iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nfi-068270

Ensembl Protein ID

CADNFIAP00005974

UniProt Accession

A1D7G5; A1D7G5_NEOFI

Genbank Protein ID

EAW21659.1

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

DS027690

Gene Name

NFIA_068280

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADNFIAG00006131	CADNFIAT00006131	CADNFIAP00005974

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-35	118.5	56	92
UBD/Beta-Prp	1.30e-76	256.7	8	334

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H ++v++++f ++ +l+vsG+dD +ikvW+l t ++l
   Q: 56   HDGPVRGIDFhPTqPLFVSGGDDYKIKVWSLQTRRCL 92
           99*********888*****************999997 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
            t +++++s+ + ++f+p++++++++  ++ti++wd+++g+l+ ++++h+++v+ ++f+p+++++v+g++D+ ikvw+l+t+ c+ tl+gh d
   Q: 8    LTKFESKSSRAKGIAFHPKRPWILVSLHSSTIQLWDYRMGTLIDRFEEHDGPVRGIDFHPTQPLFVSGGDDYKIKVWSLQTRRCLFTLNGHLD 100
           67889999************************************************************************************* PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...................... 166
           +v+++ f+++  +++s+s+d+tir+w++++++ +  t +gh++ v+c+++hp+++l++s+slD+ vr+Wd+                      
   Q: 101  YVRTVFFHRELPWILSASDDQTIRIWNWQNRSLIC-TMTGHNHYVMCAQFHPTEDLIASASLDQSVRIWDIsglrkkhsaptsmtfedqmara 192
           **********************************9.********************************************************* PP
   S: 167  .........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiri 248
                    +t+ +++   +gh++ v+++sf+++ + +vs+++d+ vklw ++ ++   v+t++gh +n +   f+p++++++s+++D++ir+
   Q: 193  npsqadmfgNTDAVVKFVLEGHDRGVNWVSFHPTLPLIVSAGDDRLVKLWRMSDTKAweVDTCRGHFQNASACLFHPHQDLILSVGEDKTIRV 285
           **9999997777777766777********************************777668********************************** PP
   S: 249  Wdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           Wdl +++ ++++++  ++++ +a+ +++ n +++g  d  v+++kl++++p
   Q: 286  WDLNKRTSVQSFKRDVDRFWVIAA-HPEINLFAAG-HDTGVMVFKLERERP 334
           ************************.5555555444.589*******98775 PP

Organism

Neosartorya fischeri

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MQSSPNMLTK FESKSSRAKG IAFHPKRPWI LVSLHSSTIQ LWDYRMGTLI DRFEEHDGPV 60
RGIDFHPTQP LFVSGGDDYK IKVWSLQTRR CLFTLNGHLD YVRTVFFHRE LPWILSASDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGTCCT CCCCAAACAT GCTTACCAAG GTACGTTGCT CCCCCTCTGT TACCCCTTAT 60
CCCCGCGCAA ACCAAGCCAC TCAACTAAAC AATTGCTTTA CGAATAGTTC GAGTCGAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

nfi:NFIA_068280

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	55.45	0.00e+00	981.00
IUUC-Aml-001758	Ailuropoda melanoleuca	49.48	0.00e+00	1218.00
IUUC-Atr-002493	Amborella trichopoda	55.65	0.00e+00	967.00
IUUC-Apl-003385	Anas platyrhynchos	44.22	0.00e+00	914.00
IUUC-Aca-005154	Anolis carolinensis	70.87	2.00e-92	329.00
IUUC-Aly-006020	Arabidopsis lyrata	54.74	0.00e+00	956.00
IUUC-Ath-007360	Arabidopsis thaliana	55.70	0.00e+00	971.00
IUUC-Ago-007992	Ashbya gossypii	53.59	0.00e+00	1284.00
IUUC-Acl-008027	Aspergillus clavatus	95.71	0.00e+00	2287.00
IUUC-Afl-008644	Aspergillus flavus	94.06	0.00e+00	2250.00
IUUC-Afu-008964	Aspergillus fumigatus	99.17	0.00e+00	2393.00
IUUC-Ani-009379	Aspergillus nidulans	91.54	0.00e+00	2222.00
IUUC-Ang-009756	Aspergillus niger	93.70	0.00e+00	2280.00
IUUC-Aor-010174	Aspergillus oryzae	93.89	0.00e+00	2246.00
IUUC-Ate-010302	Aspergillus terreus	90.98	0.00e+00	2287.00
IUUC-Ame-011229	Astyanax mexicanus	57.09	0.00e+00	1006.00
IUUC-Bgr-012300	Blumeria graminis	74.84	0.00e+00	1883.00
IUUC-Bta-012524	Bos taurus	49.84	0.00e+00	1210.00
IUUC-Bci-013781	Botrytis cinerea	79.12	0.00e+00	1991.00
IUUC-Bdi-014549	Brachypodium distachyon	46.54	0.00e+00	1140.00
IUUC-Bol-015925	Brassica oleracea	55.82	0.00e+00	967.00
IUUC-Bra-016978	Brassica rapa	55.34	0.00e+00	962.00
IUUC-Cel-018115	Caenorhabditis elegans	52.66	0.00e+00	910.00
IUUC-Cja-019107	Callithrix jacchus	48.43	0.00e+00	1196.00
IUUC-Cfa-020675	Canis familiaris	49.18	0.00e+00	1190.00
IUUC-Cpo-021813	Cavia porcellus	49.84	0.00e+00	1226.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	56.26	0.00e+00	998.00
IUUC-Csa-023523	Chlorocebus sabaeus	49.84	0.00e+00	1230.00
IUUC-Cho-024704	Choloepus hoffmanni	61.66	1.00e-120	426.00
IUUC-Cin-025572	Ciona intestinalis	47.76	0.00e+00	1178.00
IUUC-Csv-025864	Ciona savignyi	54.53	0.00e+00	942.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	78.48	0.00e+00	1958.00
IUUC-Cne-027053	Cryptococcus neoformans	55.72	0.00e+00	1332.00
IUUC-Cme-027222	Cyanidioschyzon merolae	41.92	1.00e-141	496.00
IUUC-Dre-027421	Danio rerio	50.04	0.00e+00	1218.00
IUUC-Dno-029303	Dasypus novemcinctus	49.92	0.00e+00	1229.00
IUUC-Dor-030290	Dipodomys ordii	46.49	3.00e-146	511.00
IUUC-Dse-031543	Dothistroma septosporum	74.03	0.00e+00	1818.00
IUUC-Dme-031945	Drosophila melanogaster	56.21	0.00e+00	961.00
IUUC-Ete-032873	Echinops telfairi	47.81	0.00e+00	1079.00
IUUC-Eca-033773	Equus caballus	48.71	0.00e+00	1179.00
IUUC-Eeu-034874	Erinaceus europaeus	37.75	2.00e-167	582.00
IUUC-Fca-035739	Felis catus	49.27	0.00e+00	1207.00
IUUC-Fal-037263	Ficedula albicollis	52.40	0.00e+00	879.00
IUUC-Fox-037738	Fusarium oxysporum	77.03	0.00e+00	1991.00
IUUC-Fso-038153	Fusarium solani	77.36	0.00e+00	1977.00
IUUC-Gmo-039602	Gadus morhua	46.56	0.00e+00	1128.00
IUUC-Ggr-039931	Gaeumannomyces graminis	75.45	0.00e+00	1883.00
IUUC-Gga-040590	Gallus gallus	48.88	0.00e+00	1224.00
IUUC-Gac-041318	Gasterosteus aculeatus	48.09	0.00e+00	1201.00
IUUC-Gma-043354	Glycine max	55.84	0.00e+00	970.00
IUUC-Ggo-045029	Gorilla gorilla	49.48	0.00e+00	1221.00
IUUC-Hsa-046078	Homo sapiens	49.56	0.00e+00	1223.00
IUUC-Hvu-047556	Hordeum vulgare	47.26	0.00e+00	1143.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	41.61	0.00e+00	663.00
IUUC-Kpa-049256	Komagataella pastoris	57.57	0.00e+00	1419.00
IUUC-Lch-049706	Latimeria chalumnae	49.84	0.00e+00	1206.00
IUUC-Lpe-051316	Leersia perrieri	55.04	0.00e+00	970.00
IUUC-Loc-051867	Lepisosteus oculatus	39.76	0.00e+00	827.00
IUUC-Lma-053138	Leptosphaeria maculans	84.68	0.00e+00	1543.00
IUUC-Laf-053510	Loxodonta africana	50.08	0.00e+00	1225.00
IUUC-Mcc-055836	Macaca mulatta	49.56	0.00e+00	1226.00
IUUC-Meu-056238	Macropus eugenii	51.62	0.00e+00	701.00
IUUC-Mor-057172	Magnaporthe oryzae	77.03	0.00e+00	1956.00
IUUC-Mpo-057300	Magnaporthe poae	74.47	0.00e+00	1878.00
IUUC-Mtr-058248	Medicago truncatula	55.37	0.00e+00	973.00
IUUC-Mla-059019	Melampsora laricipopulina	64.29	0.00e+00	1174.00
IUUC-Mga-059499	Meleagris gallopavo	48.84	0.00e+00	1220.00
IUUC-Mvi-060336	Microbotryum violaceum	64.04	0.00e+00	1175.00
IUUC-Mmr-061102	Microcebus murinus	49.56	0.00e+00	1217.00
IUUC-Mdo-062594	Monodelphis domestica	50.00	0.00e+00	1239.00
IUUC-Mmu-063736	Mus musculus	49.40	0.00e+00	1218.00
IUUC-Mac-065283	Musa acuminata	46.59	0.00e+00	937.00
IUUC-Mpu-066701	Mustela putorius furo	48.56	0.00e+00	1214.00
IUUC-Mlu-067392	Myotis lucifugus	48.80	0.00e+00	1214.00
IUUC-Ncr-068892	Neurospora crassa	77.74	0.00e+00	1936.00
IUUC-Nle-069634	Nomascus leucogenys	60.00	0.00e+00	868.00
IUUC-Opr-070952	Ochotona princeps	38.61	3.00e-168	584.00
IUUC-Ont-072488	Oreochromis niloticus	48.60	0.00e+00	1201.00
IUUC-Ocu-074211	Oryctolagus cuniculus	49.68	0.00e+00	1223.00
IUUC-Oba-075761	Oryza barthii	54.97	0.00e+00	968.00
IUUC-Obr-076429	Oryza brachyantha	54.85	0.00e+00	971.00
IUUC-Ogl-077364	Oryza glaberrima	54.97	0.00e+00	967.00
IUUC-Ogu-078257	Oryza glumaepatula	54.85	0.00e+00	964.00
IUUC-Oin-080029	Oryza indica	54.62	0.00e+00	969.00
IUUC-Olo-080895	Oryza longistaminata	55.18	0.00e+00	966.00
IUUC-Ome-081993	Oryza meridionalis	57.28	0.00e+00	930.00
IUUC-Oni-082874	Oryza nivara	54.74	0.00e+00	965.00
IUUC-Opu-083697	Oryza punctata	54.85	0.00e+00	969.00
IUUC-Oru-084274	Oryza rufipogon	54.85	0.00e+00	966.00
IUUC-Osa-085841	Oryza sativa	54.86	0.00e+00	970.00
IUUC-Ola-086921	Oryzias latipes	48.83	0.00e+00	1193.00
IUUC-Olu-087639	Ostreococcus lucimarinus	48.42	0.00e+00	1185.00
IUUC-Oga-087991	Otolemur garnettii	47.42	0.00e+00	1151.00
IUUC-Oar-089590	Ovis aries	49.84	0.00e+00	1226.00
IUUC-Ptr-090808	Pan troglodytes	49.48	0.00e+00	1221.00
IUUC-Pan-092475	Papio anubis	49.64	0.00e+00	1217.00
IUUC-Psi-093044	Pelodiscus sinensis	51.20	0.00e+00	845.00
IUUC-Pno-094839	Phaeosphaeria nodorum	76.92	0.00e+00	1831.00
IUUC-Ppa-095254	Physcomitrella patens	49.92	0.00e+00	1219.00
IUUC-Pfo-097493	Poecilia formosa	49.19	0.00e+00	1199.00
IUUC-Pab-098497	Pongo abelii	49.76	0.00e+00	1229.00
IUUC-Pop-099992	Populus trichocarpa	55.76	0.00e+00	965.00
IUUC-Pca-100413	Procavia capensis	53.23	1.00e-178	619.00
IUUC-Ppe-101899	Prunus persica	55.84	0.00e+00	979.00
IUUC-Pva-102126	Pteropus vampyrus	47.86	0.00e+00	1159.00
IUUC-Pgr-103376	Puccinia graminis	57.27	0.00e+00	1443.00
IUUC-Ptt-103978	Puccinia triticina	51.87	0.00e+00	1224.00
IUUC-Pte-104126	Pyrenophora teres	83.56	0.00e+00	1481.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	74.57	0.00e+00	1068.00
IUUC-Rno-105428	Rattus norvegicus	50.00	0.00e+00	1230.00
IUUC-Sce-106464	Saccharomyces cerevisiae	53.62	0.00e+00	1282.00
IUUC-Sha-107301	Sarcophilus harrisii	49.43	0.00e+00	1207.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	52.04	0.00e+00	1320.00
IUUC-Spo-108217	Schizosaccharomyces pombe	55.00	0.00e+00	1384.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	79.02	0.00e+00	1989.00
IUUC-Smo-109582	Selaginella moellendorffii	57.07	0.00e+00	1018.00
IUUC-Sit-109697	Setaria italica	54.74	0.00e+00	968.00
IUUC-Sly-111447	Solanum lycopersicum	46.33	0.00e+00	1138.00
IUUC-Stu-112564	Solanum tuberosum	46.10	0.00e+00	1134.00
IUUC-Sar-113313	Sorex araneus	40.96	4.00e-162	563.00
IUUC-Sbi-114388	Sorghum bicolor	54.74	0.00e+00	969.00
IUUC-Sre-115209	Sporisorium reilianum	62.34	0.00e+00	1120.00
IUUC-Ssc-115933	Sus scrofa	49.76	0.00e+00	1225.00
IUUC-Tgu-117109	Taeniopygia guttata	43.62	8.00e-91	325.00
IUUC-Tru-117772	Takifugu rubripes	47.86	0.00e+00	1181.00
IUUC-Tsy-119105	Tarsius syrichta	47.52	0.00e+00	924.00
IUUC-Tni-120556	Tetraodon nigroviridis	38.55	2.00e-140	491.00
IUUC-Tca-121545	Theobroma cacao	56.13	0.00e+00	983.00
IUUC-Tre-121951	Trichoderma reesei	75.43	0.00e+00	1902.00
IUUC-Tvi-122359	Trichoderma virens	76.46	0.00e+00	1932.00
IUUC-Tae-123688	Triticum aestivum	47.34	0.00e+00	1150.00
IUUC-Tur-126754	Triticum urartu	55.33	0.00e+00	978.00
IUUC-Tme-127170	Tuber melanosporum	77.24	0.00e+00	1954.00
IUUC-Tbe-127882	Tupaia belangeri	61.86	1.00e-119	423.00
IUUC-Ttr-128217	Tursiops truncatus	47.86	0.00e+00	1153.00
IUUC-Uma-129337	Ustilago maydis	61.74	0.00e+00	1108.00
IUUC-Vda-129828	Verticillium dahliae	75.16	0.00e+00	1895.00
IUUC-Vpa-130537	Vicugna pacos	49.23	0.00e+00	1208.00
IUUC-Vvi-130958	Vitis vinifera	56.18	0.00e+00	983.00
IUUC-Xtr-132857	Xenopus tropicalis	48.16	0.00e+00	1135.00
IUUC-Xma-133138	Xiphophorus maculatus	49.59	0.00e+00	1203.00
IUUC-Yli-134399	Yarrowia lipolytica	60.67	0.00e+00	1080.00
IUUC-Zma-135612	Zea mays	45.91	0.00e+00	1119.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence