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Tag Content
iUUCD ID IUUC-Mcc-055621
Ensembl Protein ID ENSMMUP00000012627.3
UniProt Accession F6YJT8; F6YJT8_MACMU
Genbank Protein ID ENSMMUP00000012627
Protein Name Protein HIRA
Genbank Nucleotide ID JSUE03005006
Gene Name HIRA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000009650.3 ENSMMUT00000013478.3 ENSMMUP00000012628.3
ENSMMUG00000009650.3 ENSMMUT00000013477.3 ENSMMUP00000012627.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.90e-16 59.3 25 54
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 25   HLACVNCVRWsNSgMYLASGGDDKLIMVWK 54
           8899******955699*************7 PP
   
Organism Macaca mulatta
Functional Description
(View)

Functional Description


     Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
 Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Protein Sequence
(Fasta)
MSPVLQEDDE KDENIPKMLC QMDNHLACVN CVRWSNSGMY LASGGDDKLI MVWKRATYIG 60
PSTVFGSSGK LANVEQWRCV SILRSHSGDV MDVAWSPHDA WLASCSVDNT VVIWNAVKFP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055621|E3,WD_repeat|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAAGCTCC TGAAGCCGAC CTGGGTCAAC CACAATGGTG AGTGCGCGCA GGGGTCCCGG 60
GAGGCCGAGC CCGCAGTCGG GTCGGGGTCT GTTGTCGAGT CGGGGCGCGC GCAAGTCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055621|E3,WD_repeat|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0043234--C:protein complex
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0031935--P:regulation of chromatin silencing
GO:0006351--P:transcription, DNA-templated
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001039 Aegilops tauschii 41.67 7.00e-80 292.00
IUUC-Aml-001723 Ailuropoda melanoleuca 96.71 0.00e+00 1709.00
IUUC-Atr-003132 Amborella trichopoda 35.11 1.00e-76 281.00
IUUC-Apl-003197 Anas platyrhynchos 84.20 0.00e+00 1576.00
IUUC-Aca-004733 Anolis carolinensis 82.40 0.00e+00 1521.00
IUUC-Aly-005446 Arabidopsis lyrata 40.46 2.00e-72 267.00
IUUC-Ath-007627 Arabidopsis thaliana 34.86 2.00e-72 267.00
IUUC-Ago-007766 Ashbya gossypii 31.04 1.00e-51 198.00
IUUC-Acl-008104 Aspergillus clavatus 29.87 1.00e-55 211.00
IUUC-Afl-008591 Aspergillus flavus 30.80 6.00e-55 209.00
IUUC-Afu-008781 Aspergillus fumigatus 34.82 2.00e-56 214.00
IUUC-Ani-009272 Aspergillus nidulans 28.82 5.00e-50 193.00
IUUC-Ang-009655 Aspergillus niger 33.72 1.00e-55 212.00
IUUC-Aor-010119 Aspergillus oryzae 30.80 2.00e-55 211.00
IUUC-Ate-010530 Aspergillus terreus 28.07 5.00e-48 186.00
IUUC-Bgr-012237 Blumeria graminis 33.52 5.00e-53 202.00
IUUC-Bta-013320 Bos taurus 90.49 0.00e+00 1686.00
IUUC-Bci-013795 Botrytis cinerea 34.01 2.00e-58 221.00
IUUC-Bdi-014075 Brachypodium distachyon 40.80 2.00e-78 287.00
IUUC-Bol-016440 Brassica oleracea 34.01 2.00e-76 281.00
IUUC-Bra-016651 Brassica rapa 39.31 7.00e-75 275.00
IUUC-Cel-018692 Caenorhabditis elegans 37.31 9.00e-65 241.00
IUUC-Cja-018987 Callithrix jacchus 98.67 0.00e+00 1736.00
IUUC-Cfa-020132 Canis familiaris 96.61 0.00e+00 1706.00
IUUC-Cpo-021484 Cavia porcellus 97.13 0.00e+00 1724.00
IUUC-Cre-022846 Chlamydomonas reinhardtii 36.15 3.00e-54 207.00
IUUC-Csa-023081 Chlorocebus sabaeus 99.49 0.00e+00 1748.00
IUUC-Cin-025182 Ciona intestinalis 54.88 1.00e-139 491.00
IUUC-Csv-026154 Ciona savignyi 54.85 2.00e-137 483.00
IUUC-Cgl-026655 Colletotrichum gloeosporioides 31.70 2.00e-57 217.00
IUUC-Cne-026891 Cryptococcus neoformans 40.88 1.00e-71 265.00
IUUC-Cme-027349 Cyanidioschyzon merolae 30.75 2.00e-49 191.00
IUUC-Dre-027655 Danio rerio 67.96 0.00e+00 1275.00
IUUC-Dno-029557 Dasypus novemcinctus 84.75 0.00e+00 1109.00
IUUC-Dor-030687 Dipodomys ordii 86.01 0.00e+00 707.00
IUUC-Dse-031334 Dothistroma septosporum 30.80 3.00e-55 210.00
IUUC-Dme-031746 Drosophila melanogaster 53.86 3.00e-137 483.00
IUUC-Ete-032384 Echinops telfairi 89.22 0.00e+00 1572.00
IUUC-Eca-033430 Equus caballus 96.20 0.00e+00 1689.00
IUUC-Fca-036121 Felis catus 96.41 0.00e+00 1704.00
IUUC-Fal-036817 Ficedula albicollis 83.47 0.00e+00 1577.00
IUUC-Fox-037906 Fusarium oxysporum 35.64 7.00e-61 228.00
IUUC-Fso-038409 Fusarium solani 33.98 7.00e-59 222.00
IUUC-Gmo-039151 Gadus morhua 85.63 1.00e-176 613.00
IUUC-Ggr-040016 Gaeumannomyces graminis 32.21 3.00e-60 227.00
IUUC-Gga-040936 Gallus gallus 84.08 0.00e+00 1634.00
IUUC-Gac-041405 Gasterosteus aculeatus 61.70 0.00e+00 1126.00
IUUC-Gma-044252 Glycine max 34.66 3.00e-77 283.00
IUUC-Ggo-045430 Gorilla gorilla 98.97 0.00e+00 1738.00
IUUC-Hsa-046442 Homo sapiens 99.08 0.00e+00 1742.00
IUUC-Hvu-047587 Hordeum vulgare 37.69 2.00e-80 294.00
IUUC-Itr-048910 Ictidomys tridecemlineatus 100.00 2.00e-155 541.00
IUUC-Kpa-049145 Komagataella pastoris 32.84 3.00e-55 210.00
IUUC-Lch-050474 Latimeria chalumnae 75.63 0.00e+00 1355.00
IUUC-Lpe-051209 Leersia perrieri 34.36 5.00e-70 259.00
IUUC-Loc-052119 Lepisosteus oculatus 71.85 0.00e+00 1304.00
IUUC-Lma-053237 Leptosphaeria maculans 37.05 7.00e-59 222.00
IUUC-Laf-053718 Loxodonta africana 95.69 0.00e+00 1695.00
IUUC-Meu-055914 Macropus eugenii 79.41 0.00e+00 1438.00
IUUC-Mor-057090 Magnaporthe oryzae 34.25 5.00e-58 219.00
IUUC-Mpo-057364 Magnaporthe poae 32.31 6.00e-63 236.00
IUUC-Mtr-057744 Medicago truncatula 36.13 3.00e-78 286.00
IUUC-Mla-058914 Melampsora laricipopulina 41.93 2.00e-73 270.00
IUUC-Mga-060181 Meleagris gallopavo 82.99 0.00e+00 1604.00
IUUC-Mvi-060432 Microbotryum violaceum 38.89 6.00e-67 249.00
IUUC-Mmr-060871 Microcebus murinus 97.13 0.00e+00 1771.00
IUUC-Mdo-062301 Monodelphis domestica 85.90 0.00e+00 1550.00
IUUC-Mmu-063888 Mus musculus 95.59 0.00e+00 1684.00
IUUC-Mac-065137 Musa acuminata 37.14 3.00e-78 286.00
IUUC-Mpu-066732 Mustela putorius furo 96.30 0.00e+00 1740.00
IUUC-Mlu-067542 Myotis lucifugus 96.00 0.00e+00 1664.00
IUUC-Nfi-068396 Neosartorya fischeri 34.82 2.00e-56 214.00
IUUC-Ncr-068842 Neurospora crassa 32.60 4.00e-59 223.00
IUUC-Nle-070156 Nomascus leucogenys 99.08 0.00e+00 1756.00
IUUC-Opr-070808 Ochotona princeps 95.87 0.00e+00 1445.00
IUUC-Ont-072105 Oreochromis niloticus 66.67 0.00e+00 1252.00
IUUC-Ocu-074962 Oryctolagus cuniculus 97.02 0.00e+00 1735.00
IUUC-Oba-075178 Oryza barthii 40.80 4.00e-78 286.00
IUUC-Obr-076399 Oryza brachyantha 35.71 9.00e-79 288.00
IUUC-Ogu-078797 Oryza glumaepatula 40.80 4.00e-78 286.00
IUUC-Oin-080085 Oryza indica 40.80 3.00e-78 286.00
IUUC-Olo-081048 Oryza longistaminata 41.04 2.00e-66 248.00
IUUC-Ome-081324 Oryza meridionalis 40.80 4.00e-78 286.00
IUUC-Oni-082548 Oryza nivara 40.80 4.00e-78 286.00
IUUC-Opu-084008 Oryza punctata 40.80 4.00e-78 286.00
IUUC-Oru-084339 Oryza rufipogon 40.52 1.00e-77 284.00
IUUC-Osa-085782 Oryza sativa 40.52 1.00e-77 284.00
IUUC-Ola-087302 Oryzias latipes 70.83 0.00e+00 748.00
IUUC-Olu-087611 Ostreococcus lucimarinus 34.43 1.00e-77 284.00
IUUC-Oga-087935 Otolemur garnettii 97.03 0.00e+00 1699.00
IUUC-Oar-089229 Ovis aries 69.12 0.00e+00 988.00
IUUC-Ptr-090715 Pan troglodytes 99.18 0.00e+00 1744.00
IUUC-Pan-092318 Papio anubis 99.39 0.00e+00 1746.00
IUUC-Psi-094053 Pelodiscus sinensis 83.89 0.00e+00 1582.00
IUUC-Pno-094985 Phaeosphaeria nodorum 34.63 3.00e-52 200.00
IUUC-Ppa-095819 Physcomitrella patens 38.27 4.00e-76 280.00
IUUC-Pfo-096857 Poecilia formosa 65.93 0.00e+00 1210.00
IUUC-Pab-098047 Pongo abelii 99.38 0.00e+00 1749.00
IUUC-Pop-099587 Populus trichocarpa 37.39 1.00e-77 285.00
IUUC-Pca-100558 Procavia capensis 95.53 0.00e+00 753.00
IUUC-Ppe-101261 Prunus persica 37.72 3.00e-79 290.00
IUUC-Pva-102683 Pteropus vampyrus 96.10 0.00e+00 1711.00
IUUC-Pgr-103660 Puccinia graminis 41.16 2.00e-67 251.00
IUUC-Ptt-103900 Puccinia triticina 42.90 4.00e-70 259.00
IUUC-Pte-104209 Pyrenophora teres 34.99 2.00e-56 214.00
IUUC-Pyt-104802 Pyrenophora triticirepentis 35.26 2.00e-56 214.00
IUUC-Rno-105137 Rattus norvegicus 95.38 0.00e+00 1712.00
IUUC-Sce-106291 Saccharomyces cerevisiae 32.93 9.00e-55 208.00
IUUC-Sha-107514 Sarcophilus harrisii 80.86 0.00e+00 1446.00
IUUC-Sja-107833 Schizosaccharomyces japonicus 35.08 4.00e-71 263.00
IUUC-Spo-108162 Schizosaccharomyces pombe 36.72 4.00e-70 259.00
IUUC-Smo-109186 Selaginella moellendorffii 40.17 1.00e-78 288.00
IUUC-Sit-109980 Setaria italica 37.04 2.00e-81 297.00
IUUC-Sly-111547 Solanum lycopersicum 36.73 2.00e-80 294.00
IUUC-Stu-112705 Solanum tuberosum 36.73 1.00e-80 295.00
IUUC-Sar-113222 Sorex araneus 89.96 0.00e+00 1490.00
IUUC-Sbi-114272 Sorghum bicolor 36.48 4.00e-80 293.00
IUUC-Sre-115061 Sporisorium reilianum 26.59 1.00e-86 315.00
IUUC-Ssc-116364 Sus scrofa 94.36 0.00e+00 1772.00
IUUC-Tgu-116645 Taeniopygia guttata 84.49 0.00e+00 1604.00
IUUC-Tru-117590 Takifugu rubripes 65.37 0.00e+00 1222.00
IUUC-Tsy-119212 Tarsius syrichta 90.88 0.00e+00 933.00
IUUC-Tni-119915 Tetraodon nigroviridis 65.48 0.00e+00 1195.00
IUUC-Tca-121765 Theobroma cacao 35.90 1.00e-77 285.00
IUUC-Tre-121887 Trichoderma reesei 33.90 4.00e-51 196.00
IUUC-Tvi-122262 Trichoderma virens 33.90 4.00e-51 196.00
IUUC-Tur-126483 Triticum urartu 41.67 1.00e-79 291.00
IUUC-Tme-127202 Tuber melanosporum 30.54 2.00e-48 187.00
IUUC-Tbe-127350 Tupaia belangeri 83.50 1.00e-180 627.00
IUUC-Ttr-129077 Tursiops truncatus 90.76 0.00e+00 1712.00
IUUC-Uma-129465 Ustilago maydis 35.68 2.00e-70 260.00
IUUC-Vda-129844 Verticillium dahliae 35.90 4.00e-58 219.00
IUUC-Vvi-131397 Vitis vinifera 36.42 3.00e-79 290.00
IUUC-Xtr-132057 Xenopus tropicalis 75.44 0.00e+00 1349.00
IUUC-Xma-134139 Xiphophorus maculatus 67.86 0.00e+00 802.00
IUUC-Yli-134424 Yarrowia lipolytica 32.96 8.00e-59 222.00
IUUC-Zma-135839 Zea mays 34.93 6.00e-79 289.00
Created Date 25-Jun-2017

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