iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098463

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

ABGA01201758

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000000398.2	ENSPPYT00000000471.2	ENSPPYP00000000452.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.90e-101	339.9	68	388

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 68   MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 145
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ +++++++    +++af
   Q: 146  FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAK----EEDAF 230
           *****************************************************************************888....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 231  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmd 316
           **************************9.78999*********..******************************976666677888888 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
             +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 317  tDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 388
           744569**********************************************************993...33344 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MSLGWLERPP ALRRAAGDGA RRLSGSRRGD VWLTSSAAGL LRSVADGSWC GGQLRARGGS 60
GRCVAGAMTG NAGEWCLMES DPGVFTELIK GFGCRGAQVE EIWSLEPENF EKLKPVHGLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAGGCCTGG GAAGAGTTTC GATGTCTCTA GGGTGGCTAG AGCGTCCTCC CGCGCTCCGT 60
CGCGCTGCAG GTGACGGCGC CCGGAGGCTG TCGGGAAGTA GGCGGGGTGA CGTGTGGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	47.59	6.00e-85	307.00
IUUC-Aml-001866	Ailuropoda melanoleuca	99.36	0.00e+00	649.00
IUUC-Atr-002966	Amborella trichopoda	45.38	1.00e-82	299.00
IUUC-Apl-003306	Anas platyrhynchos	85.47	4.00e-176	610.00
IUUC-Aca-004763	Anolis carolinensis	94.86	1.00e-178	618.00
IUUC-Aly-005581	Arabidopsis lyrata	48.33	5.00e-80	291.00
IUUC-Ath-007283	Arabidopsis thaliana	48.63	5.00e-83	300.00
IUUC-Ago-007999	Ashbya gossypii	33.33	2.00e-33	135.00
IUUC-Acl-008231	Aspergillus clavatus	43.33	1.00e-52	200.00
IUUC-Afl-008557	Aspergillus flavus	37.79	1.00e-54	206.00
IUUC-Afu-008988	Aspergillus fumigatus	44.81	1.00e-54	206.00
IUUC-Ani-009420	Aspergillus nidulans	37.93	1.00e-52	199.00
IUUC-Ang-009859	Aspergillus niger	40.82	9.00e-50	190.00
IUUC-Aor-010145	Aspergillus oryzae	37.79	1.00e-54	206.00
IUUC-Ate-010347	Aspergillus terreus	41.96	2.00e-53	202.00
IUUC-Ame-010791	Astyanax mexicanus	89.67	0.00e+00	626.00
IUUC-Bgr-012298	Blumeria graminis	37.83	1.00e-49	190.00
IUUC-Bta-013251	Bos taurus	98.40	0.00e+00	640.00
IUUC-Bci-013786	Botrytis cinerea	38.05	5.00e-58	217.00
IUUC-Bdi-014132	Brachypodium distachyon	49.54	5.00e-82	297.00
IUUC-Bol-015611	Brassica oleracea	49.70	1.00e-84	306.00
IUUC-Bra-017769	Brassica rapa	49.70	2.00e-84	305.00
IUUC-Cel-018604	Caenorhabditis elegans	47.13	2.00e-81	295.00
IUUC-Cja-019768	Callithrix jacchus	91.50	0.00e+00	655.00
IUUC-Cfa-020207	Canis familiaris	99.36	0.00e+00	649.00
IUUC-Cpo-021925	Cavia porcellus	95.21	8.00e-179	619.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.21	6.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	98.42	0.00e+00	699.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	54.18	7.00e-100	356.00
IUUC-Csv-026149	Ciona savignyi	57.86	1.00e-102	365.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.87	6.00e-52	197.00
IUUC-Cne-026955	Cryptococcus neoformans	38.14	1.00e-54	206.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.06	8.00e-48	184.00
IUUC-Dre-027409	Danio rerio	88.75	9.00e-178	615.00
IUUC-Dno-028921	Dasypus novemcinctus	98.72	0.00e+00	645.00
IUUC-Dse-031170	Dothistroma septosporum	39.94	6.00e-59	221.00
IUUC-Dme-031677	Drosophila melanogaster	59.76	5.00e-115	407.00
IUUC-Ete-032707	Echinops telfairi	68.09	3.00e-122	431.00
IUUC-Eca-033776	Equus caballus	98.96	3.00e-171	593.00
IUUC-Eeu-035305	Erinaceus europaeus	79.08	8.00e-88	316.00
IUUC-Fca-035846	Felis catus	90.91	0.00e+00	647.00
IUUC-Fal-037597	Ficedula albicollis	95.14	2.00e-158	551.00
IUUC-Fox-037670	Fusarium oxysporum	43.46	6.00e-56	211.00
IUUC-Fso-038243	Fusarium solani	50.66	2.00e-55	209.00
IUUC-Gmo-038499	Gadus morhua	83.71	8.00e-161	559.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.06	2.00e-48	186.00
IUUC-Gga-040904	Gallus gallus	94.19	0.00e+00	642.00
IUUC-Gac-042058	Gasterosteus aculeatus	88.50	3.00e-170	590.00
IUUC-Gma-043763	Glycine max	48.52	4.00e-85	308.00
IUUC-Ggo-044699	Gorilla gorilla	94.14	6.00e-172	596.00
IUUC-Hsa-046227	Homo sapiens	100.00	0.00e+00	652.00
IUUC-Hvu-047359	Hordeum vulgare	46.99	5.00e-83	301.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	89.61	0.00e+00	649.00
IUUC-Lch-049829	Latimeria chalumnae	92.01	3.00e-174	603.00
IUUC-Lpe-050899	Leersia perrieri	48.90	7.00e-79	286.00
IUUC-Loc-052264	Lepisosteus oculatus	90.13	2.00e-172	597.00
IUUC-Lma-053110	Leptosphaeria maculans	35.90	3.00e-49	189.00
IUUC-Laf-053639	Loxodonta africana	99.36	0.00e+00	649.00
IUUC-Mcc-055506	Macaca mulatta	98.16	0.00e+00	695.00
IUUC-Mor-057001	Magnaporthe oryzae	45.38	3.00e-55	208.00
IUUC-Mpo-057608	Magnaporthe poae	41.18	3.00e-33	134.00
IUUC-Mtr-057731	Medicago truncatula	49.25	3.00e-85	308.00
IUUC-Mla-059016	Melampsora laricipopulina	43.28	2.00e-43	168.00
IUUC-Mga-060178	Meleagris gallopavo	94.74	5.00e-173	599.00
IUUC-Mvi-060353	Microbotryum violaceum	38.21	1.00e-53	203.00
IUUC-Mmr-060738	Microcebus murinus	99.36	0.00e+00	649.00
IUUC-Mdo-062266	Monodelphis domestica	97.55	2.00e-119	421.00
IUUC-Mmu-063619	Mus musculus	96.81	0.00e+00	636.00
IUUC-Mac-065301	Musa acuminata	50.16	2.00e-88	318.00
IUUC-Mpu-066058	Mustela putorius furo	99.04	0.00e+00	646.00
IUUC-Mlu-067292	Myotis lucifugus	97.76	0.00e+00	634.00
IUUC-Nfi-068275	Neosartorya fischeri	37.70	2.00e-55	209.00
IUUC-Ncr-068713	Neurospora crassa	39.24	3.00e-58	218.00
IUUC-Nle-069013	Nomascus leucogenys	98.68	0.00e+00	716.00
IUUC-Opr-070628	Ochotona princeps	85.67	3.00e-173	600.00
IUUC-Ont-072688	Oreochromis niloticus	89.21	1.00e-170	592.00
IUUC-Oan-073004	Ornithorhynchus anatinus	96.71	4.00e-141	493.00
IUUC-Ocu-074303	Oryctolagus cuniculus	93.59	0.00e+00	673.00
IUUC-Oba-075002	Oryza barthii	50.15	8.00e-82	296.00
IUUC-Obr-076392	Oryza brachyantha	48.90	1.00e-79	289.00
IUUC-Ogl-077271	Oryza glaberrima	50.15	8.00e-82	296.00
IUUC-Ogu-078493	Oryza glumaepatula	50.15	1.00e-82	299.00
IUUC-Oin-080084	Oryza indica	50.15	1.00e-82	299.00
IUUC-Olo-080803	Oryza longistaminata	49.85	3.00e-82	298.00
IUUC-Ome-081146	Oryza meridionalis	47.89	6.00e-81	293.00
IUUC-Oni-082146	Oryza nivara	50.15	1.00e-82	299.00
IUUC-Opu-083633	Oryza punctata	49.53	2.00e-78	285.00
IUUC-Oru-084789	Oryza rufipogon	50.15	1.00e-82	299.00
IUUC-Osa-086196	Oryza sativa	50.15	1.00e-82	299.00
IUUC-Ola-087126	Oryzias latipes	89.46	2.00e-167	581.00
IUUC-Olu-087665	Ostreococcus lucimarinus	42.01	4.00e-69	254.00
IUUC-Oga-089140	Otolemur garnettii	91.47	0.00e+00	635.00
IUUC-Oar-090296	Ovis aries	98.08	0.00e+00	640.00
IUUC-Ptr-090566	Pan troglodytes	100.00	0.00e+00	652.00
IUUC-Pan-092052	Papio anubis	98.42	0.00e+00	698.00
IUUC-Psi-093723	Pelodiscus sinensis	94.79	8.00e-165	572.00
IUUC-Pma-094568	Petromyzon marinus	61.46	2.00e-105	375.00
IUUC-Pno-095120	Phaeosphaeria nodorum	45.65	2.00e-50	192.00
IUUC-Ppa-095761	Physcomitrella patens	47.37	1.00e-83	303.00
IUUC-Pfo-096210	Poecilia formosa	89.14	1.00e-171	595.00
IUUC-Pop-099109	Populus trichocarpa	48.37	5.00e-85	307.00
IUUC-Pca-100108	Procavia capensis	96.79	4.00e-143	500.00
IUUC-Ppe-101176	Prunus persica	50.90	3.00e-86	311.00
IUUC-Pva-102629	Pteropus vampyrus	95.59	9.00e-154	535.00
IUUC-Pgr-103419	Puccinia graminis	40.43	2.00e-56	212.00
IUUC-Pte-104207	Pyrenophora teres	44.97	3.00e-33	134.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.67	4.00e-57	214.00
IUUC-Rno-105579	Rattus norvegicus	87.00	1.00e-163	568.00
IUUC-Sha-106894	Sarcophilus harrisii	93.48	4.00e-155	540.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	38.87	3.00e-59	221.00
IUUC-Spo-108371	Schizosaccharomyces pombe	42.19	2.00e-59	221.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	39.05	8.00e-48	183.00
IUUC-Smo-109396	Selaginella moellendorffii	51.38	2.00e-88	318.00
IUUC-Sit-110630	Setaria italica	49.24	9.00e-86	310.00
IUUC-Sly-110972	Solanum lycopersicum	50.48	6.00e-81	293.00
IUUC-Stu-112185	Solanum tuberosum	50.90	5.00e-89	320.00
IUUC-Sar-113294	Sorex araneus	81.32	2.00e-166	578.00
IUUC-Sbi-113951	Sorghum bicolor	49.54	3.00e-86	311.00
IUUC-Ssc-115501	Sus scrofa	97.64	3.00e-174	603.00
IUUC-Tgu-117152	Taeniopygia guttata	94.79	2.00e-158	551.00
IUUC-Tru-118388	Takifugu rubripes	88.18	2.00e-170	591.00
IUUC-Tsy-119109	Tarsius syrichta	99.38	0.00e+00	672.00
IUUC-Tni-120048	Tetraodon nigroviridis	88.18	8.00e-171	592.00
IUUC-Tca-121750	Theobroma cacao	49.11	1.00e-88	319.00
IUUC-Tre-122130	Trichoderma reesei	39.33	1.00e-55	209.00
IUUC-Tvi-122284	Trichoderma virens	39.53	6.00e-53	201.00
IUUC-Tae-124082	Triticum aestivum	47.59	6.00e-83	300.00
IUUC-Tur-126366	Triticum urartu	43.25	1.00e-66	246.00
IUUC-Tme-127187	Tuber melanosporum	40.92	2.00e-58	218.00
IUUC-Tbe-127619	Tupaia belangeri	89.90	9.00e-145	505.00
IUUC-Ttr-128867	Tursiops truncatus	87.76	1.00e-123	435.00
IUUC-Vda-129912	Verticillium dahliae	36.82	1.00e-52	199.00
IUUC-Vpa-130552	Vicugna pacos	99.52	2.00e-125	442.00
IUUC-Vvi-130881	Vitis vinifera	51.20	1.00e-84	306.00
IUUC-Xtr-131934	Xenopus tropicalis	85.41	2.00e-173	600.00
IUUC-Xma-133312	Xiphophorus maculatus	89.14	2.00e-171	594.00
IUUC-Yli-134487	Yarrowia lipolytica	39.91	8.00e-49	187.00
IUUC-Zma-135462	Zea mays	43.69	1.00e-71	263.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence