iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007838

Ensembl Protein ID

AAS52979

UniProt Accession

Q756G8; ATG7_ASHGO

Genbank Protein ID

AAS52979.1

Protein Name

Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7

Genbank Nucleotide ID

AE016818

Gene Name

ATG7; AER298C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AER298C	AAS52979	AAS52979

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	51.19	1.00e-179	624.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
498	Glycyl thioester intermediate	{ECO:0000250}

Organism

Ashbya gossypii

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).

Protein Sequence
(Fasta)

MSQSLKFAPP FQSFVDASFF QVFSRLKLDV LRLDSHELPL HAKVDLAGLA RGSSISHVFL 60
DSQSFDEATA SLPGISLRGS FFNFNTLEEF KRLDKGRFLS EQAQLLWEAG VNGYLDEAAG 120

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Nucleotide Sequence
(Fasta)

ATGAGCCAGT CGTTGAAATT CGCTCCTCCA TTCCAGTCTT TTGTGGACGC TTCCTTCTTT 60
CAAGTATTCT CCCGTTTGAA GCTTGATGTT TTGAGGCTCG ACTCACATGA GCTGCCGCTA 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0097632--C:extrinsic component of pre-autophagosomal structure membrane
GO:0005634--C:nucleus
GO:0019778--F:Atg12 activating enzyme activity
GO:0019779--F:Atg8 activating enzyme activity
GO:0006501--P:C-terminal protein lipidation
GO:0032258--P:CVT pathway
GO:0044805--P:late nucleophagy
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0032446--P:protein modification by small protein conjugation

KEGG

ago:AGOS_AER298C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	30.63	6.00e-68	250.00
IUUC-Aml-002316	Ailuropoda melanoleuca	40.10	6.00e-116	409.00
IUUC-Atr-002579	Amborella trichopoda	38.76	3.00e-112	396.00
IUUC-Apl-003805	Anas platyrhynchos	38.38	4.00e-120	423.00
IUUC-Aca-004618	Anolis carolinensis	38.94	6.00e-106	375.00
IUUC-Aly-005670	Arabidopsis lyrata	37.30	1.00e-92	332.00
IUUC-Ath-007499	Arabidopsis thaliana	38.64	2.00e-96	344.00
IUUC-Acl-008093	Aspergillus clavatus	48.32	4.00e-109	386.00
IUUC-Afl-008663	Aspergillus flavus	47.77	3.00e-117	413.00
IUUC-Afu-008926	Aspergillus fumigatus	49.42	8.00e-106	375.00
IUUC-Ani-009156	Aspergillus nidulans	40.47	6.00e-123	432.00
IUUC-Ang-009853	Aspergillus niger	50.83	6.00e-61	224.00
IUUC-Aor-010055	Aspergillus oryzae	48.71	3.00e-115	406.00
IUUC-Ate-010281	Aspergillus terreus	42.69	2.00e-98	351.00
IUUC-Ame-010939	Astyanax mexicanus	38.52	4.00e-122	429.00
IUUC-Bgr-012006	Blumeria graminis	38.65	2.00e-121	427.00
IUUC-Bta-012336	Bos taurus	38.14	8.00e-113	399.00
IUUC-Bci-013598	Botrytis cinerea	49.20	3.00e-118	416.00
IUUC-Bdi-014170	Brachypodium distachyon	42.22	6.00e-66	243.00
IUUC-Bol-015357	Brassica oleracea	38.26	8.00e-102	362.00
IUUC-Bra-016835	Brassica rapa	38.34	5.00e-101	359.00
IUUC-Cel-018172	Caenorhabditis elegans	38.42	6.00e-107	379.00
IUUC-Cja-019544	Callithrix jacchus	38.70	2.00e-121	427.00
IUUC-Cfa-021043	Canis familiaris	38.73	8.00e-119	419.00
IUUC-Cpo-022366	Cavia porcellus	38.47	3.00e-118	416.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	34.22	1.00e-69	255.00
IUUC-Csa-023373	Chlorocebus sabaeus	38.79	1.00e-121	427.00
IUUC-Cho-024965	Choloepus hoffmanni	55.03	3.00e-40	157.00
IUUC-Cin-025710	Ciona intestinalis	40.39	2.00e-128	450.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	40.15	2.00e-128	451.00
IUUC-Cne-027083	Cryptococcus neoformans	40.40	1.00e-115	408.00
IUUC-Dre-028740	Danio rerio	36.13	2.00e-102	364.00
IUUC-Dno-029637	Dasypus novemcinctus	40.00	1.00e-117	414.00
IUUC-Dor-030492	Dipodomys ordii	38.78	7.00e-120	422.00
IUUC-Dse-031267	Dothistroma septosporum	40.26	2.00e-104	370.00
IUUC-Dme-032084	Drosophila melanogaster	37.78	2.00e-110	390.00
IUUC-Ete-032616	Echinops telfairi	36.22	2.00e-100	357.00
IUUC-Eca-033991	Equus caballus	38.28	6.00e-121	426.00
IUUC-Eeu-035126	Erinaceus europaeus	52.74	4.00e-57	214.00
IUUC-Fca-035472	Felis catus	39.15	9.00e-121	425.00
IUUC-Fal-037178	Ficedula albicollis	38.86	2.00e-117	414.00
IUUC-Fox-037901	Fusarium oxysporum	40.00	2.00e-124	437.00
IUUC-Fso-038279	Fusarium solani	40.32	3.00e-124	436.00
IUUC-Gmo-039329	Gadus morhua	40.06	5.00e-117	412.00
IUUC-Ggr-040061	Gaeumannomyces graminis	40.82	5.00e-121	426.00
IUUC-Gga-040244	Gallus gallus	39.24	2.00e-121	427.00
IUUC-Gac-041880	Gasterosteus aculeatus	47.72	3.00e-102	363.00
IUUC-Gma-043235	Glycine max	37.37	2.00e-102	364.00
IUUC-Ggo-045428	Gorilla gorilla	38.59	1.00e-120	425.00
IUUC-Hsa-046183	Homo sapiens	38.73	6.00e-121	426.00
IUUC-Hvu-047509	Hordeum vulgare	41.90	2.00e-65	242.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	39.12	2.00e-112	397.00
IUUC-Kpa-049142	Komagataella pastoris	44.96	4.00e-146	509.00
IUUC-Lch-049601	Latimeria chalumnae	34.47	4.00e-74	270.00
IUUC-Lpe-051496	Leersia perrieri	42.28	3.00e-67	248.00
IUUC-Loc-051751	Lepisosteus oculatus	38.35	3.00e-120	423.00
IUUC-Lma-053203	Leptosphaeria maculans	38.59	9.00e-94	335.00
IUUC-Laf-053424	Loxodonta africana	39.46	9.00e-122	428.00
IUUC-Mcc-054633	Macaca mulatta	38.73	5.00e-122	429.00
IUUC-Meu-056523	Macropus eugenii	37.00	1.00e-106	378.00
IUUC-Mor-056983	Magnaporthe oryzae	39.65	4.00e-129	453.00
IUUC-Mpo-057615	Magnaporthe poae	40.71	4.00e-128	449.00
IUUC-Mtr-058366	Medicago truncatula	36.77	2.00e-97	347.00
IUUC-Mla-058826	Melampsora laricipopulina	40.25	3.00e-139	486.00
IUUC-Mga-059447	Meleagris gallopavo	38.95	1.00e-120	424.00
IUUC-Mvi-060537	Microbotryum violaceum	41.36	2.00e-128	450.00
IUUC-Mmr-060676	Microcebus murinus	38.59	2.00e-120	424.00
IUUC-Mdo-062967	Monodelphis domestica	38.23	4.00e-117	412.00
IUUC-Mmu-063217	Mus musculus	39.14	4.00e-120	423.00
IUUC-Mac-065527	Musa acuminata	46.60	2.00e-92	331.00
IUUC-Mpu-066417	Mustela putorius furo	38.31	1.00e-118	418.00
IUUC-Mlu-067195	Myotis lucifugus	39.05	3.00e-122	430.00
IUUC-Nfi-068576	Neosartorya fischeri	47.11	2.00e-111	394.00
IUUC-Ncr-068867	Neurospora crassa	42.44	2.00e-130	457.00
IUUC-Nle-069447	Nomascus leucogenys	47.14	4.00e-88	315.00
IUUC-Opr-070737	Ochotona princeps	44.94	3.00e-97	347.00
IUUC-Ont-071260	Oreochromis niloticus	36.94	3.00e-113	400.00
IUUC-Oan-073622	Ornithorhynchus anatinus	36.75	2.00e-74	270.00
IUUC-Ocu-074584	Oryctolagus cuniculus	38.74	4.00e-122	429.00
IUUC-Oba-075483	Oryza barthii	40.16	4.00e-70	257.00
IUUC-Obr-076786	Oryza brachyantha	42.72	9.00e-69	253.00
IUUC-Ogl-077388	Oryza glaberrima	40.16	4.00e-70	257.00
IUUC-Ogu-078618	Oryza glumaepatula	40.16	4.00e-70	257.00
IUUC-Oin-080007	Oryza indica	39.89	5.00e-70	257.00
IUUC-Olo-080994	Oryza longistaminata	43.96	3.00e-70	258.00
IUUC-Ome-081735	Oryza meridionalis	40.16	6.00e-71	260.00
IUUC-Oni-082153	Oryza nivara	39.89	6.00e-70	257.00
IUUC-Opu-083146	Oryza punctata	43.83	2.00e-69	255.00
IUUC-Oru-084919	Oryza rufipogon	39.89	4.00e-70	257.00
IUUC-Osa-086182	Oryza sativa	39.63	4.00e-69	254.00
IUUC-Ola-086441	Oryzias latipes	37.41	6.00e-119	419.00
IUUC-Olu-087664	Ostreococcus lucimarinus	35.84	6.00e-100	355.00
IUUC-Oga-089074	Otolemur garnettii	38.69	5.00e-112	396.00
IUUC-Oar-090159	Ovis aries	38.54	5.00e-112	396.00
IUUC-Ptr-091105	Pan troglodytes	40.28	4.00e-111	392.00
IUUC-Pan-092446	Papio anubis	38.59	3.00e-121	426.00
IUUC-Psi-093372	Pelodiscus sinensis	38.43	4.00e-110	389.00
IUUC-Pma-094661	Petromyzon marinus	39.07	3.00e-101	360.00
IUUC-Pno-094813	Phaeosphaeria nodorum	38.18	4.00e-104	369.00
IUUC-Ppa-095224	Physcomitrella patens	37.37	1.00e-98	351.00
IUUC-Pfo-096565	Poecilia formosa	38.00	3.00e-111	393.00
IUUC-Pop-099702	Populus trichocarpa	37.41	4.00e-107	379.00
IUUC-Pca-100324	Procavia capensis	31.42	4.00e-56	210.00
IUUC-Ppe-101416	Prunus persica	37.04	3.00e-100	357.00
IUUC-Pva-102589	Pteropus vampyrus	36.69	9.00e-107	378.00
IUUC-Pgr-103497	Puccinia graminis	38.28	6.00e-127	445.00
IUUC-Ptt-103718	Puccinia triticina	38.27	7.00e-122	429.00
IUUC-Pte-104206	Pyrenophora teres	37.97	3.00e-92	330.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	40.55	5.00e-108	382.00
IUUC-Rno-105911	Rattus norvegicus	39.08	2.00e-120	424.00
IUUC-Sce-106413	Saccharomyces cerevisiae	51.19	0.00e+00	639.00
IUUC-Sha-106679	Sarcophilus harrisii	38.75	7.00e-121	425.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	36.63	2.00e-105	374.00
IUUC-Spo-108107	Schizosaccharomyces pombe	39.97	3.00e-113	400.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	41.05	3.00e-133	466.00
IUUC-Smo-109677	Selaginella moellendorffii	36.78	2.00e-98	351.00
IUUC-Sit-110319	Setaria italica	40.81	2.00e-73	268.00
IUUC-Sly-111215	Solanum lycopersicum	36.78	4.00e-100	356.00
IUUC-Stu-112442	Solanum tuberosum	37.92	1.00e-97	348.00
IUUC-Sar-113370	Sorex araneus	47.19	4.00e-95	340.00
IUUC-Sbi-114261	Sorghum bicolor	40.45	3.00e-70	258.00
IUUC-Sre-114997	Sporisorium reilianum	40.06	5.00e-128	449.00
IUUC-Ssc-115304	Sus scrofa	40.03	3.00e-118	416.00
IUUC-Tgu-117235	Taeniopygia guttata	38.18	1.00e-119	421.00
IUUC-Tru-118374	Takifugu rubripes	36.81	1.00e-109	388.00
IUUC-Tsy-118966	Tarsius syrichta	33.38	1.00e-85	308.00
IUUC-Tni-120269	Tetraodon nigroviridis	34.73	5.00e-95	339.00
IUUC-Tca-121245	Theobroma cacao	37.77	1.00e-109	388.00
IUUC-Tre-121966	Trichoderma reesei	39.59	1.00e-125	441.00
IUUC-Tvi-122360	Trichoderma virens	42.19	8.00e-126	442.00
IUUC-Tae-125251	Triticum aestivum	30.63	2.00e-68	251.00
IUUC-Tur-126294	Triticum urartu	42.20	2.00e-66	245.00
IUUC-Tme-127117	Tuber melanosporum	53.74	1.00e-109	388.00
IUUC-Tbe-127662	Tupaia belangeri	42.38	2.00e-39	154.00
IUUC-Ttr-129054	Tursiops truncatus	38.84	3.00e-118	417.00
IUUC-Uma-129526	Ustilago maydis	38.98	2.00e-132	464.00
IUUC-Vda-129878	Verticillium dahliae	39.56	3.00e-126	443.00
IUUC-Vpa-130264	Vicugna pacos	33.41	2.00e-52	197.00
IUUC-Vvi-131163	Vitis vinifera	36.14	4.00e-101	360.00
IUUC-Xtr-132328	Xenopus tropicalis	32.90	8.00e-72	262.00
IUUC-Xma-133015	Xiphophorus maculatus	36.87	6.00e-100	356.00
IUUC-Yli-134468	Yarrowia lipolytica	41.61	1.00e-116	411.00
IUUC-Zma-134871	Zea mays	42.90	1.00e-68	252.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence