iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035860

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02006328

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000000253.3	ENSFCAT00000000253.3	ENSFCAP00000000232.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-66	216.2	199	242
UBD/Beta-Prp	1.60e-79	267.2	108	304

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 199  GHSKWITGLSWeplhvnPEcRYVASSSKDGSVRVWDTTVGRCER 242
           8***************9889*********************986 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t +gh + vls+s+sp+g+kl+sG +   i +wd +tg+ +  +
   Q: 108  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRP 196
           5799************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 197  LAGHSKWITGLSWeplhvNPECRYVASSSKDGSVRVWDTTVGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 283
           *********98652222278899**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlv 238
           tl+gh  +v+ +++s  d  l 
   Q: 284  TLQGHGHWVNTMALS-TDYALR 304
           **************9.444444 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MAAAAAAQDE AAARDVQRLL VQFQDEGGQL LGSPFDVPVD ITPDKLQLVC NALLAQEDPV 60
PLAFFVHDAE IVSSLGKTLE SQAVETEKVL DIIYQPQAIF RVRAVTRCTS SLEGHSEAVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG CGGCGGCGGT GGGTGTGAGT GAATGGGAGT GGGGGCGCTC CGGCCCGGGG 60
TCCCCGAGCT CAGAGGGAAG CGGCAGTGGG GGCCTTCCAG CCCGGCGGCG TGGCTGACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005840--C:ribosome
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0000027--P:ribosomal large subunit assembly
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	57.73	4.00e-169	587.00
IUUC-Aml-001793	Ailuropoda melanoleuca	96.41	0.00e+00	940.00
IUUC-Atr-002507	Amborella trichopoda	58.64	2.00e-168	585.00
IUUC-Apl-003964	Anas platyrhynchos	84.80	0.00e+00	813.00
IUUC-Aly-006396	Arabidopsis lyrata	54.26	8.00e-161	560.00
IUUC-Ath-007278	Arabidopsis thaliana	54.47	1.00e-160	559.00
IUUC-Ago-007951	Ashbya gossypii	48.05	2.00e-128	452.00
IUUC-Acl-008298	Aspergillus clavatus	47.29	1.00e-120	426.00
IUUC-Afl-008581	Aspergillus flavus	51.94	7.00e-109	387.00
IUUC-Afu-008906	Aspergillus fumigatus	46.68	3.00e-120	425.00
IUUC-Ani-009189	Aspergillus nidulans	44.62	5.00e-117	414.00
IUUC-Ang-009630	Aspergillus niger	47.39	3.00e-123	435.00
IUUC-Aor-010038	Aspergillus oryzae	47.41	9.00e-127	446.00
IUUC-Ate-010278	Aspergillus terreus	46.80	4.00e-121	428.00
IUUC-Ame-011890	Astyanax mexicanus	80.97	0.00e+00	823.00
IUUC-Bgr-012011	Blumeria graminis	48.24	2.00e-130	459.00
IUUC-Bta-012964	Bos taurus	96.41	0.00e+00	941.00
IUUC-Bci-013592	Botrytis cinerea	45.34	6.00e-121	427.00
IUUC-Bdi-015035	Brachypodium distachyon	58.03	8.00e-171	593.00
IUUC-Bol-015501	Brassica oleracea	55.34	5.00e-161	560.00
IUUC-Bra-017642	Brassica rapa	55.13	2.00e-160	558.00
IUUC-Cel-018430	Caenorhabditis elegans	58.15	8.00e-167	579.00
IUUC-Cja-019125	Callithrix jacchus	95.99	0.00e+00	937.00
IUUC-Cfa-021013	Canis familiaris	95.61	0.00e+00	854.00
IUUC-Cpo-021743	Cavia porcellus	94.71	0.00e+00	931.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	46.07	8.00e-116	410.00
IUUC-Csa-024270	Chlorocebus sabaeus	96.41	0.00e+00	942.00
IUUC-Cin-025795	Ciona intestinalis	65.67	0.00e+00	681.00
IUUC-Csv-025953	Ciona savignyi	66.74	0.00e+00	681.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.46	4.00e-108	384.00
IUUC-Cne-026901	Cryptococcus neoformans	49.11	4.00e-139	488.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.47	2.00e-114	406.00
IUUC-Dre-028515	Danio rerio	78.22	0.00e+00	802.00
IUUC-Dno-029596	Dasypus novemcinctus	96.41	0.00e+00	938.00
IUUC-Dor-030494	Dipodomys ordii	95.13	0.00e+00	927.00
IUUC-Dse-031538	Dothistroma septosporum	47.62	1.00e-128	453.00
IUUC-Dme-031974	Drosophila melanogaster	60.04	8.00e-170	590.00
IUUC-Ete-032948	Echinops telfairi	96.17	3.00e-117	415.00
IUUC-Eca-033399	Equus caballus	97.24	0.00e+00	942.00
IUUC-Eeu-035013	Erinaceus europaeus	97.50	2.00e-115	409.00
IUUC-Fal-037069	Ficedula albicollis	87.25	4.00e-131	460.00
IUUC-Fox-038059	Fusarium oxysporum	46.25	1.00e-125	442.00
IUUC-Fso-038445	Fusarium solani	46.56	6.00e-126	444.00
IUUC-Gmo-039319	Gadus morhua	75.32	0.00e+00	731.00
IUUC-Ggr-040095	Gaeumannomyces graminis	47.18	5.00e-122	431.00
IUUC-Gga-040303	Gallus gallus	85.26	2.00e-129	454.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.90	0.00e+00	765.00
IUUC-Gma-043974	Glycine max	57.02	2.00e-170	592.00
IUUC-Ggo-044637	Gorilla gorilla	96.60	0.00e+00	934.00
IUUC-Hsa-046128	Homo sapiens	96.62	0.00e+00	944.00
IUUC-Hvu-047373	Hordeum vulgare	57.17	1.00e-168	585.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	96.03	0.00e+00	939.00
IUUC-Kpa-049274	Komagataella pastoris	44.67	4.00e-126	444.00
IUUC-Lch-049907	Latimeria chalumnae	82.18	0.00e+00	818.00
IUUC-Lpe-050778	Leersia perrieri	53.24	2.00e-152	532.00
IUUC-Loc-051889	Lepisosteus oculatus	80.34	0.00e+00	823.00
IUUC-Lma-053041	Leptosphaeria maculans	49.65	1.00e-117	416.00
IUUC-Laf-053598	Loxodonta africana	96.84	0.00e+00	946.00
IUUC-Mcc-055660	Macaca mulatta	96.20	0.00e+00	940.00
IUUC-Meu-056197	Macropus eugenii	80.38	0.00e+00	775.00
IUUC-Mor-056949	Magnaporthe oryzae	46.17	2.00e-119	422.00
IUUC-Mpo-057571	Magnaporthe poae	44.90	2.00e-63	236.00
IUUC-Mtr-058530	Medicago truncatula	57.45	3.00e-165	574.00
IUUC-Mla-059133	Melampsora laricipopulina	46.54	5.00e-124	437.00
IUUC-Mga-059252	Meleagris gallopavo	84.11	0.00e+00	657.00
IUUC-Mvi-060522	Microbotryum violaceum	49.80	2.00e-135	475.00
IUUC-Mmr-061117	Microcebus murinus	95.37	0.00e+00	929.00
IUUC-Mdo-062892	Monodelphis domestica	89.85	0.00e+00	892.00
IUUC-Mmu-064108	Mus musculus	95.14	0.00e+00	907.00
IUUC-Mac-064430	Musa acuminata	59.10	2.00e-173	601.00
IUUC-Mpu-065882	Mustela putorius furo	96.62	0.00e+00	940.00
IUUC-Mlu-068123	Myotis lucifugus	96.20	0.00e+00	943.00
IUUC-Nfi-068484	Neosartorya fischeri	47.18	3.00e-120	425.00
IUUC-Ncr-068649	Neurospora crassa	43.87	2.00e-116	412.00
IUUC-Nle-069140	Nomascus leucogenys	96.39	0.00e+00	933.00
IUUC-Opr-070220	Ochotona princeps	87.90	0.00e+00	814.00
IUUC-Ont-072643	Oreochromis niloticus	80.21	0.00e+00	817.00
IUUC-Ocu-074007	Oryctolagus cuniculus	95.56	0.00e+00	909.00
IUUC-Oba-075904	Oryza barthii	58.46	4.00e-172	597.00
IUUC-Obr-076618	Oryza brachyantha	58.24	7.00e-171	593.00
IUUC-Ogl-077425	Oryza glaberrima	58.46	3.00e-172	598.00
IUUC-Ogu-078586	Oryza glumaepatula	58.46	4.00e-172	597.00
IUUC-Oin-079489	Oryza indica	56.32	3.00e-163	568.00
IUUC-Olo-080766	Oryza longistaminata	58.33	4.00e-172	597.00
IUUC-Ome-081905	Oryza meridionalis	58.46	4.00e-172	597.00
IUUC-Oni-083022	Oryza nivara	58.46	2.00e-172	598.00
IUUC-Opu-083615	Oryza punctata	58.46	3.00e-172	597.00
IUUC-Oru-085076	Oryza rufipogon	58.46	2.00e-172	598.00
IUUC-Osa-085744	Oryza sativa	58.67	1.00e-172	599.00
IUUC-Ola-087290	Oryzias latipes	78.11	0.00e+00	800.00
IUUC-Olu-087898	Ostreococcus lucimarinus	52.41	5.00e-144	504.00
IUUC-Oga-088980	Otolemur garnettii	95.12	0.00e+00	925.00
IUUC-Oar-089580	Ovis aries	96.83	0.00e+00	820.00
IUUC-Ptr-090845	Pan troglodytes	95.97	0.00e+00	927.00
IUUC-Pan-092836	Papio anubis	96.41	0.00e+00	943.00
IUUC-Psi-093965	Pelodiscus sinensis	82.46	5.00e-56	208.00
IUUC-Pno-095052	Phaeosphaeria nodorum	47.02	7.00e-123	434.00
IUUC-Ppa-095432	Physcomitrella patens	58.64	2.00e-171	595.00
IUUC-Pfo-096963	Poecilia formosa	71.58	0.00e+00	700.00
IUUC-Pab-097716	Pongo abelii	92.57	0.00e+00	888.00
IUUC-Pop-099224	Populus trichocarpa	57.87	3.00e-170	591.00
IUUC-Pca-100682	Procavia capensis	92.68	0.00e+00	676.00
IUUC-Ppe-101819	Prunus persica	58.21	2.00e-169	588.00
IUUC-Pva-102338	Pteropus vampyrus	97.21	0.00e+00	721.00
IUUC-Pgr-103583	Puccinia graminis	55.23	1.00e-133	469.00
IUUC-Ptt-103737	Puccinia triticina	44.80	2.00e-100	359.00
IUUC-Pte-104150	Pyrenophora teres	49.55	9.00e-121	426.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	49.32	1.00e-120	426.00
IUUC-Rno-105987	Rattus norvegicus	94.70	0.00e+00	928.00
IUUC-Sce-106315	Saccharomyces cerevisiae	47.26	3.00e-129	455.00
IUUC-Sha-107273	Sarcophilus harrisii	90.27	0.00e+00	898.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	46.96	1.00e-119	423.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.51	4.00e-123	434.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	44.70	8.00e-117	414.00
IUUC-Smo-108855	Selaginella moellendorffii	56.06	8.00e-164	570.00
IUUC-Sit-110329	Setaria italica	58.89	4.00e-172	598.00
IUUC-Sly-111830	Solanum lycopersicum	59.53	2.00e-174	604.00
IUUC-Stu-112603	Solanum tuberosum	59.53	3.00e-174	604.00
IUUC-Sar-113504	Sorex araneus	93.66	1.00e-74	273.00
IUUC-Sbi-114560	Sorghum bicolor	57.82	8.00e-169	586.00
IUUC-Sre-115133	Sporisorium reilianum	41.79	2.00e-124	439.00
IUUC-Ssc-115903	Sus scrofa	97.26	0.00e+00	946.00
IUUC-Tgu-116798	Taeniopygia guttata	85.41	0.00e+00	856.00
IUUC-Tru-118361	Takifugu rubripes	78.32	0.00e+00	800.00
IUUC-Tsy-118849	Tarsius syrichta	96.38	0.00e+00	933.00
IUUC-Tni-120094	Tetraodon nigroviridis	78.90	0.00e+00	802.00
IUUC-Tca-121634	Theobroma cacao	57.66	4.00e-168	584.00
IUUC-Tre-122051	Trichoderma reesei	46.04	5.00e-119	421.00
IUUC-Tvi-122322	Trichoderma virens	47.50	3.00e-123	435.00
IUUC-Tae-125822	Triticum aestivum	57.60	3.00e-169	588.00
IUUC-Tur-126766	Triticum urartu	51.43	5.00e-161	560.00
IUUC-Tme-127175	Tuber melanosporum	51.37	4.00e-132	464.00
IUUC-Tbe-127779	Tupaia belangeri	94.85	0.00e+00	825.00
IUUC-Ttr-128224	Tursiops truncatus	91.82	0.00e+00	810.00
IUUC-Uma-129537	Ustilago maydis	41.82	4.00e-125	441.00
IUUC-Vda-129927	Verticillium dahliae	45.61	1.00e-110	393.00
IUUC-Vpa-130658	Vicugna pacos	83.65	0.00e+00	791.00
IUUC-Vvi-131659	Vitis vinifera	58.00	4.00e-171	594.00
IUUC-Xtr-132918	Xenopus tropicalis	77.68	0.00e+00	791.00
IUUC-Xma-133700	Xiphophorus maculatus	80.00	0.00e+00	812.00
IUUC-Yli-134478	Yarrowia lipolytica	49.49	1.00e-138	486.00
IUUC-Zma-135835	Zea mays	55.38	8.00e-166	576.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence