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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046565
UUCD1 version UUC-HoS-00616
Ensembl Protein ID ENSP00000373312.2
UniProt Accession P55735; A8MV37; B4DXJ1; Q5BJF0; Q9BRM6; Q9BUG7; SEC13_HUMAN
Genbank Protein ID BAG63403.1; AAH02634.2; AAH06167.1; AAH91506.1
Protein Name Protein SEC13 homolog; SEC13-like protein 1; SEC13-related protein
Genbank Nucleotide ID L09260; AC022384; BC006167; BC091506
Gene Name SEC13; D3S1231E; SEC13L1; SEC13R
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000157020.17 ENST00000397117.5 ENSP00000380306.1
ENSG00000157020.17 ENST00000383801.6 ENSP00000373312.2
ENSG00000157020.17 ENST00000428626.5 ENSP00000400260.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.40e-28 98.1 101 134
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd..tllvsGsdDgtikvWDl 30
           gH+++v+ +a+  +   ++l+s+s+D ++ +W+ 
   Q: 101  GHEGPVWQVAWahPMygNILASCSYDRKVIIWRE 134
           8***********9666699*************95 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:25457612, PubMed:27487210).
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:25457612, PubMed:27487210).
Protein Sequence
(Fasta)
MREPVLTWCV PLELLCSHPL PLSAFLKSQV KLYTYRACAG KDEMGKMVSV INTVDTSHED 60
MIHDAQMDYY GTRLATCSSD RSVKIFDVRN GGQILIADLR GHEGPVWQVA WAHPMYGNIL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046565|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGAGCGCGT TGCTGCCCGG AGGCTCCTAC GCCACGGCCC GTCGGGCCCG GCGCCGGAAG 60
TGAGCTGTTC CGAGGCGCCG CCGGGAGCTG CCACGTCCGA GACCTGGAGC AGCCACCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046565|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0931--ER-Golgi transport
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0012507--C:ER to Golgi transport vesicle membrane
GO:0070062--C:extracellular exosome
GO:0061700--C:GATOR2 complex
GO:0000139--C:Golgi membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005635--C:nuclear envelope
GO:0031080--C:nuclear pore outer ring
GO:0005654--C:nucleoplasm
GO:0042802--F:identical protein binding
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I
GO:0048208--P:COPII vesicle coating
GO:0006886--P:intracellular protein transport
GO:0051028--P:mRNA transport
GO:0032008--P:positive regulation of TOR signaling
GO:0007062--P:sister chromatid cohesion
KEGG hsa:6396
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000671 Aegilops tauschii 53.49 5.00e-90 324.00
IUUC-Aml-001832 Ailuropoda melanoleuca 92.76 0.00e+00 692.00
IUUC-Atr-002914 Amborella trichopoda 53.85 3.00e-89 321.00
IUUC-Apl-003992 Anas platyrhynchos 93.79 3.00e-170 590.00
IUUC-Aca-005283 Anolis carolinensis 93.17 4.00e-179 620.00
IUUC-Aly-005654 Arabidopsis lyrata 54.33 3.00e-89 321.00
IUUC-Ath-006816 Arabidopsis thaliana 54.67 2.00e-89 322.00
IUUC-Ago-007827 Ashbya gossypii 49.67 5.00e-82 297.00
IUUC-Acl-008205 Aspergillus clavatus 51.50 3.00e-80 291.00
IUUC-Afl-008748 Aspergillus flavus 51.14 1.00e-82 300.00
IUUC-Afu-008791 Aspergillus fumigatus 51.50 4.00e-80 291.00
IUUC-Ani-009152 Aspergillus nidulans 50.16 8.00e-83 300.00
IUUC-Ang-009765 Aspergillus niger 51.14 5.00e-83 300.00
IUUC-Aor-009927 Aspergillus oryzae 51.00 8.00e-80 290.00
IUUC-Ate-010248 Aspergillus terreus 50.81 9.00e-83 300.00
IUUC-Ame-011478 Astyanax mexicanus 86.65 7.00e-168 582.00
IUUC-Bgr-012276 Blumeria graminis 48.57 4.00e-81 294.00
IUUC-Bta-012700 Bos taurus 96.27 0.00e+00 642.00
IUUC-Bci-013722 Botrytis cinerea 50.50 8.00e-83 300.00
IUUC-Bdi-014818 Brachypodium distachyon 54.15 7.00e-91 327.00
IUUC-Bol-015779 Brassica oleracea 55.44 4.00e-89 321.00
IUUC-Bra-016973 Brassica rapa 54.61 4.00e-89 322.00
IUUC-Cel-018479 Caenorhabditis elegans 41.96 2.00e-70 259.00
IUUC-Cja-019956 Callithrix jacchus 97.31 0.00e+00 669.00
IUUC-Cfa-020752 Canis familiaris 97.83 0.00e+00 650.00
IUUC-Cpo-021871 Cavia porcellus 95.02 0.00e+00 632.00
IUUC-Cre-022797 Chlamydomonas reinhardtii 54.46 2.00e-95 342.00
IUUC-Csa-023393 Chlorocebus sabaeus 98.91 0.00e+00 752.00
IUUC-Cho-024786 Choloepus hoffmanni 73.64 4.00e-149 521.00
IUUC-Cin-025332 Ciona intestinalis 70.13 9.00e-132 462.00
IUUC-Csv-025926 Ciona savignyi 68.83 3.00e-128 451.00
IUUC-Cgl-026413 Colletotrichum gloeosporioides 52.22 3.00e-79 288.00
IUUC-Cne-027054 Cryptococcus neoformans 50.31 3.00e-78 285.00
IUUC-Cme-027165 Cyanidioschyzon merolae 34.35 4.00e-49 189.00
IUUC-Dre-027782 Danio rerio 87.58 2.00e-169 588.00
IUUC-Dno-029628 Dasypus novemcinctus 92.39 0.00e+00 702.00
IUUC-Dor-030650 Dipodomys ordii 79.46 1.00e-147 516.00
IUUC-Dse-031206 Dothistroma septosporum 46.95 5.00e-77 280.00
IUUC-Dme-031854 Drosophila melanogaster 58.75 4.00e-102 364.00
IUUC-Ete-032618 Echinops telfairi 67.18 8.00e-118 416.00
IUUC-Eca-033268 Equus caballus 97.51 0.00e+00 646.00
IUUC-Fca-035918 Felis catus 97.83 0.00e+00 649.00
IUUC-Fal-037551 Ficedula albicollis 92.53 1.00e-158 551.00
IUUC-Fox-037763 Fusarium oxysporum 49.17 5.00e-81 294.00
IUUC-Fso-038341 Fusarium solani 48.52 1.00e-79 289.00
IUUC-Gmo-038638 Gadus morhua 86.92 6.00e-169 586.00
IUUC-Ggr-039865 Gaeumannomyces graminis 50.00 8.00e-79 286.00
IUUC-Gga-040193 Gallus gallus 93.48 3.00e-178 617.00
IUUC-Gma-044311 Glycine max 53.85 8.00e-90 323.00
IUUC-Ggo-045252 Gorilla gorilla 99.18 0.00e+00 754.00
IUUC-Hvu-047835 Hordeum vulgare 54.82 4.00e-92 331.00
IUUC-Itr-048587 Ictidomys tridecemlineatus 97.20 0.00e+00 642.00
IUUC-Kpa-049148 Komagataella pastoris 52.65 7.00e-87 313.00
IUUC-Lch-050421 Latimeria chalumnae 89.13 5.00e-173 600.00
IUUC-Lpe-051187 Leersia perrieri 52.16 4.00e-91 330.00
IUUC-Loc-052167 Lepisosteus oculatus 87.93 3.00e-170 590.00
IUUC-Lma-053250 Leptosphaeria maculans 51.63 3.00e-81 295.00
IUUC-Laf-054304 Loxodonta africana 96.57 0.00e+00 640.00
IUUC-Mcc-055519 Macaca mulatta 98.64 0.00e+00 750.00
IUUC-Meu-056439 Macropus eugenii 94.08 0.00e+00 630.00
IUUC-Mor-057241 Magnaporthe oryzae 50.00 1.00e-78 286.00
IUUC-Mpo-057373 Magnaporthe poae 44.48 3.00e-64 238.00
IUUC-Mtr-058412 Medicago truncatula 53.85 6.00e-88 317.00
IUUC-Mla-058966 Melampsora laricipopulina 49.39 3.00e-86 311.00
IUUC-Mga-060066 Meleagris gallopavo 93.79 3.00e-170 590.00
IUUC-Mvi-060290 Microbotryum violaceum 46.34 2.00e-79 291.00
IUUC-Mmr-060717 Microcebus murinus 97.20 0.00e+00 647.00
IUUC-Mdo-062496 Monodelphis domestica 94.41 0.00e+00 633.00
IUUC-Mmu-063490 Mus musculus 96.89 0.00e+00 647.00
IUUC-Mac-065307 Musa acuminata 53.27 4.00e-87 315.00
IUUC-Mpu-066601 Mustela putorius furo 97.83 0.00e+00 650.00
IUUC-Mlu-067501 Myotis lucifugus 94.43 0.00e+00 702.00
IUUC-Nfi-068360 Neosartorya fischeri 50.38 9.00e-66 243.00
IUUC-Ncr-068928 Neurospora crassa 50.17 4.00e-83 301.00
IUUC-Nle-069028 Nomascus leucogenys 98.37 0.00e+00 748.00
IUUC-Opr-070446 Ochotona princeps 96.41 5.00e-177 613.00
IUUC-Ont-071587 Oreochromis niloticus 86.29 1.00e-169 588.00
IUUC-Oan-073211 Ornithorhynchus anatinus 91.61 8.00e-179 619.00
IUUC-Ocu-074306 Oryctolagus cuniculus 94.72 0.00e+00 632.00
IUUC-Oba-075069 Oryza barthii 53.49 3.00e-90 325.00
IUUC-Obr-076667 Oryza brachyantha 53.82 2.00e-90 325.00
IUUC-Ogl-077208 Oryza glaberrima 53.49 3.00e-90 325.00
IUUC-Ogu-078513 Oryza glumaepatula 53.49 3.00e-90 325.00
IUUC-Oin-079094 Oryza indica 53.49 3.00e-90 325.00
IUUC-Olo-080473 Oryza longistaminata 53.49 3.00e-90 325.00
IUUC-Ome-081643 Oryza meridionalis 53.49 3.00e-90 325.00
IUUC-Oni-082589 Oryza nivara 53.49 3.00e-90 325.00
IUUC-Opu-083677 Oryza punctata 53.49 3.00e-90 325.00
IUUC-Oru-084537 Oryza rufipogon 53.49 3.00e-90 325.00
IUUC-Osa-085449 Oryza sativa 53.49 3.00e-90 325.00
IUUC-Ola-087226 Oryzias latipes 86.34 2.00e-168 584.00
IUUC-Olu-087893 Ostreococcus lucimarinus 50.68 2.00e-78 285.00
IUUC-Oga-088837 Otolemur garnettii 95.79 0.00e+00 709.00
IUUC-Oar-089594 Ovis aries 96.27 0.00e+00 642.00
IUUC-Ptr-091132 Pan troglodytes 99.38 0.00e+00 656.00
IUUC-Psi-093568 Pelodiscus sinensis 93.51 1.00e-171 595.00
IUUC-Pma-094172 Petromyzon marinus 72.61 5.00e-63 233.00
IUUC-Pno-094955 Phaeosphaeria nodorum 50.33 2.00e-79 289.00
IUUC-Ppa-095578 Physcomitrella patens 55.78 8.00e-92 330.00
IUUC-Pfo-096063 Poecilia formosa 87.27 1.00e-169 588.00
IUUC-Pab-098674 Pongo abelii 98.64 0.00e+00 751.00
IUUC-Pop-099402 Populus trichocarpa 54.00 7.00e-90 323.00
IUUC-Pca-100824 Procavia capensis 75.00 4.00e-156 543.00
IUUC-Ppe-101707 Prunus persica 53.85 1.00e-87 317.00
IUUC-Pva-103161 Pteropus vampyrus 92.12 0.00e+00 691.00
IUUC-Pgr-103573 Puccinia graminis 52.94 4.00e-89 321.00
IUUC-Ptt-103700 Puccinia triticina 51.59 2.00e-82 298.00
IUUC-Pte-104267 Pyrenophora teres 50.34 1.00e-77 282.00
IUUC-Pyt-104535 Pyrenophora triticirepentis 48.98 6.00e-70 257.00
IUUC-Rno-104833 Rattus norvegicus 97.20 0.00e+00 648.00
IUUC-Sce-106437 Saccharomyces cerevisiae 50.65 2.00e-75 275.00
IUUC-Sha-106611 Sarcophilus harrisii 94.08 0.00e+00 630.00
IUUC-Sja-107654 Schizosaccharomyces japonicus 49.17 2.00e-81 295.00
IUUC-Spo-108362 Schizosaccharomyces pombe 51.90 7.00e-85 306.00
IUUC-Smo-109674 Selaginella moellendorffii 53.05 9.00e-92 330.00
IUUC-Sit-110132 Setaria italica 53.16 2.00e-90 325.00
IUUC-Sly-111254 Solanum lycopersicum 52.33 1.00e-85 309.00
IUUC-Stu-112195 Solanum tuberosum 52.32 8.00e-86 310.00
IUUC-Sbi-114229 Sorghum bicolor 53.33 1.00e-90 325.00
IUUC-Sre-114898 Sporisorium reilianum 49.00 2.00e-90 326.00
IUUC-Ssc-115995 Sus scrofa 96.69 1.00e-85 308.00
IUUC-Tgu-116793 Taeniopygia guttata 92.83 3.00e-166 577.00
IUUC-Tru-117797 Takifugu rubripes 86.60 8.00e-169 586.00
IUUC-Tsy-118967 Tarsius syrichta 91.09 4.00e-50 191.00
IUUC-Tni-120366 Tetraodon nigroviridis 85.98 2.00e-168 584.00
IUUC-Tca-121068 Theobroma cacao 53.92 7.00e-88 317.00
IUUC-Tre-121899 Trichoderma reesei 49.50 2.00e-80 292.00
IUUC-Tvi-122380 Trichoderma virens 49.67 1.00e-80 292.00
IUUC-Tae-123998 Triticum aestivum 55.15 1.00e-92 332.00
IUUC-Tur-126202 Triticum urartu 54.49 3.00e-91 328.00
IUUC-Tme-127181 Tuber melanosporum 53.57 9.00e-89 320.00
IUUC-Ttr-128448 Tursiops truncatus 83.15 2.00e-177 615.00
IUUC-Uma-129661 Ustilago maydis 49.57 2.00e-91 329.00
IUUC-Vda-129666 Verticillium dahliae 52.56 5.00e-80 290.00
IUUC-Vpa-130318 Vicugna pacos 96.14 0.00e+00 669.00
IUUC-Vvi-130868 Vitis vinifera 53.00 3.00e-88 318.00
IUUC-Xtr-131859 Xenopus tropicalis 89.44 1.00e-172 598.00
IUUC-Xma-133898 Xiphophorus maculatus 87.27 7.00e-170 589.00
IUUC-Yli-134559 Yarrowia lipolytica 53.06 4.00e-84 304.00
Created Date 25-Jun-2017

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