iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021721

Ensembl Protein ID

ENSCPOP00000009715.2

UniProt Accession

H0VHS2; H0VHS2_CAVPO

Genbank Protein ID

ENSCPOP00000009715

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02049260

Gene Name

WDR48

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000010820.3	ENSCPOT00000010918.2	ENSCPOP00000009715.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-33	113.3	193	230
UBD/Beta-Prp	8.20e-48	163.0	16	279
ULD/UDP/UFD/RAWUL	9.70e-24	83.7	553	657
ULD/UBL/SUMO	3.50e-60	200.7	544	650

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gHtd v +l +  d t  +sGs Dgti++W+l +++++
   Q: 193  GHTDNVKALLLnRDgTQCLSGSSDGTIRLWSLGQQRCI 230
           8********88*888*****************999997 PP

UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
           + +++++  p  + l+t++rd+ i++w+v++ k    ++s++ h++ v+++ +  +gk+l+++s+D t+kvw+  +g c++tl+ h+d+
   Q: 16   NGVNALQLDPALNRLFTAGRDSIIRIWSVSQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDY 104
           55677888889999*****************999999**************************************************** PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           v +l++ ++++ ++s++ dr i +wd++t + l +         lsg+++++ ++++++ g ++vsGs+ +++r+Wd +t   l +l+g
   Q: 105  VKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 193
           *********************************99*********************************************99999**99 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
            htd v+ l ++++g++++sgs dgt++lw+l +++c+ t++ h++ v+ +++ +  ++++sg+ D+ i++ dlr+ d+   +  ++
   Q: 194  -HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDTFTHVYSGGRDRKIYCTDLRNPDMRVLICEEK 279
           .*************************************************************************9988776666555 PP

ULD/UDP/UFD/RAWUL

   S: 4    sLeplesnkakddsklkkkylrcsarltVkhlkkflaeklkl........sssy....................evdllcedevLedne 64
            L+p++s++ak+   lkk++l++s++l+V++++++++ek+++        s                       +++llc+d+vL++n+
   Q: 553  YLQPHASSGAKT---LKKDRLSASDMLQVRKVMEHVYEKIINldnesqttS--SsnnekpeqekeediavlaeeKIELLCQDQVLDPNM 636
           69**********...*************************99988766653..0457999999999*********************** PP
   S: 65   tLeeikyifiwkkegpLvLqYr 86
           +L+++ ++fiwk++g+L+L+Yr
   Q: 637  DLRTV-KHFIWKSGGDLTLHYR 657
           *****.***************9 PP

ULD/UBL/SUMO

   S: 1    eskffkapvslkvagqdGsevlfklklsa....qlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcq.... 81
           ++kf+k+p++l++++++G+++l+k++lsa    q++k+me+vY+k+inld++s+++++ +++  eqe++e+++v++e+kiellcq    
   Q: 544  MPKFNKIPFYLQPHASSGAKTLKKDRLSAsdmlQVRKVMEHVYEKIINLDNESQTTSSSNNEKPEQEKEEDIAVLAEEKIELLCQdqvl 632
           8********************************************************88888889********************7777 PP
   S: 82   ..............ksGG 85
                         ksGG
   Q: 633  dpnmdlrtvkhfiwKSGG 650
           777777777777777776 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

QVSYVIRDEV EKYNRNGVNA LQLDPALNRL FTAGRDSIIR IWSVSQHKQD PYIASMEHHT 60
DWVNDIVLCC NGKTLISASS DTTVKVWNAH KGFCMSTLRT HKDYVKALAY AKDKELVASA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTTTCCT ATGTTATTCG AGACGAAGTG GAGAAGTACA ATCGAAATGG AGTAAATGCC 60
CTGCAGCTGG ACCCAGCACT AAATAGACTT TTCACGGCTG GCCGGGACTC CATCATAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021772--DUF3337
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF11816--DUF3337
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0000724--P:double-strand break repair via homologous recombination
GO:0048568--P:embryonic organ development
GO:0048872--P:homeostasis of number of cells
GO:0035264--P:multicellular organism growth
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0016579--P:protein deubiquitination
GO:1902525--P:regulation of protein monoubiquitination
GO:0072520--P:seminiferous tubule development
GO:0007338--P:single fertilization
GO:0048705--P:skeletal system morphogenesis
GO:0043588--P:skin development
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001160	Aegilops tauschii	40.41	7.00e-97	348.00
IUUC-Aml-001533	Ailuropoda melanoleuca	97.89	0.00e+00	1221.00
IUUC-Atr-003009	Amborella trichopoda	33.77	2.00e-108	386.00
IUUC-Apl-003709	Anas platyrhynchos	96.21	0.00e+00	654.00
IUUC-Aca-004875	Anolis carolinensis	96.68	0.00e+00	1248.00
IUUC-Aly-005464	Arabidopsis lyrata	39.92	1.00e-91	331.00
IUUC-Ath-006969	Arabidopsis thaliana	39.35	2.00e-87	317.00
IUUC-Acl-008203	Aspergillus clavatus	33.51	2.00e-46	181.00
IUUC-Afl-008571	Aspergillus flavus	34.73	3.00e-45	177.00
IUUC-Afu-009072	Aspergillus fumigatus	34.73	1.00e-44	175.00
IUUC-Ani-009413	Aspergillus nidulans	35.20	4.00e-47	183.00
IUUC-Ang-009571	Aspergillus niger	34.38	8.00e-44	172.00
IUUC-Aor-010064	Aspergillus oryzae	34.73	2.00e-45	177.00
IUUC-Ate-010463	Aspergillus terreus	33.71	3.00e-46	180.00
IUUC-Ame-010875	Astyanax mexicanus	93.74	0.00e+00	1081.00
IUUC-Bgr-012288	Blumeria graminis	34.42	1.00e-41	165.00
IUUC-Bta-013379	Bos taurus	98.34	0.00e+00	1227.00
IUUC-Bci-013859	Botrytis cinerea	32.83	2.00e-40	161.00
IUUC-Bdi-014645	Brachypodium distachyon	34.98	1.00e-110	394.00
IUUC-Bol-016450	Brassica oleracea	35.56	3.00e-99	355.00
IUUC-Bra-017237	Brassica rapa	33.97	3.00e-100	359.00
IUUC-Cel-018656	Caenorhabditis elegans	44.30	1.00e-155	543.00
IUUC-Cja-018804	Callithrix jacchus	97.89	0.00e+00	1220.00
IUUC-Cfa-020076	Canis familiaris	98.34	0.00e+00	1226.00
IUUC-Cre-022779	Chlamydomonas reinhardtii	30.23	6.00e-41	163.00
IUUC-Csa-023188	Chlorocebus sabaeus	98.34	0.00e+00	1226.00
IUUC-Cho-024932	Choloepus hoffmanni	97.13	0.00e+00	1230.00
IUUC-Cin-025591	Ciona intestinalis	57.39	0.00e+00	717.00
IUUC-Cgl-026540	Colletotrichum gloeosporioides	27.55	1.00e-20	95.50
IUUC-Cne-026819	Cryptococcus neoformans	35.53	3.00e-34	141.00
IUUC-Cme-027188	Cyanidioschyzon merolae	31.98	2.00e-70	260.00
IUUC-Dre-027926	Danio rerio	92.15	0.00e+00	1233.00
IUUC-Dno-029960	Dasypus novemcinctus	97.58	0.00e+00	1215.00
IUUC-Dor-030933	Dipodomys ordii	93.77	0.00e+00	704.00
IUUC-Dse-031532	Dothistroma septosporum	35.69	5.00e-45	176.00
IUUC-Dme-032168	Drosophila melanogaster	56.55	0.00e+00	677.00
IUUC-Ete-033107	Echinops telfairi	96.07	0.00e+00	1182.00
IUUC-Eca-034028	Equus caballus	98.19	0.00e+00	1224.00
IUUC-Eeu-034894	Erinaceus europaeus	95.03	0.00e+00	837.00
IUUC-Fca-035619	Felis catus	97.90	0.00e+00	908.00
IUUC-Fal-036869	Ficedula albicollis	96.53	0.00e+00	1246.00
IUUC-Fox-037907	Fusarium oxysporum	32.76	2.00e-40	161.00
IUUC-Fso-038101	Fusarium solani	33.05	5.00e-40	159.00
IUUC-Gmo-038627	Gadus morhua	93.66	0.00e+00	1244.00
IUUC-Ggr-039995	Gaeumannomyces graminis	30.70	5.00e-41	163.00
IUUC-Gga-040555	Gallus gallus	96.68	0.00e+00	1244.00
IUUC-Gac-042497	Gasterosteus aculeatus	93.66	0.00e+00	1218.00
IUUC-Gma-043089	Glycine max	34.70	1.00e-108	387.00
IUUC-Ggo-045561	Gorilla gorilla	98.34	0.00e+00	1226.00
IUUC-Hsa-045710	Homo sapiens	98.34	0.00e+00	1226.00
IUUC-Hvu-047730	Hordeum vulgare	36.00	8.00e-85	307.00
IUUC-Itr-049030	Ictidomys tridecemlineatus	97.89	0.00e+00	883.00
IUUC-Kpa-049237	Komagataella pastoris	30.77	1.00e-29	125.00
IUUC-Lch-049507	Latimeria chalumnae	94.71	0.00e+00	1225.00
IUUC-Lpe-051608	Leersia perrieri	35.41	3.00e-110	392.00
IUUC-Loc-052373	Lepisosteus oculatus	92.47	0.00e+00	1204.00
IUUC-Lma-053025	Leptosphaeria maculans	35.84	5.00e-48	186.00
IUUC-Laf-053706	Loxodonta africana	97.58	0.00e+00	1219.00
IUUC-Mcc-055046	Macaca mulatta	98.34	0.00e+00	1226.00
IUUC-Meu-056840	Macropus eugenii	78.31	1.00e-146	513.00
IUUC-Mor-057284	Magnaporthe oryzae	32.93	1.00e-42	168.00
IUUC-Mpo-057418	Magnaporthe poae	30.70	2.00e-40	161.00
IUUC-Mtr-058571	Medicago truncatula	35.05	8.00e-109	387.00
IUUC-Mla-059101	Melampsora laricipopulina	45.10	2.00e-45	178.00
IUUC-Mga-059297	Meleagris gallopavo	96.68	0.00e+00	1244.00
IUUC-Mvi-060419	Microbotryum violaceum	37.78	5.00e-38	153.00
IUUC-Mmr-061196	Microcebus murinus	91.71	0.00e+00	1130.00
IUUC-Mdo-062762	Monodelphis domestica	93.47	0.00e+00	1236.00
IUUC-Mmu-063915	Mus musculus	97.58	0.00e+00	1258.00
IUUC-Mac-065434	Musa acuminata	34.99	1.00e-106	380.00
IUUC-Mpu-065999	Mustela putorius furo	97.82	0.00e+00	806.00
IUUC-Mlu-068226	Myotis lucifugus	98.19	0.00e+00	1222.00
IUUC-Nfi-068416	Neosartorya fischeri	29.75	2.00e-55	211.00
IUUC-Ncr-068825	Neurospora crassa	31.59	2.00e-39	158.00
IUUC-Nle-069416	Nomascus leucogenys	98.34	0.00e+00	1226.00
IUUC-Opr-070515	Ochotona princeps	93.96	0.00e+00	1152.00
IUUC-Ont-072052	Oreochromis niloticus	91.29	0.00e+00	1158.00
IUUC-Oan-073636	Ornithorhynchus anatinus	93.50	0.00e+00	1235.00
IUUC-Ocu-074799	Oryctolagus cuniculus	98.19	0.00e+00	1223.00
IUUC-Oba-075146	Oryza barthii	34.77	4.00e-109	389.00
IUUC-Obr-076699	Oryza brachyantha	34.94	1.00e-110	393.00
IUUC-Ogl-077883	Oryza glaberrima	33.40	4.00e-67	248.00
IUUC-Ogu-078114	Oryza glumaepatula	35.08	2.00e-108	387.00
IUUC-Oin-079575	Oryza indica	35.12	2.00e-112	400.00
IUUC-Olo-080531	Oryza longistaminata	32.76	3.00e-99	356.00
IUUC-Ome-081368	Oryza meridionalis	40.61	2.00e-97	350.00
IUUC-Oni-082457	Oryza nivara	34.77	3.00e-109	389.00
IUUC-Opu-084050	Oryza punctata	34.64	4.00e-108	385.00
IUUC-Oru-084330	Oryza rufipogon	34.77	3.00e-109	389.00
IUUC-Osa-085408	Oryza sativa	35.12	2.00e-112	400.00
IUUC-Ola-087546	Oryzias latipes	93.27	0.00e+00	1221.00
IUUC-Olu-087710	Ostreococcus lucimarinus	31.60	2.00e-80	293.00
IUUC-Oga-087998	Otolemur garnettii	98.04	0.00e+00	1222.00
IUUC-Oar-090303	Ovis aries	98.34	0.00e+00	1227.00
IUUC-Ptr-090588	Pan troglodytes	98.34	0.00e+00	1226.00
IUUC-Pan-092722	Papio anubis	98.34	0.00e+00	1226.00
IUUC-Psi-093911	Pelodiscus sinensis	96.25	0.00e+00	1246.00
IUUC-Pma-094580	Petromyzon marinus	88.22	0.00e+00	1157.00
IUUC-Pno-095085	Phaeosphaeria nodorum	35.35	7.00e-44	172.00
IUUC-Ppa-095594	Physcomitrella patens	35.75	8.00e-113	401.00
IUUC-Pfo-096994	Poecilia formosa	93.40	0.00e+00	1216.00
IUUC-Pab-097586	Pongo abelii	98.19	0.00e+00	1224.00
IUUC-Pop-099740	Populus trichocarpa	35.20	5.00e-103	368.00
IUUC-Pca-100458	Procavia capensis	99.04	4.00e-107	382.00
IUUC-Ppe-102060	Prunus persica	34.75	1.00e-106	380.00
IUUC-Pva-102698	Pteropus vampyrus	93.66	0.00e+00	1210.00
IUUC-Pgr-103649	Puccinia graminis	34.12	3.00e-47	184.00
IUUC-Ptt-103910	Puccinia triticina	43.09	2.00e-52	201.00
IUUC-Pte-104181	Pyrenophora teres	36.14	8.00e-48	186.00
IUUC-Pyt-104439	Pyrenophora triticirepentis	35.84	2.00e-47	184.00
IUUC-Rno-104978	Rattus norvegicus	97.73	0.00e+00	1258.00
IUUC-Sha-107079	Sarcophilus harrisii	96.68	0.00e+00	1183.00
IUUC-Sja-107716	Schizosaccharomyces japonicus	30.08	6.00e-58	219.00
IUUC-Spo-108325	Schizosaccharomyces pombe	30.80	2.00e-51	197.00
IUUC-Ssl-108542	Sclerotinia sclerotiorum	29.35	7.00e-48	186.00
IUUC-Smo-109427	Selaginella moellendorffii	35.38	6.00e-110	391.00
IUUC-Sit-110755	Setaria italica	36.46	1.00e-113	404.00
IUUC-Sly-111099	Solanum lycopersicum	35.46	2.00e-99	356.00
IUUC-Sar-113408	Sorex araneus	97.87	0.00e+00	729.00
IUUC-Sbi-113789	Sorghum bicolor	35.17	4.00e-110	392.00
IUUC-Sre-114998	Sporisorium reilianum	39.93	6.00e-52	199.00
IUUC-Ssc-115434	Sus scrofa	98.34	0.00e+00	1226.00
IUUC-Tgu-116517	Taeniopygia guttata	96.68	0.00e+00	1248.00
IUUC-Tru-118174	Takifugu rubripes	93.83	0.00e+00	1224.00
IUUC-Tsy-118935	Tarsius syrichta	98.04	0.00e+00	1253.00
IUUC-Tni-119744	Tetraodon nigroviridis	94.26	0.00e+00	1191.00
IUUC-Tca-121360	Theobroma cacao	34.17	2.00e-110	393.00
IUUC-Tre-122198	Trichoderma reesei	32.56	2.00e-42	167.00
IUUC-Tvi-122389	Trichoderma virens	32.85	6.00e-43	169.00
IUUC-Tae-125576	Triticum aestivum	35.59	2.00e-112	399.00
IUUC-Tur-126699	Triticum urartu	35.31	1.00e-110	394.00
IUUC-Tme-126932	Tuber melanosporum	31.75	6.00e-54	206.00
IUUC-Tbe-127267	Tupaia belangeri	97.20	0.00e+00	681.00
IUUC-Ttr-129153	Tursiops truncatus	98.19	0.00e+00	1261.00
IUUC-Uma-129604	Ustilago maydis	42.97	6.00e-50	193.00
IUUC-Vda-129925	Verticillium dahliae	35.40	4.00e-46	180.00
IUUC-Vpa-130553	Vicugna pacos	97.46	0.00e+00	937.00
IUUC-Vvi-130995	Vitis vinifera	34.35	2.00e-105	376.00
IUUC-Xtr-132346	Xenopus tropicalis	93.21	0.00e+00	1191.00
IUUC-Xma-134266	Xiphophorus maculatus	91.60	0.00e+00	659.00
IUUC-Yli-134451	Yarrowia lipolytica	31.19	2.00e-35	144.00
IUUC-Zma-135647	Zea mays	35.29	1.00e-111	397.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence