Choloepus hoffmanni	42.25	4.00e-12	62.80
IUUC-Cgl-026548	Colletotrichum gloeosporioides	47.62	4.00e-35	139.00
IUUC-Dme-032028	Drosophila melanogaster	55.35	5.00e-38	149.00
IUUC-Ete-033117	Echinops telfairi	55.62	2.00e-36	144.00
IUUC-Fox-037761	Fusarium oxysporum	47.65	2.00e-35	140.00
IUUC-Fso-038451	Fusarium solani	46.62	2.00e-34	137.00
IUUC-Itr-047900	Ictidomys tridecemlineatus	55.00	2.00e-37	147.00
IUUC-Lma-053020	Leptosphaeria maculans	46.58	3.00e-33	133.00
IUUC-Mor-057176	Magnaporthe oryzae	46.58	6.00e-36	142.00
IUUC-Mpo-057471	Magnaporthe poae	47.30	6.00e-36	142.00
IUUC-Mac-064537	Musa acuminata	80.38	1.00e-59	221.00
IUUC-Ncr-068658	Neurospora crassa	45.89	2.00e-35	140.00
IUUC-Obr-076218	Oryza brachyantha	78.75	3.00e-59	220.00
IUUC-Pno-094810	Phaeosphaeria nodorum	44.76	1.00e-30	125.00
IUUC-Ppa-095274	Physcomitrella patens	73.12	1.00e-59	221.00
IUUC-Pca-100783	Procavia capensis	51.52	9.00e-30	122.00
IUUC-Ppe-101549	Prunus persica	83.22	1.00e-63	234.00
IUUC-Pte-104224	Pyrenophora teres	45.21	4.00e-30	123.00
IUUC-Pyt-104750	Pyrenophora triticirepentis	45.21	3.00e-30	123.00
IUUC-Ssl-108591	Sclerotinia sclerotiorum	48.95	4.00e-34	136.00
IUUC-Sly-111529	Solanum lycopersicum	78.62	7.00e-65	238.00
IUUC-Stu-111940	Solanum tuberosum	79.35	6.00e-64	235.00
IUUC-Tca-121022	Theobroma cacao	81.13	1.00e-67	247.00
IUUC-Tae-123210	Triticum aestivum	77.71	4.00e-63	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence