iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tae-125848

Ensembl Protein ID

TRIAE_CS42_3AS_TGACv1_210799_AA0679350.3

UniProt Accession

A0A1D5VH82; A0A1D5VH82_WHEAT

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIAE_CS42_3AS_TGACv1_210799_AA0679350	TRIAE_CS42_3AS_TGACv1_210799_AA0679350.3	TRIAE_CS42_3AS_TGACv1_210799_AA0679350.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.40e-54	186.6	345	827
UBD/Alpha-Helix/UBA	6.60e-12	47.8	704	743

Active Site

Position(s)	Description	Evidence
354	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
790	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenpkepkgellkslqklfeelw...... 61
           tGl NlgN+CYm Sv+Q++++++++ + ++e  + k ++ + ++ +p+ +l ++++kl + ++      
   Q: 345  TGLVNLGNSCYMASVMQVMFSTHPFISRYFEkqSLKAAF-AISKADPTLDLNMQMTKLAHGMLsgkysa 412
           7************************99998843222333.334579999*************7666666 PP
   S: 62   ..kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsd 128
             ++ ++ + pr+l++++++ ++efs+++qqDa Ef+++l+d+++++                      
   Q: 413  psQEGQEGIRPRMLKSVIAASHPEFSSMRQQDALEFFHHLIDKVDQAN--------------------- 460
           6677788*************************************9988..................... PP
   S: 129  eaeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkke........... 185
                + +++ +   + F++ ++++++c++ + ++ +  ++fl+ls+p+++ ++++++           
   Q: 461  -----PGNHELN-PCTGFKFIIEERVQCPSGKVSYnQHCDNFLTLSIPLHEATNKEQLeafhekkaamd 523
           .....3444444.4568************999888788899*********999776669********** PP
   S: 186  ................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfs 238
                            l+ cL+sf+  ee+ +   +y++  ++k++a k+++lk++P++L+l++ +f 
   Q: 524  ldgkevskeeivrprvPLEACLASFSGGEEVPE---FYSTALNSKTTAIKTTGLKTFPDYLVLQMRKF- 588
           *******************************96...********************************. PP
   S: 239  fseeqksrekinkkvefpleLdlspfcts........................................ 267
           +  e+++++k++ ++++p+ +d+s++ ++                                        
   Q: 589  VMGEGWVPKKLDVYIDVPDIIDISHMRSNgvqpgeellpegascgnkaeparpvadedivsqlantgfn 657
           66889*******************999888999999999999888888888888888888888888888 PP
   S: 268  ..................................................................... 267
                                                                                
   Q: 658  yfacqkaaintsnagieeamdwllshtgdpdinepisqdpmpaedtideaslqtlvsfgfpedvsrmal 726
           888888777777777777777777777777777777777777666666666666666666666666666 PP
   S: 268  .................peekqke........................kkkYeLiavvvHsG.slssGH 294
                            p     e                        + +Y+L+a v+H+G s+++GH
   Q: 727  kasggnieratewvfshP-----EasssvsadsstnnvkdddsnisdgSGRYKLMAFVSHMGtSTHCGH 790
           666666555555555551.....0555555566666667777888888********************* PP
   S: 295  YvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           Yva++ + +g+W  f+D+kV ++   +  +   + +Y++f++r
   Q: 791  YVAHILK-DGRWTIFNDNKVAAS--VDLPK---DMGYLYFFQR 827
           *******.9***********999..68888...999*999997 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +de  l+ lv+ GF+++  + aL a+++n+e+A+e+++++
   Q: 704  IDEASLQTLVSFGFPEDVSRMALKASGGNIERATEWVFSH 743
           58899*********************************97 PP

Organism

Triticum aestivum

Protein Sequence
(Fasta)

MFQALWAILQ GLIRFLWSYV RDATRLRRRP PRPAAMDLLR ANLHKVRIPE PTNRIHKDEC 60
CVSFDTPRSE GGLYVDMNSF LGFGREHVAW NFEKSENPVY LHIVQRRKPE PDETDRPLKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGCACTCTA TGGTGGGTTG ACAGATCTGA AAAAAAATCA CAACACGGCG GGAGAGGAAC 60
GAAGTACGGG GGAGAGGTGA TCGAGGGAGT ACCTGACGAG AGGGAATTCT GAGTGTGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0732--Signal
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cgl-026667	Colletotrichum gloeosporioides	32.96	3.00e-99	357.00
IUUC-Mor-057106	Magnaporthe oryzae	34.60	1.00e-111	398.00
IUUC-Pma-094242	Petromyzon marinus	47.80	6.00e-101	361.00
IUUC-Tre-122043	Trichoderma reesei	34.23	5.00e-109	389.00
IUUC-Tur-126732	Triticum urartu	94.34	0.00e+00	1521.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence