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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018211
UUCD1 version UUC-CaE-00651
Ensembl Protein ID Y54G9A.6
UniProt Accession Q9XWH0; BUB3_CAEEL
Genbank Protein ID CAA21698.1
Protein Name Mitotic checkpoint protein bub-3; Budding uninhibited by benzimidazole 3
Genbank Nucleotide ID BX284602
Gene Name bub-3; Y54G9A.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00013209 Y54G9A.6 Y54G9A.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMap
Protein-protein Interaction
iRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-20 73.2 108 138
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H+  v+c++f +   l+vsG++D ++k+WD 
   Q: 108  HALAVRCMEFnPMsSLIVSGGWDSSVKLWDA 138
           66679*****977799**************5 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments (PubMed:18248670, PubMed:19109417, PubMed:25987605). Promotes the formation of stable end-on bipolar attachments of chromosomes (PubMed:25987605). Necessary for expression and kinetochore localization of bub-1 (PubMed:19109417, PubMed:25987605). Plays a role in synapsis checkpoint signaling inducing apoptosis in response to unsynapsed chromosomes and thus controlling chromosomal segregation during oocyte meiosis (PubMed:26483555).
 Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments (PubMed:18248670, PubMed:19109417, PubMed:25987605). Promotes the formation of stable end-on bipolar attachments of chromosomes (PubMed:25987605). Necessary for expression and kinetochore localization of bub-1 (PubMed:19109417, PubMed:25987605). Plays a role in synapsis checkpoint signaling inducing apoptosis in response to unsynapsed chromosomes and thus controlling chromosomal segregation during oocyte meiosis (PubMed:26483555).
Protein Sequence
(Fasta)
MSTYQAATIV AAPNEFRVPF PPFVQISKVQ FQREAGSRLL AASGWDGTCR VYEVGKLGDI 60
SEKLVFTHGK PLLTCTFAGY NKVAFGGVDH NVKLADIETG NGTQLGSHAL AVRCMEFNPM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018211|E3,WD_repeat|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGGAAAGCA CAATTTCCAG ATGTCTACCT ACCAAGCGGC GACAATTGTG GCGGCTCCCA 60
ACGAGTTTCG CGTCCCGTTT CCCCCATTTG TACAAATTTC CAAAGTTCAG TTCCAAAGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018211|E3,WD_repeat|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0469--Meiosis
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005654--C:nucleoplasm
GO:0051301--P:cell division
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0033316--P:meiotic spindle assembly checkpoint
GO:0007067--P:mitotic nuclear division
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0051726--P:regulation of cell cycle
KEGG cel:CELE_Y54G9A.6
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002418 Ailuropoda melanoleuca 43.33 3.00e-77 280.00
IUUC-Atr-002511 Amborella trichopoda 38.53 9.00e-62 229.00
IUUC-Apl-003201 Anas platyrhynchos 43.03 4.00e-76 276.00
IUUC-Aca-004657 Anolis carolinensis 43.03 5.00e-76 276.00
IUUC-Aly-006428 Arabidopsis lyrata 41.16 3.00e-65 240.00
IUUC-Ath-007030 Arabidopsis thaliana 41.46 6.00e-66 243.00
IUUC-Acl-008120 Aspergillus clavatus 32.86 3.00e-53 200.00
IUUC-Afu-009061 Aspergillus fumigatus 33.43 2.00e-53 201.00
IUUC-Ani-009457 Aspergillus nidulans 34.17 5.00e-53 200.00
IUUC-Aor-009886 Aspergillus oryzae 32.86 2.00e-49 188.00
IUUC-Ate-010388 Aspergillus terreus 33.62 1.00e-49 188.00
IUUC-Ame-011039 Astyanax mexicanus 44.24 6.00e-77 279.00
IUUC-Bgr-012134 Blumeria graminis 35.20 3.00e-51 194.00
IUUC-Bta-012959 Bos taurus 43.64 7.00e-78 282.00
IUUC-Bci-013818 Botrytis cinerea 34.02 3.00e-53 201.00
IUUC-Bdi-014928 Brachypodium distachyon 39.94 2.00e-63 234.00
IUUC-Bol-015262 Brassica oleracea 39.81 1.00e-61 228.00
IUUC-Bra-016981 Brassica rapa 38.20 5.00e-63 233.00
IUUC-Cja-018807 Callithrix jacchus 43.64 7.00e-78 282.00
IUUC-Cfa-020279 Canis familiaris 46.40 2.00e-65 240.00
IUUC-Cpo-022411 Cavia porcellus 43.64 8.00e-78 282.00
IUUC-Cre-022964 Chlamydomonas reinhardtii 39.76 7.00e-54 202.00
IUUC-Csa-024046 Chlorocebus sabaeus 39.62 5.00e-51 193.00
IUUC-Cho-024930 Choloepus hoffmanni 43.03 1.00e-76 278.00
IUUC-Cin-025561 Ciona intestinalis 44.44 2.00e-79 287.00
IUUC-Csv-026129 Ciona savignyi 44.85 9.00e-80 288.00
IUUC-Cgl-026764 Colletotrichum gloeosporioides 32.10 4.00e-49 187.00
IUUC-Dre-028257 Danio rerio 43.81 4.00e-73 266.00
IUUC-Dno-029433 Dasypus novemcinctus 43.64 7.00e-78 282.00
IUUC-Dor-030318 Dipodomys ordii 43.64 8.00e-78 282.00
IUUC-Dme-031609 Drosophila melanogaster 43.98 4.00e-76 276.00
IUUC-Ete-032903 Echinops telfairi 37.27 7.00e-56 209.00
IUUC-Eca-034333 Equus caballus 43.64 8.00e-78 282.00
IUUC-Fca-035848 Felis catus 43.64 8.00e-78 282.00
IUUC-Fal-037239 Ficedula albicollis 43.03 6.00e-76 276.00
IUUC-Fox-037712 Fusarium oxysporum 34.20 4.00e-53 200.00
IUUC-Fso-038165 Fusarium solani 33.05 1.00e-52 198.00
IUUC-Gmo-039586 Gadus morhua 42.99 2.00e-74 271.00
IUUC-Gga-040565 Gallus gallus 42.69 6.00e-76 276.00
IUUC-Gac-041299 Gasterosteus aculeatus 43.50 6.00e-78 282.00
IUUC-Gma-044183 Glycine max 37.31 5.00e-61 226.00
IUUC-Ggo-045135 Gorilla gorilla 43.64 8.00e-78 282.00
IUUC-Hsa-045788 Homo sapiens 43.64 8.00e-78 282.00
IUUC-Itr-048845 Ictidomys tridecemlineatus 43.64 1.00e-77 281.00
IUUC-Lch-050423 Latimeria chalumnae 43.20 1.00e-77 282.00
IUUC-Lpe-051670 Leersia perrieri 39.63 2.00e-64 238.00
IUUC-Loc-052148 Lepisosteus oculatus 43.20 8.00e-77 278.00
IUUC-Lma-053147 Leptosphaeria maculans 34.39 3.00e-53 200.00
IUUC-Laf-054429 Loxodonta africana 43.33 1.00e-75 275.00
IUUC-Mcc-055649 Macaca mulatta 43.64 8.00e-78 282.00
IUUC-Meu-056019 Macropus eugenii 35.26 3.00e-52 197.00
IUUC-Mtr-058803 Medicago truncatula 39.02 7.00e-65 239.00
IUUC-Mla-059131 Melampsora laricipopulina 34.55 7.00e-53 199.00
IUUC-Mga-059227 Meleagris gallopavo 43.33 2.00e-75 274.00
IUUC-Mmr-060811 Microcebus murinus 43.64 8.00e-78 282.00
IUUC-Mdo-062582 Monodelphis domestica 41.94 8.00e-75 272.00
IUUC-Mmu-064048 Mus musculus 43.64 7.00e-78 282.00
IUUC-Mac-064572 Musa acuminata 39.88 5.00e-64 236.00
IUUC-Mpu-066592 Mustela putorius furo 43.64 8.00e-78 282.00
IUUC-Mlu-067466 Myotis lucifugus 43.03 3.00e-75 273.00
IUUC-Nfi-068486 Neosartorya fischeri 32.29 6.00e-52 196.00
IUUC-Nle-069273 Nomascus leucogenys 43.64 8.00e-78 282.00
IUUC-Opr-070473 Ochotona princeps 42.12 4.00e-73 266.00
IUUC-Ont-072515 Oreochromis niloticus 44.55 3.00e-78 283.00
IUUC-Oan-073344 Ornithorhynchus anatinus 44.84 6.00e-71 259.00
IUUC-Ocu-073931 Oryctolagus cuniculus 43.33 1.00e-77 281.00
IUUC-Oba-075450 Oryza barthii 39.63 8.00e-64 235.00
IUUC-Obr-076202 Oryza brachyantha 39.33 9.00e-64 235.00
IUUC-Ogl-077809 Oryza glaberrima 39.63 7.00e-64 236.00
IUUC-Ogu-077992 Oryza glumaepatula 36.89 2.00e-61 228.00
IUUC-Oin-079586 Oryza indica 39.63 8.00e-64 235.00
IUUC-Olo-080351 Oryza longistaminata 37.54 1.00e-57 215.00
IUUC-Ome-081913 Oryza meridionalis 33.13 1.00e-48 185.00
IUUC-Oni-082048 Oryza nivara 39.63 8.00e-64 235.00
IUUC-Opu-083951 Oryza punctata 39.63 7.00e-64 236.00
IUUC-Oru-084904 Oryza rufipogon 39.63 1.00e-63 235.00
IUUC-Osa-085399 Oryza sativa 39.33 1.00e-62 232.00
IUUC-Ola-086605 Oryzias latipes 43.03 5.00e-77 279.00
IUUC-Oga-088115 Otolemur garnettii 43.64 8.00e-78 282.00
IUUC-Oar-089301 Ovis aries 43.64 2.00e-77 281.00
IUUC-Pan-092156 Papio anubis 43.64 8.00e-78 282.00
IUUC-Psi-094031 Pelodiscus sinensis 43.03 2.00e-76 278.00
IUUC-Pma-094724 Petromyzon marinus 45.76 2.00e-80 291.00
IUUC-Pno-094848 Phaeosphaeria nodorum 35.71 4.00e-42 163.00
IUUC-Ppa-096018 Physcomitrella patens 38.82 3.00e-64 237.00
IUUC-Pfo-096256 Poecilia formosa 43.94 1.00e-76 278.00
IUUC-Pab-097757 Pongo abelii 43.64 8.00e-78 282.00
IUUC-Pop-099511 Populus trichocarpa 38.27 5.00e-61 226.00
IUUC-Pca-100326 Procavia capensis 47.28 2.00e-64 237.00
IUUC-Ppe-101462 Prunus persica 38.84 3.00e-62 230.00
IUUC-Pva-102523 Pteropus vampyrus 43.64 8.00e-78 282.00
IUUC-Pgr-103482 Puccinia graminis 35.19 3.00e-40 157.00
IUUC-Ptt-103911 Puccinia triticina 34.10 2.00e-51 195.00
IUUC-Pte-104350 Pyrenophora teres 35.26 1.00e-53 201.00
IUUC-Pyt-104538 Pyrenophora triticirepentis 34.97 5.00e-53 200.00
IUUC-Sha-106976 Sarcophilus harrisii 43.33 2.00e-77 281.00
IUUC-Ssl-108521 Sclerotinia sclerotiorum 32.65 2.00e-31 127.00
IUUC-Smo-109187 Selaginella moellendorffii 40.12 9.00e-66 242.00
IUUC-Sit-110412 Setaria italica 38.24 2.00e-59 221.00
IUUC-Sly-111541 Solanum lycopersicum 38.44 4.00e-60 223.00
IUUC-Stu-112371 Solanum tuberosum 38.44 4.00e-60 223.00
IUUC-Sar-113159 Sorex araneus 34.73 3.00e-40 157.00
IUUC-Sbi-114880 Sorghum bicolor 39.33 2.00e-63 234.00
IUUC-Sre-115205 Sporisorium reilianum 29.81 2.00e-39 155.00
IUUC-Ssc-116399 Sus scrofa 43.64 8.00e-78 282.00
IUUC-Tgu-117029 Taeniopygia guttata 42.86 2.00e-75 274.00
IUUC-Tru-118385 Takifugu rubripes 43.64 8.00e-76 275.00
IUUC-Tsy-118842 Tarsius syrichta 43.64 1.00e-77 281.00
IUUC-Tni-120539 Tetraodon nigroviridis 43.81 7.00e-75 272.00
IUUC-Tca-121027 Theobroma cacao 38.58 2.00e-62 231.00
IUUC-Tae-125434 Triticum aestivum 39.27 3.00e-64 237.00
IUUC-Tme-127210 Tuber melanosporum 38.39 1.00e-62 231.00
IUUC-Tbe-128159 Tupaia belangeri 56.62 5.00e-41 159.00
IUUC-Ttr-128743 Tursiops truncatus 43.64 8.00e-78 282.00
IUUC-Uma-129496 Ustilago maydis 31.51 2.00e-38 152.00
IUUC-Vda-129882 Verticillium dahliae 30.34 1.00e-47 182.00
IUUC-Vpa-130790 Vicugna pacos 46.90 4.00e-69 253.00
IUUC-Vvi-131671 Vitis vinifera 37.76 7.00e-63 232.00
IUUC-Xtr-132887 Xenopus tropicalis 41.21 7.00e-66 242.00
IUUC-Xma-134127 Xiphophorus maculatus 43.64 4.00e-76 276.00
Created Date 25-Jun-2017

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