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Tag Content
UUCD2 ID IUUC-Gac-041613
UUCD1 version UUC-GaA-00404
Ensembl Protein ID ENSGACP00000011144.1
UniProt Accession G3P0M1; G3P0M1_GASAC
Protein Name Lissencephaly-1 homolog
Gene Name pafah1b1b (1 of many); PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGACG00000008413.1 ENSGACT00000011167.1 ENSGACP00000011144.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.20e-57 187.4 336 374
UBD/Beta-Prp 2.40e-91 306.4 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ +++vs++dD+t+++WD++ ++ k
   Q: 336 GHDNWVRGILFhPGgKFIVSCADDKTLRIWDYKNKRCMK 374
    8***********999****************99998876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h s++t v f+p s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    5678889********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd+++s+s+d+t ++w++ tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++++++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIISASRDKTMKMWEVATGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKDCKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++ g c++tl gh+++v+ + f+p ++++vs+++D+++riWd++++
   Q: 283 SWAPESahptiqdatgsetkksgkagPFLLSGSRDKTIKMWDVSIGLCLMTLVGHDNWVRGILFHPGGKFIVSCADDKTLRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl h++ v+s ++ + +++v+gs d++v++w+++
   Q: 372 CMKTLCAHEHFVTSLDF-HKAAPYVVTGSVDQTVKVWECR 410
    *****************.999****************985 PP
   

Organism Gasterosteus aculeatus
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDNN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIT LGGPVSQKRD PKEWIPRPPE RYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Gac-041613|E3,WD_repeat;UBD,Beta-Prp|Gasterosteus aculeatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCTGAAGGC GAATGCAGCA GCCAACGAAA AAACAAGCAA GCGGAGCCGG AGAGACAAGA 60
CGGCCGCGGT TCACCTCCGC AACACAAGAT CCTATTCTGG AAGCGGAAAT TTCACGCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Gac-041613|E3,WD_repeat;UBD,Beta-Prp|Gasterosteus aculeatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 92.73 0.00e+00 785.00
IUUC-Apl-004024 Anas platyrhynchos 92.93 0.00e+00 807.00
IUUC-Aca-004564 Anolis carolinensis 92.68 0.00e+00 800.00
IUUC-Acl-008360 Aspergillus clavatus 46.55 1.00e-104 373.00
IUUC-Afl-008502 Aspergillus flavus 45.17 3.00e-93 335.00
IUUC-Afu-008848 Aspergillus fumigatus 46.08 2.00e-106 379.00
IUUC-Ani-009173 Aspergillus nidulans 43.07 6.00e-90 324.00
IUUC-Ang-009873 Aspergillus niger 45.06 2.00e-93 336.00
IUUC-Aor-009973 Aspergillus oryzae 43.69 9.00e-91 327.00
IUUC-Ate-010523 Aspergillus terreus 41.56 3.00e-89 322.00
IUUC-Ame-011154 Astyanax mexicanus 95.12 0.00e+00 825.00
IUUC-Bgr-011972 Blumeria graminis 46.62 1.00e-103 370.00
IUUC-Bta-013106 Bos taurus 92.93 0.00e+00 808.00
IUUC-Bci-013615 Botrytis cinerea 45.06 2.00e-99 355.00
IUUC-Cel-018459 Caenorhabditis elegans 56.45 2.00e-147 515.00
IUUC-Cja-018755 Callithrix jacchus 90.49 0.00e+00 788.00
IUUC-Cfa-020749 Canis familiaris 92.93 0.00e+00 808.00
IUUC-Cpo-022371 Cavia porcellus 92.93 0.00e+00 808.00
IUUC-Csa-023524 Chlorocebus sabaeus 91.59 0.00e+00 677.00
IUUC-Cho-024764 Choloepus hoffmanni 83.02 0.00e+00 643.00
IUUC-Cin-025753 Ciona intestinalis 70.80 2.00e-180 624.00
IUUC-Csv-025817 Ciona savignyi 70.00 0.00e+00 637.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 47.37 9.00e-98 350.00
IUUC-Cne-027087 Cryptococcus neoformans 49.36 2.00e-108 385.00
IUUC-Dre-028314 Danio rerio 94.15 0.00e+00 822.00
IUUC-Dno-029050 Dasypus novemcinctus 92.68 0.00e+00 807.00
IUUC-Dor-030222 Dipodomys ordii 85.37 0.00e+00 731.00
IUUC-Dse-031164 Dothistroma septosporum 43.38 1.00e-100 360.00
IUUC-Dme-031745 Drosophila melanogaster 71.05 2.00e-175 608.00
IUUC-Ete-032508 Echinops telfairi 77.07 0.00e+00 647.00
IUUC-Eca-034288 Equus caballus 92.23 0.00e+00 780.00
IUUC-Eeu-034984 Erinaceus europaeus 85.12 0.00e+00 727.00
IUUC-Fca-036498 Felis catus 92.93 0.00e+00 808.00
IUUC-Fal-036920 Ficedula albicollis 92.93 0.00e+00 807.00
IUUC-Fox-037996 Fusarium oxysporum 45.43 4.00e-103 368.00
IUUC-Fso-038160 Fusarium solani 42.86 1.00e-96 347.00
IUUC-Gmo-038983 Gadus morhua 95.12 0.00e+00 822.00
IUUC-Ggr-040051 Gaeumannomyces graminis 45.35 6.00e-98 350.00
IUUC-Gga-040623 Gallus gallus 92.93 0.00e+00 807.00
IUUC-Ggo-045410 Gorilla gorilla 82.96 0.00e+00 682.00
IUUC-Hsa-046358 Homo sapiens 92.93 0.00e+00 807.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 92.93 0.00e+00 808.00
IUUC-Lma-053170 Leptosphaeria maculans 45.78 1.00e-98 353.00
IUUC-Laf-053713 Loxodonta africana 90.95 0.00e+00 788.00
IUUC-Mcc-054628 Macaca mulatta 92.44 0.00e+00 805.00
IUUC-Meu-055927 Macropus eugenii 79.42 6.00e-131 459.00
IUUC-Mor-056962 Magnaporthe oryzae 44.12 2.00e-97 349.00
IUUC-Mpo-057583 Magnaporthe poae 44.84 1.00e-93 337.00
IUUC-Mla-058819 Melampsora laricipopulina 47.42 3.00e-117 415.00
IUUC-Mga-059945 Meleagris gallopavo 92.68 0.00e+00 806.00
IUUC-Mvi-060403 Microbotryum violaceum 50.23 8.00e-130 456.00
IUUC-Mmr-061289 Microcebus murinus 92.73 0.00e+00 785.00
IUUC-Mdo-061912 Monodelphis domestica 92.20 0.00e+00 800.00
IUUC-Mmu-063253 Mus musculus 92.93 0.00e+00 808.00
IUUC-Mpu-066638 Mustela putorius furo 92.93 0.00e+00 808.00
IUUC-Mlu-067267 Myotis lucifugus 91.42 0.00e+00 790.00
IUUC-Nfi-068571 Neosartorya fischeri 44.74 5.00e-99 354.00
IUUC-Ncr-068895 Neurospora crassa 48.53 7.00e-105 374.00
IUUC-Nle-069087 Nomascus leucogenys 92.84 0.00e+00 657.00
IUUC-Opr-070579 Ochotona princeps 92.68 0.00e+00 807.00
IUUC-Ont-072432 Oreochromis niloticus 95.85 0.00e+00 829.00
IUUC-Oan-073072 Ornithorhynchus anatinus 92.93 0.00e+00 808.00
IUUC-Ocu-074180 Oryctolagus cuniculus 92.68 0.00e+00 807.00
IUUC-Ola-086772 Oryzias latipes 97.07 0.00e+00 837.00
IUUC-Oga-088219 Otolemur garnettii 90.71 0.00e+00 787.00
IUUC-Oar-090394 Ovis aries 92.93 0.00e+00 808.00
IUUC-Ptr-091517 Pan troglodytes 92.93 0.00e+00 808.00
IUUC-Pan-092421 Papio anubis 92.44 0.00e+00 805.00
IUUC-Psi-093370 Pelodiscus sinensis 92.68 0.00e+00 805.00
IUUC-Pno-094815 Phaeosphaeria nodorum 46.38 2.00e-102 366.00
IUUC-Pfo-097089 Poecilia formosa 96.83 0.00e+00 836.00
IUUC-Pab-098421 Pongo abelii 92.93 0.00e+00 808.00
IUUC-Pca-100120 Procavia capensis 68.32 4.00e-154 537.00
IUUC-Pva-102960 Pteropus vampyrus 92.68 0.00e+00 803.00
IUUC-Pgr-103538 Puccinia graminis 46.76 4.00e-116 411.00
IUUC-Ptt-103990 Puccinia triticina 42.28 3.00e-44 173.00
IUUC-Pte-104261 Pyrenophora teres 46.62 1.00e-102 366.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 46.86 4.00e-103 368.00
IUUC-Rno-105123 Rattus norvegicus 92.93 0.00e+00 808.00
IUUC-Sha-107010 Sarcophilus harrisii 91.95 0.00e+00 799.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 33.26 3.00e-67 248.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 45.19 6.00e-100 357.00
IUUC-Sar-113309 Sorex araneus 91.98 0.00e+00 775.00
IUUC-Sre-115003 Sporisorium reilianum 48.86 3.00e-124 438.00
IUUC-Ssc-116148 Sus scrofa 92.93 0.00e+00 808.00
IUUC-Tgu-117299 Taeniopygia guttata 92.68 0.00e+00 805.00
IUUC-Tru-117721 Takifugu rubripes 96.34 0.00e+00 831.00
IUUC-Tsy-119493 Tarsius syrichta 92.20 0.00e+00 796.00
IUUC-Tni-120355 Tetraodon nigroviridis 97.32 0.00e+00 816.00
IUUC-Tre-121977 Trichoderma reesei 43.04 3.00e-100 358.00
IUUC-Tvi-122661 Trichoderma virens 43.20 9.00e-100 357.00
IUUC-Tme-127031 Tuber melanosporum 47.52 1.00e-102 366.00
IUUC-Tbe-127492 Tupaia belangeri 60.05 7.00e-119 420.00
IUUC-Ttr-128929 Tursiops truncatus 92.93 0.00e+00 805.00
IUUC-Uma-129347 Ustilago maydis 48.17 6.00e-123 434.00
IUUC-Vda-129837 Verticillium dahliae 45.91 9.00e-100 357.00
IUUC-Vpa-130532 Vicugna pacos 79.79 0.00e+00 628.00
IUUC-Xtr-131985 Xenopus tropicalis 93.17 0.00e+00 810.00
IUUC-Xma-133314 Xiphophorus maculatus 97.32 0.00e+00 839.00
IUUC-Yli-134403 Yarrowia lipolytica 39.10 5.00e-75 275.00
Created Date 25-Jun-2017

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