iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Hvu-047359

Ensembl Protein ID

MLOC_73711.2

UniProt Accession

F2E474; F2E474_HORVV

Genbank Protein ID

BAK02146.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AK370948

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MLOC_73711	MLOC_73711.2	MLOC_73711.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	4.10e-73	247.7	2	321

Active Site

Position(s)	Description	Evidence
82	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
157	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyA 103
           +w+++esdPg+ft+l+++  vk++ qveelysLd ++l+++ +pv+gl++lFk+ +  + +r          vv  d   ++ffa qvi N+Cat+A
   Q: 2    SWCTIESDPGVFTELIQEMQVKGV-QVEELYSLDVDSLSQL-QPVYGLIFLFKWMPGGNDERP---------VV-SDPNPNLFFARQVITNACATQA 86
           7***********************.****************.9*************9999993.........33.56678***************** PP
   S: 104  llsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfP 200
           +ls l n  +   d+G++ls+lke+t a+ p++k+la++n++ ++++hns+ar+e++ ++e++++++   ++e++hf+sy++ +g lyeldglk+ P
   Q: 87   ILSILMNRPEI--DIGPELSNLKEFTGAFAPDMKGLAINNSDSIRAAHNSFARPEPFVSDEQKAATK---DDEVYHFISYIPFEGVLYELDGLKEGP 178
           *******9998..***********************************************9997665...9************************** PP
   S: 201  ldlgkk...keteelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid..................keLlkLlkdieseeeki 276
           + lg+     e+  + + ++ v+   eri+ +++ eirfnl+ai ++r+ ++t+ l+ l+                    + L   l ++ s ++  
   Q: 179  ISLGQYlggPEDLGWLQMVQPVI--QERIERYSQSEIRFNLMAIIKNRKDVYTAELKELEKKreqilqelsneataaaekESLNGALAEVASAVASV 273
           ****9976678889*********..******************************988877799***************7778999*********** PP
   S: 277  eaqlddekekrkkfkiddirRtenydeficifikdlaregilrklvee 324
            +++  e+ek +k+k ++ rR++ny  f++ ++k la++++l  lve+
   Q: 274  GEKIVMEEEKFRKWKTENVRRKHNYIPFLFNLLKALAEKKQLTPLVEK 321
           **********************************************98 PP

Organism

Hordeum vulgare

Protein Sequence
(Fasta)

MSWCTIESDP GVFTELIQEM QVKGVQVEEL YSLDVDSLSQ LQPVYGLIFL FKWMPGGNDE 60
RPVVSDPNPN LFFARQVITN ACATQAILSI LMNRPEIDIG PELSNLKEFT GAFAPDMKGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCCACCCC CCTTCTTCAA GCCTCCCTCC CCCTCTCTGC TAGCTAGGTC TCGTCTCGTC 60
AGCACGCCCG CGCCGCCGCC CCCTCCCGTC GCCGCTGCCG TAGACTGACG GAACTCCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	95.87	0.00e+00	644.00
IUUC-Aml-001866	Ailuropoda melanoleuca	48.44	3.00e-83	300.00
IUUC-Atr-002966	Amborella trichopoda	69.37	9.00e-131	458.00
IUUC-Apl-003306	Anas platyrhynchos	44.00	5.00e-78	283.00
IUUC-Aca-004763	Anolis carolinensis	47.81	1.00e-82	298.00
IUUC-Aly-005581	Arabidopsis lyrata	73.39	1.00e-129	454.00
IUUC-Ath-007283	Arabidopsis thaliana	74.92	6.00e-135	472.00
IUUC-Ago-007999	Ashbya gossypii	36.02	6.00e-34	136.00
IUUC-Acl-008231	Aspergillus clavatus	48.74	9.00e-59	218.00
IUUC-Afl-008557	Aspergillus flavus	40.31	3.00e-57	214.00
IUUC-Afu-008988	Aspergillus fumigatus	44.67	2.00e-61	227.00
IUUC-Ani-009420	Aspergillus nidulans	41.19	7.00e-60	223.00
IUUC-Ang-009859	Aspergillus niger	42.53	2.00e-57	214.00
IUUC-Aor-010145	Aspergillus oryzae	40.31	3.00e-57	214.00
IUUC-Ate-010347	Aspergillus terreus	38.94	8.00e-57	212.00
IUUC-Ame-010791	Astyanax mexicanus	47.26	1.00e-84	305.00
IUUC-Bgr-012298	Blumeria graminis	40.18	7.00e-55	206.00
IUUC-Bta-013251	Bos taurus	48.44	4.00e-83	300.00
IUUC-Bci-013786	Botrytis cinerea	40.12	4.00e-59	220.00
IUUC-Bdi-014132	Brachypodium distachyon	90.06	5.00e-168	582.00
IUUC-Bol-015611	Brassica oleracea	74.39	3.00e-137	479.00
IUUC-Bra-017769	Brassica rapa	74.39	1.00e-136	477.00
IUUC-Cel-018604	Caenorhabditis elegans	41.54	2.00e-69	254.00
IUUC-Cja-019768	Callithrix jacchus	44.25	1.00e-77	281.00
IUUC-Cfa-020207	Canis familiaris	48.44	3.00e-83	300.00
IUUC-Cpo-021925	Cavia porcellus	46.56	3.00e-79	286.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	52.13	1.00e-85	308.00
IUUC-Csa-023958	Chlorocebus sabaeus	48.14	4.00e-83	300.00
IUUC-Cho-024928	Choloepus hoffmanni	52.70	9.00e-17	79.30
IUUC-Cin-025771	Ciona intestinalis	41.03	8.00e-69	252.00
IUUC-Csv-026149	Ciona savignyi	42.47	2.00e-70	257.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	35.02	1.00e-47	181.00
IUUC-Cne-026955	Cryptococcus neoformans	34.02	6.00e-50	189.00
IUUC-Cme-027104	Cyanidioschyzon merolae	30.42	3.00e-45	174.00
IUUC-Dre-027409	Danio rerio	46.65	4.00e-84	303.00
IUUC-Dno-028921	Dasypus novemcinctus	48.44	3.00e-83	300.00
IUUC-Dor-030891	Dipodomys ordii	43.50	5.00e-36	144.00
IUUC-Dse-031170	Dothistroma septosporum	41.46	2.00e-62	231.00
IUUC-Dme-031677	Drosophila melanogaster	48.47	2.00e-83	301.00
IUUC-Ete-032646	Echinops telfairi	42.53	2.00e-43	169.00
IUUC-Eca-033776	Equus caballus	47.19	2.00e-74	271.00
IUUC-Eeu-035305	Erinaceus europaeus	43.41	5.00e-37	146.00
IUUC-Fca-035846	Felis catus	44.38	1.00e-78	285.00
IUUC-Fal-037597	Ficedula albicollis	46.18	4.00e-72	263.00
IUUC-Fox-037670	Fusarium oxysporum	46.96	3.00e-50	190.00
IUUC-Fso-038243	Fusarium solani	46.96	5.00e-50	189.00
IUUC-Gmo-038499	Gadus morhua	44.38	2.00e-74	270.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.80	5.00e-51	193.00
IUUC-Gga-040904	Gallus gallus	48.32	9.00e-86	308.00
IUUC-Gac-042058	Gasterosteus aculeatus	47.19	9.00e-82	295.00
IUUC-Gma-043763	Glycine max	74.02	2.00e-142	496.00
IUUC-Ggo-044699	Gorilla gorilla	44.59	4.00e-70	256.00
IUUC-Hsa-046227	Homo sapiens	48.44	3.00e-83	300.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	44.44	6.00e-78	283.00
IUUC-Lch-049829	Latimeria chalumnae	49.06	7.00e-85	305.00
IUUC-Lpe-050899	Leersia perrieri	85.62	2.00e-146	510.00
IUUC-Loc-052264	Lepisosteus oculatus	47.04	7.00e-81	292.00
IUUC-Lma-053110	Leptosphaeria maculans	50.00	5.00e-52	196.00
IUUC-Laf-053639	Loxodonta africana	48.44	3.00e-83	300.00
IUUC-Mcc-055506	Macaca mulatta	48.14	4.00e-83	300.00
IUUC-Meu-056267	Macropus eugenii	42.37	6.00e-51	194.00
IUUC-Mor-057001	Magnaporthe oryzae	44.67	1.00e-52	198.00
IUUC-Mpo-057608	Magnaporthe poae	43.41	1.00e-36	144.00
IUUC-Mtr-057731	Medicago truncatula	73.72	6.00e-139	485.00
IUUC-Mla-059016	Melampsora laricipopulina	47.24	2.00e-47	180.00
IUUC-Mga-060178	Meleagris gallopavo	47.08	4.00e-77	279.00
IUUC-Mvi-060353	Microbotryum violaceum	38.30	3.00e-56	210.00
IUUC-Mmr-060738	Microcebus murinus	48.75	1.00e-83	301.00
IUUC-Mdo-062266	Monodelphis domestica	51.44	1.00e-57	214.00
IUUC-Mmu-063619	Mus musculus	48.75	5.00e-83	299.00
IUUC-Mac-065301	Musa acuminata	74.46	1.00e-144	504.00
IUUC-Mpu-066058	Mustela putorius furo	48.44	4.00e-83	300.00
IUUC-Mlu-067292	Myotis lucifugus	48.15	1.00e-83	301.00
IUUC-Nfi-068275	Neosartorya fischeri	39.31	6.00e-61	226.00
IUUC-Ncr-068713	Neurospora crassa	38.97	1.00e-57	215.00
IUUC-Nle-069013	Nomascus leucogenys	48.45	6.00e-84	303.00
IUUC-Opr-070628	Ochotona princeps	42.77	5.00e-72	263.00
IUUC-Ont-072688	Oreochromis niloticus	46.58	1.00e-80	291.00
IUUC-Oan-073004	Ornithorhynchus anatinus	49.55	4.00e-60	223.00
IUUC-Ocu-074303	Oryctolagus cuniculus	48.45	1.00e-82	299.00
IUUC-Oba-075002	Oryza barthii	82.93	5.00e-156	541.00
IUUC-Obr-076392	Oryza brachyantha	83.44	2.00e-149	520.00
IUUC-Ogl-077271	Oryza glaberrima	82.93	5.00e-156	541.00
IUUC-Ogu-078493	Oryza glumaepatula	83.23	7.00e-157	545.00
IUUC-Oin-080084	Oryza indica	83.23	7.00e-157	545.00
IUUC-Olo-080803	Oryza longistaminata	82.93	1.00e-156	543.00
IUUC-Ome-081146	Oryza meridionalis	82.34	2.00e-155	540.00
IUUC-Oni-082146	Oryza nivara	83.23	7.00e-157	545.00
IUUC-Opu-083633	Oryza punctata	84.06	2.00e-149	520.00
IUUC-Oru-084789	Oryza rufipogon	83.23	7.00e-157	545.00
IUUC-Osa-086196	Oryza sativa	83.23	7.00e-157	545.00
IUUC-Ola-087126	Oryzias latipes	46.88	9.00e-80	288.00
IUUC-Olu-087665	Ostreococcus lucimarinus	45.54	1.00e-73	268.00
IUUC-Oga-089140	Otolemur garnettii	44.96	7.00e-79	286.00
IUUC-Oar-090296	Ovis aries	48.59	3.00e-82	296.00
IUUC-Ptr-090566	Pan troglodytes	48.44	3.00e-83	300.00
IUUC-Pan-092052	Papio anubis	48.14	4.00e-83	300.00
IUUC-Psi-093723	Pelodiscus sinensis	47.84	1.00e-75	275.00
IUUC-Pma-094568	Petromyzon marinus	41.91	3.00e-62	230.00
IUUC-Pno-095120	Phaeosphaeria nodorum	49.56	4.00e-53	200.00
IUUC-Ppa-095761	Physcomitrella patens	68.91	1.00e-133	467.00
IUUC-Pfo-096210	Poecilia formosa	48.12	8.00e-83	298.00
IUUC-Pab-098463	Pongo abelii	48.45	4.00e-83	300.00
IUUC-Pop-099109	Populus trichocarpa	73.56	1.00e-141	494.00
IUUC-Pca-100108	Procavia capensis	50.21	3.00e-66	243.00
IUUC-Ppe-101176	Prunus persica	75.99	1.00e-141	494.00
IUUC-Pva-102629	Pteropus vampyrus	51.88	4.00e-68	250.00
IUUC-Pgr-103419	Puccinia graminis	48.95	6.00e-59	219.00
IUUC-Pte-104207	Pyrenophora teres	51.81	5.00e-39	152.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	41.07	7.00e-58	216.00
IUUC-Rno-105579	Rattus norvegicus	42.26	7.00e-71	259.00
IUUC-Sha-106894	Sarcophilus harrisii	47.55	4.00e-70	256.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	42.90	1.00e-64	238.00
IUUC-Spo-108371	Schizosaccharomyces pombe	44.83	4.00e-69	253.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	37.00	2.00e-46	177.00
IUUC-Smo-109396	Selaginella moellendorffii	69.33	4.00e-126	442.00
IUUC-Sit-110630	Setaria italica	81.63	7.00e-155	538.00
IUUC-Sly-110972	Solanum lycopersicum	73.87	1.00e-136	477.00
IUUC-Stu-112185	Solanum tuberosum	75.08	2.00e-148	516.00
IUUC-Sar-113294	Sorex araneus	41.69	1.00e-70	258.00
IUUC-Sbi-113951	Sorghum bicolor	81.93	1.00e-154	537.00
IUUC-Ssc-115501	Sus scrofa	46.95	2.00e-76	277.00
IUUC-Tgu-117152	Taeniopygia guttata	46.18	4.00e-72	263.00
IUUC-Tru-118388	Takifugu rubripes	46.56	8.00e-82	295.00
IUUC-Tsy-119109	Tarsius syrichta	48.45	3.00e-83	300.00
IUUC-Tni-120048	Tetraodon nigroviridis	46.56	7.00e-82	295.00
IUUC-Tca-121750	Theobroma cacao	73.95	4.00e-147	512.00
IUUC-Tre-122130	Trichoderma reesei	37.58	7.00e-54	202.00
IUUC-Tvi-122284	Trichoderma virens	37.99	3.00e-50	190.00
IUUC-Tae-124082	Triticum aestivum	98.16	0.00e+00	641.00
IUUC-Tur-126366	Triticum urartu	60.51	3.00e-99	353.00
IUUC-Tme-127187	Tuber melanosporum	41.32	1.00e-64	238.00
IUUC-Tbe-127619	Tupaia belangeri	41.86	5.00e-56	209.00
IUUC-Ttr-128867	Tursiops truncatus	44.53	2.00e-55	207.00
IUUC-Vda-129912	Verticillium dahliae	38.82	3.00e-56	210.00
IUUC-Vpa-130552	Vicugna pacos	51.69	1.00e-57	215.00
IUUC-Vvi-130881	Vitis vinifera	74.47	2.00e-140	490.00
IUUC-Xtr-131934	Xenopus tropicalis	48.47	1.00e-85	308.00
IUUC-Xma-133312	Xiphophorus maculatus	48.12	5.00e-83	299.00
IUUC-Yli-134487	Yarrowia lipolytica	38.33	2.00e-52	197.00
IUUC-Zma-135639	Zea mays	70.54	1.00e-139	488.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence