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Tag Content
iUUCD ID IUUC-Laf-053596
Ensembl Protein ID ENSLAFP00000001822.3
UniProt Accession G3SPZ4; G3SPZ4_LOXAF
Protein Name Ubiquitin-related modifier 1
Gene Name URM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSLAFG00000002178.3 ENSLAFT00000002178.3 ENSLAFP00000001822.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 41.58 2.00e-16 78.20 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Loxodonta africana
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MAAPLSVEVE FGGGAELLFN GVKKHQVTLP GQEEPWDIRN LLVWIKKNLL KERPELFIQG 60
DSVRPGILVL INDADWELLD QGELDYQLQD QDSVLFISTL HGG 103
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Protein Fasta Sequence


>IUUC-Laf-053596|ULD,UBQ_Other|Loxodonta africana
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Nucleotide Sequence
(Fasta)
ATGGCAGCGC CCTTGTCAGT GGAGGTGGAG TTCGGGTGAG TCACAGAGCT GGGGCGCCGT 60
GGGGATGGAC TGAAGTCTTC GGGCCTGGAA CTCTCCTCTC TCTGCCTTGA GGCCTGTCAC 120
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Nucleotide Fasta Sequence


>IUUC-Laf-053596|ULD,UBQ_Other|Loxodonta africana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 95.15 6.00e-52 194.00
IUUC-Atr-003089 Amborella trichopoda 56.44 4.00e-29 119.00
IUUC-Apl-003382 Anas platyrhynchos 86.02 1.00e-41 159.00
IUUC-Aca-004981 Anolis carolinensis 80.58 6.00e-46 174.00
IUUC-Aly-005517 Arabidopsis lyrata 52.13 6.00e-26 108.00
IUUC-Ath-006718 Arabidopsis thaliana 52.33 1.00e-22 97.10
IUUC-Ago-007917 Ashbya gossypii 42.57 3.00e-19 86.30
IUUC-Acl-008054 Aspergillus clavatus 63.46 3.00e-14 69.30
IUUC-Afl-008704 Aspergillus flavus 53.85 7.00e-20 87.80
IUUC-Aor-009890 Aspergillus oryzae 56.31 2.00e-24 103.00
IUUC-Bta-012448 Bos taurus 95.15 1.00e-51 193.00
IUUC-Bci-013865 Botrytis cinerea 45.63 7.00e-21 91.70
IUUC-Bdi-014980 Brachypodium distachyon 62.03 6.00e-23 98.20
IUUC-Bol-016055 Brassica oleracea 52.44 1.00e-22 97.10
IUUC-Bra-016845 Brassica rapa 52.44 1.00e-22 97.10
IUUC-Cel-018485 Caenorhabditis elegans 33.33 2.00e-10 57.00
IUUC-Cja-019587 Callithrix jacchus 97.09 3.00e-52 196.00
IUUC-Cfa-020653 Canis familiaris 94.17 2.00e-51 193.00
IUUC-Cpo-021622 Cavia porcellus 97.09 3.00e-52 196.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 52.00 2.00e-24 103.00
IUUC-Csa-023756 Chlorocebus sabaeus 97.47 1.00e-40 157.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 44.66 3.00e-20 89.70
IUUC-Cne-026953 Cryptococcus neoformans 55.24 5.00e-27 112.00
IUUC-Cme-027314 Cyanidioschyzon merolae 40.82 4.00e-17 79.00
IUUC-Dre-027884 Danio rerio 75.73 1.00e-42 163.00
IUUC-Dno-029262 Dasypus novemcinctus 90.36 3.00e-39 154.00
IUUC-Dor-030601 Dipodomys ordii 66.02 8.00e-27 111.00
IUUC-Dme-031893 Drosophila melanogaster 62.50 3.00e-31 125.00
IUUC-Ete-032773 Echinops telfairi 89.32 1.00e-46 176.00
IUUC-Eca-034187 Equus caballus 96.12 4.00e-52 195.00
IUUC-Eeu-034808 Erinaceus europaeus 91.26 3.00e-50 189.00
IUUC-Fca-036107 Felis catus 93.20 3.00e-51 192.00
IUUC-Fal-036607 Ficedula albicollis 84.95 4.00e-41 158.00
IUUC-Fox-037698 Fusarium oxysporum 46.23 2.00e-22 96.70
IUUC-Gmo-039492 Gadus morhua 73.79 7.00e-42 161.00
IUUC-Ggr-039965 Gaeumannomyces graminis 47.17 7.00e-20 89.40
IUUC-Gga-041268 Gallus gallus 85.44 4.00e-47 178.00
IUUC-Gac-042111 Gasterosteus aculeatus 79.61 1.00e-45 173.00
IUUC-Gma-043240 Glycine max 53.01 3.00e-21 92.80
IUUC-Ggo-045176 Gorilla gorilla 94.94 8.00e-32 129.00
IUUC-Hsa-046077 Homo sapiens 94.17 2.00e-43 166.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 94.51 1.00e-36 143.00
IUUC-Kpa-049157 Komagataella pastoris 47.52 2.00e-19 86.30
IUUC-Lch-049889 Latimeria chalumnae 78.64 1.00e-44 170.00
IUUC-Lpe-050783 Leersia perrieri 55.81 1.00e-21 94.00
IUUC-Loc-052400 Lepisosteus oculatus 76.70 3.00e-43 166.00
IUUC-Lma-053259 Leptosphaeria maculans 44.66 5.00e-20 89.00
IUUC-Mcc-054845 Macaca mulatta 90.00 1.00e-45 173.00
IUUC-Meu-055968 Macropus eugenii 90.29 3.00e-50 189.00
IUUC-Mor-057126 Magnaporthe oryzae 45.28 1.00e-18 84.70
IUUC-Mpo-057311 Magnaporthe poae 48.54 5.00e-21 92.80
IUUC-Mtr-058266 Medicago truncatula 54.79 4.00e-21 92.00
IUUC-Mla-058847 Melampsora laricipopulina 40.78 4.00e-14 69.70
IUUC-Mga-059468 Meleagris gallopavo 86.02 1.00e-41 160.00
IUUC-Mvi-060235 Microbotryum violaceum 35.29 1.00e-18 85.10
IUUC-Mdo-061948 Monodelphis domestica 89.32 5.00e-50 188.00
IUUC-Mmu-063946 Mus musculus 93.20 1.00e-50 190.00
IUUC-Mac-064812 Musa acuminata 58.14 2.00e-23 100.00
IUUC-Mpu-066763 Mustela putorius furo 94.17 1.00e-50 190.00
IUUC-Mlu-066970 Myotis lucifugus 98.73 1.00e-40 157.00
IUUC-Ncr-068824 Neurospora crassa 43.69 6.00e-19 85.50
IUUC-Nle-069849 Nomascus leucogenys 96.20 4.00e-40 156.00
IUUC-Opr-070227 Ochotona princeps 97.09 3.00e-52 196.00
IUUC-Ont-072530 Oreochromis niloticus 80.58 2.00e-45 173.00
IUUC-Oan-073191 Ornithorhynchus anatinus 78.79 4.00e-40 155.00
IUUC-Ocu-074460 Oryctolagus cuniculus 94.00 2.00e-49 186.00
IUUC-Oba-075499 Oryza barthii 65.15 3.00e-21 94.00
IUUC-Obr-076896 Oryza brachyantha 56.10 2.00e-20 92.40
IUUC-Ogl-077834 Oryza glaberrima 65.15 8.00e-22 94.70
IUUC-Ogu-078622 Oryza glumaepatula 65.15 8.00e-22 94.70
IUUC-Oin-079358 Oryza indica 65.15 3.00e-21 94.70
IUUC-Olo-081035 Oryza longistaminata 50.48 4.00e-22 97.40
IUUC-Oni-082425 Oryza nivara 65.15 8.00e-22 94.70
IUUC-Opu-083461 Oryza punctata 64.62 6.00e-21 93.20
IUUC-Oru-084875 Oryza rufipogon 58.90 1.00e-19 87.40
IUUC-Oga-089128 Otolemur garnettii 95.15 7.00e-52 194.00
IUUC-Oar-089896 Ovis aries 95.15 1.00e-51 193.00
IUUC-Ptr-091618 Pan troglodytes 94.94 8.00e-32 129.00
IUUC-Pan-092238 Papio anubis 97.47 2.00e-40 157.00
IUUC-Psi-093879 Pelodiscus sinensis 83.50 3.00e-46 176.00
IUUC-Pma-094484 Petromyzon marinus 79.61 2.00e-34 136.00
IUUC-Ppa-095801 Physcomitrella patens 56.63 3.00e-21 92.40
IUUC-Pfo-097192 Poecilia formosa 77.67 3.00e-44 169.00
IUUC-Pab-098203 Pongo abelii 93.20 5.00e-43 165.00
IUUC-Pop-099614 Populus trichocarpa 54.65 2.00e-22 96.30
IUUC-Pca-100507 Procavia capensis 97.47 2.00e-40 156.00
IUUC-Ppe-101174 Prunus persica 55.45 4.00e-28 115.00
IUUC-Pva-102735 Pteropus vampyrus 95.15 2.00e-48 182.00
IUUC-Pgr-103510 Puccinia graminis 39.81 8.00e-14 68.90
IUUC-Ptt-103918 Puccinia triticina 35.92 6.00e-12 62.40
IUUC-Pte-104173 Pyrenophora teres 46.67 2.00e-22 96.70
IUUC-Pyt-104806 Pyrenophora triticirepentis 46.67 2.00e-22 96.70
IUUC-Rno-105820 Rattus norvegicus 94.17 4.00e-51 192.00
IUUC-Sce-106366 Saccharomyces cerevisiae 41.58 7.00e-17 78.20
IUUC-Sja-107727 Schizosaccharomyces japonicus 42.86 1.00e-16 77.80
IUUC-Spo-108074 Schizosaccharomyces pombe 38.00 8.00e-09 51.20
IUUC-Smo-108944 Selaginella moellendorffii 60.44 3.00e-25 105.00
IUUC-Sit-110277 Setaria italica 56.98 5.00e-23 98.60
IUUC-Sly-111505 Solanum lycopersicum 52.33 1.00e-22 97.40
IUUC-Stu-112076 Solanum tuberosum 53.49 4.00e-23 99.00
IUUC-Sbi-114274 Sorghum bicolor 56.96 2.00e-22 97.10
IUUC-Sre-114953 Sporisorium reilianum 58.65 7.00e-27 111.00
IUUC-Ssc-115418 Sus scrofa 94.17 2.00e-51 193.00
IUUC-Tgu-117311 Taeniopygia guttata 84.95 5.00e-41 158.00
IUUC-Tru-118598 Takifugu rubripes 82.42 8.00e-40 154.00
IUUC-Tni-120109 Tetraodon nigroviridis 77.88 3.00e-42 162.00
IUUC-Tca-120942 Theobroma cacao 54.12 6.00e-22 95.10
IUUC-Tre-122099 Trichoderma reesei 46.88 1.00e-14 70.90
IUUC-Tvi-122285 Trichoderma virens 50.94 2.00e-19 87.40
IUUC-Tae-125193 Triticum aestivum 55.81 6.00e-22 95.10
IUUC-Tur-126677 Triticum urartu 48.98 2.00e-19 87.00
IUUC-Tme-127120 Tuber melanosporum 47.17 3.00e-23 99.80
IUUC-Tbe-128050 Tupaia belangeri 69.90 4.00e-32 129.00
IUUC-Ttr-129019 Tursiops truncatus 92.23 2.00e-48 182.00
IUUC-Uma-129483 Ustilago maydis 56.73 1.00e-24 104.00
IUUC-Vda-129690 Verticillium dahliae 40.35 1.00e-15 74.30
IUUC-Vvi-131174 Vitis vinifera 55.29 4.00e-23 98.60
IUUC-Xma-133862 Xiphophorus maculatus 77.67 3.00e-44 169.00
IUUC-Yli-134398 Yarrowia lipolytica 44.55 7.00e-18 81.30
IUUC-Zma-134964 Zea mays 58.33 2.00e-21 93.20
Created Date 25-Jun-2017

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