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Tag Content
UUCD2 ID IUUC-Aml-001931
UUCD1 version UUC-AiM-01073
Ensembl Protein ID ENSAMEP00000008649.1
UniProt Accession G1LNM1; G1LNM1_AILME
Genbank Protein ID ENSAMEP00000008649
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID ACTA01064691
Gene Name USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMEG00000008192.1 ENSAMET00000009019.1 ENSAMEP00000008649.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.80e-90 303.7 194 822
Active Site
Position(s) Description Evidence
203 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
758 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 194  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 273
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 274  VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEQQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSVPSFVDRIFGGELT 362
           *************************************************************99999999******************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 363  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktlededkeseeekdndsymkersdipsgtskhlqkkakkqakkqakn 451
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 452  qrrqqkiqgkilhlndicsidhpednecevemslqgevdvksnhiseekiihkeycvnqkdlnsqekmiesvtdnqksteevdmnnvnm 540
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 541  dndlevlassptdctrnlngayltegsgevdissgfknlnlnaalqpdeinieilneshcpgtkvyevvnedpetafctlanreafhtd 629
           ***************************************************************************************** PP
   S: 186  ..slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
             s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++f
   Q: 630  ecSIQHCLYQFTRNEKLRDANKLLCEVCTRRQFsgpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIKF 716
           *****************************666677777777777777777*********************..9999************ PP
   S: 256  pleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtev 317
           p+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++v
   Q: 717  PEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKAraanshlsnlvlhgdipqdfemqsTKGQWFHISDTHVQPV 805
           ************9999887777999************************9999999999999999999999888999************ PP
   S: 318  keeevleetgstaYvlfYkr 337
           + ++vl+   s+aY+lfY+r
   Q: 806  PTAKVLN---SQAYLLFYER 822
           *******...********98 PP
   
Organism Ailuropoda melanoleuca
Functional Description
(View)

Functional Description


     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRTKGKT VPIDDSSESL EPMCRHIRKG LEQGNLKRAL LNVEWNICQD CKTDNKVKDK 60
SEEEAEENPS VWLCLKCGHQ GCGRDSQEQH ALKHYMTPRS EPHCLVLSLD NWSVWCYLCD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aml-001931|DUB,USP|Ailuropoda melanoleuca
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGAAAGA AACGGACAAA GGGAAAAACT GTTCCAATTG ATGATTCTTC TGAATCTTTA 60
GGTATATTTC ACTGATTGAA TCTTTAAAGC TATGTATATA TCCCTAAATG GACATATATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aml-001931|DUB,USP|Ailuropoda melanoleuca
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 29.86 1.00e-29 125.00
IUUC-Atr-003015 Amborella trichopoda 32.61 2.00e-35 145.00
IUUC-Apl-004145 Anas platyrhynchos 61.04 0.00e+00 885.00
IUUC-Aca-004314 Anolis carolinensis 58.25 0.00e+00 882.00
IUUC-Aly-006422 Arabidopsis lyrata 28.62 3.00e-29 124.00
IUUC-Ath-006732 Arabidopsis thaliana 33.23 6.00e-33 136.00
IUUC-Ame-011659 Astyanax mexicanus 48.75 2.00e-110 393.00
IUUC-Bta-013362 Bos taurus 90.92 0.00e+00 1419.00
IUUC-Bdi-014624 Brachypodium distachyon 30.34 1.00e-28 121.00
IUUC-Bol-015941 Brassica oleracea 29.83 1.00e-31 132.00
IUUC-Bra-016751 Brassica rapa 29.19 2.00e-29 125.00
IUUC-Cja-019177 Callithrix jacchus 90.21 0.00e+00 1463.00
IUUC-Cfa-020051 Canis familiaris 97.09 0.00e+00 1495.00
IUUC-Cpo-021886 Cavia porcellus 81.20 0.00e+00 1289.00
IUUC-Csa-024103 Chlorocebus sabaeus 90.45 0.00e+00 1475.00
IUUC-Cho-024315 Choloepus hoffmanni 78.05 1.00e-130 460.00
IUUC-Cin-025775 Ciona intestinalis 50.35 2.00e-40 157.00
IUUC-Csv-026075 Ciona savignyi 51.43 2.00e-58 220.00
IUUC-Cme-027348 Cyanidioschyzon merolae 39.19 7.00e-20 92.40
IUUC-Dre-028388 Danio rerio 46.42 0.00e+00 655.00
IUUC-Dno-029409 Dasypus novemcinctus 88.48 0.00e+00 1411.00
IUUC-Dor-030443 Dipodomys ordii 77.96 0.00e+00 646.00
IUUC-Ete-032807 Echinops telfairi 83.97 0.00e+00 684.00
IUUC-Eca-033479 Equus caballus 92.49 0.00e+00 1471.00
IUUC-Eeu-034835 Erinaceus europaeus 84.56 0.00e+00 677.00
IUUC-Fca-036320 Felis catus 95.88 0.00e+00 1533.00
IUUC-Fal-037029 Ficedula albicollis 60.97 0.00e+00 857.00
IUUC-Gmo-039480 Gadus morhua 52.35 2.00e-113 402.00
IUUC-Gga-040527 Gallus gallus 62.67 0.00e+00 906.00
IUUC-Gac-042343 Gasterosteus aculeatus 46.74 0.00e+00 642.00
IUUC-Gma-044402 Glycine max 29.23 6.00e-33 136.00
IUUC-Ggo-045598 Gorilla gorilla 90.08 0.00e+00 1464.00
IUUC-Hsa-046598 Homo sapiens 89.96 0.00e+00 1456.00
IUUC-Hvu-047146 Hordeum vulgare 29.23 9.00e-29 122.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 88.74 0.00e+00 1451.00
IUUC-Lch-050536 Latimeria chalumnae 52.27 0.00e+00 758.00
IUUC-Lpe-050703 Leersia perrieri 30.75 2.00e-29 124.00
IUUC-Loc-051814 Lepisosteus oculatus 56.90 4.00e-129 455.00
IUUC-Laf-053732 Loxodonta africana 87.47 0.00e+00 1417.00
IUUC-Mcc-054661 Macaca mulatta 90.81 0.00e+00 1478.00
IUUC-Meu-055967 Macropus eugenii 74.03 2.00e-158 553.00
IUUC-Mtr-057945 Medicago truncatula 31.31 4.00e-34 140.00
IUUC-Mga-059551 Meleagris gallopavo 62.38 0.00e+00 914.00
IUUC-Mvi-060391 Microbotryum violaceum 32.65 6.00e-19 89.70
IUUC-Mmr-061747 Microcebus murinus 91.69 0.00e+00 1426.00
IUUC-Mdo-062220 Monodelphis domestica 68.96 0.00e+00 1046.00
IUUC-Mmu-063582 Mus musculus 81.42 0.00e+00 1244.00
IUUC-Mac-064941 Musa acuminata 32.74 9.00e-39 155.00
IUUC-Mpu-066339 Mustela putorius furo 96.61 0.00e+00 1538.00
IUUC-Mlu-067511 Myotis lucifugus 85.96 0.00e+00 1349.00
IUUC-Nle-069252 Nomascus leucogenys 90.93 0.00e+00 1482.00
IUUC-Opr-070969 Ochotona princeps 83.85 0.00e+00 1308.00
IUUC-Ont-071786 Oreochromis niloticus 50.71 8.00e-116 411.00
IUUC-Ocu-074704 Oryctolagus cuniculus 90.73 0.00e+00 1405.00
IUUC-Oba-075094 Oryza barthii 29.75 2.00e-31 131.00
IUUC-Obr-076743 Oryza brachyantha 31.99 1.00e-31 132.00
IUUC-Ogl-077739 Oryza glaberrima 29.75 2.00e-31 130.00
IUUC-Ogu-078851 Oryza glumaepatula 29.75 2.00e-31 131.00
IUUC-Oin-079402 Oryza indica 29.75 2.00e-31 131.00
IUUC-Olo-080431 Oryza longistaminata 29.75 2.00e-31 131.00
IUUC-Ome-081580 Oryza meridionalis 29.75 3.00e-31 130.00
IUUC-Oni-082644 Oryza nivara 29.75 2.00e-31 131.00
IUUC-Opu-083452 Oryza punctata 29.50 2.00e-31 131.00
IUUC-Oru-084546 Oryza rufipogon 29.75 2.00e-31 131.00
IUUC-Osa-085858 Oryza sativa 29.75 2.00e-31 131.00
IUUC-Ola-086795 Oryzias latipes 49.56 9.00e-112 397.00
IUUC-Oga-088713 Otolemur garnettii 89.84 0.00e+00 1432.00
IUUC-Oar-089887 Ovis aries 89.72 0.00e+00 1433.00
IUUC-Ptr-091670 Pan troglodytes 90.33 0.00e+00 1470.00
IUUC-Pan-092293 Papio anubis 90.81 0.00e+00 1478.00
IUUC-Psi-093101 Pelodiscus sinensis 67.02 0.00e+00 940.00
IUUC-Ppa-095622 Physcomitrella patens 30.04 3.00e-34 140.00
IUUC-Pfo-097202 Poecilia formosa 44.69 0.00e+00 641.00
IUUC-Pab-098773 Pongo abelii 92.56 0.00e+00 1144.00
IUUC-Pop-099136 Populus trichocarpa 29.90 3.00e-39 157.00
IUUC-Pca-101069 Procavia capensis 71.38 0.00e+00 872.00
IUUC-Ppe-101794 Prunus persica 31.55 1.00e-34 141.00
IUUC-Pva-103092 Pteropus vampyrus 88.00 0.00e+00 694.00
IUUC-Rno-105237 Rattus norvegicus 82.49 0.00e+00 1266.00
IUUC-Sha-106889 Sarcophilus harrisii 73.28 0.00e+00 1118.00
IUUC-Sit-110283 Setaria italica 33.04 8.00e-31 129.00
IUUC-Sly-111487 Solanum lycopersicum 30.10 1.00e-38 155.00
IUUC-Stu-112820 Solanum tuberosum 29.12 3.00e-36 147.00
IUUC-Sar-113530 Sorex araneus 83.82 0.00e+00 1323.00
IUUC-Sbi-113785 Sorghum bicolor 40.00 3.00e-25 110.00
IUUC-Ssc-116091 Sus scrofa 90.85 0.00e+00 1409.00
IUUC-Tgu-117478 Taeniopygia guttata 60.57 0.00e+00 875.00
IUUC-Tru-118640 Takifugu rubripes 53.77 8.00e-121 427.00
IUUC-Tsy-119042 Tarsius syrichta 76.45 0.00e+00 916.00
IUUC-Tni-120015 Tetraodon nigroviridis 46.31 7.00e-179 620.00
IUUC-Tca-121701 Theobroma cacao 29.34 1.00e-37 151.00
IUUC-Tae-125351 Triticum aestivum 30.15 7.00e-28 119.00
IUUC-Tur-126788 Triticum urartu 29.54 2.00e-27 118.00
IUUC-Tbe-127309 Tupaia belangeri 74.57 0.00e+00 1126.00
IUUC-Ttr-128271 Tursiops truncatus 92.38 0.00e+00 1460.00
IUUC-Vpa-130674 Vicugna pacos 90.09 0.00e+00 1349.00
IUUC-Xtr-131869 Xenopus tropicalis 51.43 0.00e+00 793.00
IUUC-Xma-134195 Xiphophorus maculatus 53.21 3.00e-116 412.00
IUUC-Zma-135157 Zea mays 31.99 2.00e-27 117.00
Created Date 25-Jun-2017

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