iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gma-043610

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

CM000839

Gene Name

LOC100793799; GLYMA_06G305800

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GLYMA06G46210	GLYMA06G46210.1	GLYMA06G46210.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.10e-117	393.0	8	514

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahe 94
           YDRQ+r+wGe++q++l++++++l+++g++G+E+lKnLvl+GvgsitvvD+++vev +l+++FL+++ + gksKA++++ +l+eln+ v+++++e
   Q: 8    YDRQLRIWGEQGQAALEKSSICLLNCGPTGSETLKNLVLGGVGSITVVDGSKVEVGDLGNNFLVDEASLGKSKAKCVCSFLQELNDAVKAKFVE 101
           ********************************************************************************************** PP
   S: 95   esiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn... 181
           es+++l e+++ Ff++f++Vv+++  + ++ k++r+c++a+v li ++++Gl G+vr+++k++ +++s++d   d++++++P+++lk +     
   Q: 102  ESPETLIETNPsFFSQFTLVVATQLVENSMIKLDRICREANVMLIFARSYGLTGFVRISVKEHAVIESKPDhflDDLRLNNPWPELKRFADdid 195
           *****************************************************************************************88888 PP
   S: 182  ......aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtks 268
                 +a+++i+++v++ k+++e+a+++ ++ ++++eek+e+k++ k++++++de+n++eai  a+k fa++ i+   +q+l++ + ++v ++
   Q: 196  lnvqdpVAHKHIPYVVILVKMADEWAKSHGGRLPSTREEKKEFKELLKAGMVAQDEDNYKEAIDSAFKVFAPRGISLeSQQILND-SSAEVDSN 288
           888899***********************************************************************99999999.88899*** PP
   S: 269  kspfwv...........................................................................sfcsnaealq... 284
           +s+fwv                                                                           sfc+na++l+   
   Q: 289  SSDFWVlvtalkdfianegggdaplegsipdmtssteqyvnlqniyhakaeadflvierlvrstlkkigrdsnsiskstikSFCKNARKLKvcr 382
           *******************************************************************************************666 PP
   S: 285  ........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagn 364
                     ++  + +++++++++     +y+llra++rf++++++ pg+++  +d+d +++l+ +a +l  ++lg+++  l +dli e++++
   Q: 383  yrliedefNSPNLPELQKYLTDEDYsiavgIYILLRAVDRFAANYNSFPGQFDSAMDED-IPRLKSTAIALL-TDLGCNGaTLAEDLINEMCRF 474
           6665555444888888999999999999*******************************.*****9999998.********************* PP
   S: 365  iipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           ++++++ ++a vgG+a+qEviK+++++f+p+  +++f+++
   Q: 475  GAAELHAVAALVGGIASQEVIKLITKQFVPMSGTYIFNGI 514
           *************************************986 PP

Organism

Glycine max

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAEPKVKYDR QLRIWGEQGQ AALEKSSICL LNCGPTGSET LKNLVLGGVG SITVVDGSKV 60
EVGDLGNNFL VDEASLGKSK AKCVCSFLQE LNDAVKAKFV EESPETLIET NPSFFSQFTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAACGAAGA AGAAATAAAC ATGGGTAAAG TTGAAATTTT TAAAATTATA TTAGGTGTAG 60
AAAAAATGTG CCGGGTGGAG GAAGAAAATT CCCTTAATCC ATGGTCCTTG CCTGCCGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

gmx:100793799

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	67.87	0.00e+00	751.00
IUUC-Aml-002333	Ailuropoda melanoleuca	41.19	3.00e-125	442.00
IUUC-Atr-002644	Amborella trichopoda	74.00	0.00e+00	794.00
IUUC-Apl-003446	Anas platyrhynchos	40.04	3.00e-116	412.00
IUUC-Aca-004450	Anolis carolinensis	39.35	9.00e-123	434.00
IUUC-Aly-005466	Arabidopsis lyrata	77.67	0.00e+00	874.00
IUUC-Ath-006692	Arabidopsis thaliana	78.24	0.00e+00	876.00
IUUC-Acl-008333	Aspergillus clavatus	33.58	2.00e-72	266.00
IUUC-Afl-008529	Aspergillus flavus	34.12	1.00e-79	290.00
IUUC-Afu-009071	Aspergillus fumigatus	33.27	8.00e-72	264.00
IUUC-Ani-009443	Aspergillus nidulans	31.26	4.00e-67	249.00
IUUC-Ang-009669	Aspergillus niger	31.90	6.00e-74	271.00
IUUC-Aor-009914	Aspergillus oryzae	34.46	2.00e-77	283.00
IUUC-Ate-010450	Aspergillus terreus	33.82	2.00e-75	276.00
IUUC-Ame-011183	Astyanax mexicanus	39.37	2.00e-122	432.00
IUUC-Bta-012583	Bos taurus	41.15	1.00e-126	446.00
IUUC-Bci-013892	Botrytis cinerea	32.42	2.00e-62	233.00
IUUC-Bdi-014592	Brachypodium distachyon	67.95	0.00e+00	750.00
IUUC-Bol-016399	Brassica oleracea	78.39	0.00e+00	879.00
IUUC-Bra-018084	Brassica rapa	75.33	0.00e+00	821.00
IUUC-Cja-020007	Callithrix jacchus	41.11	5.00e-125	441.00
IUUC-Cfa-020324	Canis familiaris	41.34	2.00e-127	449.00
IUUC-Cpo-022248	Cavia porcellus	36.42	2.00e-68	253.00
IUUC-Csa-023149	Chlorocebus sabaeus	39.12	5.00e-98	351.00
IUUC-Cho-024537	Choloepus hoffmanni	34.91	1.00e-84	306.00
IUUC-Cin-025763	Ciona intestinalis	40.60	1.00e-112	400.00
IUUC-Csv-026113	Ciona savignyi	40.15	3.00e-108	385.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.12	1.00e-58	221.00
IUUC-Cne-026884	Cryptococcus neoformans	33.52	2.00e-71	263.00
IUUC-Cme-027210	Cyanidioschyzon merolae	24.09	9.00e-14	72.00
IUUC-Dre-028140	Danio rerio	40.67	5.00e-127	447.00
IUUC-Dno-030033	Dasypus novemcinctus	39.96	2.00e-106	379.00
IUUC-Dor-030513	Dipodomys ordii	34.66	9.00e-38	151.00
IUUC-Ete-032420	Echinops telfairi	36.85	3.00e-107	382.00
IUUC-Eca-033992	Equus caballus	39.46	4.00e-97	348.00
IUUC-Eeu-034713	Erinaceus europaeus	31.54	3.00e-35	143.00
IUUC-Fca-036548	Felis catus	40.78	8.00e-126	444.00
IUUC-Fal-037600	Ficedula albicollis	40.27	5.00e-116	411.00
IUUC-Fox-038037	Fusarium oxysporum	30.25	5.00e-64	238.00
IUUC-Gmo-038562	Gadus morhua	38.07	3.00e-116	412.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.36	9.00e-66	244.00
IUUC-Gga-041129	Gallus gallus	39.96	6.00e-119	421.00
IUUC-Gac-042558	Gasterosteus aculeatus	39.21	2.00e-118	419.00
IUUC-Ggo-045611	Gorilla gorilla	41.21	7.00e-124	437.00
IUUC-Hsa-046563	Homo sapiens	41.44	5.00e-125	441.00
IUUC-Hvu-047790	Hordeum vulgare	64.78	1.00e-152	532.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	41.34	9.00e-126	443.00
IUUC-Kpa-049309	Komagataella pastoris	35.11	2.00e-76	280.00
IUUC-Lch-050038	Latimeria chalumnae	39.17	5.00e-118	417.00
IUUC-Lpe-051535	Leersia perrieri	66.60	0.00e+00	674.00
IUUC-Loc-051917	Lepisosteus oculatus	37.89	3.00e-108	385.00
IUUC-Lma-053112	Leptosphaeria maculans	32.50	2.00e-78	286.00
IUUC-Laf-053690	Loxodonta africana	41.71	1.00e-126	446.00
IUUC-Mcc-055117	Macaca mulatta	40.30	4.00e-121	428.00
IUUC-Meu-056761	Macropus eugenii	33.27	6.00e-89	321.00
IUUC-Mor-057230	Magnaporthe oryzae	32.55	3.00e-70	259.00
IUUC-Mpo-057514	Magnaporthe poae	32.42	5.00e-65	241.00
IUUC-Mtr-058551	Medicago truncatula	85.34	0.00e+00	904.00
IUUC-Mga-060144	Meleagris gallopavo	39.58	2.00e-115	409.00
IUUC-Mvi-060221	Microbotryum violaceum	33.21	2.00e-74	273.00
IUUC-Mmr-061325	Microcebus murinus	40.19	2.00e-121	429.00
IUUC-Mdo-062532	Monodelphis domestica	41.44	5.00e-125	441.00
IUUC-Mmu-063956	Mus musculus	40.78	7.00e-126	444.00
IUUC-Mac-064521	Musa acuminata	71.68	0.00e+00	796.00
IUUC-Mpu-066716	Mustela putorius furo	40.59	5.00e-116	411.00
IUUC-Mlu-067459	Myotis lucifugus	41.94	4.00e-127	447.00
IUUC-Nfi-068245	Neosartorya fischeri	33.15	4.00e-71	262.00
IUUC-Ncr-068910	Neurospora crassa	32.29	5.00e-70	258.00
IUUC-Nle-070034	Nomascus leucogenys	39.81	2.00e-118	419.00
IUUC-Opr-070552	Ochotona princeps	38.10	7.00e-97	347.00
IUUC-Ont-071426	Oreochromis niloticus	38.79	4.00e-121	428.00
IUUC-Oan-073389	Ornithorhynchus anatinus	38.79	2.00e-90	325.00
IUUC-Ocu-074911	Oryctolagus cuniculus	41.34	1.00e-126	446.00
IUUC-Oba-075437	Oryza barthii	70.25	0.00e+00	729.00
IUUC-Obr-076684	Oryza brachyantha	69.56	0.00e+00	687.00
IUUC-Ogl-077170	Oryza glaberrima	70.25	0.00e+00	729.00
IUUC-Ogu-078844	Oryza glumaepatula	69.35	0.00e+00	677.00
IUUC-Oin-079105	Oryza indica	70.06	0.00e+00	725.00
IUUC-Olo-080943	Oryza longistaminata	67.21	0.00e+00	654.00
IUUC-Oni-082891	Oryza nivara	67.75	0.00e+00	699.00
IUUC-Opu-083457	Oryza punctata	70.06	0.00e+00	727.00
IUUC-Oru-084960	Oryza rufipogon	67.14	0.00e+00	655.00
IUUC-Osa-085358	Oryza sativa	69.87	0.00e+00	721.00
IUUC-Ola-086420	Oryzias latipes	36.70	2.00e-75	276.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.42	6.00e-62	231.00
IUUC-Oga-088810	Otolemur garnettii	41.34	8.00e-126	444.00
IUUC-Oar-089196	Ovis aries	40.93	4.00e-125	441.00
IUUC-Ptr-090617	Pan troglodytes	41.44	3.00e-125	442.00
IUUC-Pan-092761	Papio anubis	41.15	4.00e-126	444.00
IUUC-Psi-093191	Pelodiscus sinensis	38.46	3.00e-117	415.00
IUUC-Pma-094380	Petromyzon marinus	40.49	3.00e-111	395.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.84	4.00e-67	250.00
IUUC-Pfo-096467	Poecilia formosa	39.32	2.00e-117	416.00
IUUC-Pab-098255	Pongo abelii	41.16	6.00e-104	370.00
IUUC-Pop-099722	Populus trichocarpa	82.22	0.00e+00	918.00
IUUC-Pca-100807	Procavia capensis	49.20	7.00e-52	197.00
IUUC-Ppe-101280	Prunus persica	82.98	0.00e+00	922.00
IUUC-Pva-102333	Pteropus vampyrus	40.19	2.00e-119	422.00
IUUC-Pte-104355	Pyrenophora teres	33.51	2.00e-76	280.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	34.41	6.00e-77	281.00
IUUC-Rno-105810	Rattus norvegicus	41.06	2.00e-125	442.00
IUUC-Sha-106770	Sarcophilus harrisii	45.39	7.00e-71	260.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.62	4.00e-76	278.00
IUUC-Spo-108276	Schizosaccharomyces pombe	31.79	8.00e-80	291.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.79	2.00e-61	230.00
IUUC-Smo-109296	Selaginella moellendorffii	53.18	5.00e-164	570.00
IUUC-Sit-110157	Setaria italica	69.79	0.00e+00	792.00
IUUC-Sly-111105	Solanum lycopersicum	75.42	0.00e+00	865.00
IUUC-Stu-112469	Solanum tuberosum	76.54	0.00e+00	873.00
IUUC-Sar-113083	Sorex araneus	37.68	4.00e-43	169.00
IUUC-Sbi-113813	Sorghum bicolor	69.60	0.00e+00	786.00
IUUC-Sre-115058	Sporisorium reilianum	34.45	3.00e-67	249.00
IUUC-Tgu-116772	Taeniopygia guttata	41.24	6.00e-117	414.00
IUUC-Tru-118686	Takifugu rubripes	38.61	2.00e-120	426.00
IUUC-Tsy-119111	Tarsius syrichta	41.91	3.00e-61	229.00
IUUC-Tni-120231	Tetraodon nigroviridis	36.82	4.00e-104	371.00
IUUC-Tca-121491	Theobroma cacao	87.38	0.00e+00	919.00
IUUC-Tre-122103	Trichoderma reesei	33.08	2.00e-71	263.00
IUUC-Tvi-122672	Trichoderma virens	31.84	6.00e-68	251.00
IUUC-Tae-125316	Triticum aestivum	68.71	0.00e+00	758.00
IUUC-Tur-126487	Triticum urartu	67.31	0.00e+00	730.00
IUUC-Tme-127097	Tuber melanosporum	34.93	3.00e-84	306.00
IUUC-Ttr-128465	Tursiops truncatus	38.33	4.00e-111	395.00
IUUC-Uma-129645	Ustilago maydis	30.96	1.00e-72	267.00
IUUC-Vpa-130529	Vicugna pacos	39.63	4.00e-115	408.00
IUUC-Vvi-131059	Vitis vinifera	84.13	0.00e+00	918.00
IUUC-Xtr-132002	Xenopus tropicalis	41.25	5.00e-126	444.00
IUUC-Xma-133930	Xiphophorus maculatus	39.81	3.00e-122	432.00
IUUC-Yli-134505	Yarrowia lipolytica	32.43	1.00e-81	296.00
IUUC-Zma-135619	Zea mays	69.41	0.00e+00	746.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence