iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035937

Ensembl Protein ID

ENSFCAP00000001762.3

UniProt Accession

M3VXI2; M3VXI2_FELCA

Genbank Protein ID

ENSFCAP00000001762

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AANG02020523

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000001904.3	ENSFCAT00000001904.3	ENSFCAP00000001762.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-16	59.7	81	136

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++lydy+a + ++L+++kGd++ ++   e++++W+++ + ++gk+G +P+n+v++++
   Q: 81   TVIALYDYKAIHHEDLSFQKGDKMVIL---EESGEWWRARSLATGKEGYIPSNYVARVD 136
           799************************...99*************************97 PP

Organism

Felis catus

Protein Sequence
(Fasta)

LGGGSSCEDP GCPQDEEREP RMGCMKSKFL QDRGKVSKTE PSALHSPVYV PDPTSAGKRV 60
SGGNKASPSR VSLPAGPDDI TVIALYDYKA IHHEDLSFQK GDKMVILEES GEWWRARSLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGGGGGGG GCTCGAGCTG CGAGGATCCG GGCTGCCCGC AGGACGAGGA GCGGGAGCCC 60
AGGTGAGTGC GGCGGACGGG GGAAGCGGGG CAGCCTGAGG GTGAGCGCGG CCTGAGGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	92.18	0.00e+00	1000.00
IUUC-Apl-003285	Anas platyrhynchos	78.60	0.00e+00	805.00
IUUC-Aca-004724	Anolis carolinensis	76.92	0.00e+00	776.00
IUUC-Ame-011954	Astyanax mexicanus	74.31	0.00e+00	743.00
IUUC-Bta-013060	Bos taurus	88.55	0.00e+00	964.00
IUUC-Cja-019817	Callithrix jacchus	87.92	0.00e+00	907.00
IUUC-Cfa-020511	Canis familiaris	90.70	0.00e+00	985.00
IUUC-Cpo-022538	Cavia porcellus	87.52	0.00e+00	911.00
IUUC-Csa-024143	Chlorocebus sabaeus	89.11	0.00e+00	916.00
IUUC-Dre-028157	Danio rerio	73.96	0.00e+00	768.00
IUUC-Dno-029761	Dasypus novemcinctus	87.08	0.00e+00	913.00
IUUC-Eca-034090	Equus caballus	88.17	0.00e+00	951.00
IUUC-Fal-036624	Ficedula albicollis	77.60	0.00e+00	797.00
IUUC-Gmo-039009	Gadus morhua	70.69	0.00e+00	737.00
IUUC-Gga-040296	Gallus gallus	74.46	0.00e+00	776.00
IUUC-Gac-042362	Gasterosteus aculeatus	72.92	0.00e+00	763.00
IUUC-Ggo-044570	Gorilla gorilla	88.76	0.00e+00	951.00
IUUC-Hsa-046378	Homo sapiens	88.76	0.00e+00	956.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	84.92	0.00e+00	912.00
IUUC-Lch-049991	Latimeria chalumnae	68.68	0.00e+00	714.00
IUUC-Loc-052904	Lepisosteus oculatus	76.48	0.00e+00	800.00
IUUC-Laf-053654	Loxodonta africana	89.90	0.00e+00	940.00
IUUC-Mcc-055317	Macaca mulatta	89.48	0.00e+00	922.00
IUUC-Mga-060194	Meleagris gallopavo	80.40	0.00e+00	759.00
IUUC-Mmr-061510	Microcebus murinus	85.88	0.00e+00	895.00
IUUC-Mdo-062035	Monodelphis domestica	83.60	0.00e+00	872.00
IUUC-Mmu-064037	Mus musculus	86.07	0.00e+00	944.00
IUUC-Mpu-066874	Mustela putorius furo	90.66	0.00e+00	944.00
IUUC-Mlu-068202	Myotis lucifugus	85.52	0.00e+00	882.00
IUUC-Nle-069222	Nomascus leucogenys	88.89	0.00e+00	916.00
IUUC-Opr-070705	Ochotona princeps	85.69	0.00e+00	937.00
IUUC-Ont-072347	Oreochromis niloticus	81.26	0.00e+00	746.00
IUUC-Oan-073193	Ornithorhynchus anatinus	68.95	0.00e+00	736.00
IUUC-Ocu-074490	Oryctolagus cuniculus	85.88	0.00e+00	896.00
IUUC-Ola-086521	Oryzias latipes	80.18	0.00e+00	758.00
IUUC-Oga-088153	Otolemur garnettii	86.90	0.00e+00	903.00
IUUC-Oar-090184	Ovis aries	86.34	0.00e+00	932.00
IUUC-Ptr-090505	Pan troglodytes	85.14	0.00e+00	899.00
IUUC-Pan-092260	Papio anubis	89.29	0.00e+00	921.00
IUUC-Psi-093685	Pelodiscus sinensis	70.35	0.00e+00	731.00
IUUC-Pma-094311	Petromyzon marinus	67.45	0.00e+00	721.00
IUUC-Pfo-096566	Poecilia formosa	74.61	0.00e+00	781.00
IUUC-Pab-098601	Pongo abelii	69.80	0.00e+00	731.00
IUUC-Pva-103021	Pteropus vampyrus	90.06	0.00e+00	939.00
IUUC-Rno-105309	Rattus norvegicus	86.08	0.00e+00	902.00
IUUC-Sha-107099	Sarcophilus harrisii	81.82	0.00e+00	860.00
IUUC-Tgu-116912	Taeniopygia guttata	76.77	0.00e+00	786.00
IUUC-Tru-118449	Takifugu rubripes	79.46	0.00e+00	747.00
IUUC-Tsy-119440	Tarsius syrichta	69.13	0.00e+00	716.00
IUUC-Tni-120005	Tetraodon nigroviridis	64.05	0.00e+00	683.00
IUUC-Tae-123706	Triticum aestivum	31.01	1.00e-21	98.60
IUUC-Tur-126022	Triticum urartu	31.01	1.00e-21	98.60
IUUC-Tbe-128144	Tupaia belangeri	74.81	0.00e+00	785.00
IUUC-Xma-133902	Xiphophorus maculatus	74.02	0.00e+00	770.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence