iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052191

Ensembl Protein ID

ENSLOCP00000009141.1

UniProt Accession

W5ML82; W5ML82_LEPOC

Genbank Protein ID

ENSLOCP00000009141

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AHAT01020850

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000007536.1	ENSLOCT00000009152.1	ENSLOCP00000009141.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	82.35	8.00e-126	446.00	IUUC-Dme-031700
E3 activity/RING/RING	98.94	2.00e-168	589.00	IUUC-Hsa-046357
E3 activity/RING/RING	99.65	6.00e-168	587.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Lepisosteus oculatus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MLTPRRDVIQ CGRMPGAPTC AFPQLHPKHE VPKFQEKKKA LIGNHMDEEM SRQTATALPT 60
GTSKCAPSQR VPALTGTTAS NNDLASLFEC PVCFDYVLPP ILQCQSGHLV CSNCRPKLTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGAGCCAC GAGGCCGTGA AACCCGAGAC GGAGCAGAGC CCAGAGGAAG GACTTGCTCC 60
TCAAAGGGGA GTGAGAAGGC TGCAGCGTGA CATTCGAAAC TTGCAGGCTG CGCAGCGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.32	4.00e-45	174.00
IUUC-Aml-001186	Ailuropoda melanoleuca	97.58	2.00e-170	591.00
IUUC-Atr-002857	Amborella trichopoda	36.06	2.00e-44	172.00
IUUC-Apl-003813	Anas platyrhynchos	99.29	2.00e-169	587.00
IUUC-Aca-005014	Anolis carolinensis	96.61	2.00e-171	594.00
IUUC-Aly-006207	Arabidopsis lyrata	33.94	1.00e-41	163.00
IUUC-Ath-007049	Arabidopsis thaliana	33.45	4.00e-42	164.00
IUUC-Ame-011196	Astyanax mexicanus	96.69	5.00e-178	616.00
IUUC-Bta-012887	Bos taurus	97.92	6.00e-171	592.00
IUUC-Bdi-014200	Brachypodium distachyon	37.55	5.00e-46	177.00
IUUC-Bol-015523	Brassica oleracea	36.36	5.00e-42	164.00
IUUC-Bra-017336	Brassica rapa	33.22	3.00e-41	161.00
IUUC-Cel-018320	Caenorhabditis elegans	67.87	3.00e-115	408.00
IUUC-Cja-019796	Callithrix jacchus	98.94	2.00e-169	588.00
IUUC-Cfa-020642	Canis familiaris	98.94	7.00e-171	592.00
IUUC-Cpo-022348	Cavia porcellus	99.29	7.00e-169	585.00
IUUC-Csa-023974	Chlorocebus sabaeus	98.94	7.00e-170	589.00
IUUC-Cin-025674	Ciona intestinalis	78.37	4.00e-135	473.00
IUUC-Csv-026233	Ciona savignyi	84.65	2.00e-132	464.00
IUUC-Dre-028041	Danio rerio	95.36	4.00e-175	607.00
IUUC-Dno-029764	Dasypus novemcinctus	99.29	8.00e-170	589.00
IUUC-Dme-031700	Drosophila melanogaster	84.27	6.00e-120	423.00
IUUC-Ete-032423	Echinops telfairi	98.88	3.00e-159	553.00
IUUC-Eca-033536	Equus caballus	99.29	2.00e-169	587.00
IUUC-Eeu-035314	Erinaceus europaeus	98.88	2.00e-159	554.00
IUUC-Fca-035362	Felis catus	97.58	1.00e-170	592.00
IUUC-Fal-037487	Ficedula albicollis	98.94	4.00e-170	590.00
IUUC-Gga-040269	Gallus gallus	99.29	2.00e-169	587.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.52	4.00e-167	579.00
IUUC-Gma-042926	Glycine max	34.44	1.00e-40	160.00
IUUC-Ggo-045444	Gorilla gorilla	98.94	7.00e-170	589.00
IUUC-Hsa-046357	Homo sapiens	98.94	7.00e-170	589.00
IUUC-Hvu-047574	Hordeum vulgare	36.96	5.00e-45	174.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	99.29	7.00e-169	585.00
IUUC-Lch-049504	Latimeria chalumnae	98.94	7.00e-169	585.00
IUUC-Lpe-050879	Leersia perrieri	40.25	1.00e-42	166.00
IUUC-Laf-053668	Loxodonta africana	99.29	2.00e-169	587.00
IUUC-Mcc-054640	Macaca mulatta	98.94	7.00e-170	589.00
IUUC-Mtr-058747	Medicago truncatula	35.19	2.00e-42	166.00
IUUC-Mga-059503	Meleagris gallopavo	99.29	3.00e-170	590.00
IUUC-Mmr-060794	Microcebus murinus	99.29	7.00e-169	585.00
IUUC-Mmu-064129	Mus musculus	99.65	3.00e-169	587.00
IUUC-Mac-065014	Musa acuminata	35.19	9.00e-43	167.00
IUUC-Mpu-066488	Mustela putorius furo	97.58	2.00e-170	590.00
IUUC-Mlu-067207	Myotis lucifugus	99.29	2.00e-170	590.00
IUUC-Nle-069706	Nomascus leucogenys	98.94	8.00e-170	589.00
IUUC-Ont-071849	Oreochromis niloticus	97.53	1.00e-167	582.00
IUUC-Ocu-074876	Oryctolagus cuniculus	98.94	2.00e-169	587.00
IUUC-Oba-075454	Oryza barthii	40.66	1.00e-42	166.00
IUUC-Obr-076037	Oryza brachyantha	35.43	2.00e-40	159.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	1.00e-42	166.00
IUUC-Ogu-078910	Oryza glumaepatula	40.83	2.00e-42	166.00
IUUC-Oin-079749	Oryza indica	40.66	1.00e-42	166.00
IUUC-Olo-080244	Oryza longistaminata	35.43	3.00e-40	159.00
IUUC-Ome-081318	Oryza meridionalis	40.66	1.00e-42	166.00
IUUC-Oni-083109	Oryza nivara	40.66	1.00e-42	166.00
IUUC-Opu-084065	Oryza punctata	41.08	6.00e-43	167.00
IUUC-Oru-084785	Oryza rufipogon	40.66	1.00e-42	166.00
IUUC-Osa-085610	Oryza sativa	40.66	1.00e-42	166.00
IUUC-Ola-086814	Oryzias latipes	97.52	4.00e-167	579.00
IUUC-Oga-088399	Otolemur garnettii	99.29	7.00e-169	585.00
IUUC-Oar-089323	Ovis aries	97.92	9.00e-171	592.00
IUUC-Ptr-090692	Pan troglodytes	99.29	1.00e-169	588.00
IUUC-Pan-092012	Papio anubis	98.94	7.00e-170	589.00
IUUC-Psi-093687	Pelodiscus sinensis	98.94	3.00e-170	590.00
IUUC-Pma-094387	Petromyzon marinus	93.31	9.00e-160	555.00
IUUC-Ppa-095212	Physcomitrella patens	36.19	5.00e-41	161.00
IUUC-Pfo-097134	Poecilia formosa	97.52	4.00e-167	579.00
IUUC-Pab-097555	Pongo abelii	98.94	7.00e-170	589.00
IUUC-Pop-099970	Populus trichocarpa	34.90	3.00e-44	172.00
IUUC-Ppe-101760	Prunus persica	36.10	3.00e-44	171.00
IUUC-Rno-104866	Rattus norvegicus	99.65	3.00e-169	587.00
IUUC-Sha-106547	Sarcophilus harrisii	98.94	3.00e-170	590.00
IUUC-Smo-109412	Selaginella moellendorffii	33.56	5.00e-39	154.00
IUUC-Sit-110595	Setaria italica	37.45	2.00e-41	162.00
IUUC-Sly-111259	Solanum lycopersicum	36.76	2.00e-41	162.00
IUUC-Stu-112474	Solanum tuberosum	33.22	7.00e-42	164.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	3.00e-42	165.00
IUUC-Tgu-116579	Taeniopygia guttata	99.29	2.00e-169	587.00
IUUC-Tru-118250	Takifugu rubripes	93.26	8.00e-159	552.00
IUUC-Tni-120488	Tetraodon nigroviridis	97.16	2.00e-163	567.00
IUUC-Tca-121228	Theobroma cacao	33.33	1.00e-41	163.00
IUUC-Tae-123647	Triticum aestivum	37.32	4.00e-45	174.00
IUUC-Tur-126049	Triticum urartu	35.04	7.00e-39	154.00
IUUC-Ttr-129166	Tursiops truncatus	98.76	2.00e-142	498.00
IUUC-Vvi-131233	Vitis vinifera	35.07	3.00e-42	165.00
IUUC-Xtr-132553	Xenopus tropicalis	98.58	1.00e-168	584.00
IUUC-Xma-133670	Xiphophorus maculatus	97.52	4.00e-167	579.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence