iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068867

Ensembl Protein ID

ESA42585

UniProt Accession

Q871U2; Q1K6Y7; V5IMK4; ATG7_NEUCR

Genbank Protein ID

CAD70899.1; ESA42585.1

Protein Name

Ubiquitin-like modifier-activating enzyme atg7; ATG12-activating enzyme E1 atg7; Autophagy-related protein 7

Genbank Nucleotide ID

BX294019; CM002240

Gene Name

apg-5; atg7; 100H1.190; NCU06672

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU06672	ESA42584	ESA42584
NCU06672	ESA42585	ESA42585

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	53.99	5.00e-116	413.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
550	Glycyl thioester intermediate	{ECO:0000250}

Organism

Neurospora crassa

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with apg-4/atg5 and apg-6/atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the apg-6/atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).

Protein Sequence
(Fasta)

MDLKFATFSS EIELPFYSAL FSSKLDHDKL DSSARPVLGL YEPRSHASPE ASTRMQILGS 60
ALTSDQDESG PLGMTRAEGY IKNVNTIEEF KNTDKNAMIK KAGEQIWDAI QDGTIYSCPS 120

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Nucleotide Sequence
(Fasta)

ATTTCCGCGC TGCTACCCTT ACCCATTGAC ACAGCTTCAG CAGTTACAGT CAAGGTGTGT 60
TCTCTGGACC ATCGTCGCCC ACTTGGTTCC TATATCGGTG AGACGTTCCC GAGTGCATCC 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0000407--C:pre-autophagosomal structure
GO:0008641--F:small protein activating enzyme activity
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

ncr:NCU06672

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	31.50	1.00e-84	306.00
IUUC-Aml-002316	Ailuropoda melanoleuca	43.57	4.00e-136	476.00
IUUC-Atr-002579	Amborella trichopoda	40.96	4.00e-142	496.00
IUUC-Apl-003805	Anas platyrhynchos	41.40	6.00e-146	509.00
IUUC-Aca-004618	Anolis carolinensis	44.05	2.00e-129	454.00
IUUC-Aly-005670	Arabidopsis lyrata	39.94	4.00e-123	433.00
IUUC-Ath-007499	Arabidopsis thaliana	40.23	1.00e-127	448.00
IUUC-Ago-007838	Ashbya gossypii	40.32	5.00e-129	452.00
IUUC-Acl-008093	Aspergillus clavatus	57.73	0.00e+00	755.00
IUUC-Afl-008663	Aspergillus flavus	58.46	0.00e+00	706.00
IUUC-Afu-008926	Aspergillus fumigatus	53.61	0.00e+00	719.00
IUUC-Ani-009156	Aspergillus nidulans	59.57	0.00e+00	777.00
IUUC-Ang-009853	Aspergillus niger	62.40	3.00e-76	275.00
IUUC-Aor-010055	Aspergillus oryzae	57.02	0.00e+00	804.00
IUUC-Ate-010281	Aspergillus terreus	52.69	0.00e+00	687.00
IUUC-Ame-010939	Astyanax mexicanus	40.03	9.00e-146	508.00
IUUC-Bgr-012006	Blumeria graminis	59.33	0.00e+00	825.00
IUUC-Bta-012336	Bos taurus	39.86	3.00e-131	460.00
IUUC-Bci-013598	Botrytis cinerea	64.77	0.00e+00	879.00
IUUC-Bdi-014170	Brachypodium distachyon	32.86	1.00e-89	323.00
IUUC-Bol-015357	Brassica oleracea	41.65	4.00e-134	469.00
IUUC-Bra-016835	Brassica rapa	41.26	9.00e-134	468.00
IUUC-Cel-018172	Caenorhabditis elegans	36.26	3.00e-100	357.00
IUUC-Cja-019544	Callithrix jacchus	41.59	5.00e-140	489.00
IUUC-Cfa-021043	Canis familiaris	41.89	8.00e-141	492.00
IUUC-Cpo-022366	Cavia porcellus	41.96	5.00e-140	489.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	37.28	1.00e-86	312.00
IUUC-Csa-023373	Chlorocebus sabaeus	41.59	5.00e-140	489.00
IUUC-Cho-024965	Choloepus hoffmanni	54.76	2.00e-51	195.00
IUUC-Cin-025710	Ciona intestinalis	44.60	9.00e-150	521.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	70.34	0.00e+00	967.00
IUUC-Cne-027083	Cryptococcus neoformans	41.85	8.00e-132	462.00
IUUC-Dre-028740	Danio rerio	37.91	7.00e-127	446.00
IUUC-Dno-029637	Dasypus novemcinctus	42.09	4.00e-134	469.00
IUUC-Dor-030492	Dipodomys ordii	41.07	2.00e-139	487.00
IUUC-Dse-031267	Dothistroma septosporum	51.57	0.00e+00	764.00
IUUC-Dme-032084	Drosophila melanogaster	39.02	1.00e-131	461.00
IUUC-Ete-032616	Echinops telfairi	39.00	2.00e-122	431.00
IUUC-Eca-033991	Equus caballus	41.59	1.00e-139	488.00
IUUC-Eeu-035126	Erinaceus europaeus	50.42	1.00e-64	239.00
IUUC-Fca-035472	Felis catus	41.86	6.00e-141	492.00
IUUC-Fal-037178	Ficedula albicollis	42.02	4.00e-148	516.00
IUUC-Fox-037901	Fusarium oxysporum	70.48	0.00e+00	967.00
IUUC-Fso-038279	Fusarium solani	72.43	0.00e+00	994.00
IUUC-Gmo-039329	Gadus morhua	41.63	3.00e-141	493.00
IUUC-Ggr-040061	Gaeumannomyces graminis	70.93	0.00e+00	949.00
IUUC-Gga-040244	Gallus gallus	42.26	2.00e-148	517.00
IUUC-Gac-041880	Gasterosteus aculeatus	40.70	5.00e-138	483.00
IUUC-Gma-043235	Glycine max	40.14	2.00e-136	478.00
IUUC-Ggo-045428	Gorilla gorilla	41.17	2.00e-139	488.00
IUUC-Hsa-046183	Homo sapiens	41.45	2.00e-140	491.00
IUUC-Hvu-047509	Hordeum vulgare	32.33	2.00e-80	292.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	42.05	6.00e-134	469.00
IUUC-Kpa-049142	Komagataella pastoris	39.34	8.00e-136	475.00
IUUC-Lch-049601	Latimeria chalumnae	42.66	6.00e-87	313.00
IUUC-Lpe-051496	Leersia perrieri	31.68	4.00e-84	304.00
IUUC-Loc-051751	Lepisosteus oculatus	42.42	2.00e-152	531.00
IUUC-Lma-053203	Leptosphaeria maculans	58.62	0.00e+00	642.00
IUUC-Laf-053424	Loxodonta africana	41.72	1.00e-141	494.00
IUUC-Mcc-054633	Macaca mulatta	41.59	2.00e-140	491.00
IUUC-Meu-056523	Macropus eugenii	37.96	4.00e-117	413.00
IUUC-Mor-056983	Magnaporthe oryzae	68.89	0.00e+00	964.00
IUUC-Mpo-057615	Magnaporthe poae	72.10	0.00e+00	992.00
IUUC-Mtr-058366	Medicago truncatula	40.14	1.00e-131	461.00
IUUC-Mla-058826	Melampsora laricipopulina	39.81	5.00e-149	519.00
IUUC-Mga-059447	Meleagris gallopavo	41.98	1.00e-147	514.00
IUUC-Mvi-060537	Microbotryum violaceum	41.41	7.00e-147	512.00
IUUC-Mmr-060676	Microcebus murinus	40.52	9.00e-141	492.00
IUUC-Mdo-062967	Monodelphis domestica	40.42	2.00e-134	471.00
IUUC-Mmu-063217	Mus musculus	41.81	4.00e-141	493.00
IUUC-Mac-065527	Musa acuminata	39.70	8.00e-125	439.00
IUUC-Mpu-066417	Mustela putorius furo	42.06	2.00e-141	494.00
IUUC-Mlu-067195	Myotis lucifugus	41.78	2.00e-145	508.00
IUUC-Nfi-068576	Neosartorya fischeri	54.58	0.00e+00	749.00
IUUC-Nle-069447	Nomascus leucogenys	49.18	3.00e-91	326.00
IUUC-Opr-070737	Ochotona princeps	48.49	3.00e-116	410.00
IUUC-Ont-071260	Oreochromis niloticus	41.11	6.00e-146	509.00
IUUC-Oan-073622	Ornithorhynchus anatinus	40.00	2.00e-93	334.00
IUUC-Ocu-074584	Oryctolagus cuniculus	41.39	2.00e-144	504.00
IUUC-Oba-075483	Oryza barthii	31.10	7.00e-81	293.00
IUUC-Obr-076786	Oryza brachyantha	31.53	1.00e-87	316.00
IUUC-Ogl-077388	Oryza glaberrima	30.92	9.00e-80	290.00
IUUC-Ogu-078618	Oryza glumaepatula	31.53	3.00e-87	315.00
IUUC-Oin-080007	Oryza indica	31.53	1.00e-82	299.00
IUUC-Olo-080994	Oryza longistaminata	31.11	5.00e-78	284.00
IUUC-Ome-081735	Oryza meridionalis	31.38	5.00e-82	297.00
IUUC-Oni-082153	Oryza nivara	31.53	2.00e-82	299.00
IUUC-Opu-083146	Oryza punctata	31.69	1.00e-81	296.00
IUUC-Oru-084919	Oryza rufipogon	31.53	9.00e-83	300.00
IUUC-Osa-086182	Oryza sativa	31.48	4.00e-83	301.00
IUUC-Ola-086441	Oryzias latipes	40.30	2.00e-145	508.00
IUUC-Olu-087664	Ostreococcus lucimarinus	39.33	4.00e-119	420.00
IUUC-Oga-089074	Otolemur garnettii	41.06	2.00e-133	467.00
IUUC-Oar-090159	Ovis aries	39.70	2.00e-131	461.00
IUUC-Ptr-091105	Pan troglodytes	43.11	1.00e-127	448.00
IUUC-Pan-092446	Papio anubis	41.59	3.00e-140	490.00
IUUC-Psi-093372	Pelodiscus sinensis	42.20	2.00e-143	501.00
IUUC-Pma-094661	Petromyzon marinus	41.46	3.00e-127	446.00
IUUC-Pno-094813	Phaeosphaeria nodorum	51.46	6.00e-178	615.00
IUUC-Ppa-095224	Physcomitrella patens	41.40	1.00e-136	478.00
IUUC-Pfo-096565	Poecilia formosa	41.59	4.00e-140	490.00
IUUC-Pop-099702	Populus trichocarpa	39.29	5.00e-139	486.00
IUUC-Pca-100324	Procavia capensis	34.45	3.00e-71	261.00
IUUC-Ppe-101416	Prunus persica	38.86	1.00e-129	455.00
IUUC-Pva-102589	Pteropus vampyrus	38.64	6.00e-125	439.00
IUUC-Pgr-103497	Puccinia graminis	40.25	2.00e-148	517.00
IUUC-Ptt-103718	Puccinia triticina	39.08	3.00e-146	510.00
IUUC-Pte-104206	Pyrenophora teres	56.45	5.00e-179	619.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	54.57	0.00e+00	690.00
IUUC-Rno-105911	Rattus norvegicus	41.94	1.00e-141	494.00
IUUC-Sce-106413	Saccharomyces cerevisiae	53.99	5.00e-117	413.00
IUUC-Sha-106679	Sarcophilus harrisii	40.95	5.00e-140	489.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	39.88	4.00e-137	479.00
IUUC-Spo-108107	Schizosaccharomyces pombe	41.96	5.00e-138	482.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	64.04	0.00e+00	876.00
IUUC-Smo-109677	Selaginella moellendorffii	38.64	8.00e-121	426.00
IUUC-Sit-110319	Setaria italica	41.60	2.00e-76	278.00
IUUC-Sly-111215	Solanum lycopersicum	39.83	2.00e-135	474.00
IUUC-Stu-112442	Solanum tuberosum	39.83	2.00e-136	477.00
IUUC-Sar-113370	Sorex araneus	47.89	1.00e-99	355.00
IUUC-Sbi-114261	Sorghum bicolor	42.90	1.00e-73	269.00
IUUC-Sre-114997	Sporisorium reilianum	40.40	1.00e-149	521.00
IUUC-Ssc-115304	Sus scrofa	42.05	3.00e-139	486.00
IUUC-Tgu-117235	Taeniopygia guttata	41.06	3.00e-145	507.00
IUUC-Tru-118374	Takifugu rubripes	41.03	1.00e-141	495.00
IUUC-Tsy-118966	Tarsius syrichta	34.30	2.00e-100	358.00
IUUC-Tni-120269	Tetraodon nigroviridis	40.21	2.00e-126	444.00
IUUC-Tca-121245	Theobroma cacao	38.80	4.00e-139	486.00
IUUC-Tre-121966	Trichoderma reesei	71.47	0.00e+00	976.00
IUUC-Tvi-122360	Trichoderma virens	70.74	0.00e+00	956.00
IUUC-Tae-125251	Triticum aestivum	31.75	2.00e-85	309.00
IUUC-Tur-126294	Triticum urartu	31.47	4.00e-80	291.00
IUUC-Tme-127117	Tuber melanosporum	56.26	0.00e+00	705.00
IUUC-Tbe-127662	Tupaia belangeri	44.29	2.00e-39	155.00
IUUC-Ttr-129054	Tursiops truncatus	40.89	2.00e-139	488.00
IUUC-Uma-129526	Ustilago maydis	39.01	9.00e-149	518.00
IUUC-Vda-129878	Verticillium dahliae	66.18	0.00e+00	924.00
IUUC-Vpa-130264	Vicugna pacos	36.65	2.00e-72	265.00
IUUC-Vvi-131163	Vitis vinifera	38.05	5.00e-137	479.00
IUUC-Xtr-132328	Xenopus tropicalis	32.82	1.00e-90	325.00
IUUC-Xma-133015	Xiphophorus maculatus	40.06	4.00e-127	447.00
IUUC-Yli-134468	Yarrowia lipolytica	40.86	4.00e-133	466.00
IUUC-Zma-134871	Zea mays	31.71	7.00e-86	310.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence