iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-009112

Ensembl Protein ID

CADAFUAP00003891

UniProt Accession

Q4WHP6; PAN2_ASPFU

Genbank Protein ID

EAL87559.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit pan2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AAHF01000008

Gene Name

AFUA_2G04650; pan2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00003891	CADAFUAT00003891	CADAFUAP00003891

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.00e-11	40.7	479	814

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs......... 85
           Gl+ + +  + N++LQ L +ip +r+l l++  +++  e      ++ll+++  lf  l k + ++ + ++llk+++++ e  +         
   Q: 479  GLETHIANSFTNALLQLLKFIPLVRNLALHHAASTCIYE------TCLLCEMGYLFDMLEKANGQNCQATNLLKTFSSYREASNlglleenlt 565
           788888899*********************888888765......7*******************************9999866443333333 PP
   S: 86   .gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssr.....eepfldl 172
            ++     q + +f+l+q+                          ++ +    +++ +++ +    +++i+c  c+n+ +r      ++ ++ 
   Q: 566  tKSLSSAIQSVNRFFLNQIA-------------------------HDFRMIVPSSDDLDHRLSTIASESIRCMFCQNEIVRpgnslANELIYP 633
           22223333333333333333.........................344667777888888889999999999999999977222223445566 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf......sfseeqksrekinkkvefple. 258
           ++++++ + +    ++++L++  ++e+ +   + +c+ c+++q+++ + +++++P vLil+           +s  ++ +e +   v+  +  
   Q: 634  TIDIKQARRNPAFRFSSILRASIERETQN---RGWCNYCRRYQQVTIRKSIHRMPLVLILNAALSnaicrrLWSIPGWLPEEVGIAVDNGQVm 723
           8889999988888************9987...59**************************866552222224555666666666666655442 PP
   S: 259  .LdlspfctspeekqkekkkYeLiavvvHsG..slssGHYvayvkn........ekgkWllfdDskVtevkeeevleetg..staYvlfYk 336
            ++ ++  t+ ++k  + + YeL++ v+     ++++ H v++++          k++W lf+D  Vtev+++e l++++  +++ +l Y+
   Q: 724  cFEGDELKTQLQNKLPNLVVYELVGLVSEIDipEHQKPHLVSFINVsissrepeAKNRWHLFNDFLVTEVDKDEALRFNQpwKSPCILAYQ 814
           34444666666667777**********9998889999*********888888766888*******************99999888888887 PP

Organism

Aspergillus fumigatus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pab1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MEADWDELSR IPVPPPSPHG LPTVATTIAF DDVSELLWAG NEFGRITSFY GPELQRYTSV 60
RAHPVSDGPV RQILFHERGV ISLSPKSVHM ITRRGLTQWH ISHEEMTDLY CMSFTAQLNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCCG ATTGGGACGA ATTGTCGCGC ATTCCGGTGC CTCCTCCAAG CCCGCATGGC 60
CTGCCGACCG TCGCGACGAC AATAGCATTC GACGATGTGT CAGAATTACT TTGGGCCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

afm:AFUA_2G04650

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.42	4.00e-148	517.00
IUUC-Apl-003500	Anas platyrhynchos	31.57	1.00e-131	462.00
IUUC-Aca-004930	Anolis carolinensis	31.40	7.00e-146	509.00
IUUC-Acl-008214	Aspergillus clavatus	92.89	0.00e+00	2201.00
IUUC-Ang-009531	Aspergillus niger	86.74	0.00e+00	2077.00
IUUC-Ame-011259	Astyanax mexicanus	31.15	3.00e-146	511.00
IUUC-Bta-012371	Bos taurus	31.77	8.00e-149	519.00
IUUC-Bci-013684	Botrytis cinerea	49.64	0.00e+00	1061.00
IUUC-Cja-019297	Callithrix jacchus	31.21	3.00e-147	514.00
IUUC-Cfa-020489	Canis familiaris	31.59	3.00e-147	514.00
IUUC-Cpo-022392	Cavia porcellus	31.57	1.00e-148	519.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.51	3.00e-147	514.00
IUUC-Csv-025841	Ciona savignyi	29.26	3.00e-119	421.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	51.28	0.00e+00	1145.00
IUUC-Cne-026932	Cryptococcus neoformans	34.09	2.00e-155	541.00
IUUC-Dre-028482	Danio rerio	28.40	2.00e-75	276.00
IUUC-Dno-029398	Dasypus novemcinctus	31.27	2.00e-148	518.00
IUUC-Dor-030307	Dipodomys ordii	31.35	2.00e-89	322.00
IUUC-Dme-032111	Drosophila melanogaster	28.78	2.00e-74	272.00
IUUC-Eca-033985	Equus caballus	31.59	1.00e-147	515.00
IUUC-Eeu-034928	Erinaceus europaeus	30.00	4.00e-40	158.00
IUUC-Fca-035587	Felis catus	31.53	6.00e-149	520.00
IUUC-Fal-037587	Ficedula albicollis	31.86	3.00e-146	511.00
IUUC-Fso-038133	Fusarium solani	45.94	0.00e+00	985.00
IUUC-Gmo-039076	Gadus morhua	27.92	2.00e-71	262.00
IUUC-Ggr-039957	Gaeumannomyces graminis	47.30	0.00e+00	1011.00
IUUC-Gga-040948	Gallus gallus	32.38	2.00e-145	508.00
IUUC-Gac-042396	Gasterosteus aculeatus	28.91	8.00e-78	284.00
IUUC-Ggo-045412	Gorilla gorilla	31.33	8.00e-148	516.00
IUUC-Hsa-046076	Homo sapiens	31.33	2.00e-147	515.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.31	3.00e-130	457.00
IUUC-Kpa-049178	Komagataella pastoris	33.30	7.00e-169	586.00
IUUC-Lch-050279	Latimeria chalumnae	39.43	1.00e-64	239.00
IUUC-Loc-052872	Lepisosteus oculatus	29.71	8.00e-77	280.00
IUUC-Lma-052986	Leptosphaeria maculans	52.66	0.00e+00	1201.00
IUUC-Laf-054181	Loxodonta africana	31.49	1.00e-146	512.00
IUUC-Mcc-054812	Macaca mulatta	31.71	1.00e-147	515.00
IUUC-Meu-056325	Macropus eugenii	31.60	1.00e-147	516.00
IUUC-Mor-057246	Magnaporthe oryzae	43.14	0.00e+00	868.00
IUUC-Mpo-057464	Magnaporthe poae	46.76	0.00e+00	1019.00
IUUC-Mla-058911	Melampsora laricipopulina	34.66	1.00e-164	572.00
IUUC-Mga-059335	Meleagris gallopavo	32.32	3.00e-145	508.00
IUUC-Mvi-060461	Microbotryum violaceum	34.43	5.00e-163	566.00
IUUC-Mmr-060636	Microcebus murinus	31.77	3.00e-146	511.00
IUUC-Mmu-063503	Mus musculus	31.39	5.00e-149	520.00
IUUC-Mpu-066670	Mustela putorius furo	31.51	9.00e-148	516.00
IUUC-Mlu-068119	Myotis lucifugus	31.47	1.00e-150	526.00
IUUC-Nfi-068398	Neosartorya fischeri	98.19	0.00e+00	2298.00
IUUC-Ncr-068927	Neurospora crassa	43.33	0.00e+00	882.00
IUUC-Nle-069651	Nomascus leucogenys	30.58	2.00e-141	495.00
IUUC-Opr-070614	Ochotona princeps	31.21	8.00e-146	509.00
IUUC-Ont-072433	Oreochromis niloticus	29.66	6.00e-80	291.00
IUUC-Oan-073283	Ornithorhynchus anatinus	40.63	3.00e-59	222.00
IUUC-Ocu-074401	Oryctolagus cuniculus	31.40	2.00e-146	512.00
IUUC-Ola-087522	Oryzias latipes	30.80	1.00e-145	509.00
IUUC-Oga-088226	Otolemur garnettii	31.58	5.00e-148	517.00
IUUC-Oar-089241	Ovis aries	31.83	2.00e-151	528.00
IUUC-Pan-092297	Papio anubis	31.63	3.00e-135	474.00
IUUC-Psi-094043	Pelodiscus sinensis	30.97	2.00e-134	472.00
IUUC-Pma-094394	Petromyzon marinus	30.37	6.00e-137	480.00
IUUC-Pno-095053	Phaeosphaeria nodorum	51.67	0.00e+00	1072.00
IUUC-Ppa-095188	Physcomitrella patens	28.25	2.00e-111	395.00
IUUC-Pfo-097517	Poecilia formosa	31.41	7.00e-147	513.00
IUUC-Pca-100471	Procavia capensis	31.52	8.00e-148	516.00
IUUC-Pva-102805	Pteropus vampyrus	32.48	3.00e-88	318.00
IUUC-Pte-104021	Pyrenophora teres	52.31	0.00e+00	1202.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	53.25	0.00e+00	1195.00
IUUC-Rno-105471	Rattus norvegicus	31.84	3.00e-150	524.00
IUUC-Sce-106235	Saccharomyces cerevisiae	31.04	1.00e-134	472.00
IUUC-Sha-106883	Sarcophilus harrisii	31.65	4.00e-142	497.00
IUUC-Spo-108169	Schizosaccharomyces pombe	35.89	0.00e+00	649.00
IUUC-Sar-113323	Sorex araneus	33.00	4.00e-119	421.00
IUUC-Sre-115075	Sporisorium reilianum	41.76	1.00e-65	244.00
IUUC-Ssc-116363	Sus scrofa	31.47	4.00e-144	504.00
IUUC-Tru-118427	Takifugu rubripes	30.89	2.00e-146	511.00
IUUC-Tni-120218	Tetraodon nigroviridis	28.90	4.00e-82	298.00
IUUC-Tre-122177	Trichoderma reesei	49.68	0.00e+00	1129.00
IUUC-Tme-127176	Tuber melanosporum	46.63	0.00e+00	921.00
IUUC-Tbe-127641	Tupaia belangeri	32.62	2.00e-28	119.00
IUUC-Ttr-128888	Tursiops truncatus	32.77	9.00e-97	347.00
IUUC-Uma-129361	Ustilago maydis	42.14	4.00e-66	245.00
IUUC-Xtr-132811	Xenopus tropicalis	28.22	1.00e-72	266.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence