iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028839

UUCD1 version

UUC-DaR-01357

Ensembl Protein ID

ENSDARP00000011487.5

UniProt Accession

Q9W6H5; UBC9A_DANRE

Genbank Protein ID

AAD28601.1; AAH59506.1

Protein Name

SUMO-conjugating enzyme UBC9-A; RING-type E3 SUMO transferase UBC9-A; SUMO-protein ligase A; Ubiquitin carrier protein 9-A; Ubiquitin carrier protein I-A; Ubiquitin-conjugating enzyme E2 I-A; Ubiquitin-protein ligase I-A

Genbank Nucleotide ID

AF128240; BC059506

Gene Name

ube2ib; ube2ia; ubc9a; ube2i

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000007438.7	ENSDART00000022999.7	ENSDARP00000011487.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.20e-49	168.6	8	149

Active Site

Position(s)	Description	Evidence
93	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvdesd....ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsi 85
           Rl++e k+++kd+p g++a p+++ d    l++we++i G+++tp+egg+Fkl++ f++dYP++PPk+kf+ ++fhPnvy++G+vClsi
   Q: 8    RLAQERKAWRKDHPFGFVAVPMKNPDgtmnLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSI 96
           99*****************99998877777*********************************************************** PP
   S: 86   lkeeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           l+e+++W+pa++++++ll+iq+ll+epn+++p+++ea++++++nr ey+k+vr
   Q: 97   LEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVR 149
           ***************************************************98 PP

Organism

Danio rerio

Functional Description
(View)

Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis.

Protein Sequence
(Fasta)

MSGIALSRLA QERKAWRKDH PFGFVAVPMK NPDGTMNLMN WECAIPGKKG TPWEGGLFKL 60
RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED KDWRPAITIK QILLGIQELL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTAGACTGC TTCAGACCCG AATGTGTTTT CGGGAGGGAA ACTCCTTTGC TTTGGTTCCG 60
AGGCAAACGC GGTTCGAGTG AGCGGCCCAC GAGACGATAA ACACTGGGAT TCACGCGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR027230--Ubc9
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0019789--F:SUMO transferase activity
GO:0051301--P:cell division
GO:0007059--P:chromosome segregation
GO:0060216--P:definitive hemopoiesis
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0007067--P:mitotic nuclear division
GO:0016925--P:protein sumoylation
GO:0031099--P:regeneration
GO:0007088--P:regulation of mitotic nuclear division

KEGG

dre:30622

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000510	Aegilops tauschii	64.76	1.00e-38	152.00
IUUC-Atr-002982	Amborella trichopoda	64.10	2.00e-49	187.00
IUUC-Aly-005652	Arabidopsis lyrata	66.23	6.00e-60	223.00
IUUC-Ath-007084	Arabidopsis thaliana	66.23	6.00e-60	223.00
IUUC-Afl-008563	Aspergillus flavus	62.50	9.00e-50	189.00
IUUC-Afu-008873	Aspergillus fumigatus	65.25	2.00e-47	181.00
IUUC-Ang-009740	Aspergillus niger	68.61	2.00e-48	184.00
IUUC-Aor-010170	Aspergillus oryzae	63.16	4.00e-50	190.00
IUUC-Ate-010410	Aspergillus terreus	65.99	2.00e-50	191.00
IUUC-Bci-013748	Botrytis cinerea	61.59	2.00e-47	181.00
IUUC-Bdi-014883	Brachypodium distachyon	64.94	2.00e-58	218.00
IUUC-Bol-016125	Brassica oleracea	66.03	2.00e-51	194.00
IUUC-Bra-017235	Brassica rapa	66.03	2.00e-51	194.00
IUUC-Cel-018448	Caenorhabditis elegans	76.28	1.00e-74	271.00
IUUC-Cme-027203	Cyanidioschyzon merolae	58.97	2.00e-49	187.00
IUUC-Dse-031366	Dothistroma septosporum	62.91	6.00e-56	209.00
IUUC-Fso-038166	Fusarium solani	64.63	5.00e-57	213.00
IUUC-Ggr-039892	Gaeumannomyces graminis	65.93	5.00e-53	201.00
IUUC-Gma-043827	Glycine max	66.24	4.00e-61	226.00
IUUC-Hvu-047363	Hordeum vulgare	62.34	7.00e-57	213.00
IUUC-Lpe-051643	Leersia perrieri	65.58	2.00e-59	222.00
IUUC-Lma-053142	Leptosphaeria maculans	62.25	2.00e-57	214.00
IUUC-Mla-059115	Melampsora laricipopulina	65.82	3.00e-62	230.00
IUUC-Mvi-060328	Microbotryum violaceum	62.18	1.00e-47	182.00
IUUC-Mac-065019	Musa acuminata	65.38	4.00e-60	223.00
IUUC-Nfi-068567	Neosartorya fischeri	63.82	9.00e-51	192.00
IUUC-Oba-075371	Oryza barthii	64.74	6.00e-59	219.00
IUUC-Ogl-077506	Oryza glaberrima	64.74	6.00e-59	219.00
IUUC-Ogu-078474	Oryza glumaepatula	64.74	6.00e-59	219.00
IUUC-Oin-080036	Oryza indica	64.74	6.00e-59	219.00
IUUC-Olo-080940	Oryza longistaminata	58.44	6.00e-50	189.00
IUUC-Ome-081909	Oryza meridionalis	64.29	5.00e-58	216.00
IUUC-Oni-082340	Oryza nivara	64.74	6.00e-59	219.00
IUUC-Opu-083206	Oryza punctata	64.74	5.00e-59	219.00
IUUC-Oru-084239	Oryza rufipogon	64.74	6.00e-59	219.00
IUUC-Osa-086213	Oryza sativa	64.74	6.00e-59	219.00
IUUC-Pno-094954	Phaeosphaeria nodorum	61.29	4.00e-56	210.00
IUUC-Ppa-095314	Physcomitrella patens	64.74	4.00e-59	220.00
IUUC-Pop-099063	Populus trichocarpa	66.23	8.00e-60	222.00
IUUC-Ppe-101501	Prunus persica	66.67	4.00e-51	193.00
IUUC-Pte-104067	Pyrenophora teres	58.94	2.00e-55	207.00
IUUC-Pyt-104436	Pyrenophora triticirepentis	58.94	1.00e-55	208.00
IUUC-Sce-106308	Saccharomyces cerevisiae	57.05	2.00e-53	201.00
IUUC-Smo-108685	Selaginella moellendorffii	66.67	8.00e-52	196.00
IUUC-Sit-109792	Setaria italica	65.58	3.00e-59	220.00
IUUC-Sly-110998	Solanum lycopersicum	63.46	4.00e-59	220.00
IUUC-Stu-111975	Solanum tuberosum	66.23	4.00e-54	203.00
IUUC-Sbi-114672	Sorghum bicolor	65.58	3.00e-59	220.00
IUUC-Sre-114957	Sporisorium reilianum	68.59	3.00e-65	240.00
IUUC-Tae-125311	Triticum aestivum	65.58	3.00e-59	220.00
IUUC-Tur-126625	Triticum urartu	64.94	1.00e-58	218.00
IUUC-Uma-129582	Ustilago maydis	68.59	8.00e-65	239.00
IUUC-Vvi-130948	Vitis vinifera	64.74	5.00e-59	219.00
IUUC-Zma-135055	Zea mays	65.58	2.00e-59	221.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence