iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	18636104; 11806825

Classification

Family	E-value	Score	Start	End
E1	1.70e-231	768.8	500	992

Active Site

Position(s)	Description	Evidence
681	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveah 93
           YD+Q +++G+++qe+l ++++++vGag++GcEllKnL ++Gv     g i+++Dmd++e+snlnrqFLfr++dvg +K+e+aa+a++ +n+dv++ea 
   Q: 500  YDGQAAVFGWPYQECLFRQRWFVVGAGAIGCELLKNLSMMGVacgegGLIKITDMDQIEISNLNRQFLFRRRDVGGKKSECAARAVTAFNSDVRIEAL 597
           ************************************************************************************************** PP
   S: 94   eesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtie 188
            e++  ++e+i+   Ff ++++V++aldn++arr+++r+c+++r pl+esgt+G++G+++v++++lte+ys+s dpp+k+iP+ctlk++pn+++hti+
   Q: 598  AERVGLETEHIFndeFFGELNGVANALDNVDARRYMDRRCVYYRLPLLESGTMGTKGNTQVVYPYLTESYSSSVDPPEKEIPVCTLKNFPNEIQHTIQ 695
           **********99************************************************************************************** PP
   S: 189  wa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv 274
           wa            +++nk+l++e+g++e+ +kl s ++ ++++kvk++l +++++++e++i++a+++f++ ++n+i q+l+sf++d++t+s+++fw+
   Q: 696  WAreqfetffaqpgEMANKFLSDERGFNEHVDKLISGQQIDILQKVKDALIDARPSSAEDCIRWARNQFQELYHNNIAQMLHSFPPDQLTDSGAKFWS 793
           ************************************************************************************************** PP
   S: 275  ...............................................................sfcsnaealqvpekvekdeevvkasaplylllral 309
                                                                            ++ aea++++e+++++++v++++ ++++l+++l
   Q: 794  gakrcphvlnfdpskeehfnfvfaasiliaelygvqpildreevirvalsvnpepfepksgvkIAVTDAEAKEQNERGASSMIVDDDA-AIEALKLKL 890
           ***********************************************************************************87555.69******* PP
   S: 310  erfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg......kfeplknff 399
            +++ k+++k ++++fekddds  +++++taa+nlrae+++i p +d++++k+iag+iipaiatt+a+v+Gl+++E++Kvv++      ++e +kn+f
   Q: 891  ATLNVKSTSKLNCVDFEKDDDSnhHMEFITAASNLRAENYDILP-ADRMRTKQIAGKIIPAIATTTAAVAGLVCIELYKVVDAngipktPMERFKNTF 987
           ********************************************.*************************************98886666677***** PP
   S: 400  lfdae 404
           l++++
   Q: 988  LNLSM 992
           *9887 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MTTILELTSA NKTNNKATNN KLQREGENEY PPAKRSKTDD EEEPTVVGNG TIVGAPKQQT 60
LSGVNQSGNV NVETTKNTEG QDGEKMDTSN NAGGVGGNSD ELLDKNLYSR QIYTLGESAM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGCCGAAA GCTCATCATC AGATTCTTCT CTTTTAAGCC ACCATTATTC GAACTGCATC 60
AGTTTTCATC AATTAAAAAC TATTTTCAGT GGTTCTGATC TTTCGTGATT AATGACTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0040007--P:growth
GO:0002119--P:nematode larval development
GO:0045138--P:nematode male tail tip morphogenesis
GO:0050905--P:neuromuscular process
GO:0048477--P:oogenesis
GO:0016567--P:protein ubiquitination
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	39.48	0.00e+00	637.00
IUUC-Aml-001311	Ailuropoda melanoleuca	49.13	0.00e+00	946.00
IUUC-Atr-002684	Amborella trichopoda	39.77	0.00e+00	643.00
IUUC-Apl-004158	Anas platyrhynchos	38.64	6.00e-176	610.00
IUUC-Aca-004620	Anolis carolinensis	48.55	0.00e+00	943.00
IUUC-Aly-005515	Arabidopsis lyrata	37.76	0.00e+00	655.00
IUUC-Ath-006891	Arabidopsis thaliana	37.70	0.00e+00	657.00
IUUC-Ago-007873	Ashbya gossypii	44.15	0.00e+00	763.00
IUUC-Acl-008181	Aspergillus clavatus	46.16	0.00e+00	799.00
IUUC-Afl-008455	Aspergillus flavus	46.25	0.00e+00	780.00
IUUC-Afu-009065	Aspergillus fumigatus	46.45	0.00e+00	830.00
IUUC-Ani-009371	Aspergillus nidulans	44.78	0.00e+00	775.00
IUUC-Ang-009737	Aspergillus niger	45.59	0.00e+00	806.00
IUUC-Aor-010007	Aspergillus oryzae	46.25	0.00e+00	779.00
IUUC-Ate-010466	Aspergillus terreus	45.54	0.00e+00	808.00
IUUC-Ame-010933	Astyanax mexicanus	50.14	0.00e+00	919.00
IUUC-Bgr-012281	Blumeria graminis	43.86	0.00e+00	799.00
IUUC-Bta-012767	Bos taurus	49.47	0.00e+00	956.00
IUUC-Bci-013721	Botrytis cinerea	46.09	0.00e+00	789.00
IUUC-Bdi-014843	Brachypodium distachyon	38.94	0.00e+00	636.00
IUUC-Bol-015161	Brassica oleracea	37.80	0.00e+00	660.00
IUUC-Bra-017707	Brassica rapa	37.86	0.00e+00	666.00
IUUC-Cja-019152	Callithrix jacchus	49.42	0.00e+00	955.00
IUUC-Cfa-020622	Canis familiaris	48.31	0.00e+00	918.00
IUUC-Cpo-022526	Cavia porcellus	49.66	0.00e+00	938.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	39.25	0.00e+00	648.00
IUUC-Csa-023780	Chlorocebus sabaeus	49.57	0.00e+00	954.00
IUUC-Cho-024682	Choloepus hoffmanni	33.90	2.00e-84	306.00
IUUC-Cin-025790	Ciona intestinalis	49.19	0.00e+00	944.00
IUUC-Csv-026084	Ciona savignyi	46.45	0.00e+00	886.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	44.75	0.00e+00	798.00
IUUC-Cne-026960	Cryptococcus neoformans	46.66	0.00e+00	816.00
IUUC-Cme-027290	Cyanidioschyzon merolae	39.87	0.00e+00	668.00
IUUC-Dre-028149	Danio rerio	49.66	0.00e+00	932.00
IUUC-Dno-028884	Dasypus novemcinctus	49.09	0.00e+00	948.00
IUUC-Dor-030229	Dipodomys ordii	47.25	0.00e+00	897.00
IUUC-Dse-031524	Dothistroma septosporum	44.48	0.00e+00	800.00
IUUC-Dme-032045	Drosophila melanogaster	46.85	0.00e+00	875.00
IUUC-Ete-033124	Echinops telfairi	38.03	5.00e-130	457.00
IUUC-Eca-033330	Equus caballus	49.37	0.00e+00	953.00
IUUC-Eeu-035323	Erinaceus europaeus	39.77	6.00e-133	467.00
IUUC-Fca-036255	Felis catus	49.47	0.00e+00	956.00
IUUC-Fal-037445	Ficedula albicollis	39.06	5.00e-180	623.00
IUUC-Fox-038007	Fusarium oxysporum	47.46	2.00e-129	454.00
IUUC-Fso-038339	Fusarium solani	44.83	0.00e+00	780.00
IUUC-Gmo-039338	Gadus morhua	48.77	0.00e+00	906.00
IUUC-Ggr-039823	Gaeumannomyces graminis	45.30	0.00e+00	827.00
IUUC-Gga-040747	Gallus gallus	38.94	2.00e-173	602.00
IUUC-Gac-041773	Gasterosteus aculeatus	48.49	0.00e+00	912.00
IUUC-Gma-043165	Glycine max	38.31	0.00e+00	660.00
IUUC-Ggo-045336	Gorilla gorilla	49.66	0.00e+00	934.00
IUUC-Hsa-045982	Homo sapiens	49.57	0.00e+00	930.00
IUUC-Hvu-047846	Hordeum vulgare	38.87	0.00e+00	647.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	49.57	0.00e+00	958.00
IUUC-Kpa-049112	Komagataella pastoris	42.87	0.00e+00	753.00
IUUC-Lch-050371	Latimeria chalumnae	49.86	0.00e+00	965.00
IUUC-Lpe-051299	Leersia perrieri	37.80	0.00e+00	652.00
IUUC-Loc-052936	Lepisosteus oculatus	49.63	0.00e+00	967.00
IUUC-Lma-053315	Leptosphaeria maculans	45.97	0.00e+00	839.00
IUUC-Laf-053948	Loxodonta africana	48.99	0.00e+00	929.00
IUUC-Mcc-055843	Macaca mulatta	49.57	0.00e+00	955.00
IUUC-Meu-056258	Macropus eugenii	48.89	0.00e+00	937.00
IUUC-Mor-057269	Magnaporthe oryzae	45.45	0.00e+00	822.00
IUUC-Mpo-057435	Magnaporthe poae	45.39	0.00e+00	815.00
IUUC-Mtr-058572	Medicago truncatula	37.96	4.00e-180	624.00
IUUC-Mla-059176	Melampsora laricipopulina	46.59	0.00e+00	831.00
IUUC-Mga-059721	Meleagris gallopavo	38.74	3.00e-169	587.00
IUUC-Mvi-060437	Microbotryum violaceum	45.16	0.00e+00	783.00
IUUC-Mmr-061405	Microcebus murinus	48.84	0.00e+00	926.00
IUUC-Mdo-062032	Monodelphis domestica	48.00	0.00e+00	910.00
IUUC-Mmu-063280	Mus musculus	48.99	0.00e+00	945.00
IUUC-Mac-065505	Musa acuminata	37.51	0.00e+00	627.00
IUUC-Mpu-066409	Mustela putorius furo	49.76	0.00e+00	959.00
IUUC-Mlu-067217	Myotis lucifugus	48.80	0.00e+00	932.00
IUUC-Nfi-068407	Neosartorya fischeri	46.54	0.00e+00	815.00
IUUC-Ncr-068698	Neurospora crassa	45.14	0.00e+00	827.00
IUUC-Nle-070072	Nomascus leucogenys	47.04	0.00e+00	850.00
IUUC-Opr-070715	Ochotona princeps	36.08	2.00e-167	582.00
IUUC-Ont-071671	Oreochromis niloticus	49.29	0.00e+00	942.00
IUUC-Oan-073268	Ornithorhynchus anatinus	40.26	4.00e-167	580.00
IUUC-Ocu-074544	Oryctolagus cuniculus	50.05	0.00e+00	961.00
IUUC-Oba-075120	Oryza barthii	37.82	0.00e+00	627.00
IUUC-Obr-076557	Oryza brachyantha	38.17	0.00e+00	630.00
IUUC-Ogl-077887	Oryza glaberrima	37.82	0.00e+00	627.00
IUUC-Ogu-078305	Oryza glumaepatula	38.23	0.00e+00	640.00
IUUC-Oin-080154	Oryza indica	38.23	0.00e+00	640.00
IUUC-Olo-081089	Oryza longistaminata	38.23	0.00e+00	643.00
IUUC-Ome-081942	Oryza meridionalis	37.38	0.00e+00	630.00
IUUC-Oni-082365	Oryza nivara	37.57	0.00e+00	630.00
IUUC-Opu-083977	Oryza punctata	37.70	0.00e+00	639.00
IUUC-Oru-084469	Oryza rufipogon	38.23	0.00e+00	641.00
IUUC-Osa-085949	Oryza sativa	37.82	0.00e+00	635.00
IUUC-Ola-087002	Oryzias latipes	49.58	0.00e+00	948.00
IUUC-Olu-087687	Ostreococcus lucimarinus	38.76	0.00e+00	640.00
IUUC-Oga-088594	Otolemur garnettii	49.57	0.00e+00	934.00
IUUC-Oar-090068	Ovis aries	49.37	0.00e+00	957.00
IUUC-Ptr-090609	Pan troglodytes	38.57	5.00e-179	620.00
IUUC-Pan-092114	Papio anubis	49.66	0.00e+00	958.00
IUUC-Psi-093489	Pelodiscus sinensis	38.75	0.00e+00	629.00
IUUC-Pma-094214	Petromyzon marinus	42.60	9.00e-33	131.00
IUUC-Pno-095154	Phaeosphaeria nodorum	46.27	0.00e+00	843.00
IUUC-Ppa-095416	Physcomitrella patens	39.32	0.00e+00	679.00
IUUC-Pfo-097184	Poecilia formosa	49.23	0.00e+00	926.00
IUUC-Pab-097861	Pongo abelii	49.57	0.00e+00	924.00
IUUC-Pop-098934	Populus trichocarpa	38.07	0.00e+00	664.00
IUUC-Pca-100347	Procavia capensis	47.32	0.00e+00	766.00
IUUC-Ppe-102012	Prunus persica	37.55	0.00e+00	645.00
IUUC-Pva-102584	Pteropus vampyrus	49.47	0.00e+00	962.00
IUUC-Pgr-103336	Puccinia graminis	45.11	0.00e+00	812.00
IUUC-Ptt-103939	Puccinia triticina	45.71	0.00e+00	812.00
IUUC-Pte-104200	Pyrenophora teres	45.90	0.00e+00	835.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	45.56	0.00e+00	832.00
IUUC-Rno-105462	Rattus norvegicus	49.18	0.00e+00	941.00
IUUC-Sce-106245	Saccharomyces cerevisiae	42.64	0.00e+00	762.00
IUUC-Sha-107142	Sarcophilus harrisii	48.99	0.00e+00	947.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	45.74	0.00e+00	827.00
IUUC-Spo-108034	Schizosaccharomyces pombe	46.61	0.00e+00	808.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	44.53	0.00e+00	801.00
IUUC-Smo-108912	Selaginella moellendorffii	40.50	0.00e+00	694.00
IUUC-Sit-110281	Setaria italica	39.54	0.00e+00	651.00
IUUC-Sly-110914	Solanum lycopersicum	39.90	0.00e+00	675.00
IUUC-Stu-112109	Solanum tuberosum	39.82	0.00e+00	683.00
IUUC-Sar-113737	Sorex araneus	48.90	0.00e+00	951.00
IUUC-Sbi-114520	Sorghum bicolor	39.34	0.00e+00	650.00
IUUC-Sre-115148	Sporisorium reilianum	46.31	0.00e+00	824.00
IUUC-Ssc-115777	Sus scrofa	49.32	0.00e+00	952.00
IUUC-Tgu-116565	Taeniopygia guttata	38.65	6.00e-175	607.00
IUUC-Tru-118742	Takifugu rubripes	48.73	0.00e+00	907.00
IUUC-Tsy-119436	Tarsius syrichta	34.99	1.00e-142	499.00
IUUC-Tni-120401	Tetraodon nigroviridis	49.39	0.00e+00	926.00
IUUC-Tca-121672	Theobroma cacao	38.93	0.00e+00	662.00
IUUC-Tre-122009	Trichoderma reesei	45.42	0.00e+00	767.00
IUUC-Tvi-122259	Trichoderma virens	46.01	0.00e+00	773.00
IUUC-Tae-125702	Triticum aestivum	38.40	0.00e+00	662.00
IUUC-Tur-126189	Triticum urartu	39.16	0.00e+00	635.00
IUUC-Tme-127055	Tuber melanosporum	44.09	0.00e+00	734.00
IUUC-Tbe-127587	Tupaia belangeri	41.17	6.00e-151	526.00
IUUC-Ttr-128331	Tursiops truncatus	49.37	0.00e+00	941.00
IUUC-Uma-129387	Ustilago maydis	46.60	0.00e+00	816.00
IUUC-Vda-129977	Verticillium dahliae	44.74	0.00e+00	744.00
IUUC-Vpa-130716	Vicugna pacos	37.20	1.00e-165	575.00
IUUC-Vvi-130857	Vitis vinifera	38.74	0.00e+00	649.00
IUUC-Xtr-132026	Xenopus tropicalis	40.82	0.00e+00	669.00
IUUC-Xma-133805	Xiphophorus maculatus	49.15	0.00e+00	926.00
IUUC-Yli-134547	Yarrowia lipolytica	44.42	0.00e+00	791.00
IUUC-Zma-134970	Zea mays	38.69	0.00e+00	672.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence