iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mac-065563

Ensembl Protein ID

GSMUA_Achr6P19960_001

UniProt Accession

M0T8J4; M0T8J4_MUSAM

Protein Name

3-isopropylmalate dehydrogenase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GSMUA_Achr6G19960_001	GSMUA_Achr6T19960_001	GSMUA_Achr6P19960_001

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.10e-25	87.3	526	558
UBD/Beta-Prp	3.80e-43	148.6	263	432

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDl 30
           gH++ v+c+++  s+ ++l+s+sdD+ti++W l
   Q: 526  GHSGTVNCVSWnpSNpHMLASASDDHTIRIWGL 558
           8***********877899*************97 PP

UBD/Beta-Prp

   S: 86   cvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           ++++l++h d+v+ l+fs +g++l+s s dr + +w+++++ +l     lsgh + v +v+++pd++ l +++  ++vr Wd+ +g++
   Q: 263  TTQVLREHHDEVWFLQFSNQGKYLASSSIDRSAIIWEVREDGELTLkhKLSGHLKPVLMVAWSPDDSQLLTCGMEEVVRRWDVHSGEC 350
           6789999************99*****************99999865679999************999999****************** PP
   S: 172  lrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght.dnvksvrfspnderlvsgssDgsiriWdlrsg 254
           l+  ++ +     s  + ++gkel sg +d+t+ +wdl  +e +++++g++ + +++v++++++ +++s   + +i + d +++
   Q: 351  LHVYEK-NGVGLISCGWFPDGKELFSGVTDRTICFWDLDGKE-LDSWKGQRtSKTSDVAVTKDGRHMISLCRETVILLLDRETK 432
           **9987.444444444888899****************6555.99999977356778999999999999999999998887765 PP

Organism

Musa acuminata

Functional Description
(View)

Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.

Protein Sequence
(Fasta)

MGGVEDNEPP SKRVKTSSLE LENLSNTSSL SEFINPLGGL MARPLPSQGR EDMVGSKGVI 60
KKVEFVRIIT KALYSLGYER SGAVLEEESG IPLHSSAVDI FRKQVLEGNW DESVIALQKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAGGTG TAGAAGACAA TGAACCACCC TCAAAACGTG TCAAAACATC CTCACTAGAA 60
TTGGAGAACC TCTCAAATAC TTCGTCTCTT TCTGAGTTCA TCAATCCTTT GGGAGGCCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0028--Amino-acid biosynthesis
KW-0100--Branched-chain amino acid biosynthesis
KW-0181--Complete proteome
KW-0432--Leucine biosynthesis
KW-0479--Metal-binding
KW-0520--NAD
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR006595--CTLH_C
IPR019818--IsoCit/isopropylmalate_DH_CS
IPR024084--IsoPropMal-DH-like_dom
IPR004429--Isopropylmalate_DH
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50897--CTLH
PS00470--IDH_IMDH
PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00180--Iso_dh
PF00400--WD40

SMART

SM00668--CTLH
SM01329--Iso_dh
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0003862--F:3-isopropylmalate dehydrogenase activity
GO:0000287--F:magnesium ion binding
GO:0051287--F:NAD binding
GO:0009098--P:leucine biosynthetic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000905	Aegilops tauschii	68.68	0.00e+00	785.00
IUUC-Aml-001381	Ailuropoda melanoleuca	37.67	1.00e-86	313.00
IUUC-Atr-002649	Amborella trichopoda	65.16	0.00e+00	773.00
IUUC-Apl-003200	Anas platyrhynchos	38.84	3.00e-84	305.00
IUUC-Aca-005122	Anolis carolinensis	39.80	8.00e-89	320.00
IUUC-Aly-006260	Arabidopsis lyrata	61.98	0.00e+00	725.00
IUUC-Ath-007549	Arabidopsis thaliana	61.10	0.00e+00	713.00
IUUC-Ago-007896	Ashbya gossypii	24.89	3.00e-34	139.00
IUUC-Acl-008259	Aspergillus clavatus	36.70	7.00e-90	324.00
IUUC-Afl-008669	Aspergillus flavus	34.89	2.00e-84	306.00
IUUC-Afu-008972	Aspergillus fumigatus	37.30	5.00e-68	250.00
IUUC-Ani-009455	Aspergillus nidulans	31.04	6.00e-74	271.00
IUUC-Ang-009832	Aspergillus niger	32.80	1.00e-77	283.00
IUUC-Aor-010221	Aspergillus oryzae	36.06	6.00e-88	318.00
IUUC-Ate-010262	Aspergillus terreus	35.96	1.00e-91	330.00
IUUC-Ame-010615	Astyanax mexicanus	39.01	6.00e-85	308.00
IUUC-Bgr-012047	Blumeria graminis	34.82	3.00e-77	282.00
IUUC-Bta-012566	Bos taurus	38.20	8.00e-84	303.00
IUUC-Bci-013589	Botrytis cinerea	32.49	5.00e-76	278.00
IUUC-Bdi-014338	Brachypodium distachyon	69.52	0.00e+00	841.00
IUUC-Bol-015143	Brassica oleracea	63.16	0.00e+00	727.00
IUUC-Bra-017245	Brassica rapa	62.41	0.00e+00	716.00
IUUC-Cja-019082	Callithrix jacchus	37.48	1.00e-86	313.00
IUUC-Cfa-020788	Canis familiaris	38.00	2.00e-83	302.00
IUUC-Cpo-022453	Cavia porcellus	38.17	3.00e-84	305.00
IUUC-Csa-023815	Chlorocebus sabaeus	36.70	2.00e-66	246.00
IUUC-Csv-026251	Ciona savignyi	40.60	4.00e-87	314.00
IUUC-Cgl-026607	Colletotrichum gloeosporioides	31.76	6.00e-68	251.00
IUUC-Cne-026805	Cryptococcus neoformans	30.89	7.00e-42	164.00
IUUC-Dre-027404	Danio rerio	39.41	5.00e-86	311.00
IUUC-Dno-029089	Dasypus novemcinctus	37.59	5.00e-85	308.00
IUUC-Dor-030714	Dipodomys ordii	36.84	3.00e-60	225.00
IUUC-Dse-031569	Dothistroma septosporum	31.50	4.00e-68	251.00
IUUC-Dme-032077	Drosophila melanogaster	37.45	4.00e-88	318.00
IUUC-Eca-033943	Equus caballus	38.17	5.00e-84	304.00
IUUC-Fca-036556	Felis catus	38.40	9.00e-79	286.00
IUUC-Fal-036639	Ficedula albicollis	37.15	8.00e-86	310.00
IUUC-Fox-037720	Fusarium oxysporum	33.01	1.00e-71	263.00
IUUC-Fso-038206	Fusarium solani	31.43	8.00e-70	257.00
IUUC-Gmo-039395	Gadus morhua	37.62	2.00e-83	302.00
IUUC-Ggr-039738	Gaeumannomyces graminis	32.82	5.00e-76	278.00
IUUC-Gga-040577	Gallus gallus	37.86	2.00e-88	319.00
IUUC-Gac-041352	Gasterosteus aculeatus	37.09	4.00e-90	325.00
IUUC-Gma-042660	Glycine max	66.03	0.00e+00	746.00
IUUC-Ggo-044684	Gorilla gorilla	37.48	9.00e-87	313.00
IUUC-Hsa-046838	Homo sapiens	37.48	9.00e-87	313.00
IUUC-Hvu-047226	Hordeum vulgare	68.58	0.00e+00	807.00
IUUC-Itr-048020	Ictidomys tridecemlineatus	37.48	1.00e-86	313.00
IUUC-Lch-049848	Latimeria chalumnae	37.08	1.00e-68	253.00
IUUC-Lpe-050963	Leersia perrieri	72.24	0.00e+00	876.00
IUUC-Loc-052708	Lepisosteus oculatus	40.20	5.00e-89	321.00
IUUC-Lma-053156	Leptosphaeria maculans	32.74	6.00e-78	284.00
IUUC-Laf-054153	Loxodonta africana	38.39	8.00e-87	313.00
IUUC-Mcc-054742	Macaca mulatta	37.48	9.00e-87	313.00
IUUC-Meu-056633	Macropus eugenii	27.85	2.00e-21	96.30
IUUC-Mor-056939	Magnaporthe oryzae	35.85	3.00e-83	302.00
IUUC-Mpo-057600	Magnaporthe poae	32.95	2.00e-75	276.00
IUUC-Mtr-057962	Medicago truncatula	64.00	0.00e+00	753.00
IUUC-Mla-058912	Melampsora laricipopulina	37.21	5.00e-81	294.00
IUUC-Mga-059811	Meleagris gallopavo	36.14	1.00e-69	256.00
IUUC-Mvi-060274	Microbotryum violaceum	36.10	8.00e-92	331.00
IUUC-Mmr-060823	Microcebus murinus	37.67	4.00e-87	315.00
IUUC-Mdo-062394	Monodelphis domestica	39.10	3.00e-88	319.00
IUUC-Mmu-063924	Mus musculus	37.48	6.00e-87	314.00
IUUC-Mpu-066858	Mustela putorius furo	38.68	8.00e-86	310.00
IUUC-Mlu-067659	Myotis lucifugus	37.48	1.00e-86	313.00
IUUC-Nfi-068498	Neosartorya fischeri	37.36	1.00e-89	323.00
IUUC-Ncr-068832	Neurospora crassa	32.69	6.00e-69	254.00
IUUC-Nle-069654	Nomascus leucogenys	38.00	2.00e-83	302.00
IUUC-Ont-071547	Oreochromis niloticus	39.41	8.00e-92	330.00
IUUC-Oan-073045	Ornithorhynchus anatinus	35.48	2.00e-75	276.00
IUUC-Ocu-073812	Oryctolagus cuniculus	37.09	2.00e-85	309.00
IUUC-Oba-075071	Oryza barthii	72.59	0.00e+00	888.00
IUUC-Obr-076614	Oryza brachyantha	71.72	0.00e+00	870.00
IUUC-Ogl-076963	Oryza glaberrima	74.44	0.00e+00	855.00
IUUC-Ogu-078436	Oryza glumaepatula	74.44	0.00e+00	855.00
IUUC-Oin-080021	Oryza indica	74.44	0.00e+00	854.00
IUUC-Olo-080298	Oryza longistaminata	74.44	0.00e+00	855.00
IUUC-Ome-081202	Oryza meridionalis	72.76	0.00e+00	888.00
IUUC-Oni-082604	Oryza nivara	72.59	0.00e+00	887.00
IUUC-Opu-083763	Oryza punctata	72.24	0.00e+00	885.00
IUUC-Oru-084243	Oryza rufipogon	72.59	0.00e+00	887.00
IUUC-Osa-086153	Oryza sativa	72.21	0.00e+00	769.00
IUUC-Ola-086670	Oryzias latipes	36.41	7.00e-92	330.00
IUUC-Oga-088723	Otolemur garnettii	37.36	3.00e-80	291.00
IUUC-Oar-090125	Ovis aries	37.67	5.00e-87	314.00
IUUC-Ptr-090787	Pan troglodytes	38.00	2.00e-83	302.00
IUUC-Pan-092573	Papio anubis	34.75	3.00e-41	162.00
IUUC-Psi-093579	Pelodiscus sinensis	40.25	7.00e-84	303.00
IUUC-Pma-094254	Petromyzon marinus	41.27	5.00e-78	284.00
IUUC-Pno-094912	Phaeosphaeria nodorum	34.45	5.00e-81	295.00
IUUC-Ppa-095307	Physcomitrella patens	54.39	1.00e-168	585.00
IUUC-Pfo-096394	Poecilia formosa	39.21	3.00e-91	328.00
IUUC-Pab-098459	Pongo abelii	37.28	1.00e-84	306.00
IUUC-Pop-099989	Populus trichocarpa	66.67	0.00e+00	778.00
IUUC-Ppe-101227	Prunus persica	65.22	0.00e+00	792.00
IUUC-Pva-102404	Pteropus vampyrus	35.60	3.00e-71	262.00
IUUC-Ptt-103705	Puccinia triticina	25.08	2.00e-44	173.00
IUUC-Pte-104023	Pyrenophora teres	35.70	1.00e-83	303.00
IUUC-Pyt-104759	Pyrenophora triticirepentis	34.95	2.00e-83	303.00
IUUC-Rno-105335	Rattus norvegicus	37.60	4.00e-83	301.00
IUUC-Sce-106152	Saccharomyces cerevisiae	36.29	1.00e-18	88.20
IUUC-Sha-106497	Sarcophilus harrisii	38.32	2.00e-84	305.00
IUUC-Sja-107894	Schizosaccharomyces japonicus	36.72	2.00e-85	308.00
IUUC-Spo-108235	Schizosaccharomyces pombe	35.20	3.00e-84	305.00
IUUC-Smo-109054	Selaginella moellendorffii	55.00	0.00e+00	633.00
IUUC-Sit-110575	Setaria italica	69.05	0.00e+00	858.00
IUUC-Sly-111282	Solanum lycopersicum	61.30	0.00e+00	683.00
IUUC-Stu-112726	Solanum tuberosum	60.42	0.00e+00	715.00
IUUC-Sar-113539	Sorex araneus	45.66	2.00e-37	149.00
IUUC-Sbi-114344	Sorghum bicolor	69.73	0.00e+00	858.00
IUUC-Sre-115051	Sporisorium reilianum	31.87	7.00e-51	194.00
IUUC-Ssc-115532	Sus scrofa	37.48	1.00e-86	313.00
IUUC-Tgu-116728	Taeniopygia guttata	37.36	7.00e-87	313.00
IUUC-Tru-118471	Takifugu rubripes	38.55	5.00e-94	337.00
IUUC-Tsy-119284	Tarsius syrichta	32.04	2.00e-63	236.00
IUUC-Tni-119720	Tetraodon nigroviridis	37.19	9.00e-88	317.00
IUUC-Tca-121103	Theobroma cacao	66.90	0.00e+00	781.00
IUUC-Tre-122234	Trichoderma reesei	33.40	1.00e-74	273.00
IUUC-Tae-125508	Triticum aestivum	67.58	0.00e+00	827.00
IUUC-Tur-126726	Triticum urartu	65.38	0.00e+00	788.00
IUUC-Tme-126972	Tuber melanosporum	37.04	4.00e-100	358.00
IUUC-Ttr-129184	Tursiops truncatus	36.40	2.00e-77	282.00
IUUC-Uma-129354	Ustilago maydis	35.79	1.00e-43	171.00
IUUC-Vda-129770	Verticillium dahliae	32.62	5.00e-67	248.00
IUUC-Vpa-130400	Vicugna pacos	38.00	1.00e-82	299.00
IUUC-Vvi-130991	Vitis vinifera	63.95	0.00e+00	735.00
IUUC-Xtr-132619	Xenopus tropicalis	37.74	3.00e-85	308.00
IUUC-Xma-134128	Xiphophorus maculatus	39.21	1.00e-91	330.00
IUUC-Yli-134521	Yarrowia lipolytica	36.08	1.00e-82	300.00
IUUC-Zma-135772	Zea mays	70.47	0.00e+00	832.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence