iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071502

Ensembl Protein ID

ENSONIP00000016364.1

UniProt Accession

I3K5G9; I3K5G9_ORENI

Genbank Protein ID

ENSONIP00000016364

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AERX01024666

Gene Name

usp5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000013010.1	ENSONIT00000016379.1	ENSONIP00000016364.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.40e-59	200.5	324	826
UBD/Alpha-Helix/UBA	3.50e-18	65.5	697	734

Active Site

Position(s)	Description	Evidence
333	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
789	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk....................avs 69
           tG+kNlgN+CY+NSv+Q+L+ ip++++ + + +  k+ +e+p++p++++ ++++kl   l++++ +                     ++
   Q: 324  TGMKNLGNSCYLNSVMQVLFTIPDFQSKYVS-NIDKIIDEAPSDPTQDFKTQVAKLGYGLLSGDYSkpapdpgeengaaeprgdqiGIA 411
           7******************************.888888999*******************63333333455556666666666666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           p+++++ +++ ++efs+++qqDaqEfl ++++ +e+++                             ++ s  s+ F++ ++++i+c++
   Q: 412  PQMFKALVGRGHPEFSTNRQQDAQEFLLHFINMVERNC-----------------------------RSGSNPSEAFRFLVEERIVCQQ 471
           **************************************.............................6778899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke.......................slqdcLesftkeeelegenkyycekckkkqeaekklklk 224
            ++ + ++   + ++lpvp+++ t++e                        ++ c+++ +++e l++   ++++  ++k++a+k++++ 
   Q: 472  SQKAKYTQRVDYIVQLPVPMDQATNTEelqeaerrreegdssaptvraqiPFTACMAALSEPEILTD---FWSSAVQGKTTATKTTRFA 557
           **********************99999***************************************7...******************* PP
   S: 225  klPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.............................................. 267
           ++P+ L++++k+f+f  + ++++k++ ++++p++Ldls   ++                                              
   Q: 558  SFPDHLVIQIKKFTFGLD-WVPKKLDVSIDVPDTLDLSGLRATgqqpgeellpevappplmtpdvevkapvlddstvsqlcemgfplea 645
           ***************997.*******************877775566666666666666666666666655555555555555555555 PP
   S: 268  .......peekqke........................................................................... 274
                  +                                                                                 
   Q: 646  crkavyyT-----Gntgidaamnwimshmddpdfsaplvlpgcssgpgttpteslseehlativsmgfsrdqatkalratsnvldravd 729
           55555550.....0555555555555555555555555555555555555555666666777777777777777777777777788888 PP
   S: 275  .......................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevl 323
                                                  + kYeL+a ++H+G s+ +GHYva++k+ +++W+ f+D+kV ++  e+  
   Q: 730  wifshlddlesmdvseggrsaaeseggrdpppgprvrdgPGKYELFAFISHMGtSTMCGHYVAHIKK-DQQWVIFNDQKVCAS--EKPP 815
           888888888888888888888888999999999999999****************************.999*********999..7888 PP
   S: 324  eetgstaYvlfYkr 337
           +   + +Y++fY+r
   Q: 816  K---DLGYLYFYRR 826
           8...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ l+ +v+MGF+r++a +aLra++n l++Av++++++
   Q: 697  EEHLATIVSMGFSRDQATKALRATSNVLDRAVDWIFSH 734
           7889********************************97 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MADVGELLMS VLSTIRVPKP GDRVHKDECA LSFSSPESEG GLYVCMNSFL GLGSQYVDRH 60
HARSGQRAYL HITRTRKAKK EDDGNSGSGH PPKKKPTRLA IGIEGGFDVE QEQYEEDVKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGACG TTGGTGAGCT TTTGATGTCG GTTTTGTCCA CAATTCGGGT CCCGAAACCC 60
GGGGACCGCG TCCACAAAGA CGAATGCGCC TTGTCATTTT CCTCACCGGT GAGCCATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0009953--P:dorsal/ventral pattern formation
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	42.71	3.00e-178	619.00
IUUC-Aml-002104	Ailuropoda melanoleuca	65.73	0.00e+00	1149.00
IUUC-Atr-002580	Amborella trichopoda	44.99	0.00e+00	707.00
IUUC-Apl-003774	Anas platyrhynchos	65.61	0.00e+00	1122.00
IUUC-Aca-005368	Anolis carolinensis	67.38	0.00e+00	1188.00
IUUC-Aly-005727	Arabidopsis lyrata	46.53	0.00e+00	715.00
IUUC-Ath-006974	Arabidopsis thaliana	46.65	0.00e+00	716.00
IUUC-Ago-007890	Ashbya gossypii	27.11	8.00e-76	278.00
IUUC-Acl-008057	Aspergillus clavatus	35.08	2.00e-129	456.00
IUUC-Afl-008547	Aspergillus flavus	36.75	3.00e-117	416.00
IUUC-Afu-008805	Aspergillus fumigatus	34.27	2.00e-114	407.00
IUUC-Ani-009441	Aspergillus nidulans	33.77	3.00e-100	359.00
IUUC-Ang-009720	Aspergillus niger	34.17	3.00e-116	412.00
IUUC-Aor-010111	Aspergillus oryzae	34.49	4.00e-126	445.00
IUUC-Ate-010531	Aspergillus terreus	33.01	2.00e-107	383.00
IUUC-Ame-011893	Astyanax mexicanus	88.16	0.00e+00	1328.00
IUUC-Bgr-012183	Blumeria graminis	33.57	8.00e-119	421.00
IUUC-Bta-013179	Bos taurus	65.88	0.00e+00	1155.00
IUUC-Bci-013858	Botrytis cinerea	35.25	9.00e-129	454.00
IUUC-Bdi-014904	Brachypodium distachyon	44.87	0.00e+00	674.00
IUUC-Bol-015296	Brassica oleracea	47.07	0.00e+00	721.00
IUUC-Bra-017939	Brassica rapa	47.19	0.00e+00	730.00
IUUC-Cel-018625	Caenorhabditis elegans	33.58	3.00e-123	436.00
IUUC-Cja-019063	Callithrix jacchus	64.71	0.00e+00	1137.00
IUUC-Cfa-020976	Canis familiaris	68.24	0.00e+00	1174.00
IUUC-Cpo-022265	Cavia porcellus	68.24	0.00e+00	1180.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	42.66	2.00e-116	413.00
IUUC-Csa-024177	Chlorocebus sabaeus	66.75	0.00e+00	1056.00
IUUC-Cho-024702	Choloepus hoffmanni	60.60	0.00e+00	675.00
IUUC-Cin-025411	Ciona intestinalis	49.21	0.00e+00	794.00
IUUC-Csv-026347	Ciona savignyi	46.18	0.00e+00	771.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.29	6.00e-114	405.00
IUUC-Cne-026831	Cryptococcus neoformans	36.32	7.00e-126	444.00
IUUC-Cme-027335	Cyanidioschyzon merolae	28.73	5.00e-39	156.00
IUUC-Dre-027982	Danio rerio	87.81	0.00e+00	1386.00
IUUC-Dno-029034	Dasypus novemcinctus	66.24	0.00e+00	1157.00
IUUC-Dse-031467	Dothistroma septosporum	34.25	5.00e-123	435.00
IUUC-Dme-032075	Drosophila melanogaster	47.10	0.00e+00	769.00
IUUC-Ete-032865	Echinops telfairi	59.91	0.00e+00	1013.00
IUUC-Eca-034059	Equus caballus	65.73	0.00e+00	1154.00
IUUC-Eeu-035304	Erinaceus europaeus	62.47	0.00e+00	1051.00
IUUC-Fca-035515	Felis catus	66.00	0.00e+00	1158.00
IUUC-Fal-037271	Ficedula albicollis	67.72	0.00e+00	1111.00
IUUC-Fox-037745	Fusarium oxysporum	36.04	6.00e-130	458.00
IUUC-Fso-038158	Fusarium solani	35.66	1.00e-126	447.00
IUUC-Gmo-039071	Gadus morhua	89.82	0.00e+00	1424.00
IUUC-Ggr-040098	Gaeumannomyces graminis	35.02	5.00e-122	432.00
IUUC-Gga-040635	Gallus gallus	65.81	0.00e+00	1182.00
IUUC-Gac-042528	Gasterosteus aculeatus	92.11	0.00e+00	1486.00
IUUC-Gma-043614	Glycine max	45.05	0.00e+00	685.00
IUUC-Ggo-044602	Gorilla gorilla	66.00	0.00e+00	1157.00
IUUC-Hsa-045959	Homo sapiens	66.00	0.00e+00	1157.00
IUUC-Hvu-047563	Hordeum vulgare	47.21	3.00e-165	575.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	65.53	0.00e+00	1156.00
IUUC-Kpa-049156	Komagataella pastoris	31.40	1.00e-99	357.00
IUUC-Lch-049648	Latimeria chalumnae	68.92	0.00e+00	1167.00
IUUC-Lpe-051523	Leersia perrieri	45.27	0.00e+00	679.00
IUUC-Loc-052520	Lepisosteus oculatus	69.98	0.00e+00	1143.00
IUUC-Lma-053216	Leptosphaeria maculans	34.06	3.00e-107	384.00
IUUC-Laf-054327	Loxodonta africana	65.65	0.00e+00	1145.00
IUUC-Mcc-055443	Macaca mulatta	66.00	0.00e+00	1157.00
IUUC-Meu-056298	Macropus eugenii	67.19	0.00e+00	818.00
IUUC-Mor-057106	Magnaporthe oryzae	37.72	1.00e-132	467.00
IUUC-Mpo-057589	Magnaporthe poae	35.77	1.00e-127	451.00
IUUC-Mtr-058680	Medicago truncatula	47.07	0.00e+00	715.00
IUUC-Mla-058903	Melampsora laricipopulina	33.69	2.00e-118	420.00
IUUC-Mga-059669	Meleagris gallopavo	64.99	0.00e+00	1113.00
IUUC-Mvi-060476	Microbotryum violaceum	35.92	2.00e-122	433.00
IUUC-Mmr-060575	Microcebus murinus	65.76	0.00e+00	1152.00
IUUC-Mdo-062183	Monodelphis domestica	66.83	0.00e+00	1148.00
IUUC-Mmu-063592	Mus musculus	65.88	0.00e+00	1154.00
IUUC-Mac-065634	Musa acuminata	46.99	1.00e-108	387.00
IUUC-Mpu-066082	Mustela putorius furo	67.75	0.00e+00	1165.00
IUUC-Mlu-067345	Myotis lucifugus	65.06	0.00e+00	1144.00
IUUC-Nfi-068558	Neosartorya fischeri	35.71	4.00e-124	438.00
IUUC-Ncr-068960	Neurospora crassa	35.15	5.00e-117	415.00
IUUC-Nle-070173	Nomascus leucogenys	68.12	0.00e+00	1172.00
IUUC-Opr-070556	Ochotona princeps	66.94	0.00e+00	1174.00
IUUC-Ocu-074861	Oryctolagus cuniculus	68.24	0.00e+00	1178.00
IUUC-Oba-075109	Oryza barthii	45.50	0.00e+00	694.00
IUUC-Obr-076292	Oryza brachyantha	46.11	0.00e+00	677.00
IUUC-Ogl-077065	Oryza glaberrima	46.47	0.00e+00	719.00
IUUC-Ogu-078776	Oryza glumaepatula	45.02	0.00e+00	706.00
IUUC-Oin-080048	Oryza indica	45.87	0.00e+00	711.00
IUUC-Olo-080711	Oryza longistaminata	43.46	0.00e+00	632.00
IUUC-Ome-081506	Oryza meridionalis	44.39	0.00e+00	639.00
IUUC-Oni-082320	Oryza nivara	44.77	0.00e+00	691.00
IUUC-Opu-083801	Oryza punctata	45.08	0.00e+00	674.00
IUUC-Oru-085139	Oryza rufipogon	44.94	0.00e+00	689.00
IUUC-Osa-085713	Oryza sativa	46.59	0.00e+00	722.00
IUUC-Ola-086951	Oryzias latipes	92.61	0.00e+00	1437.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.38	9.00e-170	590.00
IUUC-Oga-088625	Otolemur garnettii	65.22	0.00e+00	1148.00
IUUC-Oar-089995	Ovis aries	64.95	0.00e+00	1140.00
IUUC-Ptr-090640	Pan troglodytes	65.48	0.00e+00	1157.00
IUUC-Pan-091974	Papio anubis	65.42	0.00e+00	1150.00
IUUC-Psi-093957	Pelodiscus sinensis	66.16	0.00e+00	1193.00
IUUC-Pma-094242	Petromyzon marinus	68.77	9.00e-157	546.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.71	6.00e-105	375.00
IUUC-Ppa-095901	Physcomitrella patens	47.04	0.00e+00	755.00
IUUC-Pfo-097148	Poecilia formosa	95.54	0.00e+00	1501.00
IUUC-Pab-098068	Pongo abelii	60.99	0.00e+00	1011.00
IUUC-Pop-098943	Populus trichocarpa	47.43	0.00e+00	712.00
IUUC-Pca-100738	Procavia capensis	65.84	0.00e+00	800.00
IUUC-Ppe-101315	Prunus persica	45.39	0.00e+00	692.00
IUUC-Pva-102154	Pteropus vampyrus	65.65	0.00e+00	1146.00
IUUC-Pgr-103343	Puccinia graminis	33.53	8.00e-104	371.00
IUUC-Ptt-103928	Puccinia triticina	30.94	1.00e-105	377.00
IUUC-Pte-104306	Pyrenophora teres	34.37	6.00e-104	372.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.18	1.00e-104	374.00
IUUC-Rno-105801	Rattus norvegicus	66.12	0.00e+00	1156.00
IUUC-Sce-106304	Saccharomyces cerevisiae	27.45	5.00e-68	252.00
IUUC-Sha-107635	Sarcophilus harrisii	67.47	0.00e+00	1160.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.97	9.00e-98	351.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.41	7.00e-111	395.00
IUUC-Smo-108848	Selaginella moellendorffii	47.28	0.00e+00	707.00
IUUC-Sit-110728	Setaria italica	45.81	0.00e+00	739.00
IUUC-Sly-111523	Solanum lycopersicum	45.65	0.00e+00	732.00
IUUC-Sbi-114419	Sorghum bicolor	46.36	0.00e+00	726.00
IUUC-Sre-115225	Sporisorium reilianum	33.98	1.00e-118	421.00
IUUC-Ssc-115686	Sus scrofa	65.10	0.00e+00	1150.00
IUUC-Tgu-117346	Taeniopygia guttata	65.74	0.00e+00	1163.00
IUUC-Tru-118350	Takifugu rubripes	88.23	0.00e+00	1441.00
IUUC-Tni-120658	Tetraodon nigroviridis	89.70	0.00e+00	1412.00
IUUC-Tca-121585	Theobroma cacao	47.19	0.00e+00	699.00
IUUC-Tre-122043	Trichoderma reesei	34.01	9.00e-118	417.00
IUUC-Tvi-122303	Trichoderma virens	34.30	3.00e-119	422.00
IUUC-Tae-125686	Triticum aestivum	45.37	0.00e+00	692.00
IUUC-Tur-126732	Triticum urartu	43.13	0.00e+00	656.00
IUUC-Tme-126909	Tuber melanosporum	34.89	5.00e-117	415.00
IUUC-Tbe-127261	Tupaia belangeri	60.36	0.00e+00	708.00
IUUC-Uma-129599	Ustilago maydis	34.99	6.00e-123	435.00
IUUC-Vda-129688	Verticillium dahliae	34.29	3.00e-119	422.00
IUUC-Vvi-131116	Vitis vinifera	45.50	0.00e+00	681.00
IUUC-Xtr-131953	Xenopus tropicalis	65.62	0.00e+00	1097.00
IUUC-Xma-133837	Xiphophorus maculatus	95.42	0.00e+00	1499.00
IUUC-Yli-134510	Yarrowia lipolytica	36.64	1.00e-125	443.00
IUUC-Zma-135786	Zea mays	45.16	0.00e+00	681.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence