iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035739

Ensembl Protein ID

ENSFCAP00000003623.3

UniProt Accession

M3W182; M3W182_FELCA

Genbank Protein ID

ENSFCAP00000003623

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

AANG02106462

Gene Name

COPA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000003927.3	ENSFCAT00000003928.3	ENSFCAP00000003623.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-36	122.0	130	160
UBD/Beta-Prp	1.10e-75	254.6	3	321

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH+  v c +f ++ +l+vs+s D t++vWD
   Q: 130  GHNHYVMCAQFhPSeDLVVSASLDQTVRVWD 160
           8***********666**************** PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           ++++++++ + f+p++++++t+  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl gh d
   Q: 3    ETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLD 91
           567889999******************************************************************************** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.................. 166
           +++++ f+ +  +++s+s+d+tirvw++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+                  
   Q: 92   YIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDIsglrkknlspgavesdvr 179
           ***********************************.***************************************************** PP
   S: 167  .........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDg 244
                     t+ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   v+t++gh +nv++  f+p++e+++s s+D+
   Q: 180  gitgvdlfgTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAweVDTCRGHYNNVSCAVFHPRQELILSNSEDK 268
           *********888888888777********************************888888****************************** PP
   S: 245  siriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           sir+Wd+ +++ ++t+ + +++++  a+ +++ n +++g  d+   ++kl++++p
   Q: 269  SIRVWDMSKRTGVQTFRRDHDRFWVLAA-HPNLNLFAAG-HDGGMIVFKLERERP 321
           ****************************.5554444444.589999999988765 PP

Organism

Felis catus

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

QFETKSARVK GLSFHPKRPW ILTSLHNGVI QLWDYRMCTL IDKFDEHDGP VRGIDFHKQQ 60
PLFVSGGDDY KIKVWNYKLR RCLFTLLGHL DYIRTTFFHH EYPWILSASD DQTIRVWNWQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATTCGAGA CCAAGAGCGC GCGGGTCAAA GGTAAATGGA GAAGACGAGG GGGAGCTCGA 60
GGACCGGGTG TCGGGGGCGG TGCTGTCTCG GGGGGGGGGG GTGACCGAGG CCGAGTCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0030157--P:pancreatic juice secretion
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	53.47	0.00e+00	1309.00
IUUC-Aml-001758	Ailuropoda melanoleuca	98.94	0.00e+00	2508.00
IUUC-Atr-002493	Amborella trichopoda	53.40	0.00e+00	1298.00
IUUC-Apl-003385	Anas platyrhynchos	94.40	0.00e+00	2040.00
IUUC-Aca-005154	Anolis carolinensis	96.57	2.00e-119	420.00
IUUC-Aly-006020	Arabidopsis lyrata	60.57	0.00e+00	1079.00
IUUC-Ath-007058	Arabidopsis thaliana	60.98	0.00e+00	1073.00
IUUC-Ago-007992	Ashbya gossypii	44.66	0.00e+00	1023.00
IUUC-Acl-008027	Aspergillus clavatus	56.32	0.00e+00	992.00
IUUC-Afl-008644	Aspergillus flavus	56.38	0.00e+00	993.00
IUUC-Afu-008964	Aspergillus fumigatus	48.75	0.00e+00	1184.00
IUUC-Ani-009379	Aspergillus nidulans	55.84	0.00e+00	1001.00
IUUC-Ang-009756	Aspergillus niger	49.60	0.00e+00	1201.00
IUUC-Aor-010174	Aspergillus oryzae	56.38	0.00e+00	992.00
IUUC-Ate-010302	Aspergillus terreus	49.16	0.00e+00	1215.00
IUUC-Ame-011229	Astyanax mexicanus	85.93	0.00e+00	2178.00
IUUC-Bgr-012300	Blumeria graminis	48.16	0.00e+00	1135.00
IUUC-Bta-012524	Bos taurus	98.05	0.00e+00	2458.00
IUUC-Bci-013781	Botrytis cinerea	48.31	0.00e+00	1184.00
IUUC-Bdi-014549	Brachypodium distachyon	54.03	0.00e+00	1331.00
IUUC-Bol-015925	Brassica oleracea	60.62	0.00e+00	1067.00
IUUC-Bra-016978	Brassica rapa	59.79	0.00e+00	1061.00
IUUC-Cel-018115	Caenorhabditis elegans	63.81	0.00e+00	1120.00
IUUC-Cja-019107	Callithrix jacchus	95.85	0.00e+00	2432.00
IUUC-Cfa-020675	Canis familiaris	97.55	0.00e+00	2447.00
IUUC-Cpo-021813	Cavia porcellus	97.72	0.00e+00	2473.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	63.52	0.00e+00	1095.00
IUUC-Csa-023523	Chlorocebus sabaeus	97.72	0.00e+00	2484.00
IUUC-Cho-024704	Choloepus hoffmanni	84.70	0.00e+00	1916.00
IUUC-Cin-025572	Ciona intestinalis	72.18	0.00e+00	1864.00
IUUC-Csv-025864	Ciona savignyi	70.25	0.00e+00	1748.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	56.59	0.00e+00	1012.00
IUUC-Cne-027053	Cryptococcus neoformans	51.81	0.00e+00	1238.00
IUUC-Cme-027222	Cyanidioschyzon merolae	39.16	2.00e-140	493.00
IUUC-Dre-027421	Danio rerio	85.95	0.00e+00	2216.00
IUUC-Dno-029303	Dasypus novemcinctus	97.49	0.00e+00	2471.00
IUUC-Dor-030290	Dipodomys ordii	96.81	0.00e+00	1108.00
IUUC-Dse-031543	Dothistroma septosporum	46.14	0.00e+00	1110.00
IUUC-Dme-031945	Drosophila melanogaster	68.33	0.00e+00	1687.00
IUUC-Ete-032873	Echinops telfairi	93.02	0.00e+00	2167.00
IUUC-Eca-033773	Equus caballus	95.62	0.00e+00	2402.00
IUUC-Eeu-034874	Erinaceus europaeus	85.81	0.00e+00	1526.00
IUUC-Fal-037263	Ficedula albicollis	86.89	0.00e+00	2118.00
IUUC-Fox-037738	Fusarium oxysporum	48.11	0.00e+00	1206.00
IUUC-Fso-038153	Fusarium solani	48.67	0.00e+00	1197.00
IUUC-Gmo-039602	Gadus morhua	81.59	0.00e+00	2033.00
IUUC-Ggr-039931	Gaeumannomyces graminis	55.69	0.00e+00	1004.00
IUUC-Gga-040590	Gallus gallus	95.37	0.00e+00	2393.00
IUUC-Gac-041318	Gasterosteus aculeatus	85.30	0.00e+00	2193.00
IUUC-Gma-043567	Glycine max	54.23	0.00e+00	1320.00
IUUC-Ggo-045029	Gorilla gorilla	98.21	0.00e+00	2508.00
IUUC-Hsa-046078	Homo sapiens	98.21	0.00e+00	2508.00
IUUC-Hvu-047556	Hordeum vulgare	54.75	0.00e+00	1345.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	97.84	0.00e+00	1752.00
IUUC-Kpa-049256	Komagataella pastoris	44.63	0.00e+00	1075.00
IUUC-Lch-049706	Latimeria chalumnae	91.71	0.00e+00	2297.00
IUUC-Lpe-051316	Leersia perrieri	62.07	0.00e+00	1096.00
IUUC-Loc-051867	Lepisosteus oculatus	71.83	0.00e+00	1211.00
IUUC-Lma-053138	Leptosphaeria maculans	56.27	0.00e+00	1019.00
IUUC-Laf-053510	Loxodonta africana	96.99	0.00e+00	2460.00
IUUC-Mcc-055836	Macaca mulatta	97.97	0.00e+00	2490.00
IUUC-Meu-056238	Macropus eugenii	93.34	0.00e+00	1186.00
IUUC-Mor-057172	Magnaporthe oryzae	48.36	0.00e+00	1190.00
IUUC-Mpo-057300	Magnaporthe poae	48.60	0.00e+00	1176.00
IUUC-Mtr-058248	Medicago truncatula	54.60	0.00e+00	1347.00
IUUC-Mla-059019	Melampsora laricipopulina	57.47	0.00e+00	1038.00
IUUC-Mga-059499	Meleagris gallopavo	95.21	0.00e+00	2387.00
IUUC-Mvi-060336	Microbotryum violaceum	52.54	0.00e+00	1260.00
IUUC-Mmr-061102	Microcebus murinus	98.70	0.00e+00	2465.00
IUUC-Mdo-062594	Monodelphis domestica	96.59	0.00e+00	2491.00
IUUC-Mmu-063736	Mus musculus	97.80	0.00e+00	2489.00
IUUC-Mac-065272	Musa acuminata	50.16	0.00e+00	1203.00
IUUC-Mpu-066701	Mustela putorius furo	97.65	0.00e+00	2429.00
IUUC-Mlu-067392	Myotis lucifugus	96.43	0.00e+00	2437.00
IUUC-Nfi-068270	Neosartorya fischeri	56.68	0.00e+00	995.00
IUUC-Ncr-068892	Neurospora crassa	49.28	0.00e+00	1177.00
IUUC-Nle-069634	Nomascus leucogenys	97.75	0.00e+00	1360.00
IUUC-Opr-070952	Ochotona princeps	86.13	0.00e+00	1817.00
IUUC-Ont-072488	Oreochromis niloticus	87.24	0.00e+00	2206.00
IUUC-Ocu-074211	Oryctolagus cuniculus	97.80	0.00e+00	2472.00
IUUC-Oba-075761	Oryza barthii	61.95	0.00e+00	1095.00
IUUC-Obr-076429	Oryza brachyantha	61.95	0.00e+00	1094.00
IUUC-Ogl-077364	Oryza glaberrima	61.95	0.00e+00	1095.00
IUUC-Ogu-078257	Oryza glumaepatula	62.20	0.00e+00	1095.00
IUUC-Oin-079274	Oryza indica	61.83	0.00e+00	1094.00
IUUC-Olo-080466	Oryza longistaminata	61.85	0.00e+00	1080.00
IUUC-Ome-081993	Oryza meridionalis	63.75	0.00e+00	1018.00
IUUC-Oni-082874	Oryza nivara	62.20	0.00e+00	1094.00
IUUC-Opu-083885	Oryza punctata	53.46	0.00e+00	1318.00
IUUC-Oru-084274	Oryza rufipogon	61.95	0.00e+00	1095.00
IUUC-Osa-085565	Oryza sativa	61.95	0.00e+00	1095.00
IUUC-Ola-086921	Oryzias latipes	86.93	0.00e+00	2202.00
IUUC-Olu-087639	Ostreococcus lucimarinus	55.42	0.00e+00	1354.00
IUUC-Oga-087991	Otolemur garnettii	92.46	0.00e+00	2328.00
IUUC-Oar-089590	Ovis aries	98.13	0.00e+00	2482.00
IUUC-Ptr-090808	Pan troglodytes	98.29	0.00e+00	2509.00
IUUC-Pan-092475	Papio anubis	97.24	0.00e+00	2472.00
IUUC-Psi-093044	Pelodiscus sinensis	79.03	0.00e+00	1681.00
IUUC-Pno-094839	Phaeosphaeria nodorum	47.82	0.00e+00	1115.00
IUUC-Ppa-095254	Physcomitrella patens	55.92	0.00e+00	1387.00
IUUC-Pfo-097493	Poecilia formosa	86.99	0.00e+00	2178.00
IUUC-Pab-098497	Pongo abelii	97.72	0.00e+00	2486.00
IUUC-Pop-099992	Populus trichocarpa	55.75	0.00e+00	1329.00
IUUC-Pca-100413	Procavia capensis	90.93	0.00e+00	1036.00
IUUC-Ppe-101899	Prunus persica	62.44	0.00e+00	1105.00
IUUC-Pva-102126	Pteropus vampyrus	94.72	0.00e+00	2388.00
IUUC-Pgr-103376	Puccinia graminis	52.47	0.00e+00	1297.00
IUUC-Ptt-103978	Puccinia triticina	47.02	0.00e+00	1084.00
IUUC-Pte-104126	Pyrenophora teres	56.45	0.00e+00	978.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	46.63	2.00e-178	619.00
IUUC-Rno-105428	Rattus norvegicus	97.24	0.00e+00	2466.00
IUUC-Sce-106464	Saccharomyces cerevisiae	43.00	0.00e+00	1001.00
IUUC-Sha-107301	Sarcophilus harrisii	96.89	0.00e+00	2440.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	45.48	0.00e+00	1084.00
IUUC-Spo-108217	Schizosaccharomyces pombe	46.90	0.00e+00	1129.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	48.51	0.00e+00	1191.00
IUUC-Smo-109582	Selaginella moellendorffii	64.80	0.00e+00	1142.00
IUUC-Sit-109697	Setaria italica	61.47	0.00e+00	1087.00
IUUC-Sly-111447	Solanum lycopersicum	54.33	0.00e+00	1345.00
IUUC-Stu-112564	Solanum tuberosum	54.20	0.00e+00	1345.00
IUUC-Sar-113313	Sorex araneus	88.85	0.00e+00	1506.00
IUUC-Sbi-114388	Sorghum bicolor	53.95	0.00e+00	1333.00
IUUC-Sre-115209	Sporisorium reilianum	56.84	0.00e+00	1033.00
IUUC-Ssc-115933	Sus scrofa	98.05	0.00e+00	2481.00
IUUC-Tgu-117109	Taeniopygia guttata	79.73	0.00e+00	736.00
IUUC-Tru-117772	Takifugu rubripes	86.57	0.00e+00	2179.00
IUUC-Tsy-119105	Tarsius syrichta	84.31	0.00e+00	2104.00
IUUC-Tni-120556	Tetraodon nigroviridis	72.21	0.00e+00	1676.00
IUUC-Tca-121046	Theobroma cacao	53.86	0.00e+00	1356.00
IUUC-Tre-121951	Trichoderma reesei	56.42	0.00e+00	1009.00
IUUC-Tvi-122359	Trichoderma virens	56.69	0.00e+00	1014.00
IUUC-Tae-125527	Triticum aestivum	53.47	0.00e+00	1314.00
IUUC-Tur-126754	Triticum urartu	61.24	0.00e+00	1087.00
IUUC-Tme-127170	Tuber melanosporum	50.04	0.00e+00	1222.00
IUUC-Tbe-127882	Tupaia belangeri	96.79	0.00e+00	843.00
IUUC-Ttr-128217	Tursiops truncatus	96.50	0.00e+00	2435.00
IUUC-Uma-129337	Ustilago maydis	56.16	0.00e+00	1030.00
IUUC-Vda-129828	Verticillium dahliae	48.12	0.00e+00	1176.00
IUUC-Vpa-130537	Vicugna pacos	98.37	0.00e+00	2468.00
IUUC-Vvi-130958	Vitis vinifera	62.19	0.00e+00	1099.00
IUUC-Xtr-132857	Xenopus tropicalis	88.78	0.00e+00	2255.00
IUUC-Xma-133138	Xiphophorus maculatus	86.75	0.00e+00	2175.00
IUUC-Yli-134399	Yarrowia lipolytica	50.35	0.00e+00	864.00
IUUC-Zma-134855	Zea mays	57.08	0.00e+00	830.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence