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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064337
UUCD1 version UUC-MuM-00763
Ensembl Protein ID ENSMUSP00000071495.7
UniProt Accession Q8K2I9; Q8C444; Q99KS0; Q9CTC6; Q9QZG7; FBH1_MOUSE
Genbank Protein ID BAB23095.1; BAC38767.1; AAH04036.1; AAH31393.1; AAF03151.1
Protein Name F-box DNA helicase 1; F-box only protein 18
Genbank Nucleotide ID AK003964; AK083118; BC004036; BC031393; AF184275
Gene Name Fbxo18; Fbh1; Fbx18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000058594.15 ENSMUST00000071564.13 ENSMUSP00000071495.7
ENSMUSG00000058594.15 ENSMUST00000131893.1 ENSMUSP00000116392.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 89.87 0.00e+00 1943.00 IUUC-Hsa-046650
E3 adaptor/Cullin RING/SCF/F-box 28.88 2.00e-41 166.00 IUUC-Spo-108147
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:24108124). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (By similarity).
 3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:24108124). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (By similarity).
Protein Sequence
(Fasta)
MRRFKRKHLT VVDCHHLARS HLAVTQPFSQ RWTNRDPNHG LYPRPRTKGR NRGRGCQRYI 60
SEFFLAGHQH CTNDMAKSNS VGQDSCQDAE GDMILTAESS CTLPQVDNGE ARLGSSGSAQ 120
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Protein Fasta Sequence


>IUUC-Mmu-064337|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
AGCGAAGAGG CGGAGCTCGC GGAGGAAGTC TGCAGTCGTC TGTGCTCGCT GTCTGGGCCG 60
AAGGAGGGGC TTGCTGGTCG GGGAAAGGCT GAATGTCCGG CGGCATCGCC TGGGTGGTGT 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064337|E3,F-box|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR014017--DNA_helicase_UvrD-like_C
IPR000212--DNA_helicase_UvrD/REP
IPR001810--F-box_dom
IPR027417--P-loop_NTPase
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF13361--UvrD_C
SMART

SM00256--FBOX
Gene Ontology

GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0043138--F:3'-5' DNA helicase activity
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0003678--F:DNA helicase activity
GO:0015616--F:DNA translocase activity
GO:0003690--F:double-stranded DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0008219--P:cell death
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000737--P:DNA catabolic process, endonucleolytic
GO:0000724--P:double-strand break repair via homologous recombination
GO:0035562--P:negative regulation of chromatin binding
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001934--P:positive regulation of protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0072429--P:response to intra-S DNA damage checkpoint signaling
KEGG mmu:50755
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000424 Aegilops tauschii 43.48 2.00e-03 39.30
IUUC-Aml-001396 Ailuropoda melanoleuca 88.72 0.00e+00 1885.00
IUUC-Atr-002826 Amborella trichopoda 41.27 7.00e-04 40.40
IUUC-Apl-003317 Anas platyrhynchos 48.21 0.00e+00 926.00
IUUC-Aca-004498 Anolis carolinensis 53.67 0.00e+00 939.00
IUUC-Aly-006174 Arabidopsis lyrata 30.38 8.00e-05 39.30
IUUC-Ath-007293 Arabidopsis thaliana 37.68 4.00e-03 37.70
IUUC-Ani-009226 Aspergillus nidulans 30.83 1.00e-05 45.40
IUUC-Ate-010526 Aspergillus terreus 39.71 8.00e-04 39.70
IUUC-Ame-011808 Astyanax mexicanus 57.89 3.00e-132 464.00
IUUC-Bta-013250 Bos taurus 86.90 0.00e+00 1842.00
IUUC-Bol-015348 Brassica oleracea 37.68 3.00e-03 38.10
IUUC-Cja-019638 Callithrix jacchus 90.34 0.00e+00 1944.00
IUUC-Cfa-020195 Canis familiaris 90.33 0.00e+00 1808.00
IUUC-Cpo-022269 Cavia porcellus 84.70 0.00e+00 1755.00
IUUC-Cre-022611 Chlamydomonas reinhardtii 40.28 4.00e-08 54.30
IUUC-Csa-024060 Chlorocebus sabaeus 90.95 0.00e+00 1737.00
IUUC-Cho-025003 Choloepus hoffmanni 89.39 0.00e+00 711.00
IUUC-Cin-025694 Ciona intestinalis 27.71 1.00e-28 120.00
IUUC-Dre-028083 Danio rerio 50.11 0.00e+00 848.00
IUUC-Dno-029203 Dasypus novemcinctus 84.81 0.00e+00 1727.00
IUUC-Dor-030477 Dipodomys ordii 96.93 0.00e+00 793.00
IUUC-Ete-032861 Echinops telfairi 85.95 0.00e+00 1808.00
IUUC-Eca-033205 Equus caballus 89.10 0.00e+00 1931.00
IUUC-Eeu-034784 Erinaceus europaeus 85.51 0.00e+00 1186.00
IUUC-Fca-035797 Felis catus 88.84 0.00e+00 1895.00
IUUC-Gmo-038855 Gadus morhua 46.36 4.00e-120 426.00
IUUC-Gga-040326 Gallus gallus 50.53 0.00e+00 972.00
IUUC-Gac-042240 Gasterosteus aculeatus 46.48 0.00e+00 711.00
IUUC-Ggo-045050 Gorilla gorilla 86.23 0.00e+00 1785.00
IUUC-Hsa-046650 Homo sapiens 89.67 0.00e+00 1877.00
IUUC-Itr-047965 Ictidomys tridecemlineatus 94.83 0.00e+00 763.00
IUUC-Lch-050231 Latimeria chalumnae 49.67 9.00e-159 553.00
IUUC-Loc-051884 Lepisosteus oculatus 49.25 0.00e+00 979.00
IUUC-Lma-053267 Leptosphaeria maculans 25.45 4.00e-03 37.40
IUUC-Laf-053843 Loxodonta africana 88.15 0.00e+00 1875.00
IUUC-Mcc-055570 Macaca mulatta 90.06 0.00e+00 1905.00
IUUC-Meu-056798 Macropus eugenii 66.41 2.00e-148 520.00
IUUC-Mtr-057915 Medicago truncatula 36.76 6.00e-04 40.40
IUUC-Mga-059648 Meleagris gallopavo 50.98 0.00e+00 926.00
IUUC-Mmr-060757 Microcebus murinus 87.50 0.00e+00 1818.00
IUUC-Mdo-061913 Monodelphis domestica 68.83 0.00e+00 1352.00
IUUC-Mpu-066483 Mustela putorius furo 88.05 0.00e+00 1898.00
IUUC-Mlu-068204 Myotis lucifugus 83.13 0.00e+00 1766.00
IUUC-Ncr-068735 Neurospora crassa 37.50 4.00e-03 37.40
IUUC-Nle-070053 Nomascus leucogenys 89.96 0.00e+00 1847.00
IUUC-Opr-070588 Ochotona princeps 83.84 0.00e+00 1756.00
IUUC-Ont-072655 Oreochromis niloticus 46.37 0.00e+00 736.00
IUUC-Oan-073351 Ornithorhynchus anatinus 61.66 0.00e+00 1279.00
IUUC-Ocu-074465 Oryctolagus cuniculus 88.17 0.00e+00 1801.00
IUUC-Oin-079176 Oryza indica 23.94 1.00e-04 41.60
IUUC-Olu-087831 Ostreococcus lucimarinus 32.01 4.00e-63 237.00
IUUC-Oga-089088 Otolemur garnettii 86.60 0.00e+00 1790.00
IUUC-Oar-089870 Ovis aries 86.23 0.00e+00 1805.00
IUUC-Ptr-090957 Pan troglodytes 89.86 0.00e+00 1856.00
IUUC-Pan-092632 Papio anubis 89.96 0.00e+00 1852.00
IUUC-Psi-093035 Pelodiscus sinensis 54.95 0.00e+00 1119.00
IUUC-Pno-094870 Phaeosphaeria nodorum 24.91 2.00e-03 38.50
IUUC-Ppa-095660 Physcomitrella patens 38.36 5.00e-04 40.80
IUUC-Pfo-096902 Poecilia formosa 44.07 0.00e+00 664.00
IUUC-Pab-098206 Pongo abelii 89.80 0.00e+00 1747.00
IUUC-Pop-098801 Populus trichocarpa 34.72 6.00e-04 40.00
IUUC-Pca-100238 Procavia capensis 82.31 0.00e+00 1729.00
IUUC-Ppe-101748 Prunus persica 35.94 8.00e-03 36.60
IUUC-Pva-103182 Pteropus vampyrus 87.48 0.00e+00 1815.00
IUUC-Pte-104033 Pyrenophora teres 33.90 2.00e-02 35.00
IUUC-Pyt-104599 Pyrenophora triticirepentis 25.00 4.00e-03 37.40
IUUC-Rno-105141 Rattus norvegicus 96.64 0.00e+00 2086.00
IUUC-Sce-106341 Saccharomyces cerevisiae 25.76 3.00e-03 37.00
IUUC-Sha-106827 Sarcophilus harrisii 66.06 0.00e+00 1400.00
IUUC-Sja-107882 Schizosaccharomyces japonicus 29.14 4.00e-41 163.00
IUUC-Spo-108147 Schizosaccharomyces pombe 28.88 3.00e-41 164.00
IUUC-Ssl-108584 Sclerotinia sclerotiorum 25.00 2.00e-03 38.10
IUUC-Sly-111170 Solanum lycopersicum 33.33 6.30e-02 32.70
IUUC-Sre-115025 Sporisorium reilianum 33.33 2.00e-39 157.00
IUUC-Ssc-116188 Sus scrofa 93.68 0.00e+00 1254.00
IUUC-Tgu-116612 Taeniopygia guttata 57.05 4.00e-156 544.00
IUUC-Tsy-119560 Tarsius syrichta 82.26 2.00e-115 410.00
IUUC-Tni-120734 Tetraodon nigroviridis 45.24 0.00e+00 703.00
IUUC-Tca-121338 Theobroma cacao 33.01 1.10e-02 36.20
IUUC-Tre-122089 Trichoderma reesei 40.74 3.00e-04 40.80
IUUC-Tme-127009 Tuber melanosporum 26.85 3.00e-03 38.10
IUUC-Tbe-127431 Tupaia belangeri 87.91 0.00e+00 1588.00
IUUC-Ttr-128744 Tursiops truncatus 85.96 0.00e+00 1788.00
IUUC-Uma-129536 Ustilago maydis 33.05 7.00e-42 166.00
IUUC-Vpa-130123 Vicugna pacos 73.91 4.00e-99 355.00
IUUC-Vvi-131025 Vitis vinifera 37.50 3.00e-03 37.70
IUUC-Xtr-132902 Xenopus tropicalis 58.26 0.00e+00 1003.00
IUUC-Xma-133978 Xiphophorus maculatus 45.07 2.00e-146 513.00
Created Date 25-Jun-2017

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