iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-094043

Ensembl Protein ID

ENSPSIP00000003427.1

UniProt Accession

K7F5W7; K7F5W7_PELSI

Genbank Protein ID

ENSPSIP00000003427

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AGCU01140805

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000003267.1	ENSPSIT00000003444.1	ENSPSIP00000003427.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-19	69.9	525	915

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l ++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 525  NAYCNCMIQVLYFLEPVRCLVQN---HLCQK------EFCLGCELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlGLILADSDEAT 604
           56*********************...55654......57********************************999944599999999998 PP
   S: 97   afl.ldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
             + l +l ++ ++    + +++++e+e+ +  +    ++++  ++++s+i +lF  ++++  +c +c+++++r ++ l ++l+ p+++
   Q: 605  GKVnLGRLIQSWNRfiltQLHQETQEQEGPQ--AYRGVSSSSFGSSGDSVIGQLFSCEVENCSMC-RCGKETVRVSSTLLFTLSYPESN 690
           6554899999998866533333333333333..4455588999******************9999.8*******************887 PP
   S: 181  et.kkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts. 267
           ++    ++ ++L+       le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e+     k + ++ f++++  +  + + 
   Q: 691  DKtRDYEFAEILKRSIC---LEQNTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSSKEA--DFWKTQAEFAFKKTVMKKGGL-Ei 773
           65023355555554444...5666679***************************998854444..334777777777553333222.23 PP
   S: 268  ............................................................peekqkekkkYeLiavvvHsG.slssGHY 295
                                                                       ++++q++++ Y+L+a vvH      +G  
   Q: 774  pkrkeispgewkdlgnaeagpsypsleelkniwlpysirmkltknkeldvcnwiesdelsSSDDQDSTYVYDLMATVVHILdPRTGGSL 862
           4555566666667777777777777777777777777777766666666666666666664444444*************977789999 PP
   S: 296  vayvkn...........ekgkWllfdDskVtevkeeevleetg..staYvlfY 335
           v ++k            ++++W+lf+D  +++v++ e +++    + + +l+Y
   Q: 863  VGHIKVgetyhqrkegvTHQQWYLFNDFLIEPVDKCEAVQFDMnwKVPAILYY 915
           999*99999988877777888*********99998776665444555555555 PP

Organism

Pelodiscus sinensis

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEYAPTLHPA LDPVLDPHLN PSLLQNVELD PEGVPLEGIP VPESVHIMEG 60
MYSELHTVVS EVGVPVSTSH FDLHEEMLWV GNHGGHATSF FGPALERYSS FQVSSSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGCTCTG AGCGCGCCCT CTCATTGGTC CCGGTCCCTG CCAGGCGGAG GGAACCCTCA 60
GCCTGAGGAG TGGTTGAGCA GGCGGAGCCA GAGGCGCTGG AAGTTGCCAT GCCATTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	82.13	0.00e+00	1951.00
IUUC-Apl-003500	Anas platyrhynchos	89.20	0.00e+00	1932.00
IUUC-Aca-004930	Anolis carolinensis	87.31	0.00e+00	2054.00
IUUC-Acl-008214	Aspergillus clavatus	31.49	4.00e-148	519.00
IUUC-Afu-009112	Aspergillus fumigatus	31.13	6.00e-136	478.00
IUUC-Ang-009531	Aspergillus niger	30.65	1.00e-139	490.00
IUUC-Ame-011259	Astyanax mexicanus	74.67	0.00e+00	1772.00
IUUC-Bta-012371	Bos taurus	82.43	0.00e+00	1949.00
IUUC-Bci-013684	Botrytis cinerea	29.81	2.00e-115	410.00
IUUC-Cja-019297	Callithrix jacchus	79.34	0.00e+00	1890.00
IUUC-Cfa-020489	Canis familiaris	81.93	0.00e+00	1934.00
IUUC-Cpo-022392	Cavia porcellus	81.80	0.00e+00	1960.00
IUUC-Csa-023220	Chlorocebus sabaeus	82.46	0.00e+00	1959.00
IUUC-Csv-025841	Ciona savignyi	46.73	1.00e-134	474.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	29.73	3.00e-88	320.00
IUUC-Cne-026932	Cryptococcus neoformans	32.11	1.00e-121	430.00
IUUC-Dre-028482	Danio rerio	72.17	0.00e+00	1712.00
IUUC-Dno-029398	Dasypus novemcinctus	82.40	0.00e+00	1954.00
IUUC-Dor-030307	Dipodomys ordii	73.74	0.00e+00	1011.00
IUUC-Dme-032111	Drosophila melanogaster	41.08	0.00e+00	846.00
IUUC-Eca-033985	Equus caballus	82.43	0.00e+00	1954.00
IUUC-Eeu-034928	Erinaceus europaeus	75.10	0.00e+00	698.00
IUUC-Fca-035587	Felis catus	81.96	0.00e+00	1950.00
IUUC-Fal-037587	Ficedula albicollis	86.53	0.00e+00	2027.00
IUUC-Fso-038133	Fusarium solani	29.46	6.00e-121	428.00
IUUC-Gmo-039076	Gadus morhua	71.91	0.00e+00	1684.00
IUUC-Ggr-039957	Gaeumannomyces graminis	31.62	1.00e-129	457.00
IUUC-Gga-040948	Gallus gallus	89.22	0.00e+00	2107.00
IUUC-Gac-042396	Gasterosteus aculeatus	72.24	0.00e+00	1731.00
IUUC-Ggo-045412	Gorilla gorilla	81.96	0.00e+00	1948.00
IUUC-Hsa-046076	Homo sapiens	82.13	0.00e+00	1953.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	75.92	0.00e+00	1748.00
IUUC-Kpa-049178	Komagataella pastoris	39.47	7.00e-59	222.00
IUUC-Lch-050279	Latimeria chalumnae	77.76	0.00e+00	930.00
IUUC-Loc-052872	Lepisosteus oculatus	75.58	0.00e+00	1774.00
IUUC-Lma-052986	Leptosphaeria maculans	31.37	4.00e-91	329.00
IUUC-Laf-054181	Loxodonta africana	80.66	0.00e+00	1902.00
IUUC-Mcc-054812	Macaca mulatta	82.35	0.00e+00	1948.00
IUUC-Meu-056325	Macropus eugenii	84.19	0.00e+00	1991.00
IUUC-Mor-057246	Magnaporthe oryzae	28.80	5.00e-110	392.00
IUUC-Mpo-057464	Magnaporthe poae	31.75	1.00e-134	474.00
IUUC-Mla-058911	Melampsora laricipopulina	32.19	2.00e-85	311.00
IUUC-Mga-059335	Meleagris gallopavo	89.45	0.00e+00	2017.00
IUUC-Mvi-060461	Microbotryum violaceum	33.46	2.00e-134	473.00
IUUC-Mmr-060636	Microcebus murinus	82.60	0.00e+00	1952.00
IUUC-Mmu-063503	Mus musculus	80.55	0.00e+00	1908.00
IUUC-Mpu-066670	Mustela putorius furo	82.35	0.00e+00	1948.00
IUUC-Mlu-068119	Myotis lucifugus	81.88	0.00e+00	1975.00
IUUC-Nfi-068398	Neosartorya fischeri	31.98	2.00e-145	510.00
IUUC-Ncr-068927	Neurospora crassa	28.82	1.00e-116	414.00
IUUC-Nle-069651	Nomascus leucogenys	78.77	0.00e+00	1842.00
IUUC-Opr-070614	Ochotona princeps	80.85	0.00e+00	1899.00
IUUC-Ont-072433	Oreochromis niloticus	73.16	0.00e+00	1764.00
IUUC-Oan-073283	Ornithorhynchus anatinus	68.74	0.00e+00	1299.00
IUUC-Ocu-074401	Oryctolagus cuniculus	80.73	0.00e+00	1939.00
IUUC-Ola-087522	Oryzias latipes	73.13	0.00e+00	1719.00
IUUC-Oga-088226	Otolemur garnettii	81.17	0.00e+00	1943.00
IUUC-Oar-089241	Ovis aries	82.41	0.00e+00	1956.00
IUUC-Pan-092297	Papio anubis	81.73	0.00e+00	1723.00
IUUC-Pma-094394	Petromyzon marinus	66.06	0.00e+00	1466.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.75	2.00e-136	480.00
IUUC-Ppa-095188	Physcomitrella patens	30.91	1.00e-147	517.00
IUUC-Pfo-097517	Poecilia formosa	73.95	0.00e+00	1773.00
IUUC-Pca-100471	Procavia capensis	81.80	0.00e+00	1799.00
IUUC-Pva-102805	Pteropus vampyrus	76.98	0.00e+00	1483.00
IUUC-Pte-104021	Pyrenophora teres	31.65	5.00e-149	521.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	31.47	4.00e-148	518.00
IUUC-Rno-105471	Rattus norvegicus	80.82	0.00e+00	1914.00
IUUC-Sce-106235	Saccharomyces cerevisiae	36.84	8.00e-52	199.00
IUUC-Sha-106883	Sarcophilus harrisii	82.90	0.00e+00	1823.00
IUUC-Spo-108169	Schizosaccharomyces pombe	31.53	1.00e-131	464.00
IUUC-Sar-113323	Sorex araneus	80.22	0.00e+00	1405.00
IUUC-Sre-115075	Sporisorium reilianum	29.62	1.00e-58	222.00
IUUC-Ssc-116363	Sus scrofa	81.59	0.00e+00	1942.00
IUUC-Tru-118427	Takifugu rubripes	73.85	0.00e+00	1816.00
IUUC-Tni-120218	Tetraodon nigroviridis	74.14	0.00e+00	1807.00
IUUC-Tre-122177	Trichoderma reesei	30.27	2.00e-139	490.00
IUUC-Tme-127176	Tuber melanosporum	31.20	9.00e-126	444.00
IUUC-Tbe-127641	Tupaia belangeri	78.30	0.00e+00	725.00
IUUC-Ttr-128888	Tursiops truncatus	78.80	0.00e+00	1169.00
IUUC-Uma-129361	Ustilago maydis	39.18	2.00e-54	208.00
IUUC-Xtr-132811	Xenopus tropicalis	79.87	0.00e+00	1896.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence