iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020138

Ensembl Protein ID

ENSCAFP00000010248.3

UniProt Accession

F1PU02; F1PU02_CANLF

Genbank Protein ID

ENSCAFP00000010248

Protein Name

Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

Genbank Nucleotide ID

AAEX03012884

Gene Name

EIF3F; EIF3S5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000006884.3	ENSCAFT00000011058.3	ENSCAFP00000010248.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/JAMM	99.63	3.00e-160	561.00	IUUC-Hsa-046860

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

AAAPTPSDAP ASASDPRTAA ATTAAPGQTP ASTPAPAQTP AQSLPGPALP GPFPGGRVVR 60
LHPVILASIV DSYERRNEGA ARVIGTLLGT VDKHSVEVTN CFSVPHNESE DEVAVDMEFA 120

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Nucleotide Sequence
(Fasta)

GCCGCCGCAC CCACACCTTC TGACGCGGTG AAGAAGTGCC TTTAAAACGC ACTTTATCGT 60
CCACTACCCC TTTGAAGTCT GGAAACTCTG GGTCCACCTG GCGGCCGCTG AGCAGTCGGA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0016020--C:membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003743--F:translation initiation factor activity
GO:0031369--F:translation initiation factor binding
GO:0001731--P:formation of translation preinitiation complex
GO:0075522--P:IRES-dependent viral translational initiation
GO:0016579--P:protein deubiquitination
GO:0006446--P:regulation of translational initiation
GO:0006413--P:translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001150	Aegilops tauschii	36.54	4.00e-46	178.00
IUUC-Aml-001527	Ailuropoda melanoleuca	99.63	1.00e-159	555.00
IUUC-Atr-002686	Amborella trichopoda	40.68	4.00e-49	188.00
IUUC-Apl-003977	Anas platyrhynchos	90.62	6.00e-122	429.00
IUUC-Aca-004335	Anolis carolinensis	90.37	2.00e-148	518.00
IUUC-Aly-005945	Arabidopsis lyrata	38.40	3.00e-49	188.00
IUUC-Ath-007045	Arabidopsis thaliana	38.78	3.00e-49	188.00
IUUC-Acl-008365	Aspergillus clavatus	34.80	4.00e-41	161.00
IUUC-Afl-008742	Aspergillus flavus	35.53	3.00e-40	159.00
IUUC-Afu-009030	Aspergillus fumigatus	34.43	9.00e-41	160.00
IUUC-Ani-009212	Aspergillus nidulans	35.42	1.00e-41	163.00
IUUC-Ang-009712	Aspergillus niger	34.43	7.00e-40	157.00
IUUC-Aor-009885	Aspergillus oryzae	35.53	8.00e-42	164.00
IUUC-Ate-010315	Aspergillus terreus	35.53	2.00e-39	156.00
IUUC-Ame-010801	Astyanax mexicanus	52.41	1.00e-67	249.00
IUUC-Bgr-011982	Blumeria graminis	34.91	4.00e-40	158.00
IUUC-Bta-012804	Bos taurus	98.58	6.00e-166	576.00
IUUC-Bci-013891	Botrytis cinerea	34.91	5.00e-35	141.00
IUUC-Bdi-014328	Brachypodium distachyon	38.06	6.00e-48	184.00
IUUC-Bol-015446	Brassica oleracea	38.78	2.00e-50	192.00
IUUC-Bra-016862	Brassica rapa	39.16	7.00e-51	194.00
IUUC-Cel-018171	Caenorhabditis elegans	34.84	5.00e-46	177.00
IUUC-Cja-019335	Callithrix jacchus	99.63	2.00e-162	565.00
IUUC-Cpo-022109	Cavia porcellus	87.27	3.00e-136	478.00
IUUC-Cre-022664	Chlamydomonas reinhardtii	38.06	3.00e-57	214.00
IUUC-Csa-023994	Chlorocebus sabaeus	99.63	2.00e-162	564.00
IUUC-Cho-024351	Choloepus hoffmanni	76.47	6.00e-115	407.00
IUUC-Cin-025801	Ciona intestinalis	54.20	1.00e-87	316.00
IUUC-Csv-025805	Ciona savignyi	55.02	1.00e-85	309.00
IUUC-Cgl-026643	Colletotrichum gloeosporioides	31.87	3.00e-35	142.00
IUUC-Cne-026868	Cryptococcus neoformans	28.78	9.00e-28	117.00
IUUC-Cme-027328	Cyanidioschyzon merolae	27.22	2.00e-22	99.80
IUUC-Dre-028085	Danio rerio	79.93	3.00e-129	454.00
IUUC-Dno-030099	Dasypus novemcinctus	99.25	6.00e-159	553.00
IUUC-Dor-030324	Dipodomys ordii	90.67	2.00e-140	491.00
IUUC-Dse-031314	Dothistroma septosporum	36.26	2.00e-44	172.00
IUUC-Dme-031926	Drosophila melanogaster	48.89	2.00e-76	278.00
IUUC-Ete-032569	Echinops telfairi	92.81	6.00e-153	532.00
IUUC-Eca-033502	Equus caballus	94.31	2.00e-155	541.00
IUUC-Eeu-034883	Erinaceus europaeus	81.62	1.00e-82	298.00
IUUC-Fca-035873	Felis catus	99.63	1.00e-159	555.00
IUUC-Fal-036921	Ficedula albicollis	91.85	1.00e-149	521.00
IUUC-Fox-037765	Fusarium oxysporum	32.73	6.00e-30	124.00
IUUC-Fso-038240	Fusarium solani	33.09	3.00e-32	132.00
IUUC-Gmo-038864	Gadus morhua	78.07	3.00e-129	454.00
IUUC-Ggr-039862	Gaeumannomyces graminis	31.52	4.00e-30	125.00
IUUC-Gga-040952	Gallus gallus	91.91	7.00e-151	526.00
IUUC-Gac-041677	Gasterosteus aculeatus	79.18	2.00e-129	455.00
IUUC-Gma-043061	Glycine max	40.68	8.00e-49	187.00
IUUC-Ggo-045591	Gorilla gorilla	99.63	7.00e-163	566.00
IUUC-Hsa-046860	Homo sapiens	99.63	2.00e-162	564.00
IUUC-Hvu-047410	Hordeum vulgare	31.08	5.00e-20	90.10
IUUC-Itr-048211	Ictidomys tridecemlineatus	99.25	5.00e-159	553.00
IUUC-Lch-049410	Latimeria chalumnae	73.79	8.00e-87	312.00
IUUC-Lpe-051102	Leersia perrieri	39.61	2.00e-46	179.00
IUUC-Loc-052016	Lepisosteus oculatus	68.86	5.00e-114	403.00
IUUC-Lma-053157	Leptosphaeria maculans	34.27	8.00e-43	167.00
IUUC-Laf-054568	Loxodonta africana	98.90	6.00e-162	563.00
IUUC-Mcc-054613	Macaca mulatta	99.63	1.00e-162	565.00
IUUC-Meu-056832	Macropus eugenii	72.86	9.00e-83	299.00
IUUC-Mor-057104	Magnaporthe oryzae	31.32	6.00e-30	124.00
IUUC-Mtr-058445	Medicago truncatula	40.30	2.00e-57	215.00
IUUC-Mla-059038	Melampsora laricipopulina	30.69	1.00e-31	130.00
IUUC-Mga-059548	Meleagris gallopavo	91.53	2.00e-129	454.00
IUUC-Mvi-060520	Microbotryum violaceum	27.95	7.00e-22	97.80
IUUC-Mdo-062376	Monodelphis domestica	94.03	1.00e-150	525.00
IUUC-Mmu-063254	Mus musculus	98.88	2.00e-158	551.00
IUUC-Mac-065635	Musa acuminata	40.73	1.00e-51	196.00
IUUC-Mpu-066314	Mustela putorius furo	99.63	1.00e-159	555.00
IUUC-Mlu-067512	Myotis lucifugus	97.76	6.00e-157	546.00
IUUC-Nfi-068262	Neosartorya fischeri	34.43	9.00e-41	160.00
IUUC-Ncr-068872	Neurospora crassa	32.36	8.00e-33	134.00
IUUC-Nle-070118	Nomascus leucogenys	99.63	1.00e-159	555.00
IUUC-Opr-071228	Ochotona princeps	99.15	5.00e-139	486.00
IUUC-Ont-072600	Oreochromis niloticus	80.30	3.00e-132	463.00
IUUC-Oan-073584	Ornithorhynchus anatinus	93.22	5.00e-133	466.00
IUUC-Ocu-074542	Oryctolagus cuniculus	99.25	8.00e-159	552.00
IUUC-Oba-075923	Oryza barthii	38.63	9.00e-50	190.00
IUUC-Obr-076313	Oryza brachyantha	39.61	6.00e-48	184.00
IUUC-Ogl-076932	Oryza glaberrima	38.63	9.00e-50	190.00
IUUC-Ogu-078152	Oryza glumaepatula	38.63	9.00e-50	190.00
IUUC-Oin-079528	Oryza indica	38.63	9.00e-50	190.00
IUUC-Olo-080401	Oryza longistaminata	38.63	9.00e-50	190.00
IUUC-Ome-081553	Oryza meridionalis	38.27	2.00e-49	188.00
IUUC-Oni-082090	Oryza nivara	38.63	1.00e-49	189.00
IUUC-Opu-083583	Oryza punctata	39.61	2.00e-47	182.00
IUUC-Oru-084492	Oryza rufipogon	38.63	9.00e-50	190.00
IUUC-Osa-085383	Oryza sativa	38.63	9.00e-50	190.00
IUUC-Ola-086835	Oryzias latipes	79.18	7.00e-129	452.00
IUUC-Olu-087716	Ostreococcus lucimarinus	29.32	7.00e-28	117.00
IUUC-Oga-088886	Otolemur garnettii	98.88	2.00e-158	551.00
IUUC-Oar-090079	Ovis aries	98.58	1.00e-166	578.00
IUUC-Ptr-091457	Pan troglodytes	99.63	2.00e-162	564.00
IUUC-Pan-092317	Papio anubis	99.46	3.00e-107	380.00
IUUC-Psi-093129	Pelodiscus sinensis	85.33	7.00e-130	456.00
IUUC-Pma-094488	Petromyzon marinus	72.01	6.00e-124	436.00
IUUC-Pno-095049	Phaeosphaeria nodorum	34.27	5.00e-43	168.00
IUUC-Ppa-095341	Physcomitrella patens	41.20	1.00e-63	236.00
IUUC-Pfo-096286	Poecilia formosa	78.81	9.00e-130	456.00
IUUC-Pab-097765	Pongo abelii	99.63	2.00e-162	564.00
IUUC-Pop-099131	Populus trichocarpa	40.30	1.00e-53	202.00
IUUC-Pca-100524	Procavia capensis	82.48	5.00e-108	383.00
IUUC-Ppe-101934	Prunus persica	41.44	2.00e-58	219.00
IUUC-Pva-102577	Pteropus vampyrus	98.88	7.00e-159	553.00
IUUC-Pgr-103521	Puccinia graminis	29.87	8.00e-31	127.00
IUUC-Pte-104304	Pyrenophora teres	34.97	2.00e-43	169.00
IUUC-Pyt-104563	Pyrenophora triticirepentis	34.97	1.00e-43	170.00
IUUC-Rno-105717	Rattus norvegicus	99.25	6.00e-159	553.00
IUUC-Sha-107190	Sarcophilus harrisii	94.25	7.00e-147	513.00
IUUC-Sja-107918	Schizosaccharomyces japonicus	35.19	2.00e-45	176.00
IUUC-Spo-108355	Schizosaccharomyces pombe	35.84	2.00e-45	176.00
IUUC-Smo-109374	Selaginella moellendorffii	43.91	5.00e-68	250.00
IUUC-Sit-110119	Setaria italica	39.16	2.00e-48	185.00
IUUC-Sly-111570	Solanum lycopersicum	36.93	2.00e-45	175.00
IUUC-Stu-112308	Solanum tuberosum	39.24	2.00e-51	196.00
IUUC-Sar-113515	Sorex araneus	96.81	9.00e-52	196.00
IUUC-Sbi-114605	Sorghum bicolor	38.78	2.00e-48	186.00
IUUC-Sre-114906	Sporisorium reilianum	39.42	3.00e-51	195.00
IUUC-Tgu-117087	Taeniopygia guttata	89.83	5.00e-127	446.00
IUUC-Tru-117700	Takifugu rubripes	78.81	3.00e-129	454.00
IUUC-Tni-120470	Tetraodon nigroviridis	79.55	5.00e-130	456.00
IUUC-Tca-121109	Theobroma cacao	39.54	3.00e-47	181.00
IUUC-Tre-122095	Trichoderma reesei	33.94	4.00e-32	132.00
IUUC-Tvi-122580	Trichoderma virens	33.57	2.00e-31	129.00
IUUC-Tae-125129	Triticum aestivum	38.79	9.00e-51	193.00
IUUC-Tur-126658	Triticum urartu	36.06	6.00e-42	164.00
IUUC-Tme-127043	Tuber melanosporum	38.87	7.00e-48	184.00
IUUC-Tbe-127927	Tupaia belangeri	99.63	1.00e-159	555.00
IUUC-Ttr-129231	Tursiops truncatus	99.25	4.00e-159	553.00
IUUC-Uma-129578	Ustilago maydis	39.05	2.00e-50	192.00
IUUC-Vda-129730	Verticillium dahliae	32.36	7.00e-37	147.00
IUUC-Vpa-130677	Vicugna pacos	64.75	5.00e-42	164.00
IUUC-Vvi-130968	Vitis vinifera	41.06	6.00e-53	200.00
IUUC-Xtr-132203	Xenopus tropicalis	84.39	1.00e-136	478.00
IUUC-Xma-133972	Xiphophorus maculatus	78.44	2.00e-129	454.00
IUUC-Yli-134553	Yarrowia lipolytica	36.33	5.00e-40	157.00
IUUC-Zma-134941	Zea mays	38.40	8.00e-44	170.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence