iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046217

Ensembl Protein ID

ENSP00000331313.6

UniProt Accession

Q9BYB4; Q9H2S2; Q9H4M4; GNB1L_HUMAN

Genbank Protein ID

AAG36826.1; AAG53933.1; AAG12162.1; BAB68408.1; BAB33315.1; CAG30382.1; AAH12060.1

Protein Name

Guanine nucleotide-binding protein subunit beta-like protein 1; DGCRK3; WD repeat-containing protein 14; WD40 repeat-containing protein deleted in VCFS

Genbank Nucleotide ID

AF238328; AF301895; AY007378; AB049212; AB051432; CR456496; BC012060

Gene Name

GNB1L; GY2; KIAA1645; WDR14; FKSG1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185838.13	ENST00000329517.10	ENSP00000331313.6
ENSG00000185838.13	ENST00000405009.5	ENSP00000384626.1
ENSG00000185838.13	ENST00000453108.1	ENSP00000389412.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
circRNADb	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-22	79.4	294	323

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDl 30
           H++ v c+af  d+ll++Gs D  i +W+l
   Q: 294  HSAAVQCVAFtADGLLAAGSKDQRISLWSL 323
           999*******977***************96 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MTAPCPPPPP DPQFVLRGTQ SPVHALHFCE GAQAQGRPLL FSGSQSGLVH IWSLQTRRAV 60
TTLDGHGGQC VTWLQTLPQG RQLLSQGRDL KLCLWDLAEG RSAVVDSVCL ESVGFCRSSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATGCGCCGG GTCGTACACG GCGGCCGCGC GCACGCTGGG GGCGTGGCTG CGCGATGTAA 60
TCGGTCTCTG GACGCTGCGC GGCGCTCCTA GGAGCAGGCG TTCCCGACTC CGGCAAGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0035176--P:social behavior

KEGG

hsa:54584

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000703	Aegilops tauschii	26.33	4.00e-27	115.00
IUUC-Aml-001556	Ailuropoda melanoleuca	85.30	4.00e-149	520.00
IUUC-Atr-002691	Amborella trichopoda	45.64	3.00e-31	129.00
IUUC-Apl-003227	Anas platyrhynchos	62.38	3.00e-117	414.00
IUUC-Aly-006168	Arabidopsis lyrata	30.24	7.00e-35	141.00
IUUC-Ath-007145	Arabidopsis thaliana	29.71	6.00e-33	134.00
IUUC-Acl-008132	Aspergillus clavatus	26.61	1.00e-17	84.30
IUUC-Afl-008655	Aspergillus flavus	23.64	3.00e-20	93.20
IUUC-Afu-008778	Aspergillus fumigatus	24.28	4.00e-16	79.30
IUUC-Ang-009760	Aspergillus niger	24.58	3.00e-15	76.60
IUUC-Bgr-012119	Blumeria graminis	25.59	5.00e-19	89.00
IUUC-Bta-012556	Bos taurus	75.40	5.00e-137	480.00
IUUC-Bdi-014151	Brachypodium distachyon	27.47	2.00e-26	113.00
IUUC-Bol-016319	Brassica oleracea	29.18	2.00e-33	136.00
IUUC-Bra-016675	Brassica rapa	29.18	2.00e-33	136.00
IUUC-Cja-019523	Callithrix jacchus	92.06	4.00e-169	587.00
IUUC-Cfa-021217	Canis familiaris	84.94	2.00e-149	521.00
IUUC-Cpo-021506	Cavia porcellus	82.80	8.00e-145	506.00
IUUC-Csa-023674	Chlorocebus sabaeus	93.65	2.00e-172	598.00
IUUC-Cgl-026723	Colletotrichum gloeosporioides	24.02	2.00e-18	87.00
IUUC-Cme-027295	Cyanidioschyzon merolae	31.90	2.00e-09	57.00
IUUC-Dre-027592	Danio rerio	51.56	5.00e-87	314.00
IUUC-Dno-029880	Dasypus novemcinctus	67.94	4.00e-116	410.00
IUUC-Dor-030266	Dipodomys ordii	85.41	2.00e-92	332.00
IUUC-Dse-031212	Dothistroma septosporum	25.58	1.00e-23	104.00
IUUC-Dme-032209	Drosophila melanogaster	29.77	5.00e-30	124.00
IUUC-Eca-033371	Equus caballus	85.03	1.00e-148	518.00
IUUC-Fca-035558	Felis catus	82.75	3.00e-146	510.00
IUUC-Fal-036794	Ficedula albicollis	61.83	2.00e-116	412.00
IUUC-Gmo-038742	Gadus morhua	51.10	3.00e-85	308.00
IUUC-Gga-040868	Gallus gallus	59.31	2.00e-112	399.00
IUUC-Gac-041646	Gasterosteus aculeatus	51.74	6.00e-91	327.00
IUUC-Gma-044269	Glycine max	30.50	4.00e-35	142.00
IUUC-Ggo-044553	Gorilla gorilla	98.41	0.00e+00	625.00
IUUC-Hvu-047647	Hordeum vulgare	29.18	1.00e-32	134.00
IUUC-Itr-048649	Ictidomys tridecemlineatus	83.71	3.00e-151	527.00
IUUC-Lch-050134	Latimeria chalumnae	57.86	1.00e-106	379.00
IUUC-Lpe-051524	Leersia perrieri	30.14	1.00e-29	124.00
IUUC-Loc-051757	Lepisosteus oculatus	45.33	1.00e-75	276.00
IUUC-Laf-053733	Loxodonta africana	81.90	4.00e-147	513.00
IUUC-Mcc-055477	Macaca mulatta	93.62	3.00e-154	537.00
IUUC-Meu-056758	Macropus eugenii	57.91	2.00e-84	305.00
IUUC-Mtr-058616	Medicago truncatula	31.46	4.00e-35	142.00
IUUC-Mga-059637	Meleagris gallopavo	60.52	6.00e-83	300.00
IUUC-Mvi-060385	Microbotryum violaceum	25.44	2.00e-20	94.00
IUUC-Mmr-061675	Microcebus murinus	84.71	3.00e-151	527.00
IUUC-Mdo-062782	Monodelphis domestica	69.81	5.00e-118	417.00
IUUC-Mmu-064058	Mus musculus	81.47	2.00e-149	521.00
IUUC-Mac-065262	Musa acuminata	36.36	4.00e-28	119.00
IUUC-Mpu-066633	Mustela putorius furo	84.35	7.00e-139	487.00
IUUC-Mlu-067333	Myotis lucifugus	84.13	7.00e-147	513.00
IUUC-Nfi-068581	Neosartorya fischeri	26.20	3.00e-18	86.30
IUUC-Nle-069485	Nomascus leucogenys	87.62	3.00e-156	544.00
IUUC-Opr-071206	Ochotona princeps	61.95	2.00e-71	261.00
IUUC-Oan-073361	Ornithorhynchus anatinus	57.30	3.00e-83	301.00
IUUC-Ocu-073923	Oryctolagus cuniculus	81.79	6.00e-142	497.00
IUUC-Oba-075743	Oryza barthii	42.53	2.00e-28	120.00
IUUC-Obr-076879	Oryza brachyantha	28.41	1.00e-30	127.00
IUUC-Ogl-077813	Oryza glaberrima	30.56	8.00e-36	144.00
IUUC-Ogu-078196	Oryza glumaepatula	42.53	2.00e-28	120.00
IUUC-Oin-080131	Oryza indica	30.56	4.00e-36	145.00
IUUC-Olo-080613	Oryza longistaminata	38.82	1.00e-25	110.00
IUUC-Ome-081912	Oryza meridionalis	30.14	7.00e-33	134.00
IUUC-Oni-082813	Oryza nivara	44.59	3.00e-29	122.00
IUUC-Opu-083663	Oryza punctata	30.00	4.00e-36	145.00
IUUC-Oru-085102	Oryza rufipogon	30.57	1.00e-33	137.00
IUUC-Osa-086204	Oryza sativa	30.56	4.00e-36	145.00
IUUC-Ola-086541	Oryzias latipes	42.15	4.00e-68	251.00
IUUC-Olu-087776	Ostreococcus lucimarinus	29.44	7.00e-13	66.60
IUUC-Oga-088039	Otolemur garnettii	84.98	7.00e-156	543.00
IUUC-Oar-089515	Ovis aries	44.88	1.00e-55	209.00
IUUC-Ptr-091291	Pan troglodytes	98.73	0.00e+00	627.00
IUUC-Pan-092644	Papio anubis	95.24	4.00e-175	607.00
IUUC-Psi-093646	Pelodiscus sinensis	60.50	7.00e-113	400.00
IUUC-Ppa-095698	Physcomitrella patens	32.23	9.00e-37	147.00
IUUC-Pfo-096601	Poecilia formosa	50.16	4.00e-87	314.00
IUUC-Pab-098407	Pongo abelii	95.87	2.00e-177	614.00
IUUC-Pop-099193	Populus trichocarpa	29.10	2.00e-34	139.00
IUUC-Pca-100366	Procavia capensis	79.62	2.00e-137	481.00
IUUC-Ppe-101608	Prunus persica	34.62	5.00e-29	122.00
IUUC-Pva-102775	Pteropus vampyrus	84.71	1.00e-149	522.00
IUUC-Pte-104132	Pyrenophora teres	24.32	3.00e-11	63.20
IUUC-Rno-105626	Rattus norvegicus	79.55	9.00e-146	509.00
IUUC-Sha-106539	Sarcophilus harrisii	66.04	2.00e-111	395.00
IUUC-Sja-107694	Schizosaccharomyces japonicus	34.04	1.00e-16	80.90
IUUC-Spo-108326	Schizosaccharomyces pombe	24.93	5.00e-16	79.00
IUUC-Smo-108756	Selaginella moellendorffii	30.89	6.00e-33	134.00
IUUC-Sit-109771	Setaria italica	28.19	5.00e-32	132.00
IUUC-Sly-111138	Solanum lycopersicum	29.46	6.00e-34	138.00
IUUC-Stu-112425	Solanum tuberosum	30.00	7.00e-35	141.00
IUUC-Sbi-114356	Sorghum bicolor	28.15	7.00e-29	121.00
IUUC-Ssc-115256	Sus scrofa	75.48	2.00e-130	458.00
IUUC-Tgu-116774	Taeniopygia guttata	61.51	5.00e-99	353.00
IUUC-Tru-117900	Takifugu rubripes	44.12	6.00e-72	264.00
IUUC-Tsy-119540	Tarsius syrichta	82.95	9.00e-58	216.00
IUUC-Tni-120252	Tetraodon nigroviridis	50.63	2.00e-87	315.00
IUUC-Tca-121717	Theobroma cacao	28.61	2.00e-32	133.00
IUUC-Tre-122069	Trichoderma reesei	24.41	7.00e-17	81.60
IUUC-Tvi-122673	Trichoderma virens	25.23	1.00e-17	84.00
IUUC-Tae-124693	Triticum aestivum	29.79	3.00e-31	129.00
IUUC-Tme-127222	Tuber melanosporum	25.58	5.00e-21	95.50
IUUC-Ttr-129240	Tursiops truncatus	83.87	3.00e-83	301.00
IUUC-Vda-129913	Verticillium dahliae	25.97	1.00e-17	84.30
IUUC-Vvi-131718	Vitis vinifera	28.46	9.00e-33	134.00
IUUC-Xtr-132109	Xenopus tropicalis	55.66	2.00e-97	348.00
IUUC-Xma-133366	Xiphophorus maculatus	50.78	1.00e-87	316.00
IUUC-Zma-135563	Zea mays	26.74	3.00e-23	102.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence