iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-22	78.8	730	759
UBD/Beta-Prp	1.90e-47	162.7	665	817

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           Ht+ +t+++f ++  +l+++s D+t++vWD
   Q: 730  HTAMITDIRFsPSqLRLATSSFDKTVRVWD 759
           88889*****977689************** PP

UBD/Beta-Prp

   S: 31   dgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdlet 125
           d+ ++  dv++g +   + s+   + +vt++ fs+dgk+l++++ D+ + +w  +t k+  tl++h++++++++fsps+ +l++ s d+t+rvwd ++
   Q: 665  DAVTRCMDVSKGFTfteVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWDADN 762
           555566666666665567778888889**************************************************99***************9987 PP
   S: 126  gqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltggh 179
           +  +  t+ gh+++v+++ +hp + +l+ s+ +D+ +r W++++g++ r  +gg 
   Q: 763  KGYSLRTFMGHSSMVTSLDFHPIKdDLICSCDNDNEIRYWSINNGSCTRVYKGGS 817
           654445****************9999*********************99998854 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Transcription repressor subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and SEUSS to repress AGAMOUS expression. Also plays a role in ovule and pollen development (PubMed:11782418, PubMed:15277686, PubMed:7743940). Implicated in embryo and floral development (PubMed:18390806). Involved in post-synthesis cell wall modifications necessary for mucilage extrusion from seeds upon imbibition, probably by promoting the expression of genes required for mucilage maturation (PubMed:21362134, PubMed:21402796). Involved in vegetative leaf morphogenesis at later stages of leaf development by restricting cell expansion during leaf growth (PubMed:15208345). Regulates the maintenance on leaf polarity and meristem activity as well as the initiation of embryonic shoot apical meristem (SAM) development (PubMed:19837869).

Protein Sequence
(Fasta)

MSQTNWEADK MLDVYIHDYL VKRDLKATAQ AFQAEGKVSS DPVAIDAPGG FLFEWWSVFW 60
DIFIARTNEK HSEVAASYIE TQMIKAREQQ LQQSQHPQVS QQQQQQQQQQ IQMQQLLLQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAGCTGAG CTACTTCTAA TGCTTTTTTA CAGAGAGATG CTTTCTTCTT CTTTCTCTCG 60
AACTTTCTCT CTCTAAATAT TTTGTTTCGT TTTCTCTCTC TCTCTCTATT TACTTTCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0287--Flowering
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0030154--P:cell differentiation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071217--P:cellular response to external biotic stimulus
GO:0009908--P:flower development
GO:0010393--P:galacturonan metabolic process
GO:0010073--P:meristem maintenance
GO:0080001--P:mucilage extrusion from seed coat
GO:0048359--P:mucilage metabolic process involved in seed coat development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0009944--P:polarity specification of adaxial/abaxial axis
GO:0051512--P:positive regulation of unidimensional cell growth
GO:0045995--P:regulation of embryonic development
GO:0009909--P:regulation of flower development
GO:2000024--P:regulation of leaf development
GO:1902183--P:regulation of shoot apical meristem development
GO:0009733--P:response to auxin
GO:0009617--P:response to bacterium
GO:0046898--P:response to cycloheximide
GO:0009620--P:response to fungus
GO:0001666--P:response to hypoxia
GO:0009624--P:response to nematode
GO:0006979--P:response to oxidative stress
GO:1902074--P:response to salt
GO:0010272--P:response to silver ion
GO:0009414--P:response to water deprivation
GO:0009611--P:response to wounding
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT4G32551

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000855	Aegilops tauschii	61.02	1.00e-136	479.00
IUUC-Atr-002973	Amborella trichopoda	62.32	0.00e+00	764.00
IUUC-Aly-006446	Arabidopsis lyrata	93.38	0.00e+00	1293.00
IUUC-Bdi-014395	Brachypodium distachyon	57.09	0.00e+00	709.00
IUUC-Bol-015720	Brassica oleracea	83.86	0.00e+00	1127.00
IUUC-Bra-017481	Brassica rapa	84.04	0.00e+00	1171.00
IUUC-Gma-043258	Glycine max	69.22	0.00e+00	904.00
IUUC-Hvu-047499	Hordeum vulgare	62.39	3.00e-147	514.00
IUUC-Lpe-051536	Leersia perrieri	65.23	5.00e-157	547.00
IUUC-Mtr-058613	Medicago truncatula	68.87	0.00e+00	910.00
IUUC-Mac-064770	Musa acuminata	60.20	0.00e+00	826.00
IUUC-Oba-075419	Oryza barthii	53.30	0.00e+00	645.00
IUUC-Obr-076118	Oryza brachyantha	53.67	0.00e+00	695.00
IUUC-Ogl-077064	Oryza glaberrima	55.96	0.00e+00	715.00
IUUC-Ogu-078816	Oryza glumaepatula	52.03	0.00e+00	631.00
IUUC-Oin-079642	Oryza indica	63.95	6.00e-153	534.00
IUUC-Olo-080338	Oryza longistaminata	62.59	4.00e-146	511.00
IUUC-Ome-081901	Oryza meridionalis	64.63	5.00e-147	515.00
IUUC-Oni-082753	Oryza nivara	53.30	0.00e+00	649.00
IUUC-Opu-083283	Oryza punctata	51.90	4.00e-178	617.00
IUUC-Oru-084538	Oryza rufipogon	53.30	0.00e+00	642.00
IUUC-Osa-086142	Oryza sativa	56.22	0.00e+00	718.00
IUUC-Ppa-095985	Physcomitrella patens	64.29	9.00e-156	542.00
IUUC-Pop-098994	Populus trichocarpa	70.77	0.00e+00	978.00
IUUC-Ppe-102018	Prunus persica	69.31	0.00e+00	929.00
IUUC-Smo-108724	Selaginella moellendorffii	52.02	0.00e+00	699.00
IUUC-Sit-109866	Setaria italica	65.91	2.00e-152	532.00
IUUC-Sly-110921	Solanum lycopersicum	68.35	0.00e+00	862.00
IUUC-Sbi-113848	Sorghum bicolor	65.83	2.00e-155	542.00
IUUC-Tca-121720	Theobroma cacao	71.14	0.00e+00	909.00
IUUC-Tae-124192	Triticum aestivum	57.07	0.00e+00	712.00
IUUC-Tur-126743	Triticum urartu	51.00	5.00e-177	614.00
IUUC-Vvi-131473	Vitis vinifera	69.22	0.00e+00	941.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence