iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010933

Ensembl Protein ID

ENSAMXP00000015742.1

UniProt Accession

W5L7D0; W5L7D0_ASTMX

Genbank Protein ID

ENSAMXP00000015742

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01043580

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000015276.1	ENSAMXT00000015742.1	ENSAMXP00000015742.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.20e-225	748.1	452	931

Active Site

Position(s)	Description	Evidence
632	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkeln 85
           YD+Qi+++G++ qe l +++++lvGag++GcEllKn++++G+    g++ v+Dmdt+e+snlnrqFLfr++dv k K+e+aa+a+k++n
   Q: 452  YDGQIAVFGSKMQELLAKQRYFLVGAGAIGCELLKNFAMMGLasgeGEVIVTDMDTIEKSNLNRQFLFRPWDVTKMKSETAAAAVKQMN 540
           ***************************************************************************************** PP
   S: 86   pdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkti 171
           p+v+++ h++++ +++e+++   Ff+ +d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+i
   Q: 541  PSVRITGHQNRVGPDTEKVYdddFFESLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSI 629
           ***************************************************************************************** PP
   S: 172  Pfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           P+ctlk++pna+eht++wa            + + ++l +++++ e++ kl  ++++e++++v ++l++  ++ +++++++a+++++ +
   Q: 630  PICTLKNFPNAIEHTLQWArdefeglfkqpaENAMQYL-TDPKFMERTLKLPGAQPLEVLEAVYKSLVTDCPRGWDDCVTWARNHWQCQ 717
           ****************************9998899998.78888999999*************************************** PP
   S: 249  tinsikqllksfecdivtkskspfwv..........................................sfcsnaealqvp........e 287
           ++n+i+qll++f++d++t+s++pfw+                                           + ++ + ++vp        +
   Q: 718  YNNNIRQLLHNFPPDQLTSSGAPFWSgpkrcphplefstsndlhmdyvlaganlyaqtyglqgstdraALAKLLQDIKVPeftpksgvK 806
           *************************************************************9999999555555555555444444446 PP
   S: 288  kvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipai 369
            +++d+e ++a+a+     l+ l++ l  +e+ ++ k + ++fekddd   ++d++ aa+nlrae+++i+p +d+++ k iag+iipai
   Q: 807  IHVSDQELQSANASvddsrLEELKTLLPAVEASNQFKLQAIDFEKDDDTnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGKIIPAI 894
           6666666666666677778****************************************************.***************** PP
   S: 370  attnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           att+a+v Gl+++E++K+v+g  k e++kn f+++a+
   Q: 895  ATTTAAVVGLVCLELLKIVQGhkKLEAYKNGFMNLAL 931
           *********************9999*******99875 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MSSSPLSKKR RVSGSETKTG SHCSSSNSVR TELSHTPANG MAKNGNDAEI DEGLYSRQLY 60
VLGHDAMKRM QSSNVLISGL RGLGVEIAKN VILGGVKTVT LHDQGVAEWN DLSSQFYLRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGTGAGGC GTTTCAGGGA CAGATTCATT CATGTTACAC ACAGATACAG GTCACTTACA 60
TTTGTGAATG TATACAGTCA GCATAGCCAA ATCTGATCTG AGCAAAACCT CTCTCTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0007409--P:axonogenesis
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	46.30	0.00e+00	894.00
IUUC-Aml-001311	Ailuropoda melanoleuca	77.99	0.00e+00	1733.00
IUUC-Atr-002684	Amborella trichopoda	44.04	0.00e+00	879.00
IUUC-Apl-004158	Anas platyrhynchos	43.51	0.00e+00	740.00
IUUC-Aca-004620	Anolis carolinensis	79.02	0.00e+00	1722.00
IUUC-Aly-005515	Arabidopsis lyrata	44.84	0.00e+00	913.00
IUUC-Ath-006891	Arabidopsis thaliana	46.28	0.00e+00	922.00
IUUC-Ago-007873	Ashbya gossypii	53.60	0.00e+00	1036.00
IUUC-Acl-008181	Aspergillus clavatus	55.76	0.00e+00	1080.00
IUUC-Afl-008455	Aspergillus flavus	54.37	0.00e+00	1022.00
IUUC-Afu-009065	Aspergillus fumigatus	55.18	0.00e+00	1095.00
IUUC-Ani-009371	Aspergillus nidulans	54.25	0.00e+00	1055.00
IUUC-Ang-009737	Aspergillus niger	55.05	0.00e+00	1068.00
IUUC-Aor-010007	Aspergillus oryzae	54.37	0.00e+00	1022.00
IUUC-Ate-010466	Aspergillus terreus	54.40	0.00e+00	1087.00
IUUC-Bgr-012281	Blumeria graminis	52.69	0.00e+00	1048.00
IUUC-Bta-012767	Bos taurus	79.41	0.00e+00	1762.00
IUUC-Bci-013721	Botrytis cinerea	54.68	0.00e+00	1018.00
IUUC-Bdi-014335	Brachypodium distachyon	44.80	0.00e+00	895.00
IUUC-Bol-015665	Brassica oleracea	44.73	0.00e+00	905.00
IUUC-Bra-017252	Brassica rapa	43.38	0.00e+00	898.00
IUUC-Cel-018260	Caenorhabditis elegans	50.38	0.00e+00	961.00
IUUC-Cja-019152	Callithrix jacchus	78.85	0.00e+00	1742.00
IUUC-Cfa-020622	Canis familiaris	77.15	0.00e+00	1679.00
IUUC-Cpo-022526	Cavia porcellus	78.56	0.00e+00	1733.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	47.05	0.00e+00	880.00
IUUC-Csa-023780	Chlorocebus sabaeus	79.04	0.00e+00	1753.00
IUUC-Cho-024682	Choloepus hoffmanni	38.08	1.00e-107	384.00
IUUC-Cin-025790	Ciona intestinalis	65.05	0.00e+00	1375.00
IUUC-Csv-026084	Ciona savignyi	61.97	0.00e+00	1356.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	54.45	0.00e+00	1087.00
IUUC-Cne-026960	Cryptococcus neoformans	57.45	0.00e+00	1121.00
IUUC-Cme-027290	Cyanidioschyzon merolae	44.00	0.00e+00	802.00
IUUC-Dre-028149	Danio rerio	92.91	0.00e+00	1973.00
IUUC-Dno-028884	Dasypus novemcinctus	78.94	0.00e+00	1746.00
IUUC-Dor-030229	Dipodomys ordii	76.11	0.00e+00	1679.00
IUUC-Dse-031524	Dothistroma septosporum	53.74	0.00e+00	1053.00
IUUC-Dme-032045	Drosophila melanogaster	60.24	0.00e+00	1283.00
IUUC-Ete-032544	Echinops telfairi	67.87	0.00e+00	702.00
IUUC-Eca-033330	Equus caballus	78.56	0.00e+00	1748.00
IUUC-Eeu-034717	Erinaceus europaeus	43.50	5.00e-162	564.00
IUUC-Fca-036255	Felis catus	78.94	0.00e+00	1740.00
IUUC-Fal-037445	Ficedula albicollis	47.59	0.00e+00	858.00
IUUC-Fox-038007	Fusarium oxysporum	52.98	8.00e-162	563.00
IUUC-Fso-038339	Fusarium solani	54.63	0.00e+00	1044.00
IUUC-Gmo-039338	Gadus morhua	85.93	0.00e+00	1809.00
IUUC-Ggr-039823	Gaeumannomyces graminis	53.70	0.00e+00	1099.00
IUUC-Gga-040365	Gallus gallus	46.52	0.00e+00	771.00
IUUC-Gac-041773	Gasterosteus aculeatus	85.65	0.00e+00	1820.00
IUUC-Gma-043198	Glycine max	44.67	0.00e+00	877.00
IUUC-Ggo-045336	Gorilla gorilla	78.94	0.00e+00	1735.00
IUUC-Hsa-045982	Homo sapiens	78.75	0.00e+00	1730.00
IUUC-Hvu-047418	Hordeum vulgare	45.69	0.00e+00	875.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	79.13	0.00e+00	1758.00
IUUC-Kpa-049112	Komagataella pastoris	51.28	0.00e+00	991.00
IUUC-Lch-050371	Latimeria chalumnae	82.44	0.00e+00	1800.00
IUUC-Lpe-051299	Leersia perrieri	44.13	0.00e+00	870.00
IUUC-Loc-052936	Lepisosteus oculatus	88.76	0.00e+00	1900.00
IUUC-Lma-053315	Leptosphaeria maculans	54.22	0.00e+00	1093.00
IUUC-Laf-053948	Loxodonta africana	77.81	0.00e+00	1698.00
IUUC-Mcc-055843	Macaca mulatta	78.94	0.00e+00	1752.00
IUUC-Meu-056258	Macropus eugenii	78.00	0.00e+00	1707.00
IUUC-Mor-057269	Magnaporthe oryzae	54.47	0.00e+00	1083.00
IUUC-Mpo-057435	Magnaporthe poae	54.43	0.00e+00	1078.00
IUUC-Mtr-058572	Medicago truncatula	44.64	0.00e+00	853.00
IUUC-Mla-059176	Melampsora laricipopulina	56.54	0.00e+00	1092.00
IUUC-Mga-059721	Meleagris gallopavo	43.15	0.00e+00	721.00
IUUC-Mvi-060437	Microbotryum violaceum	54.03	0.00e+00	1060.00
IUUC-Mmr-061405	Microcebus murinus	76.68	0.00e+00	1687.00
IUUC-Mdo-062032	Monodelphis domestica	76.50	0.00e+00	1674.00
IUUC-Mmu-063280	Mus musculus	78.47	0.00e+00	1729.00
IUUC-Mac-065505	Musa acuminata	46.06	0.00e+00	886.00
IUUC-Mpu-066409	Mustela putorius furo	78.56	0.00e+00	1748.00
IUUC-Mlu-067217	Myotis lucifugus	78.38	0.00e+00	1730.00
IUUC-Nfi-068407	Neosartorya fischeri	55.18	0.00e+00	1075.00
IUUC-Ncr-068698	Neurospora crassa	55.10	0.00e+00	1092.00
IUUC-Nle-070072	Nomascus leucogenys	74.77	0.00e+00	1622.00
IUUC-Opr-070715	Ochotona princeps	42.42	0.00e+00	741.00
IUUC-Ont-071671	Oreochromis niloticus	88.42	0.00e+00	1887.00
IUUC-Oan-073306	Ornithorhynchus anatinus	47.23	0.00e+00	701.00
IUUC-Ocu-074544	Oryctolagus cuniculus	79.13	0.00e+00	1761.00
IUUC-Oba-075120	Oryza barthii	45.36	0.00e+00	873.00
IUUC-Obr-076557	Oryza brachyantha	45.88	0.00e+00	858.00
IUUC-Ogl-077887	Oryza glaberrima	44.78	0.00e+00	875.00
IUUC-Ogu-078305	Oryza glumaepatula	43.71	0.00e+00	862.00
IUUC-Oin-079370	Oryza indica	44.33	0.00e+00	855.00
IUUC-Olo-081089	Oryza longistaminata	43.80	0.00e+00	863.00
IUUC-Ome-081942	Oryza meridionalis	45.45	0.00e+00	875.00
IUUC-Oni-082365	Oryza nivara	45.36	0.00e+00	875.00
IUUC-Opu-083977	Oryza punctata	45.07	0.00e+00	883.00
IUUC-Oru-084469	Oryza rufipogon	43.80	0.00e+00	865.00
IUUC-Osa-085949	Oryza sativa	44.69	0.00e+00	882.00
IUUC-Ola-087002	Oryzias latipes	87.75	0.00e+00	1869.00
IUUC-Olu-087687	Ostreococcus lucimarinus	45.62	0.00e+00	821.00
IUUC-Oga-088594	Otolemur garnettii	78.96	0.00e+00	1732.00
IUUC-Oar-090068	Ovis aries	79.25	0.00e+00	1755.00
IUUC-Ptr-090581	Pan troglodytes	44.53	0.00e+00	740.00
IUUC-Pan-092114	Papio anubis	79.04	0.00e+00	1754.00
IUUC-Psi-093489	Pelodiscus sinensis	43.27	0.00e+00	755.00
IUUC-Pma-094214	Petromyzon marinus	59.76	9.00e-53	199.00
IUUC-Pno-095154	Phaeosphaeria nodorum	53.73	0.00e+00	1090.00
IUUC-Ppa-095227	Physcomitrella patens	45.90	0.00e+00	894.00
IUUC-Pfo-097184	Poecilia formosa	86.12	0.00e+00	1844.00
IUUC-Pab-097861	Pongo abelii	78.75	0.00e+00	1720.00
IUUC-Pop-098934	Populus trichocarpa	43.49	0.00e+00	899.00
IUUC-Pca-100347	Procavia capensis	76.08	0.00e+00	1387.00
IUUC-Ppe-102012	Prunus persica	44.40	0.00e+00	885.00
IUUC-Pva-102584	Pteropus vampyrus	78.75	0.00e+00	1768.00
IUUC-Pgr-103336	Puccinia graminis	55.04	0.00e+00	1064.00
IUUC-Ptt-103939	Puccinia triticina	54.29	0.00e+00	1055.00
IUUC-Pte-104200	Pyrenophora teres	54.27	0.00e+00	1088.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	53.25	0.00e+00	1077.00
IUUC-Rno-105462	Rattus norvegicus	78.56	0.00e+00	1722.00
IUUC-Sce-106245	Saccharomyces cerevisiae	51.52	0.00e+00	1046.00
IUUC-Sha-107142	Sarcophilus harrisii	77.81	0.00e+00	1722.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	54.91	0.00e+00	1110.00
IUUC-Spo-108034	Schizosaccharomyces pombe	54.48	0.00e+00	1071.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	55.24	0.00e+00	1045.00
IUUC-Smo-109211	Selaginella moellendorffii	44.89	0.00e+00	872.00
IUUC-Sit-110281	Setaria italica	45.49	0.00e+00	889.00
IUUC-Sly-110914	Solanum lycopersicum	44.99	0.00e+00	896.00
IUUC-Stu-112109	Solanum tuberosum	44.40	0.00e+00	892.00
IUUC-Sar-113737	Sorex araneus	78.75	0.00e+00	1734.00
IUUC-Sbi-114520	Sorghum bicolor	46.17	0.00e+00	892.00
IUUC-Sre-115148	Sporisorium reilianum	55.27	0.00e+00	1082.00
IUUC-Ssc-115777	Sus scrofa	78.87	0.00e+00	1743.00
IUUC-Tgu-116565	Taeniopygia guttata	42.30	0.00e+00	736.00
IUUC-Tru-118742	Takifugu rubripes	88.13	0.00e+00	1821.00
IUUC-Tsy-119436	Tarsius syrichta	37.90	1.00e-180	627.00
IUUC-Tni-120401	Tetraodon nigroviridis	87.46	0.00e+00	1811.00
IUUC-Tca-121672	Theobroma cacao	44.67	0.00e+00	891.00
IUUC-Tre-122009	Trichoderma reesei	53.17	0.00e+00	1030.00
IUUC-Tvi-122259	Trichoderma virens	54.00	0.00e+00	1017.00
IUUC-Tae-125113	Triticum aestivum	46.25	0.00e+00	855.00
IUUC-Tur-126330	Triticum urartu	46.30	0.00e+00	893.00
IUUC-Tme-127055	Tuber melanosporum	53.85	0.00e+00	993.00
IUUC-Tbe-127487	Tupaia belangeri	74.86	0.00e+00	835.00
IUUC-Ttr-128331	Tursiops truncatus	78.09	0.00e+00	1720.00
IUUC-Uma-129387	Ustilago maydis	55.81	0.00e+00	1078.00
IUUC-Vda-129977	Verticillium dahliae	53.80	0.00e+00	996.00
IUUC-Vpa-130716	Vicugna pacos	41.82	0.00e+00	724.00
IUUC-Vvi-130857	Vitis vinifera	45.12	0.00e+00	896.00
IUUC-Xtr-132026	Xenopus tropicalis	64.66	0.00e+00	1267.00
IUUC-Xma-133805	Xiphophorus maculatus	86.89	0.00e+00	1835.00
IUUC-Yli-134547	Yarrowia lipolytica	52.76	0.00e+00	1073.00
IUUC-Zma-135052	Zea mays	46.04	0.00e+00	897.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence