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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046888
UUCD1 version UUC-HoS-00320
Ensembl Protein ID ENSP00000231948.4
UniProt Accession Q96SW2; B2R6H4; C9IZA9; C9JAH6; Q6AI62; Q6NVZ0; Q9UHW4; CRBN_HUMAN
Genbank Protein ID BAB55162.1; BAG35471.1; AAH17419.1; AAH67811.1; AAF17211.1; CAH10361.1
Protein Name Protein cereblon
Genbank Nucleotide ID AK027507; AK312577; AC024060; BC067811; AF117230; CR627060
Gene Name CRBN; AD-006
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000113851.13 ENST00000424814.5 ENSP00000411047.1
ENSG00000113851.13 ENST00000231948.8 ENSP00000231948.4
ENSG00000113851.13 ENST00000432408.6 ENSP00000412499.2
ENSG00000113851.13 ENST00000450014.1 ENSP00000392073.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 17588513; 20223979; 21207098
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
 Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
Protein Sequence
(Fasta)
MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL 60
GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046888|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCTCCTTTG CGGGTAAACA GACATGGCCG GCGAAGGAGA TCAGCAGGAC GCTGCGCACA 60
ACATGGGCAA CCACCTGCCG CTCCTGCCTG GTAACCGCCC GGAGTAGTTC CCTGTAGTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046888|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR034750--CULT
IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR004910--Yippee/Mis18/Cereblon
PROSITE

PS51788--CULT
PS51787--LON_N
Pfam

PF02190--LON_substr_bdg
PF03226--Yippee-Mis18
SMART

SM00464--LON
Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0034766--P:negative regulation of ion transmembrane transport
GO:0032463--P:negative regulation of protein homooligomerization
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG hsa:51185
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000549 Aegilops tauschii 29.95 1.00e-23 104.00
IUUC-Aml-002159 Ailuropoda melanoleuca 96.18 0.00e+00 858.00
IUUC-Atr-002820 Amborella trichopoda 38.25 4.00e-37 149.00
IUUC-Apl-003508 Anas platyrhynchos 79.87 0.00e+00 743.00
IUUC-Aca-004675 Anolis carolinensis 83.49 0.00e+00 726.00
IUUC-Aly-005404 Arabidopsis lyrata 36.32 6.00e-38 152.00
IUUC-Ath-006819 Arabidopsis thaliana 35.79 2.00e-37 150.00
IUUC-Ani-009423 Aspergillus nidulans 38.60 4.60e-02 33.10
IUUC-Ame-010773 Astyanax mexicanus 66.96 7.00e-174 603.00
IUUC-Bta-012711 Bos taurus 94.37 0.00e+00 851.00
IUUC-Bdi-014416 Brachypodium distachyon 28.73 8.00e-45 174.00
IUUC-Bol-015668 Brassica oleracea 36.73 3.00e-39 156.00
IUUC-Bra-016836 Brassica rapa 36.15 1.00e-39 157.00
IUUC-Cja-019624 Callithrix jacchus 99.55 0.00e+00 887.00
IUUC-Cpo-022319 Cavia porcellus 96.15 0.00e+00 854.00
IUUC-Csa-023791 Chlorocebus sabaeus 99.77 0.00e+00 891.00
IUUC-Cho-024850 Choloepus hoffmanni 96.82 0.00e+00 694.00
IUUC-Csv-025832 Ciona savignyi 43.77 3.00e-88 319.00
IUUC-Cgl-026484 Colletotrichum gloeosporioides 31.82 2.30e-01 30.40
IUUC-Dre-028071 Danio rerio 67.63 8.00e-177 613.00
IUUC-Dno-029431 Dasypus novemcinctus 97.74 0.00e+00 872.00
IUUC-Dor-030571 Dipodomys ordii 81.00 0.00e+00 682.00
IUUC-Dme-031920 Drosophila melanogaster 27.74 5.00e-37 149.00
IUUC-Eca-033462 Equus caballus 96.83 0.00e+00 860.00
IUUC-Fca-036279 Felis catus 96.13 0.00e+00 851.00
IUUC-Fal-037498 Ficedula albicollis 77.68 0.00e+00 714.00
IUUC-Fox-037856 Fusarium oxysporum 42.86 2.70e-01 30.40
IUUC-Gmo-038734 Gadus morhua 71.00 6.00e-180 623.00
IUUC-Gga-040615 Gallus gallus 83.41 0.00e+00 753.00
IUUC-Gac-041426 Gasterosteus aculeatus 71.27 0.00e+00 631.00
IUUC-Gma-043891 Glycine max 36.45 5.00e-40 159.00
IUUC-Ggo-045108 Gorilla gorilla 99.55 0.00e+00 889.00
IUUC-Itr-047937 Ictidomys tridecemlineatus 97.28 0.00e+00 823.00
IUUC-Lch-050189 Latimeria chalumnae 75.68 7.00e-178 616.00
IUUC-Lpe-050808 Leersia perrieri 41.53 7.00e-42 165.00
IUUC-Loc-051762 Lepisosteus oculatus 78.09 0.00e+00 656.00
IUUC-Laf-053882 Loxodonta africana 95.05 0.00e+00 847.00
IUUC-Mcc-054883 Macaca mulatta 99.77 0.00e+00 891.00
IUUC-Mtr-058216 Medicago truncatula 37.33 9.00e-41 161.00
IUUC-Mdo-062260 Monodelphis domestica 87.39 0.00e+00 778.00
IUUC-Mmu-063438 Mus musculus 93.48 0.00e+00 855.00
IUUC-Mac-064610 Musa acuminata 44.00 9.00e-46 178.00
IUUC-Mpu-066362 Mustela putorius furo 95.95 0.00e+00 861.00
IUUC-Nle-069908 Nomascus leucogenys 99.77 0.00e+00 890.00
IUUC-Ont-072223 Oreochromis niloticus 72.45 0.00e+00 641.00
IUUC-Ocu-074151 Oryctolagus cuniculus 97.26 0.00e+00 819.00
IUUC-Oba-075882 Oryza barthii 39.90 6.00e-42 165.00
IUUC-Obr-076670 Oryza brachyantha 38.83 5.00e-40 159.00
IUUC-Ogl-077753 Oryza glaberrima 39.90 6.00e-42 165.00
IUUC-Ogu-078786 Oryza glumaepatula 39.90 6.00e-42 165.00
IUUC-Oin-079191 Oryza indica 39.90 5.00e-42 165.00
IUUC-Olo-080357 Oryza longistaminata 39.90 5.00e-42 165.00
IUUC-Ome-081227 Oryza meridionalis 29.76 1.00e-18 87.80
IUUC-Oni-082557 Oryza nivara 39.90 6.00e-42 165.00
IUUC-Opu-083920 Oryza punctata 39.90 4.00e-41 162.00
IUUC-Oru-085227 Oryza rufipogon 39.90 6.00e-42 165.00
IUUC-Ola-087321 Oryzias latipes 71.39 4.00e-174 604.00
IUUC-Oga-088413 Otolemur garnettii 95.95 0.00e+00 863.00
IUUC-Oar-089512 Ovis aries 93.54 0.00e+00 849.00
IUUC-Ptr-090764 Pan troglodytes 100.00 0.00e+00 892.00
IUUC-Pan-091942 Papio anubis 99.77 0.00e+00 891.00
IUUC-Psi-092985 Pelodiscus sinensis 85.26 0.00e+00 731.00
IUUC-Ppa-095670 Physcomitrella patens 37.18 4.00e-46 179.00
IUUC-Pfo-097251 Poecilia formosa 76.02 0.00e+00 637.00
IUUC-Pab-097842 Pongo abelii 99.55 0.00e+00 890.00
IUUC-Pop-099118 Populus trichocarpa 36.75 2.00e-43 170.00
IUUC-Pca-101077 Procavia capensis 83.78 0.00e+00 724.00
IUUC-Ppe-101706 Prunus persica 38.24 2.00e-41 163.00
IUUC-Pva-102245 Pteropus vampyrus 81.33 3.00e-150 524.00
IUUC-Rno-105788 Rattus norvegicus 93.48 0.00e+00 854.00
IUUC-Smo-109165 Selaginella moellendorffii 42.03 1.00e-46 181.00
IUUC-Sit-109818 Setaria italica 40.50 2.00e-42 167.00
IUUC-Sly-111062 Solanum lycopersicum 38.58 5.00e-44 172.00
IUUC-Sbi-114298 Sorghum bicolor 38.86 2.00e-43 170.00
IUUC-Ssc-115779 Sus scrofa 95.84 0.00e+00 742.00
IUUC-Tgu-117378 Taeniopygia guttata 80.27 0.00e+00 732.00
IUUC-Tru-118515 Takifugu rubripes 71.07 8.00e-172 596.00
IUUC-Tsy-119555 Tarsius syrichta 86.88 0.00e+00 775.00
IUUC-Tni-119679 Tetraodon nigroviridis 72.06 2.00e-172 598.00
IUUC-Tca-121374 Theobroma cacao 37.64 1.00e-32 134.00
IUUC-Tae-123098 Triticum aestivum 33.01 2.00e-53 203.00
IUUC-Tur-126689 Triticum urartu 29.82 6.00e-16 79.00
IUUC-Vpa-130719 Vicugna pacos 82.47 0.00e+00 734.00
IUUC-Vvi-131014 Vitis vinifera 40.33 1.00e-40 160.00
IUUC-Xtr-131811 Xenopus tropicalis 73.36 0.00e+00 650.00
IUUC-Xma-133238 Xiphophorus maculatus 75.77 0.00e+00 638.00
Created Date 25-Jun-2017

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