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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-063864
UUCD1 version UUC-MuM-00068
Ensembl Protein ID ENSMUSP00000006565.6
UniProt Accession Q9JJ66; Q3TGP1; Q8BPG4; Q99LK3; CDC20_MOUSE
Genbank Protein ID BAA97451.1; AAL25714.1; BAC36109.1; BAC36132.1; BAC38922.1; BAE40507.1; AAH03215.1
Protein Name Cell division cycle protein 20 homolog; p55CDC
Genbank Nucleotide ID AB045313; AF312208; AK075998; AK076030; AK083459; AK168650; BC003215
Gene Name Cdc20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000006398.15 ENSMUST00000006565.12 ENSMUSP00000006565.6
ENSMUSG00000006398.15 ENSMUST00000183942.1 ENSMUSP00000139345.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20 CDC20 19900895
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.60e-29 101.1 307 336
E3 adaptor/Cullin RING/APC_C/CDC20 7.90e-147 489.5 172 478
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvW 28
    gH+ +v++l++ +d ++l+sG++D+ + vW
   Q: 307 GHSQEVCGLRWaPDgRHLASGGNDNIVNVW 336
    8***********999*************** PP
   


   E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
    p+++ldape+r+d+ylnL+dWss nvlavaL++svylw+a +gd+ +l ++ +++d+++sv+wi+eg++lavGt+++ev+++Dv+++k+
   Q: 172 PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQLLQMeQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKR 260
    689************************************************899*********************************** PP
   S: 89 vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse....Plk 173
    +r++t+hsarv++LsWn+++lssGsr+g+i+h+dvrv+e++++tl++h+qevCGl+w+ d+++LasGGnDn v+vw + e Pl+
   Q: 261 LRNMTSHSARVSSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNIVNVWPSGPGEsgwaPLQ 349
    *****************************************************************************999888999*** PP
   S: 174 kfkehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvae 262
    +f++h++avka+aw+Pwq+++La+GGGt+Dr+i++wn+++ga+l+++d++sqvcs+lws+++kel+s+hGfa+n++++wkyp+++kvae
   Q: 350 TFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGACLSAVDVHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438
    ***************************************************************************************** PP
   S: 263 lkgheaRvlslalspdgeaivtaagDetlrfwklfdkkka 302
    lkgh+aRvl l++spdg+++++aa+Detlr+w++f++++a
   Q: 439 LKGHTARVLGLTMSPDGATVASAAADETLRLWRCFEMDPA 478
    ************************************9875 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Protein Sequence
(Fasta)
MAQFVFESDL HSLLQLDAPI PNAPVARWQR KAKEATGPAP SPMRAANRSH SAGRTPGRTP 60
GKSSSKVQTT PSKPGGDRFI PQRSASQMEV ASFLLSKENQ PEDRGTPTKK EHQKAWSLNL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063864|E3,CDC20;E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCAATGAAC GCTAGCAGCG GAGAGTTTAA GAACAACAGT CCGGCGTGTC CTTAGCTTGT 60
CTGGAAAAGA ACGCGTTCGG CAGGCGCACT GACGCGCTGC GAGGAGCTGG GGGTTTGTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063864|E3,CDC20;E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033187--CDC20
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0000922--C:spindle pole
GO:0019899--F:enzyme binding
GO:0008022--F:protein C-terminus binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007064--P:mitotic sister chromatid cohesion
GO:0090307--P:mitotic spindle assembly
GO:0008284--P:positive regulation of cell proliferation
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination
GO:0050773--P:regulation of dendrite development
GO:0040020--P:regulation of meiotic nuclear division

KEGG mmu:107995
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000638 Aegilops tauschii 44.51 7.00e-109 387.00
IUUC-Aml-001545 Ailuropoda melanoleuca 94.99 0.00e+00 929.00
IUUC-Atr-003103 Amborella trichopoda 46.68 5.00e-109 388.00
IUUC-Apl-003255 Anas platyrhynchos 80.45 0.00e+00 752.00
IUUC-Aca-004920 Anolis carolinensis 75.64 0.00e+00 768.00
IUUC-Aly-006303 Arabidopsis lyrata 49.02 3.00e-109 388.00
IUUC-Ath-006795 Arabidopsis thaliana 46.71 7.00e-108 384.00
IUUC-Ate-010479 Aspergillus terreus 40.78 1.00e-91 330.00
IUUC-Ame-010850 Astyanax mexicanus 60.70 3.00e-91 328.00
IUUC-Bgr-012059 Blumeria graminis 48.87 3.00e-93 335.00
IUUC-Bta-012625 Bos taurus 94.19 0.00e+00 924.00
IUUC-Bci-013607 Botrytis cinerea 46.49 3.00e-96 345.00
IUUC-Bdi-014344 Brachypodium distachyon 46.62 1.00e-107 383.00
IUUC-Bol-015368 Brassica oleracea 46.12 7.00e-107 382.00
IUUC-Bra-016738 Brassica rapa 46.86 2.00e-106 380.00
IUUC-Cja-019132 Callithrix jacchus 93.99 0.00e+00 928.00
IUUC-Cfa-020780 Canis familiaris 94.39 0.00e+00 923.00
IUUC-Cpo-022223 Cavia porcellus 95.19 0.00e+00 886.00
IUUC-Cre-022701 Chlamydomonas reinhardtii 50.82 8.00e-120 424.00
IUUC-Csa-023666 Chlorocebus sabaeus 94.59 0.00e+00 927.00
IUUC-Cho-024920 Choloepus hoffmanni 93.26 6.00e-155 540.00
IUUC-Cin-025675 Ciona intestinalis 51.00 5.00e-136 478.00
IUUC-Csv-026019 Ciona savignyi 51.04 1.00e-131 463.00
IUUC-Cgl-026465 Colletotrichum gloeosporioides 40.56 2.00e-95 343.00
IUUC-Cme-027234 Cyanidioschyzon merolae 51.91 1.00e-105 377.00
IUUC-Dre-028026 Danio rerio 60.36 0.00e+00 634.00
IUUC-Dno-028865 Dasypus novemcinctus 93.20 0.00e+00 908.00
IUUC-Dor-030958 Dipodomys ordii 94.79 0.00e+00 929.00
IUUC-Dse-031391 Dothistroma septosporum 39.60 5.00e-97 348.00
IUUC-Dme-031905 Drosophila melanogaster 49.63 1.00e-143 503.00
IUUC-Ete-032387 Echinops telfairi 88.38 0.00e+00 874.00
IUUC-Eca-033522 Equus caballus 85.77 0.00e+00 837.00
IUUC-Eeu-035059 Erinaceus europaeus 83.20 0.00e+00 782.00
IUUC-Fca-036346 Felis catus 94.78 0.00e+00 842.00
IUUC-Fal-037558 Ficedula albicollis 79.37 0.00e+00 788.00
IUUC-Fox-037850 Fusarium oxysporum 44.65 8.00e-96 344.00
IUUC-Fso-038375 Fusarium solani 44.56 2.00e-96 346.00
IUUC-Gmo-039284 Gadus morhua 63.04 0.00e+00 633.00
IUUC-Ggr-039864 Gaeumannomyces graminis 47.97 4.00e-98 352.00
IUUC-Gga-040790 Gallus gallus 79.13 0.00e+00 810.00
IUUC-Gac-041431 Gasterosteus aculeatus 62.43 0.00e+00 627.00
IUUC-Gma-043489 Glycine max 46.99 2.00e-107 382.00
IUUC-Ggo-045052 Gorilla gorilla 94.79 0.00e+00 927.00
IUUC-Hsa-046305 Homo sapiens 94.79 0.00e+00 927.00
IUUC-Hvu-047476 Hordeum vulgare 44.90 1.00e-108 386.00
IUUC-Itr-048461 Ictidomys tridecemlineatus 95.79 0.00e+00 892.00
IUUC-Lch-050174 Latimeria chalumnae 60.23 1.00e-171 595.00
IUUC-Lpe-050954 Leersia perrieri 46.97 3.00e-99 355.00
IUUC-Loc-052638 Lepisosteus oculatus 62.52 0.00e+00 627.00
IUUC-Lma-052998 Leptosphaeria maculans 43.11 2.00e-99 356.00
IUUC-Laf-053742 Loxodonta africana 93.79 0.00e+00 917.00
IUUC-Mcc-054948 Macaca mulatta 94.59 0.00e+00 927.00
IUUC-Meu-056013 Macropus eugenii 85.51 2.00e-140 492.00
IUUC-Mor-057277 Magnaporthe oryzae 41.78 4.00e-96 345.00
IUUC-Mpo-057624 Magnaporthe poae 50.81 4.00e-96 345.00
IUUC-Mtr-057725 Medicago truncatula 46.38 4.00e-100 358.00
IUUC-Mga-060102 Meleagris gallopavo 79.37 0.00e+00 811.00
IUUC-Mmr-061615 Microcebus murinus 93.69 0.00e+00 923.00
IUUC-Mdo-061982 Monodelphis domestica 87.76 0.00e+00 766.00
IUUC-Mac-064861 Musa acuminata 47.10 6.00e-109 387.00
IUUC-Mpu-066502 Mustela putorius furo 94.79 0.00e+00 917.00
IUUC-Mlu-067277 Myotis lucifugus 86.63 0.00e+00 855.00
IUUC-Ncr-068951 Neurospora crassa 44.56 2.00e-93 336.00
IUUC-Nle-070149 Nomascus leucogenys 94.39 0.00e+00 920.00
IUUC-Opr-070778 Ochotona princeps 93.59 0.00e+00 675.00
IUUC-Ont-071660 Oreochromis niloticus 61.35 3.00e-178 618.00
IUUC-Oan-073677 Ornithorhynchus anatinus 75.70 0.00e+00 696.00
IUUC-Ocu-073797 Oryctolagus cuniculus 94.57 0.00e+00 924.00
IUUC-Oba-075946 Oryza barthii 47.10 4.00e-106 378.00
IUUC-Obr-076018 Oryza brachyantha 45.62 9.00e-107 380.00
IUUC-Ogl-077254 Oryza glaberrima 46.97 3.00e-99 355.00
IUUC-Ogu-078521 Oryza glumaepatula 47.32 3.00e-106 379.00
IUUC-Oin-080094 Oryza indica 46.97 3.00e-99 355.00
IUUC-Olo-080449 Oryza longistaminata 47.19 2.00e-99 356.00
IUUC-Ome-081186 Oryza meridionalis 47.07 2.00e-106 380.00
IUUC-Oni-082243 Oryza nivara 46.97 3.00e-99 355.00
IUUC-Opu-084007 Oryza punctata 46.97 5.00e-99 354.00
IUUC-Oru-084562 Oryza rufipogon 47.32 6.00e-106 378.00
IUUC-Osa-086094 Oryza sativa 46.97 4.00e-99 355.00
IUUC-Ola-086907 Oryzias latipes 60.87 7.00e-166 577.00
IUUC-Olu-087647 Ostreococcus lucimarinus 50.49 3.00e-118 418.00
IUUC-Oga-088184 Otolemur garnettii 93.40 0.00e+00 914.00
IUUC-Oar-090023 Ovis aries 88.71 0.00e+00 814.00
IUUC-Ptr-090935 Pan troglodytes 93.87 0.00e+00 864.00
IUUC-Pan-091845 Papio anubis 94.59 0.00e+00 927.00
IUUC-Psi-093188 Pelodiscus sinensis 80.54 0.00e+00 841.00
IUUC-Pma-094187 Petromyzon marinus 54.77 4.00e-149 521.00
IUUC-Pno-094809 Phaeosphaeria nodorum 41.94 6.00e-101 361.00
IUUC-Ppa-095457 Physcomitrella patens 49.41 3.00e-111 395.00
IUUC-Pfo-097429 Poecilia formosa 59.36 2.00e-162 565.00
IUUC-Pab-098603 Pongo abelii 94.59 0.00e+00 927.00
IUUC-Pop-099654 Populus trichocarpa 46.38 3.00e-103 368.00
IUUC-Pca-101062 Procavia capensis 92.79 0.00e+00 894.00
IUUC-Ppe-101865 Prunus persica 46.40 3.00e-96 345.00
IUUC-Pva-102925 Pteropus vampyrus 93.59 0.00e+00 944.00
IUUC-Pte-104142 Pyrenophora teres 42.60 3.00e-98 352.00
IUUC-Pyt-104693 Pyrenophora triticirepentis 42.44 3.00e-98 352.00
IUUC-Rno-106005 Rattus norvegicus 97.60 0.00e+00 958.00
IUUC-Sha-107472 Sarcophilus harrisii 87.80 0.00e+00 877.00
IUUC-Sja-107919 Schizosaccharomyces japonicus 42.36 4.00e-94 338.00
IUUC-Spo-108075 Schizosaccharomyces pombe 51.74 1.00e-95 343.00
IUUC-Ssl-108507 Sclerotinia sclerotiorum 47.80 1.00e-95 343.00
IUUC-Smo-108922 Selaginella moellendorffii 49.03 4.00e-123 434.00
IUUC-Sit-110732 Setaria italica 45.81 2.00e-107 382.00
IUUC-Sly-111202 Solanum lycopersicum 43.48 3.00e-105 375.00
IUUC-Stu-112024 Solanum tuberosum 42.12 1.00e-105 377.00
IUUC-Sar-113092 Sorex araneus 89.78 0.00e+00 862.00
IUUC-Sbi-114558 Sorghum bicolor 44.84 2.00e-107 382.00
IUUC-Ssc-115710 Sus scrofa 94.59 0.00e+00 926.00
IUUC-Tgu-117100 Taeniopygia guttata 78.77 0.00e+00 788.00
IUUC-Tru-118184 Takifugu rubripes 59.62 2.00e-138 485.00
IUUC-Tsy-118892 Tarsius syrichta 95.74 2.00e-160 557.00
IUUC-Tni-120474 Tetraodon nigroviridis 59.24 9.00e-168 583.00
IUUC-Tca-120949 Theobroma cacao 46.15 2.00e-105 375.00
IUUC-Tre-122211 Trichoderma reesei 39.96 3.00e-96 345.00
IUUC-Tvi-122531 Trichoderma virens 40.75 3.00e-97 349.00
IUUC-Tae-123017 Triticum aestivum 44.03 6.00e-109 387.00
IUUC-Tur-126018 Triticum urartu 45.43 6.00e-102 364.00
IUUC-Tbe-127384 Tupaia belangeri 95.96 2.00e-173 602.00
IUUC-Ttr-128511 Tursiops truncatus 94.39 0.00e+00 919.00
IUUC-Vda-129993 Verticillium dahliae 40.26 2.00e-96 347.00
IUUC-Vvi-131245 Vitis vinifera 45.57 9.00e-94 337.00
IUUC-Xtr-131993 Xenopus tropicalis 73.68 0.00e+00 760.00
IUUC-Xma-133332 Xiphophorus maculatus 62.57 3.00e-178 618.00
IUUC-Zma-135135 Zea mays 46.23 1.00e-105 377.00
Created Date 25-Jun-2017

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