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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018508
Ensembl Protein ID C50C3.6
UniProt Accession P34369; PRP8_CAEEL
Genbank Protein ID CCD66122.1
Protein Name Pre-mRNA-splicing factor 8 homolog
Genbank Nucleotide ID FO080718
Gene Name prp-8; C50C3.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004187 C50C3.6 C50C3.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDPINAMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Jab_MPN 60.78 0.00e+00 2882.00 IUUC-Sce-106157
UBD/Jab_MPN 60.69 0.00e+00 2879.00 IUUC-Ots-000011
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
 Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
Protein Sequence
(Fasta)
MANYGGHPQT EPHAIPDSIL EEKSRKWKQL QGKRYSEKKK FGMSDTQKEE MPPEHVRKVI 60
RDHGDMTSRK YRHDKRVYLG ALKYMPHAVL KLLENMPMPW EQIRDVKVLY HITGAITFVN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018508|UBD,Jab_MPN|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCCAACT ACGGCGGTCA TCCCCAAACT GAACCACATG CTATCCCGGA TTCAATTCTG 60
GAAGAAAAGT CTCGAAAATG GAAACAACTT CAAGGAAAGC GGTATTCGGA GAAAAAGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018508|UBD,Jab_MPN|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0747--Spliceosome
Interpro

IPR000555--JAMM/MPN+_dom
IPR012591--PRO8NT
IPR012592--PROCN
IPR012984--PROCT
IPR027652--PRP8
IPR021983--PRP8_domainIV
IPR019581--Prp8_U5-snRNA-bd
IPR019580--Prp8_U6-snRNA-bd
IPR012337--RNaseH-like_dom
IPR019582--RRM_spliceosomal_PrP8
Pfam

PF01398--JAB
PF08082--PRO8NT
PF08083--PROCN
PF08084--PROCT
PF12134--PRP8_domainIV
PF10598--RRM_4
PF10597--U5_2-snRNA_bdg
PF10596--U6-snRNA_bdg
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0005681--C:spliceosomal complex
GO:0030623--F:U5 snRNA binding
GO:0017070--F:U6 snRNA binding
GO:0000398--P:mRNA splicing, via spliceosome
KEGG cel:CELE_C50C3.6
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001091 Aegilops tauschii 81.24 0.00e+00 3859.00
IUUC-Aml-002261 Ailuropoda melanoleuca 86.44 0.00e+00 4125.00
IUUC-Atr-002524 Amborella trichopoda 80.65 0.00e+00 3897.00
IUUC-Apl-004039 Anas platyrhynchos 87.13 0.00e+00 4020.00
IUUC-Aca-005394 Anolis carolinensis 87.33 0.00e+00 3353.00
IUUC-Aly-005909 Arabidopsis lyrata 79.97 0.00e+00 3873.00
IUUC-Ath-007237 Arabidopsis thaliana 80.43 0.00e+00 3867.00
IUUC-Ago-007815 Ashbya gossypii 60.41 0.00e+00 2944.00
IUUC-Acl-008111 Aspergillus clavatus 72.25 0.00e+00 3509.00
IUUC-Afl-008609 Aspergillus flavus 73.02 0.00e+00 2170.00
IUUC-Afu-009078 Aspergillus fumigatus 72.81 0.00e+00 2309.00
IUUC-Ani-009297 Aspergillus nidulans 72.36 0.00e+00 2283.00
IUUC-Ang-009749 Aspergillus niger 72.59 0.00e+00 3527.00
IUUC-Aor-010106 Aspergillus oryzae 72.80 0.00e+00 3533.00
IUUC-Ate-010566 Aspergillus terreus 72.73 0.00e+00 3529.00
IUUC-Ame-011416 Astyanax mexicanus 86.98 0.00e+00 4159.00
IUUC-Bgr-012078 Blumeria graminis 69.55 0.00e+00 2191.00
IUUC-Bta-013532 Bos taurus 86.44 0.00e+00 4125.00
IUUC-Bci-013914 Botrytis cinerea 72.42 0.00e+00 2301.00
IUUC-Bdi-014349 Brachypodium distachyon 80.83 0.00e+00 3883.00
IUUC-Bol-015707 Brassica oleracea 80.61 0.00e+00 3871.00
IUUC-Bra-017086 Brassica rapa 79.85 0.00e+00 3845.00
IUUC-Cja-019483 Callithrix jacchus 86.44 0.00e+00 4125.00
IUUC-Cfa-021018 Canis familiaris 86.44 0.00e+00 4125.00
IUUC-Cpo-022159 Cavia porcellus 86.44 0.00e+00 4125.00
IUUC-Cre-022998 Chlamydomonas reinhardtii 79.26 0.00e+00 3749.00
IUUC-Csa-023885 Chlorocebus sabaeus 86.44 0.00e+00 4125.00
IUUC-Cho-024639 Choloepus hoffmanni 86.94 0.00e+00 2414.00
IUUC-Cin-025356 Ciona intestinalis 74.95 0.00e+00 671.00
IUUC-Csv-025880 Ciona savignyi 84.73 0.00e+00 4057.00
IUUC-Cgl-026713 Colletotrichum gloeosporioides 69.98 0.00e+00 3384.00
IUUC-Cne-026874 Cryptococcus neoformans 73.36 0.00e+00 2163.00
IUUC-Cme-027252 Cyanidioschyzon merolae 33.15 0.00e+00 998.00
IUUC-Dre-027996 Danio rerio 86.89 0.00e+00 4161.00
IUUC-Dno-029708 Dasypus novemcinctus 87.54 0.00e+00 3865.00
IUUC-Dor-030119 Dipodomys ordii 83.46 0.00e+00 3719.00
IUUC-Dse-031333 Dothistroma septosporum 71.66 0.00e+00 3432.00
IUUC-Dme-031908 Drosophila melanogaster 86.25 0.00e+00 4114.00
IUUC-Ete-032766 Echinops telfairi 85.51 0.00e+00 3397.00
IUUC-Eca-034109 Equus caballus 86.44 0.00e+00 4125.00
IUUC-Eeu-035094 Erinaceus europaeus 88.42 0.00e+00 2132.00
IUUC-Fca-035567 Felis catus 88.32 0.00e+00 3449.00
IUUC-Fal-036613 Ficedula albicollis 86.54 0.00e+00 4133.00
IUUC-Fox-037855 Fusarium oxysporum 71.31 0.00e+00 3449.00
IUUC-Fso-038078 Fusarium solani 70.92 0.00e+00 3438.00
IUUC-Gmo-038986 Gadus morhua 84.84 0.00e+00 4089.00
IUUC-Ggr-039855 Gaeumannomyces graminis 70.75 0.00e+00 3416.00
IUUC-Gga-040719 Gallus gallus 86.54 0.00e+00 4133.00
IUUC-Gac-042502 Gasterosteus aculeatus 86.23 0.00e+00 4146.00
IUUC-Gma-043317 Glycine max 81.09 0.00e+00 3892.00
IUUC-Ggo-045622 Gorilla gorilla 81.61 0.00e+00 3821.00
IUUC-Hsa-046060 Homo sapiens 86.44 0.00e+00 4125.00
IUUC-Hvu-047251 Hordeum vulgare 82.36 0.00e+00 3651.00
IUUC-Itr-048517 Ictidomys tridecemlineatus 85.30 0.00e+00 2119.00
IUUC-Kpa-049289 Komagataella pastoris 64.42 0.00e+00 3071.00
IUUC-Lch-049690 Latimeria chalumnae 85.26 0.00e+00 3831.00
IUUC-Lpe-050868 Leersia perrieri 79.74 0.00e+00 3860.00
IUUC-Loc-052365 Lepisosteus oculatus 86.37 0.00e+00 4134.00
IUUC-Lma-053043 Leptosphaeria maculans 71.59 0.00e+00 3518.00
IUUC-Laf-053582 Loxodonta africana 86.44 0.00e+00 4125.00
IUUC-Mcc-055024 Macaca mulatta 86.44 0.00e+00 4125.00
IUUC-Meu-056637 Macropus eugenii 85.31 0.00e+00 4024.00
IUUC-Mor-057244 Magnaporthe oryzae 70.00 0.00e+00 3367.00
IUUC-Mpo-057580 Magnaporthe poae 70.83 0.00e+00 3423.00
IUUC-Mtr-058326 Medicago truncatula 80.96 0.00e+00 3913.00
IUUC-Mla-059121 Melampsora laricipopulina 73.21 0.00e+00 3454.00
IUUC-Mga-059789 Meleagris gallopavo 86.54 0.00e+00 4133.00
IUUC-Mvi-060563 Microbotryum violaceum 71.76 0.00e+00 3457.00
IUUC-Mmr-060880 Microcebus murinus 85.67 0.00e+00 4076.00
IUUC-Mdo-062237 Monodelphis domestica 86.59 0.00e+00 4123.00
IUUC-Mmu-064177 Mus musculus 86.40 0.00e+00 4127.00
IUUC-Mac-065558 Musa acuminata 79.22 0.00e+00 3700.00
IUUC-Mpu-066903 Mustela putorius furo 86.44 0.00e+00 4125.00
IUUC-Mlu-067424 Myotis lucifugus 86.33 0.00e+00 4120.00
IUUC-Nfi-068265 Neosartorya fischeri 72.70 0.00e+00 2305.00
IUUC-Ncr-068963 Neurospora crassa 70.98 0.00e+00 3427.00
IUUC-Nle-069111 Nomascus leucogenys 87.93 0.00e+00 2935.00
IUUC-Opr-070706 Ochotona princeps 85.16 0.00e+00 4028.00
IUUC-Ont-071405 Oreochromis niloticus 86.85 0.00e+00 4157.00
IUUC-Oan-073481 Ornithorhynchus anatinus 88.21 0.00e+00 1998.00
IUUC-Ocu-074231 Oryctolagus cuniculus 86.44 0.00e+00 4125.00
IUUC-Oba-075452 Oryza barthii 81.16 0.00e+00 3831.00
IUUC-Obr-076377 Oryza brachyantha 81.11 0.00e+00 3833.00
IUUC-Ogl-077666 Oryza glaberrima 80.70 0.00e+00 3873.00
IUUC-Ogu-078187 Oryza glumaepatula 81.11 0.00e+00 3832.00
IUUC-Oin-079234 Oryza indica 80.98 0.00e+00 3827.00
IUUC-Olo-080543 Oryza longistaminata 81.07 0.00e+00 3830.00
IUUC-Ome-081541 Oryza meridionalis 80.18 0.00e+00 3838.00
IUUC-Oni-082712 Oryza nivara 82.84 0.00e+00 3103.00
IUUC-Opu-083904 Oryza punctata 80.61 0.00e+00 3864.00
IUUC-Oru-084749 Oryza rufipogon 80.70 0.00e+00 3871.00
IUUC-Osa-085504 Oryza sativa 81.21 0.00e+00 1961.00
IUUC-Ola-087464 Oryzias latipes 86.53 0.00e+00 3922.00
IUUC-Olu-087705 Ostreococcus lucimarinus 78.82 0.00e+00 3814.00
IUUC-Oga-087910 Otolemur garnettii 96.12 4.00e-73 264.00
IUUC-Oar-089892 Ovis aries 86.33 0.00e+00 4120.00
IUUC-Ptr-090562 Pan troglodytes 91.22 0.00e+00 884.00
IUUC-Pan-092555 Papio anubis 87.15 0.00e+00 4080.00
IUUC-Psi-094049 Pelodiscus sinensis 86.41 0.00e+00 4127.00
IUUC-Pma-094240 Petromyzon marinus 85.16 0.00e+00 3933.00
IUUC-Pno-095146 Phaeosphaeria nodorum 70.35 0.00e+00 3403.00
IUUC-Ppa-095776 Physcomitrella patens 81.02 0.00e+00 3892.00
IUUC-Pfo-097177 Poecilia formosa 86.81 0.00e+00 4148.00
IUUC-Pab-097961 Pongo abelii 86.44 0.00e+00 4125.00
IUUC-Pop-099731 Populus trichocarpa 80.68 0.00e+00 3900.00
IUUC-Pca-100655 Procavia capensis 85.85 0.00e+00 1496.00
IUUC-Ppe-101199 Prunus persica 78.99 0.00e+00 3789.00
IUUC-Pva-103175 Pteropus vampyrus 90.07 0.00e+00 3340.00
IUUC-Pgr-103467 Puccinia graminis 73.23 0.00e+00 3461.00
IUUC-Ptt-103770 Puccinia triticina 67.75 0.00e+00 3128.00
IUUC-Pte-104210 Pyrenophora teres 71.23 0.00e+00 3492.00
IUUC-Pyt-104572 Pyrenophora triticirepentis 71.84 0.00e+00 2265.00
IUUC-Rno-105997 Rattus norvegicus 86.40 0.00e+00 4127.00
IUUC-Sce-106157 Saccharomyces cerevisiae 61.20 0.00e+00 2913.00
IUUC-Sha-107355 Sarcophilus harrisii 86.55 0.00e+00 4123.00
IUUC-Sja-107760 Schizosaccharomyces japonicus 73.15 0.00e+00 3476.00
IUUC-Spo-108160 Schizosaccharomyces pombe 73.10 0.00e+00 3494.00
IUUC-Ssl-108519 Sclerotinia sclerotiorum 72.28 0.00e+00 2292.00
IUUC-Smo-109278 Selaginella moellendorffii 80.63 0.00e+00 3880.00
IUUC-Sit-110777 Setaria italica 80.53 0.00e+00 3867.00
IUUC-Sly-110889 Solanum lycopersicum 80.99 0.00e+00 3908.00
IUUC-Stu-112016 Solanum tuberosum 80.95 0.00e+00 3906.00
IUUC-Sar-113245 Sorex araneus 83.97 0.00e+00 2388.00
IUUC-Sbi-114423 Sorghum bicolor 80.26 0.00e+00 1739.00
IUUC-Sre-115077 Sporisorium reilianum 65.29 0.00e+00 3149.00
IUUC-Ssc-116211 Sus scrofa 86.86 0.00e+00 3986.00
IUUC-Tgu-116697 Taeniopygia guttata 86.54 0.00e+00 4133.00
IUUC-Tru-117984 Takifugu rubripes 86.85 0.00e+00 4161.00
IUUC-Tsy-118893 Tarsius syrichta 87.01 0.00e+00 1405.00
IUUC-Tni-120620 Tetraodon nigroviridis 88.25 0.00e+00 3108.00
IUUC-Tca-121331 Theobroma cacao 80.98 0.00e+00 3896.00
IUUC-Tre-122031 Trichoderma reesei 71.40 0.00e+00 3445.00
IUUC-Tvi-122603 Trichoderma virens 71.05 0.00e+00 3429.00
IUUC-Tae-125167 Triticum aestivum 80.79 0.00e+00 3895.00
IUUC-Tur-126772 Triticum urartu 81.07 0.00e+00 3856.00
IUUC-Tme-126899 Tuber melanosporum 72.32 0.00e+00 3524.00
IUUC-Tbe-127364 Tupaia belangeri 91.57 0.00e+00 2774.00
IUUC-Ttr-129009 Tursiops truncatus 85.89 0.00e+00 4093.00
IUUC-Vda-130015 Verticillium dahliae 70.41 0.00e+00 2233.00
IUUC-Vpa-130769 Vicugna pacos 87.72 0.00e+00 1060.00
IUUC-Vvi-131030 Vitis vinifera 80.69 0.00e+00 3876.00
IUUC-Xtr-132067 Xenopus tropicalis 86.81 0.00e+00 4129.00
IUUC-Xma-134252 Xiphophorus maculatus 86.81 0.00e+00 4146.00
IUUC-Yli-134434 Yarrowia lipolytica 65.27 0.00e+00 3098.00
IUUC-Zma-134994 Zea mays 80.48 0.00e+00 3869.00
Created Date 25-Jun-2017

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