iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000000478.3	ENSMMUT00000044403.2	ENSMMUP00000037419.2
ENSMMUG00000000478.3	ENSMMUT00000000705.3	ENSMMUP00000000653.3
ENSMMUG00000000478.3	ENSMMUT00000068346.1	ENSMMUP00000058006.1
ENSMMUG00000000478.3	ENSMMUT00000070759.1	ENSMMUP00000042617.1
ENSMMUG00000000478.3	ENSMMUT00000073559.1	ENSMMUP00000049514.1
ENSMMUG00000000478.3	ENSMMUT00000054725.1	ENSMMUP00000057641.1
ENSMMUG00000000478.3	ENSMMUT00000071284.1	ENSMMUP00000048417.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	5.10e-51	173.8	99	289

Active Site

Position(s)	Description	Evidence
106	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
109	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
283		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 99   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekqtsvadLLASFNDQSTSD 187
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 188  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHIFPEGS-E 272
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 273  PKVYLLYRPGHYDILYK 289
           ***************96 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE AWVTPSPCWD MTDPCLLQIA 60
VQNPLVSERL ELSVLYKEYA EDDNIYQQKI KDLHKKYSYI RKTRPDGNCF YRAFGFSHLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATGGAG GGAGGAGTCA AGAACAGTTT AGGCTTCTCG CGTACATGAT TGGGTGGACC 60
GAGATGTCAC TCACAAGTAT AGGCCTTGGA GGAGGAACAG AACCAGAAGA AGAGCCCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	92.10	3.00e-152	530.00
IUUC-Apl-003233	Anas platyrhynchos	58.46	7.00e-19	84.70
IUUC-Aca-004648	Anolis carolinensis	80.14	2.00e-133	468.00
IUUC-Aly-005710	Arabidopsis lyrata	41.96	2.00e-51	195.00
IUUC-Ath-007112	Arabidopsis thaliana	41.03	3.00e-50	191.00
IUUC-Afl-008439	Aspergillus flavus	34.18	2.00e-08	52.80
IUUC-Ame-010662	Astyanax mexicanus	77.58	1.00e-126	445.00
IUUC-Bta-013533	Bos taurus	92.73	2.00e-149	520.00
IUUC-Bol-016100	Brassica oleracea	40.97	2.00e-50	192.00
IUUC-Bra-017705	Brassica rapa	37.70	5.00e-45	174.00
IUUC-Cel-018295	Caenorhabditis elegans	35.78	8.00e-41	160.00
IUUC-Cja-019190	Callithrix jacchus	93.77	1.00e-150	525.00
IUUC-Cfa-020430	Canis familiaris	93.33	3.00e-146	510.00
IUUC-Cpo-022355	Cavia porcellus	93.43	1.00e-150	525.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	36.59	3.00e-43	168.00
IUUC-Csa-023286	Chlorocebus sabaeus	96.89	1.00e-157	548.00
IUUC-Cin-025507	Ciona intestinalis	39.39	3.00e-41	160.00
IUUC-Csv-026273	Ciona savignyi	46.39	1.00e-65	242.00
IUUC-Dre-027843	Danio rerio	74.30	2.00e-123	435.00
IUUC-Dno-029165	Dasypus novemcinctus	99.00	8.00e-118	415.00
IUUC-Dor-030943	Dipodomys ordii	93.43	1.00e-150	525.00
IUUC-Dme-031922	Drosophila melanogaster	56.96	3.00e-75	275.00
IUUC-Ete-032296	Echinops telfairi	96.23	9.00e-89	320.00
IUUC-Eca-033695	Equus caballus	92.22	1.00e-144	505.00
IUUC-Fca-036441	Felis catus	93.33	4.00e-146	510.00
IUUC-Gmo-038908	Gadus morhua	75.18	3.00e-123	434.00
IUUC-Ggr-040020	Gaeumannomyces graminis	30.56	1.00e-31	131.00
IUUC-Gga-040460	Gallus gallus	76.47	8.00e-130	456.00
IUUC-Gac-042417	Gasterosteus aculeatus	75.75	3.00e-119	421.00
IUUC-Gma-043712	Glycine max	38.67	2.00e-48	185.00
IUUC-Ggo-044552	Gorilla gorilla	100.00	7.00e-92	329.00
IUUC-Hsa-046766	Homo sapiens	93.77	8.00e-151	525.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	93.43	1.00e-150	525.00
IUUC-Lch-050602	Latimeria chalumnae	75.93	9.00e-116	409.00
IUUC-Laf-053705	Loxodonta africana	93.43	1.00e-150	525.00
IUUC-Meu-056569	Macropus eugenii	80.28	6.00e-132	463.00
IUUC-Mtr-057712	Medicago truncatula	40.42	1.00e-43	169.00
IUUC-Mvi-060358	Microbotryum violaceum	34.93	6.00e-14	71.20
IUUC-Mmr-061123	Microcebus murinus	92.40	1.00e-123	436.00
IUUC-Mdo-062613	Monodelphis domestica	81.66	2.00e-120	424.00
IUUC-Mmu-063658	Mus musculus	93.43	1.00e-150	525.00
IUUC-Mac-065274	Musa acuminata	37.80	7.00e-39	154.00
IUUC-Mpu-066172	Mustela putorius furo	93.77	8.00e-151	525.00
IUUC-Mlu-066966	Myotis lucifugus	93.08	7.00e-150	523.00
IUUC-Nle-069519	Nomascus leucogenys	87.70	2.00e-92	332.00
IUUC-Ont-071901	Oreochromis niloticus	76.95	1.00e-121	429.00
IUUC-Ola-087331	Oryzias latipes	80.90	7.00e-86	309.00
IUUC-Oga-088064	Otolemur garnettii	93.77	8.00e-151	525.00
IUUC-Oar-089251	Ovis aries	91.54	9.00e-144	502.00
IUUC-Ptr-091430	Pan troglodytes	93.77	2.00e-150	525.00
IUUC-Psi-093823	Pelodiscus sinensis	82.08	2.00e-130	458.00
IUUC-Pma-094366	Petromyzon marinus	75.88	3.00e-102	364.00
IUUC-Pfo-096734	Poecilia formosa	75.46	1.00e-110	392.00
IUUC-Pab-097919	Pongo abelii	92.80	1.00e-123	435.00
IUUC-Pop-099401	Populus trichocarpa	41.20	6.00e-48	184.00
IUUC-Ppe-101977	Prunus persica	42.80	4.00e-49	188.00
IUUC-Pva-102499	Pteropus vampyrus	93.31	9.00e-146	508.00
IUUC-Rno-105233	Rattus norvegicus	93.43	1.00e-150	525.00
IUUC-Sha-107081	Sarcophilus harrisii	91.85	2.00e-144	504.00
IUUC-Sly-111640	Solanum lycopersicum	39.37	5.00e-46	177.00
IUUC-Ssc-116202	Sus scrofa	93.77	8.00e-151	525.00
IUUC-Tru-117664	Takifugu rubripes	72.47	2.00e-119	421.00
IUUC-Tca-121467	Theobroma cacao	41.57	2.00e-47	182.00
IUUC-Tbe-128116	Tupaia belangeri	98.76	1.00e-92	332.00
IUUC-Ttr-128622	Tursiops truncatus	93.08	3.00e-148	517.00
IUUC-Vvi-131389	Vitis vinifera	41.03	6.00e-50	191.00
IUUC-Xma-134191	Xiphophorus maculatus	75.84	1.00e-111	395.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence