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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108166
UUCD1 version UUC-ScP-00281
Ensembl Protein ID SPAC19B12.10.1:pep
UniProt Accession Q9P371; SST2_SCHPO
Genbank Protein ID CAC00558.1
Protein Name AMSH-like protease sst2; Suppressor of ste12 deletion protein 2
Genbank Nucleotide ID CU329670
Gene Name sst2; SPAC19B12.10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC19B12.10 SPAC19B12.10.1 SPAC19B12.10.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
HINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProt
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Jab_MPN 54.55 3.00e-43 174.00 IUUC-Hsa-046543
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.
 Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.
Protein Sequence
(Fasta)
MNILQGSEAP LSYEEIASRA GAFDFNKNIP LKNWLRTSTT ISKQAHVYVS EHDYSNGVFL 60
LFRYCELFMK CQKHPDAAAY KKELFDYYQG VRNALEEIEL IKPIVKEQYE QYQCQKNDLD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108166|UBD,Jab_MPN|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGATCTTCC ACCAGCAGTC TACCAATTTA GCTCAGCAGC TTTCGTTTAA TACAAAGGTT 60
AGCTCTACCT GCTTTTAACA GCAATTGCTC GGATTTTGCA GTTTCCTTAT TAGTTCAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108166|UBD,Jab_MPN|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
IPR015063--USP8_dimer
Pfam

PF01398--JAB
PF08969--USP8_dimer
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0032153--C:cell division site
GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0070530--F:K63-linked polyubiquitin binding
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0008237--F:metallopeptidase activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0045324--P:late endosome to vacuole transport
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG spo:SPAC19B12.10
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000506 Aegilops tauschii 52.49 1.00e-50 192.00
IUUC-Aml-001743 Ailuropoda melanoleuca 46.01 2.00e-48 184.00
IUUC-Atr-002473 Amborella trichopoda 59.85 2.00e-47 181.00
IUUC-Apl-003560 Anas platyrhynchos 34.52 2.00e-50 191.00
IUUC-Aca-004523 Anolis carolinensis 32.32 3.00e-50 190.00
IUUC-Aly-005808 Arabidopsis lyrata 39.88 3.00e-51 194.00
IUUC-Ath-007385 Arabidopsis thaliana 51.12 3.00e-48 184.00
IUUC-Afl-008565 Aspergillus flavus 58.95 4.00e-64 236.00
IUUC-Ani-009164 Aspergillus nidulans 58.12 5.00e-64 236.00
IUUC-Ang-009659 Aspergillus niger 59.38 2.00e-66 244.00
IUUC-Aor-010102 Aspergillus oryzae 58.95 4.00e-64 236.00
IUUC-Ate-010360 Aspergillus terreus 55.07 2.00e-64 237.00
IUUC-Ame-011255 Astyanax mexicanus 52.30 4.00e-48 183.00
IUUC-Bgr-012260 Blumeria graminis 61.98 1.00e-67 248.00
IUUC-Bta-012791 Bos taurus 51.32 2.00e-49 187.00
IUUC-Bdi-014845 Brachypodium distachyon 47.85 2.00e-49 188.00
IUUC-Bol-015371 Brassica oleracea 31.34 1.00e-54 205.00
IUUC-Bra-017428 Brassica rapa 39.12 2.00e-52 197.00
IUUC-Cja-019600 Callithrix jacchus 45.05 7.00e-49 186.00
IUUC-Cfa-020729 Canis familiaris 49.23 1.00e-47 181.00
IUUC-Cpo-021625 Cavia porcellus 33.26 1.00e-51 194.00
IUUC-Cre-022989 Chlamydomonas reinhardtii 45.11 2.00e-33 132.00
IUUC-Csa-023635 Chlorocebus sabaeus 41.96 4.00e-49 186.00
IUUC-Cho-024802 Choloepus hoffmanni 54.22 4.00e-47 180.00
IUUC-Cin-025539 Ciona intestinalis 51.35 2.00e-41 160.00
IUUC-Csv-026138 Ciona savignyi 50.68 2.00e-40 157.00
IUUC-Dre-027852 Danio rerio 51.70 7.00e-48 182.00
IUUC-Dno-028859 Dasypus novemcinctus 41.96 1.00e-49 188.00
IUUC-Dor-030785 Dipodomys ordii 34.00 3.00e-47 180.00
IUUC-Dse-031153 Dothistroma septosporum 54.17 4.00e-52 197.00
IUUC-Dme-031787 Drosophila melanogaster 33.73 1.00e-58 218.00
IUUC-Ete-032842 Echinops telfairi 33.75 1.00e-50 191.00
IUUC-Eca-033504 Equus caballus 45.91 2.00e-50 190.00
IUUC-Eeu-034738 Erinaceus europaeus 59.48 4.00e-39 153.00
IUUC-Fca-035810 Felis catus 46.33 3.00e-49 187.00
IUUC-Fal-037252 Ficedula albicollis 33.81 3.00e-50 190.00
IUUC-Fox-037879 Fusarium oxysporum 51.30 9.00e-52 196.00
IUUC-Fso-038095 Fusarium solani 55.81 2.00e-43 167.00
IUUC-Gmo-038927 Gadus morhua 50.00 8.00e-48 182.00
IUUC-Ggr-039788 Gaeumannomyces graminis 50.00 5.00e-52 196.00
IUUC-Gga-041246 Gallus gallus 33.88 2.00e-49 187.00
IUUC-Gac-041538 Gasterosteus aculeatus 31.11 1.00e-51 195.00
IUUC-Gma-042650 Glycine max 51.69 4.00e-49 186.00
IUUC-Ggo-045287 Gorilla gorilla 41.18 8.00e-49 185.00
IUUC-Hsa-046543 Homo sapiens 40.78 2.00e-48 184.00
IUUC-Hvu-047336 Hordeum vulgare 53.57 2.00e-33 134.00
IUUC-Itr-048682 Ictidomys tridecemlineatus 33.10 8.00e-50 189.00
IUUC-Kpa-049381 Komagataella pastoris 33.10 1.00e-54 205.00
IUUC-Lch-049954 Latimeria chalumnae 33.87 4.00e-51 193.00
IUUC-Lpe-051096 Leersia perrieri 53.46 9.00e-47 179.00
IUUC-Loc-052848 Lepisosteus oculatus 51.14 1.00e-47 181.00
IUUC-Lma-053221 Leptosphaeria maculans 57.81 1.00e-63 236.00
IUUC-Laf-053773 Loxodonta africana 45.87 4.00e-50 190.00
IUUC-Mcc-055868 Macaca mulatta 41.96 4.00e-49 186.00
IUUC-Meu-056009 Macropus eugenii 51.72 1.00e-47 181.00
IUUC-Mor-057282 Magnaporthe oryzae 51.55 3.00e-54 204.00
IUUC-Mpo-057473 Magnaporthe poae 50.00 4.00e-52 197.00
IUUC-Mtr-058598 Medicago truncatula 32.68 2.00e-55 207.00
IUUC-Mla-058952 Melampsora laricipopulina 50.00 2.00e-13 64.30
IUUC-Mga-059613 Meleagris gallopavo 50.28 2.00e-48 184.00
IUUC-Mmr-061327 Microcebus murinus 57.82 2.00e-47 181.00
IUUC-Mdo-062377 Monodelphis domestica 50.57 6.00e-47 179.00
IUUC-Mmu-064307 Mus musculus 34.43 2.00e-48 184.00
IUUC-Mac-065426 Musa acuminata 50.49 9.00e-54 202.00
IUUC-Mpu-066259 Mustela putorius furo 33.02 2.00e-48 184.00
IUUC-Mlu-067130 Myotis lucifugus 42.35 3.00e-49 187.00
IUUC-Ncr-068670 Neurospora crassa 53.37 6.00e-54 203.00
IUUC-Nle-069588 Nomascus leucogenys 44.64 6.00e-48 182.00
IUUC-Opr-070292 Ochotona princeps 52.30 8.00e-48 182.00
IUUC-Ont-072010 Oreochromis niloticus 51.72 4.00e-48 183.00
IUUC-Oan-073314 Ornithorhynchus anatinus 42.76 2.00e-26 110.00
IUUC-Ocu-073794 Oryctolagus cuniculus 46.01 3.00e-48 183.00
IUUC-Oba-075358 Oryza barthii 49.20 3.00e-47 180.00
IUUC-Obr-076024 Oryza brachyantha 46.92 2.00e-47 181.00
IUUC-Ogl-077100 Oryza glaberrima 52.81 2.00e-49 188.00
IUUC-Ogu-078047 Oryza glumaepatula 49.20 5.00e-47 180.00
IUUC-Oin-079545 Oryza indica 49.20 5.00e-47 180.00
IUUC-Olo-080359 Oryza longistaminata 49.20 4.00e-47 180.00
IUUC-Ome-081619 Oryza meridionalis 49.20 5.00e-47 180.00
IUUC-Oni-082079 Oryza nivara 49.20 5.00e-47 180.00
IUUC-Opu-083914 Oryza punctata 52.81 2.00e-49 187.00
IUUC-Oru-085251 Oryza rufipogon 49.20 5.00e-47 180.00
IUUC-Osa-085426 Oryza sativa 49.20 5.00e-47 180.00
IUUC-Oga-088669 Otolemur garnettii 42.35 9.00e-50 188.00
IUUC-Oar-089535 Ovis aries 46.05 4.00e-50 190.00
IUUC-Ptr-090610 Pan troglodytes 41.57 5.00e-49 186.00
IUUC-Pan-091924 Papio anubis 33.33 5.00e-49 186.00
IUUC-Psi-093069 Pelodiscus sinensis 31.85 5.00e-51 193.00
IUUC-Pma-094125 Petromyzon marinus 54.67 2.00e-46 177.00
IUUC-Pno-094896 Phaeosphaeria nodorum 57.29 2.00e-63 235.00
IUUC-Ppa-095880 Physcomitrella patens 48.79 2.00e-50 191.00
IUUC-Pfo-096766 Poecilia formosa 32.41 1.00e-53 202.00
IUUC-Pab-098080 Pongo abelii 33.33 4.00e-50 190.00
IUUC-Pop-098795 Populus trichocarpa 50.24 6.00e-51 192.00
IUUC-Pca-100352 Procavia capensis 34.43 4.00e-50 190.00
IUUC-Ppe-101461 Prunus persica 50.00 9.00e-50 189.00
IUUC-Pva-102762 Pteropus vampyrus 42.75 5.00e-51 192.00
IUUC-Pgr-103491 Puccinia graminis 46.98 3.00e-38 151.00
IUUC-Ptt-103871 Puccinia triticina 47.85 2.00e-38 151.00
IUUC-Pte-104295 Pyrenophora teres 57.29 4.00e-63 233.00
IUUC-Pyt-104611 Pyrenophora triticirepentis 57.29 3.00e-63 234.00
IUUC-Rno-104938 Rattus norvegicus 50.77 1.00e-47 181.00
IUUC-Sha-107154 Sarcophilus harrisii 35.29 1.00e-52 198.00
IUUC-Sja-107679 Schizosaccharomyces japonicus 53.36 4.00e-131 459.00
IUUC-Smo-109437 Selaginella moellendorffii 53.98 5.00e-48 181.00
IUUC-Sit-110118 Setaria italica 49.20 1.00e-48 185.00
IUUC-Sly-111040 Solanum lycopersicum 42.28 1.00e-53 201.00
IUUC-Stu-112649 Solanum tuberosum 46.25 8.00e-54 202.00
IUUC-Sar-112924 Sorex araneus 54.22 1.00e-46 178.00
IUUC-Sbi-114439 Sorghum bicolor 43.43 1.00e-47 181.00
IUUC-Ssc-116248 Sus scrofa 46.36 2.00e-51 194.00
IUUC-Tgu-117057 Taeniopygia guttata 49.66 6.00e-38 149.00
IUUC-Tru-118459 Takifugu rubripes 52.30 2.00e-48 184.00
IUUC-Tsy-119100 Tarsius syrichta 57.14 6.00e-46 176.00
IUUC-Tni-120745 Tetraodon nigroviridis 52.54 5.00e-49 186.00
IUUC-Tca-121398 Theobroma cacao 53.07 2.00e-50 191.00
IUUC-Tre-121910 Trichoderma reesei 47.31 3.00e-42 164.00
IUUC-Tvi-122647 Trichoderma virens 43.17 2.00e-43 167.00
IUUC-Tae-124826 Triticum aestivum 47.64 3.00e-51 194.00
IUUC-Tur-126001 Triticum urartu 47.20 9.00e-51 192.00
IUUC-Tme-126874 Tuber melanosporum 61.38 2.00e-65 241.00
IUUC-Tbe-127977 Tupaia belangeri 50.00 1.00e-20 92.40
IUUC-Ttr-129114 Tursiops truncatus 58.50 2.00e-47 181.00
IUUC-Vpa-130821 Vicugna pacos 55.42 2.00e-47 181.00
IUUC-Vvi-131419 Vitis vinifera 40.49 2.00e-51 194.00
IUUC-Xtr-132499 Xenopus tropicalis 46.11 3.00e-46 177.00
IUUC-Xma-133318 Xiphophorus maculatus 52.00 3.00e-47 180.00
IUUC-Yli-134641 Yarrowia lipolytica 62.50 8.00e-55 205.00
Created Date 25-Jun-2017

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