iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005263

UUCD1 version

UUC-AnC-00531

Ensembl Protein ID

ENSACAP00000004464.3

UniProt Accession

G1KCY0; G1KCY0_ANOCA

Protein Name

Uncharacterized protein

Gene Name

HUWE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000004234.3	ENSACAT00000004565.3	ENSACAP00000004464.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-122	409.3	4105	4439
UBD/Alpha-Helix/UBA	5.70e-08	32.6	1380	1417

Active Site

Position(s)	Description	Evidence
4407	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 4105 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 4190
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4191 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4274
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4275 LVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQANSIQIQWFWRALRSFDQADRA 4360
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s+e+l+++Ll+Ai+e+ +gF+l
   Q: 4361 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECsEGFGL 4439
           *********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1380 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1417
           89**********************.7***********98 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLL CDRPEREQLK SLLLSVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGGACCAGG AAGCCGAAAA ATCATAAAAA TGAAAGTGGA CCGAACTAAG CTGAAGAAAA 60
CGCCTACTGA GGCTGTAAGT ATCAGTTTTG TGATCTTGAG TTTCCTGTAG AAACACCATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA
SM00678--WWE

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006284--P:base-excision repair
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	41.03	8.00e-107	383.00
IUUC-Aml-001684	Ailuropoda melanoleuca	92.49	0.00e+00	3148.00
IUUC-Atr-003044	Amborella trichopoda	52.93	1.00e-126	449.00
IUUC-Apl-003729	Anas platyrhynchos	93.54	0.00e+00	696.00
IUUC-Aly-006083	Arabidopsis lyrata	51.99	5.00e-127	451.00
IUUC-Ath-007472	Arabidopsis thaliana	51.99	2.00e-127	451.00
IUUC-Ago-008005	Ashbya gossypii	46.06	1.00e-132	469.00
IUUC-Acl-008254	Aspergillus clavatus	46.83	4.00e-135	477.00
IUUC-Afl-008712	Aspergillus flavus	45.75	3.00e-137	483.00
IUUC-Afu-009022	Aspergillus fumigatus	46.64	1.00e-134	476.00
IUUC-Ani-009412	Aspergillus nidulans	47.20	1.00e-136	483.00
IUUC-Ang-009771	Aspergillus niger	47.20	2.00e-135	479.00
IUUC-Aor-010186	Aspergillus oryzae	45.02	3.00e-127	450.00
IUUC-Ate-010253	Aspergillus terreus	46.32	6.00e-136	480.00
IUUC-Ame-011067	Astyanax mexicanus	81.13	0.00e+00	3697.00
IUUC-Bgr-012043	Blumeria graminis	46.80	1.00e-139	492.00
IUUC-Bta-012813	Bos taurus	92.08	0.00e+00	3170.00
IUUC-Bci-013995	Botrytis cinerea	46.34	1.00e-138	489.00
IUUC-Bdi-014884	Brachypodium distachyon	51.99	1.00e-127	452.00
IUUC-Bol-016533	Brassica oleracea	58.33	3.00e-89	320.00
IUUC-Bra-016637	Brassica rapa	43.49	1.00e-124	442.00
IUUC-Cel-018179	Caenorhabditis elegans	61.72	0.00e+00	648.00
IUUC-Cja-018741	Callithrix jacchus	92.34	0.00e+00	3161.00
IUUC-Cfa-020083	Canis familiaris	91.84	0.00e+00	4149.00
IUUC-Cpo-021923	Cavia porcellus	91.77	0.00e+00	3147.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	49.42	3.00e-120	424.00
IUUC-Csa-023853	Chlorocebus sabaeus	92.44	0.00e+00	3167.00
IUUC-Cho-024718	Choloepus hoffmanni	99.47	0.00e+00	813.00
IUUC-Cin-025627	Ciona intestinalis	41.25	0.00e+00	1889.00
IUUC-Csv-025824	Ciona savignyi	43.81	0.00e+00	892.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	45.31	4.00e-138	487.00
IUUC-Cne-027095	Cryptococcus neoformans	41.59	2.00e-106	381.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.24	4.00e-116	413.00
IUUC-Dre-028525	Danio rerio	82.46	0.00e+00	3665.00
IUUC-Dno-029680	Dasypus novemcinctus	91.35	0.00e+00	3100.00
IUUC-Dor-030902	Dipodomys ordii	92.29	0.00e+00	1157.00
IUUC-Dse-031197	Dothistroma septosporum	46.76	2.00e-139	492.00
IUUC-Dme-032122	Drosophila melanogaster	68.19	0.00e+00	793.00
IUUC-Ete-032690	Echinops telfairi	87.86	0.00e+00	1232.00
IUUC-Eca-033915	Equus caballus	91.98	0.00e+00	3153.00
IUUC-Eeu-034963	Erinaceus europaeus	87.57	0.00e+00	1843.00
IUUC-Fca-035824	Felis catus	92.44	0.00e+00	3158.00
IUUC-Fox-037756	Fusarium oxysporum	46.08	3.00e-138	488.00
IUUC-Fso-038464	Fusarium solani	54.72	1.00e-137	485.00
IUUC-Gmo-039073	Gadus morhua	81.73	0.00e+00	2758.00
IUUC-Ggr-039946	Gaeumannomyces graminis	44.82	2.00e-135	478.00
IUUC-Gga-040309	Gallus gallus	98.70	0.00e+00	657.00
IUUC-Gac-042430	Gasterosteus aculeatus	81.66	0.00e+00	3711.00
IUUC-Gma-043129	Glycine max	47.70	7.00e-127	450.00
IUUC-Ggo-044785	Gorilla gorilla	92.60	0.00e+00	3138.00
IUUC-Hsa-046879	Homo sapiens	92.65	0.00e+00	3143.00
IUUC-Hvu-047697	Hordeum vulgare	44.99	4.00e-128	454.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	96.44	0.00e+00	1457.00
IUUC-Kpa-049228	Komagataella pastoris	48.96	2.00e-141	498.00
IUUC-Lch-050252	Latimeria chalumnae	88.29	0.00e+00	2955.00
IUUC-Lpe-051550	Leersia perrieri	51.99	2.00e-127	452.00
IUUC-Loc-052472	Lepisosteus oculatus	84.28	0.00e+00	3772.00
IUUC-Lma-053159	Leptosphaeria maculans	44.62	3.00e-137	484.00
IUUC-Laf-054154	Loxodonta africana	91.56	0.00e+00	3126.00
IUUC-Mcc-055085	Macaca mulatta	91.66	0.00e+00	4121.00
IUUC-Meu-056727	Macropus eugenii	87.39	0.00e+00	1977.00
IUUC-Mor-057201	Magnaporthe oryzae	45.60	5.00e-136	480.00
IUUC-Mpo-057597	Magnaporthe poae	45.36	4.00e-134	474.00
IUUC-Mtr-058273	Medicago truncatula	52.69	5.00e-127	450.00
IUUC-Mla-058888	Melampsora laricipopulina	49.37	1.00e-116	412.00
IUUC-Mvi-060320	Microbotryum violaceum	40.46	2.00e-124	442.00
IUUC-Mmr-060820	Microcebus murinus	91.58	0.00e+00	4121.00
IUUC-Mdo-062930	Monodelphis domestica	91.64	0.00e+00	4143.00
IUUC-Mmu-063601	Mus musculus	92.49	0.00e+00	3074.00
IUUC-Mac-065557	Musa acuminata	52.33	2.00e-119	425.00
IUUC-Mpu-066653	Mustela putorius furo	89.95	0.00e+00	3028.00
IUUC-Mlu-067418	Myotis lucifugus	92.24	0.00e+00	3224.00
IUUC-Nfi-068278	Neosartorya fischeri	46.83	3.00e-135	478.00
IUUC-Ncr-068813	Neurospora crassa	45.88	5.00e-138	487.00
IUUC-Nle-069418	Nomascus leucogenys	92.34	0.00e+00	3116.00
IUUC-Opr-070187	Ochotona princeps	83.82	0.00e+00	883.00
IUUC-Ont-071300	Oreochromis niloticus	81.92	0.00e+00	3686.00
IUUC-Oan-073046	Ornithorhynchus anatinus	86.72	0.00e+00	4333.00
IUUC-Ocu-074178	Oryctolagus cuniculus	92.34	0.00e+00	3202.00
IUUC-Oba-075757	Oryza barthii	51.76	2.00e-127	451.00
IUUC-Obr-076553	Oryza brachyantha	51.76	2.00e-126	448.00
IUUC-Ogl-077520	Oryza glaberrima	51.76	2.00e-127	451.00
IUUC-Ogu-078278	Oryza glumaepatula	51.76	2.00e-127	452.00
IUUC-Oin-079767	Oryza indica	51.76	2.00e-127	452.00
IUUC-Olo-080380	Oryza longistaminata	51.28	1.00e-125	446.00
IUUC-Ome-081925	Oryza meridionalis	51.28	1.00e-125	446.00
IUUC-Oni-082619	Oryza nivara	51.76	2.00e-127	452.00
IUUC-Opu-083684	Oryza punctata	51.28	1.00e-125	446.00
IUUC-Oru-084501	Oryza rufipogon	51.76	2.00e-127	451.00
IUUC-Osa-086251	Oryza sativa	51.76	9.00e-126	444.00
IUUC-Ola-087437	Oryzias latipes	84.39	0.00e+00	1882.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.50	3.00e-114	405.00
IUUC-Oga-088903	Otolemur garnettii	92.23	0.00e+00	3141.00
IUUC-Oar-090210	Ovis aries	91.43	0.00e+00	4121.00
IUUC-Ptr-090502	Pan troglodytes	92.65	0.00e+00	3138.00
IUUC-Pan-092368	Papio anubis	90.87	0.00e+00	4142.00
IUUC-Pma-094246	Petromyzon marinus	74.60	0.00e+00	1281.00
IUUC-Pno-094871	Phaeosphaeria nodorum	53.23	1.00e-135	479.00
IUUC-Ppa-095657	Physcomitrella patens	51.58	6.00e-126	447.00
IUUC-Pfo-096232	Poecilia formosa	81.05	0.00e+00	3703.00
IUUC-Pab-098583	Pongo abelii	92.65	0.00e+00	3142.00
IUUC-Pop-099613	Populus trichocarpa	52.93	4.00e-128	453.00
IUUC-Pca-100310	Procavia capensis	80.84	0.00e+00	1137.00
IUUC-Ppe-102109	Prunus persica	52.46	4.00e-127	451.00
IUUC-Pva-102116	Pteropus vampyrus	92.34	0.00e+00	3207.00
IUUC-Pgr-103465	Puccinia graminis	43.48	5.00e-128	454.00
IUUC-Ptt-103813	Puccinia triticina	41.40	1.00e-115	412.00
IUUC-Pte-104018	Pyrenophora teres	52.85	2.00e-134	475.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.87	4.00e-134	474.00
IUUC-Rno-105889	Rattus norvegicus	83.05	0.00e+00	2685.00
IUUC-Sce-106449	Saccharomyces cerevisiae	44.83	1.00e-129	459.00
IUUC-Sha-106961	Sarcophilus harrisii	90.14	0.00e+00	4100.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.73	9.00e-129	456.00
IUUC-Spo-108024	Schizosaccharomyces pombe	45.87	7.00e-132	466.00
IUUC-Smo-109640	Selaginella moellendorffii	50.77	9.00e-131	462.00
IUUC-Sit-110598	Setaria italica	52.46	4.00e-128	454.00
IUUC-Sly-111285	Solanum lycopersicum	51.67	6.00e-128	453.00
IUUC-Stu-112582	Solanum tuberosum	32.35	7.00e-57	215.00
IUUC-Sar-113291	Sorex araneus	87.22	0.00e+00	2537.00
IUUC-Sbi-114042	Sorghum bicolor	52.46	2.00e-128	455.00
IUUC-Sre-114958	Sporisorium reilianum	48.45	6.00e-140	490.00
IUUC-Ssc-115754	Sus scrofa	92.60	0.00e+00	3160.00
IUUC-Tru-118570	Takifugu rubripes	80.94	0.00e+00	2829.00
IUUC-Tsy-119159	Tarsius syrichta	90.72	0.00e+00	1855.00
IUUC-Tni-120836	Tetraodon nigroviridis	77.62	0.00e+00	1999.00
IUUC-Tca-121479	Theobroma cacao	51.52	3.00e-125	444.00
IUUC-Tre-121909	Trichoderma reesei	53.65	1.00e-133	473.00
IUUC-Tvi-122370	Trichoderma virens	53.41	1.00e-133	473.00
IUUC-Tae-125214	Triticum aestivum	51.04	7.00e-126	446.00
IUUC-Tme-127172	Tuber melanosporum	46.50	7.00e-142	499.00
IUUC-Tbe-127506	Tupaia belangeri	88.04	0.00e+00	1338.00
IUUC-Ttr-129253	Tursiops truncatus	83.79	0.00e+00	1970.00
IUUC-Uma-129355	Ustilago maydis	48.18	8.00e-142	496.00
IUUC-Vda-129886	Verticillium dahliae	47.63	3.00e-139	491.00
IUUC-Vpa-130708	Vicugna pacos	91.10	0.00e+00	2672.00
IUUC-Vvi-131170	Vitis vinifera	51.22	2.00e-127	450.00
IUUC-Xtr-132123	Xenopus tropicalis	88.68	0.00e+00	3040.00
IUUC-Xma-133869	Xiphophorus maculatus	81.05	0.00e+00	3728.00
IUUC-Yli-134657	Yarrowia lipolytica	45.82	3.00e-131	464.00
IUUC-Zma-135570	Zea mays	44.58	8.00e-129	456.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence