iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012695

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-like-conjugating enzyme ATG3; Autophagy-related protein 3

Genbank Nucleotide ID

BC120110

Gene Name

ATG3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000009084.3	ENSBTAT00000011976.3	ENSBTAP00000011976.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E2/Autophagy_C	46.62	6.00e-63	238.00	IUUC-Ath-006802
E2/Autophagy_C	98.09	2.00e-171	598.00	IUUC-Hsa-046449
E2/Autophagy_C	34.26	2.00e-38	154.00	IUUC-Sce-106172

Active Site

Position(s)	Description	Evidence
264	Glycyl thioester intermediate	{ECO:0000250}

Organism

Bos taurus

Functional Description
(View)

E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway (By similarity).

Protein Sequence
(Fasta)

MQNVINTVKG KALEVAEYLT PVLKESKFKE TGVITPEEFV AAGDHLVHHC PTWQWATGEE 60
LKVKAYLPSG KQFLVTKNVP CYKRCKQMEY SDELEAIIEE DDGDGGWVDT YHNTGIAGIT 120

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Nucleotide Sequence
(Fasta)

ACGTGAGGCC CAGGTGGCGG CGGAGCTACG GCGAGAGAGT GAGAGGAAGA AGGGGAAGCC 60
GGAAGGGGCG CGAGTGAAGC TTGGTGGAGA AGACAGCTCC CCAGAGGGCG AGGGGTGCGC 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR007135--Autophagy-rel_prot_3
IPR019461--Autophagy-rel_prot_3_C
IPR007134--Autophagy-rel_prot_3_N

Pfam

PF03987--Autophagy_act_C
PF10381--Autophagy_C
PF03986--Autophagy_N

Gene Ontology

GO:0000153--C:cytoplasmic ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0019777--F:Atg12 transferase activity
GO:0019776--F:Atg8 ligase activity
GO:0016874--F:ligase activity
GO:0000045--P:autophagosome assembly
GO:0043653--P:mitochondrial fragmentation involved in apoptotic process
GO:0000422--P:mitophagy
GO:0050765--P:negative regulation of phagocytosis
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport
GO:0016567--P:protein ubiquitination
GO:1902017--P:regulation of cilium assembly

KEGG

bta:508571

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001111	Aegilops tauschii	44.19	4.00e-48	184.00
IUUC-Aml-002081	Ailuropoda melanoleuca	98.41	7.00e-172	595.00
IUUC-Atr-002712	Amborella trichopoda	45.42	8.00e-53	200.00
IUUC-Apl-003956	Anas platyrhynchos	75.97	2.00e-119	421.00
IUUC-Aca-004578	Anolis carolinensis	88.25	1.00e-159	555.00
IUUC-Aly-005823	Arabidopsis lyrata	46.62	4.00e-66	244.00
IUUC-Ath-006802	Arabidopsis thaliana	46.96	2.00e-66	246.00
IUUC-Ago-007855	Ashbya gossypii	37.91	3.00e-23	102.00
IUUC-Acl-008147	Aspergillus clavatus	50.63	5.00e-17	81.60
IUUC-Afl-008483	Aspergillus flavus	36.05	1.00e-33	137.00
IUUC-Afu-008818	Aspergillus fumigatus	31.94	4.00e-37	148.00
IUUC-Ani-009481	Aspergillus nidulans	51.76	8.00e-18	84.30
IUUC-Ang-009800	Aspergillus niger	37.84	4.00e-21	95.10
IUUC-Aor-010150	Aspergillus oryzae	36.05	1.00e-33	137.00
IUUC-Ate-010545	Aspergillus terreus	53.95	3.00e-17	82.00
IUUC-Ame-011793	Astyanax mexicanus	82.76	1.00e-153	535.00
IUUC-Bgr-012167	Blumeria graminis	48.84	1.00e-17	84.00
IUUC-Bci-013972	Botrytis cinerea	54.05	2.00e-18	86.70
IUUC-Bdi-014756	Brachypodium distachyon	44.93	1.00e-59	223.00
IUUC-Bol-015091	Brassica oleracea	44.27	2.00e-61	229.00
IUUC-Bra-017220	Brassica rapa	44.19	1.00e-63	236.00
IUUC-Cel-018143	Caenorhabditis elegans	50.80	8.00e-81	293.00
IUUC-Cja-018991	Callithrix jacchus	93.33	4.00e-174	603.00
IUUC-Cfa-020070	Canis familiaris	98.39	3.00e-170	590.00
IUUC-Cpo-021860	Cavia porcellus	98.09	3.00e-172	597.00
IUUC-Cre-022948	Chlamydomonas reinhardtii	55.93	2.00e-40	159.00
IUUC-Csa-023881	Chlorocebus sabaeus	98.09	4.00e-172	596.00
IUUC-Cho-024852	Choloepus hoffmanni	85.03	8.00e-156	542.00
IUUC-Cin-025787	Ciona intestinalis	63.49	3.00e-109	387.00
IUUC-Csv-026369	Ciona savignyi	62.97	1.00e-106	379.00
IUUC-Cgl-026680	Colletotrichum gloeosporioides	35.03	1.00e-19	90.50
IUUC-Cne-026905	Cryptococcus neoformans	37.50	2.00e-49	189.00
IUUC-Dre-028811	Danio rerio	79.81	1.00e-150	525.00
IUUC-Dno-030081	Dasypus novemcinctus	93.35	2.00e-166	578.00
IUUC-Dor-030183	Dipodomys ordii	97.71	1.00e-73	269.00
IUUC-Dse-031539	Dothistroma septosporum	43.48	7.00e-12	64.70
IUUC-Dme-031805	Drosophila melanogaster	60.91	1.00e-102	365.00
IUUC-Ete-033171	Echinops telfairi	92.36	9.00e-166	575.00
IUUC-Eca-034083	Equus caballus	99.68	3.00e-174	603.00
IUUC-Eeu-034804	Erinaceus europaeus	95.22	2.00e-163	568.00
IUUC-Fca-036289	Felis catus	99.04	1.00e-173	602.00
IUUC-Fal-037060	Ficedula albicollis	92.36	3.00e-159	554.00
IUUC-Fox-038051	Fusarium oxysporum	40.34	1.00e-18	87.00
IUUC-Fso-038124	Fusarium solani	48.24	2.00e-19	89.70
IUUC-Gmo-039538	Gadus morhua	81.07	3.00e-147	513.00
IUUC-Ggr-039880	Gaeumannomyces graminis	34.55	2.00e-20	92.80
IUUC-Gga-041108	Gallus gallus	92.04	2.00e-158	551.00
IUUC-Gac-041558	Gasterosteus aculeatus	81.90	2.00e-149	521.00
IUUC-Gma-043969	Glycine max	45.55	2.00e-63	235.00
IUUC-Ggo-045071	Gorilla gorilla	98.09	9.00e-173	598.00
IUUC-Hsa-046449	Homo sapiens	98.09	9.00e-173	598.00
IUUC-Hvu-047451	Hordeum vulgare	45.48	3.00e-59	222.00
IUUC-Itr-048360	Ictidomys tridecemlineatus	99.04	2.00e-173	600.00
IUUC-Kpa-049096	Komagataella pastoris	40.00	6.00e-25	107.00
IUUC-Lch-049726	Latimeria chalumnae	83.44	7.00e-158	549.00
IUUC-Lpe-050734	Leersia perrieri	43.51	1.00e-51	196.00
IUUC-Loc-051983	Lepisosteus oculatus	84.44	2.00e-148	517.00
IUUC-Lma-053038	Leptosphaeria maculans	35.56	3.00e-32	132.00
IUUC-Laf-054510	Loxodonta africana	88.36	7.00e-159	552.00
IUUC-Mcc-054792	Macaca mulatta	98.09	4.00e-172	596.00
IUUC-Meu-055965	Macropus eugenii	84.08	3.00e-139	487.00
IUUC-Mor-057292	Magnaporthe oryzae	31.28	2.00e-36	146.00
IUUC-Mtr-058282	Medicago truncatula	47.14	6.00e-66	244.00
IUUC-Mla-059144	Melampsora laricipopulina	64.10	2.00e-26	113.00
IUUC-Mga-059509	Meleagris gallopavo	92.04	1.00e-158	551.00
IUUC-Mvi-060281	Microbotryum violaceum	36.16	2.00e-47	182.00
IUUC-Mmr-061788	Microcebus murinus	98.73	1.00e-172	598.00
IUUC-Mdo-062922	Monodelphis domestica	96.18	2.00e-169	587.00
IUUC-Mmu-064249	Mus musculus	98.09	1.00e-172	598.00
IUUC-Mac-064843	Musa acuminata	45.28	8.00e-65	240.00
IUUC-Mpu-065717	Mustela putorius furo	98.41	5.00e-169	586.00
IUUC-Mlu-067151	Myotis lucifugus	95.30	9.00e-156	542.00
IUUC-Nfi-068551	Neosartorya fischeri	34.55	3.00e-36	145.00
IUUC-Ncr-068846	Neurospora crassa	32.63	3.00e-34	139.00
IUUC-Nle-069790	Nomascus leucogenys	98.09	9.00e-173	598.00
IUUC-Ont-072517	Oreochromis niloticus	84.08	5.00e-148	516.00
IUUC-Oan-073285	Ornithorhynchus anatinus	89.66	8.00e-104	369.00
IUUC-Ocu-074695	Oryctolagus cuniculus	98.41	1.00e-172	598.00
IUUC-Oba-075515	Oryza barthii	44.86	3.00e-64	238.00
IUUC-Obr-076787	Oryza brachyantha	45.73	1.00e-63	236.00
IUUC-Ogl-077440	Oryza glaberrima	43.67	1.00e-64	239.00
IUUC-Ogu-078294	Oryza glumaepatula	44.86	3.00e-64	238.00
IUUC-Oin-079452	Oryza indica	45.48	6.00e-64	237.00
IUUC-Olo-080450	Oryza longistaminata	45.00	1.00e-62	233.00
IUUC-Ome-081514	Oryza meridionalis	44.86	4.00e-64	238.00
IUUC-Oni-082677	Oryza nivara	45.48	6.00e-64	237.00
IUUC-Opu-083925	Oryza punctata	46.13	1.00e-63	236.00
IUUC-Oru-084828	Oryza rufipogon	45.00	6.00e-63	234.00
IUUC-Osa-085937	Oryza sativa	45.48	6.00e-64	237.00
IUUC-Ola-086559	Oryzias latipes	78.28	3.00e-91	327.00
IUUC-Olu-087766	Ostreococcus lucimarinus	41.48	6.00e-59	220.00
IUUC-Oga-087983	Otolemur garnettii	97.78	8.00e-172	595.00
IUUC-Oar-089281	Ovis aries	99.68	8.00e-175	605.00
IUUC-Ptr-090983	Pan troglodytes	98.09	9.00e-173	598.00
IUUC-Pan-092457	Papio anubis	97.77	1.00e-171	595.00
IUUC-Psi-094046	Pelodiscus sinensis	87.59	7.00e-146	509.00
IUUC-Pno-094925	Phaeosphaeria nodorum	33.70	2.00e-31	129.00
IUUC-Ppa-095487	Physcomitrella patens	44.74	1.00e-64	239.00
IUUC-Pfo-096968	Poecilia formosa	84.81	7.00e-149	519.00
IUUC-Pab-098621	Pongo abelii	97.45	4.00e-170	590.00
IUUC-Pop-100007	Populus trichocarpa	46.76	7.00e-65	240.00
IUUC-Pca-100590	Procavia capensis	79.94	1.00e-134	472.00
IUUC-Ppe-101657	Prunus persica	47.12	3.00e-64	238.00
IUUC-Pva-102446	Pteropus vampyrus	99.04	8.00e-174	602.00
IUUC-Pgr-103604	Puccinia graminis	58.33	5.00e-26	112.00
IUUC-Ptt-103941	Puccinia triticina	59.76	7.00e-26	111.00
IUUC-Pte-104252	Pyrenophora teres	37.78	4.00e-32	132.00
IUUC-Pyt-104556	Pyrenophora triticirepentis	37.31	2.00e-31	129.00
IUUC-Rno-106025	Rattus norvegicus	97.77	2.00e-172	598.00
IUUC-Sce-106172	Saccharomyces cerevisiae	34.26	2.00e-38	152.00
IUUC-Sha-106858	Sarcophilus harrisii	95.54	2.00e-167	581.00
IUUC-Sja-107905	Schizosaccharomyces japonicus	47.83	1.00e-27	116.00
IUUC-Spo-108185	Schizosaccharomyces pombe	45.00	2.00e-19	89.00
IUUC-Smo-108883	Selaginella moellendorffii	43.05	2.00e-56	212.00
IUUC-Sit-110512	Setaria italica	45.61	1.00e-60	226.00
IUUC-Sly-111238	Solanum lycopersicum	46.03	2.00e-68	252.00
IUUC-Stu-112441	Solanum tuberosum	46.67	2.00e-69	255.00
IUUC-Sar-113039	Sorex araneus	84.06	1.00e-121	428.00
IUUC-Sbi-113776	Sorghum bicolor	46.23	5.00e-59	221.00
IUUC-Sre-115074	Sporisorium reilianum	52.94	3.00e-22	99.40
IUUC-Ssc-115262	Sus scrofa	99.36	1.00e-173	602.00
IUUC-Tgu-116790	Taeniopygia guttata	92.36	6.00e-159	553.00
IUUC-Tru-118160	Takifugu rubripes	78.48	2.00e-143	501.00
IUUC-Tsy-119145	Tarsius syrichta	80.25	1.00e-128	452.00
IUUC-Tni-119937	Tetraodon nigroviridis	76.19	2.00e-138	484.00
IUUC-Tca-121323	Theobroma cacao	46.96	8.00e-63	233.00
IUUC-Tre-121993	Trichoderma reesei	45.63	5.00e-20	91.70
IUUC-Tvi-122332	Trichoderma virens	45.63	3.00e-20	92.40
IUUC-Tae-124391	Triticum aestivum	45.82	3.00e-60	225.00
IUUC-Tur-126679	Triticum urartu	45.82	2.00e-59	222.00
IUUC-Tme-127159	Tuber melanosporum	38.24	9.00e-12	63.90
IUUC-Ttr-128261	Tursiops truncatus	99.66	2.00e-160	557.00
IUUC-Uma-129572	Ustilago maydis	48.08	1.00e-22	100.00
IUUC-Vda-129966	Verticillium dahliae	31.10	8.00e-39	154.00
IUUC-Vpa-130698	Vicugna pacos	86.98	1.00e-152	531.00
IUUC-Xtr-132878	Xenopus tropicalis	84.76	7.00e-155	539.00
IUUC-Xma-134017	Xiphophorus maculatus	84.49	6.00e-149	520.00
IUUC-Yli-134373	Yarrowia lipolytica	35.92	6.00e-20	91.70
IUUC-Zma-135222	Zea mays	43.45	1.00e-61	229.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence