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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-006615
UUCD1 version UUC-ArT-01472
Ensembl Protein ID AT1G55250.1
UniProt Accession Q9C895; Q058L1; Q8LDW7; BRE1B_ARATH
Genbank Protein ID AAG51572.1; AEE33210.1; AEE33211.1; AAM62973.1; ABJ17142.1
Protein Name E3 ubiquitin-protein ligase BRE1-like 2; Protein HISTONE MONOUBIQUITINATION 2; RING-type E3 ubiquitin transferase BRE1-like 2
Genbank Nucleotide ID AC027034; CP002684; CP002684; AY085755; BT029207
Gene Name HUB2; BRE1B; At1g55250/At1g55255; F7A10.17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT1G55250 AT1G55250.1 AT1G55250.1
AT1G55250 AT1G55250.3 AT1G55250.3
AT1G55250 AT1G55250.4 AT1G55250.4
AT1G55250 AT1G55250.2 AT1G55250.2
AT1G55250 AT1G55250.5 AT1G55250.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
Protein-protein Interaction
iRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18798874; 19286969
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.60e-05 24.7 848 886
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C +C++++k+ ++++ C H+f+++C+q+      ++ ++ +CP C
   Q: 848  CGVCFDRPKE-VVIVKCYHLFCQQCIQRS-----LEIRHRKCPGC 886
           99******99.***************777.....699999****9 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me. It thereby plays a central role in histone code and gene regulation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6.
 E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me. It thereby plays a central role in histone code and gene regulation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6.
Protein Sequence
(Fasta)
MENQESDEPM QKKPHLLDSV SPNSMARNSS PSHPIAKSVS FFDCDFSLLC LRLVDYEIDV 60
DATVLQLQNQ KLVQQLDLQK KQLYDVESKI QELQLNQTSY DDELISVNQL WNQLVDDLIL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-006615|E3,RING|Arabidopsis thaliana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGAATC AGGAATCGGA CGAGCCGATG CAGAAGAAGC CTCATCTTTT AGACTCCGTT 60
TCTCCGAATT CCATGGCTCG TAACTCTTCA CCTTCTCACC CTATAGCTAA AAGTGTAAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-006615|E3,RING|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005634--C:nucleus
GO:0042803--F:protein homodimerization activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0045087--P:innate immune response
GO:0009965--P:leaf morphogenesis
GO:0010162--P:seed dormancy process
GO:0010228--P:vegetative to reproductive phase transition of meristem
KEGG ath:AT1G55250
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001027 Aegilops tauschii 45.20 1.00e-124 439.00
IUUC-Apl-003407 Anas platyrhynchos 28.52 2.00e-26 113.00
IUUC-Aly-006469 Arabidopsis lyrata 93.33 0.00e+00 1530.00
IUUC-Ago-007988 Ashbya gossypii 37.88 9.00e-12 64.70
IUUC-Acl-008319 Aspergillus clavatus 34.72 6.00e-10 58.90
IUUC-Ang-009601 Aspergillus niger 26.32 1.00e-10 60.80
IUUC-Aor-010142 Aspergillus oryzae 26.70 4.00e-10 59.70
IUUC-Ate-010547 Aspergillus terreus 36.11 2.00e-10 60.10
IUUC-Bci-013926 Botrytis cinerea 39.62 1.00e-08 54.30
IUUC-Bdi-015006 Brachypodium distachyon 49.05 0.00e+00 695.00
IUUC-Bol-016588 Brassica oleracea 85.71 0.00e+00 1372.00
IUUC-Bra-017335 Brassica rapa 85.60 0.00e+00 1337.00
IUUC-Cre-022940 Chlamydomonas reinhardtii 40.85 5.00e-10 58.90
IUUC-Cho-024616 Choloepus hoffmanni 27.78 5.00e-20 92.80
IUUC-Cin-025174 Ciona intestinalis 32.46 3.00e-29 123.00
IUUC-Csv-025830 Ciona savignyi 29.73 9.00e-27 115.00
IUUC-Cgl-026569 Colletotrichum gloeosporioides 43.75 2.00e-09 56.60
IUUC-Cne-026878 Cryptococcus neoformans 47.92 7.00e-12 65.50
IUUC-Cme-027134 Cyanidioschyzon merolae 40.32 6.00e-14 71.60
IUUC-Dre-028171 Danio rerio 31.34 6.00e-30 125.00
IUUC-Ete-033164 Echinops telfairi 27.62 4.00e-21 96.70
IUUC-Ggr-040117 Gaeumannomyces graminis 38.33 4.00e-11 62.80
IUUC-Lma-053312 Leptosphaeria maculans 45.10 4.00e-12 66.20
IUUC-Mpo-057568 Magnaporthe poae 38.33 5.00e-11 62.40
IUUC-Mtr-058247 Medicago truncatula 52.60 0.00e+00 794.00
IUUC-Mla-059072 Melampsora laricipopulina 24.25 8.00e-18 85.10
IUUC-Ncr-068695 Neurospora crassa 37.29 3.00e-10 59.70
IUUC-Nle-069058 Nomascus leucogenys 27.44 2.00e-20 94.00
IUUC-Olo-080612 Oryza longistaminata 48.03 0.00e+00 647.00
IUUC-Opu-083683 Oryza punctata 48.93 0.00e+00 675.00
IUUC-Osa-085839 Oryza sativa 48.93 0.00e+00 679.00
IUUC-Ptr-091602 Pan troglodytes 27.44 2.00e-20 94.00
IUUC-Psi-093554 Pelodiscus sinensis 28.16 1.00e-21 98.60
IUUC-Pno-095079 Phaeosphaeria nodorum 44.44 9.00e-14 71.60
IUUC-Ppa-095651 Physcomitrella patens 39.79 2.00e-143 502.00
IUUC-Pop-100039 Populus trichocarpa 61.37 0.00e+00 994.00
IUUC-Pte-104415 Pyrenophora teres 44.44 1.00e-13 71.20
IUUC-Pyt-104762 Pyrenophora triticirepentis 44.44 1.00e-13 71.20
IUUC-Sja-107993 Schizosaccharomyces japonicus 32.80 2.00e-14 73.60
IUUC-Spo-108304 Schizosaccharomyces pombe 50.00 2.00e-14 73.60
IUUC-Ssl-108546 Sclerotinia sclerotiorum 41.51 3.00e-09 56.60
IUUC-Smo-109550 Selaginella moellendorffii 40.40 2.00e-144 506.00
IUUC-Tsy-118808 Tarsius syrichta 27.21 2.00e-20 94.00
IUUC-Tae-123217 Triticum aestivum 50.36 0.00e+00 743.00
IUUC-Tur-126160 Triticum urartu 49.05 0.00e+00 659.00
IUUC-Tme-127177 Tuber melanosporum 43.40 9.00e-11 61.60
IUUC-Vda-129815 Verticillium dahliae 44.68 1.00e-09 57.80
IUUC-Vpa-130237 Vicugna pacos 24.49 2.00e-20 94.40
IUUC-Xtr-132589 Xenopus tropicalis 28.90 8.00e-26 112.00
IUUC-Yli-134445 Yarrowia lipolytica 31.43 3.00e-11 63.20
Created Date 25-Jun-2017

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