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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046955
UUCD1 version UUC-HoS-00147
Ensembl Protein ID ENSP00000364403.3
UniProt Accession Q5T4S7; A8MPT2; A8MQ33; A8MQB1; O60646; O75050; Q4QRK5; Q5T4S8; Q5T4S9; Q5TBN8; Q5TBP2; Q6DKH8; Q6P4A4; Q7L8P7; Q8IXJ4; Q8TDN5; Q8WV67; Q9HA46; Q9P2N9; Q9UG82; UBR4_HUMAN
Genbank Protein ID AAL83880.1; BAB14011.1; CAI19268.1; CAI19268.1; CAI19269.1; CAI19269.1; CAI19271.1; CAI19272.1; CAI19272.1; CAI19273.1; CAI19274.1; CAI20972.1; CAI20972.1; CAI20973.1; CAI20973.1; CAI20974.1; CAI20974.1; BAA92545.1; BAA32307.1; AAH18694.2; AAH63573.1; AAH73905.1; AAH96758.1; CAD43719.1; CAB43227.1; AAC09360.1
Protein Name E3 ubiquitin-protein ligase UBR4; 600 kDa retinoblastoma protein-associated factor; N-recognin-4; RING-type E3 ubiquitin transferase UBR4; Retinoblastoma-associated factor of 600 kDa; Zinc finger UBR1-type protein 1
Genbank Nucleotide ID AF348492; AK022322; AL137127; AL357564; AL137127; AL357564; AL137127; AL137127; AL357564; AL137127; AL137127; AL357564; AL137127; AL357564; AL137127; AL357564; AL137127; AB037728; AB007931; BC018694; BC063573; BC073905; BC096758; AJ505016; AL049972; AF055010
Gene Name UBR4; KIAA0462; KIAA1307; RBAF600; ZUBR1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000127481.14 ENST00000375254.7 ENSP00000364403.3
ENSG00000127481.14 ENST00000375225.7 ENSP00000364373.3
ENSG00000127481.14 ENST00000375218.3 ENSP00000364366.3
ENSG00000127481.14 ENST00000425413.5 ENSP00000395313.1
ENSG00000127481.14 ENST00000417040.1 ENSP00000404897.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/N-recognin/UBR-box UBR 18162545
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
Protein Sequence
(Fasta)
MATSGGEEAA AAAPAPGTPA TGADTTPGWE VAVRPLLSAS YSAFEMKELP QLVASVIESE 60
SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV AAACKVLIEF SLLRLENPDE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046955|E3,UBR-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGAGGGAGCC GCAGTAGTAC GACGGAAGAT GGCGACGAGC GGCGGCGAAG AGGCGGCGGC 60
AGCGGCTCCG GCGCCGGGGA CCCCGGCAAC GGGGGCGGAC ACGACCCCGG GCTGGGAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046955|E3,UBR-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0945--Host-virus interaction
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025704--E3_Ub_ligase_UBR4
IPR017986--WD40_repeat_dom
IPR003126--Znf_UBR
PROSITE

PS51157--ZF_UBR
Pfam

PF13764--E3_UbLigase_R4
PF02207--zf-UBR
SMART

SM00396--ZnF_UBR1
Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0101003--C:ficolin-1-rich granule membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0035579--C:specific granule membrane
GO:0070821--C:tertiary granule membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043312--P:neutrophil degranulation
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process
KEGG hsa:23352
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000915 Aegilops tauschii 31.66 0.00e+00 974.00
IUUC-Aml-001346 Ailuropoda melanoleuca 97.96 0.00e+00 9614.00
IUUC-Atr-002587 Amborella trichopoda 35.17 2.00e-147 519.00
IUUC-Apl-003678 Anas platyrhynchos 91.59 0.00e+00 5665.00
IUUC-Aca-004517 Anolis carolinensis 91.54 0.00e+00 932.00
IUUC-Aly-006117 Arabidopsis lyrata 32.33 0.00e+00 899.00
IUUC-Ath-007289 Arabidopsis thaliana 31.66 0.00e+00 899.00
IUUC-Ame-011965 Astyanax mexicanus 82.75 0.00e+00 4741.00
IUUC-Bta-012498 Bos taurus 96.84 0.00e+00 9494.00
IUUC-Bdi-014555 Brachypodium distachyon 30.82 0.00e+00 974.00
IUUC-Bol-015522 Brassica oleracea 31.50 0.00e+00 923.00
IUUC-Bra-017090 Brassica rapa 31.51 0.00e+00 857.00
IUUC-Cel-018504 Caenorhabditis elegans 25.64 2.00e-161 565.00
IUUC-Cja-018983 Callithrix jacchus 99.36 0.00e+00 9746.00
IUUC-Cfa-020612 Canis familiaris 98.08 0.00e+00 9655.00
IUUC-Cpo-021700 Cavia porcellus 97.81 0.00e+00 9635.00
IUUC-Csa-023771 Chlorocebus sabaeus 99.57 0.00e+00 9717.00
IUUC-Cho-024474 Choloepus hoffmanni 91.11 0.00e+00 4819.00
IUUC-Cin-025247 Ciona intestinalis 58.16 0.00e+00 1038.00
IUUC-Csv-026255 Ciona savignyi 58.13 0.00e+00 1063.00
IUUC-Dre-028796 Danio rerio 84.80 0.00e+00 5113.00
IUUC-Dno-030056 Dasypus novemcinctus 97.69 0.00e+00 9613.00
IUUC-Dor-030711 Dipodomys ordii 94.54 0.00e+00 6915.00
IUUC-Dme-032113 Drosophila melanogaster 44.44 0.00e+00 1960.00
IUUC-Ete-032334 Echinops telfairi 89.27 0.00e+00 4776.00
IUUC-Eca-033327 Equus caballus 98.23 0.00e+00 9682.00
IUUC-Eeu-034698 Erinaceus europaeus 85.75 0.00e+00 1220.00
IUUC-Fca-035430 Felis catus 97.43 0.00e+00 9510.00
IUUC-Fal-037566 Ficedula albicollis 91.11 0.00e+00 5612.00
IUUC-Gmo-038674 Gadus morhua 83.68 0.00e+00 8052.00
IUUC-Ggr-039732 Gaeumannomyces graminis 42.86 2.90e-01 30.00
IUUC-Gga-040641 Gallus gallus 92.76 0.00e+00 9244.00
IUUC-Gac-041870 Gasterosteus aculeatus 84.22 0.00e+00 8358.00
IUUC-Gma-042722 Glycine max 31.36 0.00e+00 946.00
IUUC-Ggo-045360 Gorilla gorilla 99.50 0.00e+00 9774.00
IUUC-Hvu-047255 Hordeum vulgare 31.52 0.00e+00 967.00
IUUC-Itr-048714 Ictidomys tridecemlineatus 95.71 0.00e+00 3928.00
IUUC-Lch-049893 Latimeria chalumnae 81.22 0.00e+00 5000.00
IUUC-Lpe-050948 Leersia perrieri 31.40 0.00e+00 896.00
IUUC-Loc-052019 Lepisosteus oculatus 83.78 0.00e+00 8197.00
IUUC-Laf-054238 Loxodonta africana 97.38 0.00e+00 9544.00
IUUC-Mcc-054905 Macaca mulatta 99.55 0.00e+00 9750.00
IUUC-Meu-056297 Macropus eugenii 87.39 0.00e+00 8460.00
IUUC-Mtr-058169 Medicago truncatula 32.19 0.00e+00 943.00
IUUC-Mga-059621 Meleagris gallopavo 92.13 0.00e+00 9207.00
IUUC-Mmr-061395 Microcebus murinus 99.40 0.00e+00 3004.00
IUUC-Mdo-063037 Monodelphis domestica 92.18 0.00e+00 4626.00
IUUC-Mmu-063200 Mus musculus 96.92 0.00e+00 9455.00
IUUC-Mac-065267 Musa acuminata 31.10 0.00e+00 883.00
IUUC-Mpu-066639 Mustela putorius furo 98.20 0.00e+00 9629.00
IUUC-Mlu-067172 Myotis lucifugus 97.29 0.00e+00 9633.00
IUUC-Nle-069162 Nomascus leucogenys 99.53 0.00e+00 8501.00
IUUC-Opr-070567 Ochotona princeps 94.28 0.00e+00 3532.00
IUUC-Ont-072364 Oreochromis niloticus 82.50 0.00e+00 4995.00
IUUC-Oan-072804 Ornithorhynchus anatinus 83.97 0.00e+00 2014.00
IUUC-Ocu-074637 Oryctolagus cuniculus 97.74 0.00e+00 9623.00
IUUC-Oba-075215 Oryza barthii 34.25 0.00e+00 829.00
IUUC-Obr-076704 Oryza brachyantha 31.89 0.00e+00 944.00
IUUC-Ogl-077593 Oryza glaberrima 36.08 0.00e+00 651.00
IUUC-Ogu-078732 Oryza glumaepatula 31.38 0.00e+00 895.00
IUUC-Oin-079805 Oryza indica 32.74 0.00e+00 739.00
IUUC-Olo-080261 Oryza longistaminata 34.30 0.00e+00 833.00
IUUC-Ome-081392 Oryza meridionalis 33.91 0.00e+00 871.00
IUUC-Oni-082086 Oryza nivara 34.02 0.00e+00 832.00
IUUC-Opu-083535 Oryza punctata 34.08 0.00e+00 837.00
IUUC-Oru-084735 Oryza rufipogon 34.02 0.00e+00 833.00
IUUC-Ola-086799 Oryzias latipes 84.07 0.00e+00 8248.00
IUUC-Olu-087777 Ostreococcus lucimarinus 27.28 2.00e-85 313.00
IUUC-Oga-088126 Otolemur garnettii 95.60 0.00e+00 1554.00
IUUC-Oar-090428 Ovis aries 95.55 0.00e+00 9300.00
IUUC-Ptr-091407 Pan troglodytes 99.90 0.00e+00 9784.00
IUUC-Pan-091777 Papio anubis 99.09 0.00e+00 9737.00
IUUC-Psi-093587 Pelodiscus sinensis 92.35 0.00e+00 9280.00
IUUC-Ppa-095781 Physcomitrella patens 32.25 0.00e+00 983.00
IUUC-Pfo-097449 Poecilia formosa 84.30 0.00e+00 8364.00
IUUC-Pab-098450 Pongo abelii 98.35 0.00e+00 9614.00
IUUC-Pop-100041 Populus trichocarpa 32.12 0.00e+00 913.00
IUUC-Pca-100663 Procavia capensis 90.73 0.00e+00 2871.00
IUUC-Ppe-101386 Prunus persica 32.41 0.00e+00 829.00
IUUC-Pva-102701 Pteropus vampyrus 98.02 0.00e+00 4097.00
IUUC-Ptt-103987 Puccinia triticina 23.66 8.00e-03 33.90
IUUC-Rno-105367 Rattus norvegicus 96.12 0.00e+00 5806.00
IUUC-Sha-107490 Sarcophilus harrisii 92.58 0.00e+00 5698.00
IUUC-Smo-109103 Selaginella moellendorffii 33.26 0.00e+00 910.00
IUUC-Sit-110670 Setaria italica 31.77 0.00e+00 959.00
IUUC-Sly-110952 Solanum lycopersicum 32.22 0.00e+00 900.00
IUUC-Stu-112624 Solanum tuberosum 31.68 4.00e-157 549.00
IUUC-Sar-113180 Sorex araneus 90.85 0.00e+00 4264.00
IUUC-Sbi-114596 Sorghum bicolor 31.88 0.00e+00 939.00
IUUC-Ssc-115377 Sus scrofa 99.26 0.00e+00 3001.00
IUUC-Tgu-117330 Taeniopygia guttata 90.22 0.00e+00 5593.00
IUUC-Tru-117635 Takifugu rubripes 83.51 0.00e+00 8283.00
IUUC-Tsy-119551 Tarsius syrichta 90.66 0.00e+00 4616.00
IUUC-Tni-119727 Tetraodon nigroviridis 83.28 0.00e+00 8261.00
IUUC-Tca-121017 Theobroma cacao 31.88 0.00e+00 943.00
IUUC-Tae-122892 Triticum aestivum 35.37 2.00e-25 109.00
IUUC-Tur-126292 Triticum urartu 32.68 0.00e+00 969.00
IUUC-Ttr-128332 Tursiops truncatus 96.68 0.00e+00 8469.00
IUUC-Vpa-130615 Vicugna pacos 91.73 0.00e+00 2616.00
IUUC-Vvi-131435 Vitis vinifera 34.16 0.00e+00 822.00
IUUC-Xtr-132130 Xenopus tropicalis 90.28 0.00e+00 2110.00
IUUC-Xma-133859 Xiphophorus maculatus 82.38 0.00e+00 5067.00
Created Date 25-Jun-2017

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