iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sly-111523

Ensembl Protein ID

Solyc07g063650.2.1

UniProt Accession

K4CH48; K4CH48_SOLLC

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Solyc07g063650.2	Solyc07g063650.2.1	Solyc07g063650.2.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-53	182.1	308	798
UBD/Alpha-Helix/UBA	2.80e-17	63.0	675	713

Active Site

Position(s)	Description	Evidence
317	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
761	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelre.lllekkkeklneenpkepkgellkslqklfeel..................w.kskkkavspr 71
           tGl NlgN+CY+ +++Q++++++++ + +++++  ++   ++p +p+ +l ++l+kl + l                  + ++k++ + pr
   Q: 308  TGLVNLGNSCYLAATMQVMFSTRSFCSrYYFDQRLKEAFTTAPADPTVDLNMQLTKLAHGLlsgkysgpvlekdntanaVsSQKQEGIRPR 398
           7************************6523444566666677899*****************9999999988888876652689999***** PP
   S: 72   ellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnv 162
           ++++++++ ++efs+++qqDa Ef+ +++dq+e+                                 +   s+ F++ ++++++c + + v
   Q: 399  MFKSVIAASHPEFSTMRQQDALEFFLHFIDQVERIN---------------------------SGTPNFDPSRSFKFGIEERLQCSSGK-V 461
           ********************************9966...........................22233447899***********7655.5 PP
   S: 163  ssreepfldlslpvpgkeetkke.............................slqdcLesftkeeelegenkyycekckkkqeaekklklk 224
           +  + + + lsl++p ++  +k+                             sl+dcL+ f+++ee+++   +y++  +++++a k+ +l+
   Q: 462  TYNRRNDYILSLNIPLERAINKKelaefqnlkaeraaggkelsadeivrprvSLKDCLDCFSAPEEVHD---FYSTALTARTTAIKTAGLT 549
           5555566777777776665555567999***************************************97...******************* PP
   S: 225  klPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts................................................ 267
           ++P++L+lh+ +f + ee+++++k++ ++++p+++d+s++ ++                                                
   Q: 550  SFPDYLVLHMRKF-VMEEGWVPKKLDVYIDVPETIDISSMRSNgiqpgeellpdsaagdgeqsiklladddivaqlvsmgfnllhcqkaai 639
           *************.67889********************9999999999999999888888888888888888888888888888888887 PP
   S: 268  ....................................peekqke................................................ 274
                                               +     +                                                
   Q: 640  ntsnsgveaamdwllnhmndpdidapisenvqnpdiD-----Qskvdtlvsfgfeeklahkalkasggdvekatewifsspsastaadmdv 725
           7777777777777777777777766666655555550.....0555556666666666666666677777777777777777777888888 PP
   S: 275  ...............kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                            kY+L++ v+H G s+++GHYva++++ +g+W+ f+D+kV ++k   +       +Y++f++r
   Q: 726  ttssgaavdtlmpdgGGKYRLLGFVSHIGtSTHCGHYVAHINK-DGRWVIFNDEKVGVSKNPPMDM-----GYLYFFER 798
           8888889999999999**************************9.9************997655555.....99999987 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           +d++k++ lv+ GF++++a +aL a+++++e A+e++++
   Q: 675  IDQSKVDTLVSFGFEEKLAHKALKASGGDVEKATEWIFS 713
           79***********************************97 PP

Organism

Solanum lycopersicum

Protein Sequence
(Fasta)

MELLRSNLAR VRIPEPTTRI YKHECCISFD TPKSDGGLFV DMSTFLAFGR DCVDWNYEKT 60
GNPVYLHIKQ TKKADAEDRP SKKPTLLAIG LDGGFDNSEP QYEEFYEIVI LPDNVTLPFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGCTTCCT TTCTTCATTT GGGAATTAGG GAGAAAGGCG GTTGCTGAAT ATTTGAGCAA 60
AGAATCCATA CGAATATATA TACACTATTT TTTCCTCTTC TTCTTGTAGC TCTCGGCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sly:101266142

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	62.79	0.00e+00	988.00
IUUC-Aml-002104	Ailuropoda melanoleuca	47.26	0.00e+00	743.00
IUUC-Atr-002580	Amborella trichopoda	76.25	0.00e+00	630.00
IUUC-Apl-003774	Anas platyrhynchos	48.06	0.00e+00	742.00
IUUC-Aca-005368	Anolis carolinensis	48.50	0.00e+00	783.00
IUUC-Aly-005727	Arabidopsis lyrata	71.82	0.00e+00	1184.00
IUUC-Ath-006974	Arabidopsis thaliana	71.82	0.00e+00	1186.00
IUUC-Ago-007890	Ashbya gossypii	28.23	1.00e-72	266.00
IUUC-Acl-008057	Aspergillus clavatus	34.47	2.00e-118	419.00
IUUC-Afl-008547	Aspergillus flavus	36.48	9.00e-112	396.00
IUUC-Afu-008805	Aspergillus fumigatus	34.29	5.00e-109	387.00
IUUC-Ani-009441	Aspergillus nidulans	36.55	2.00e-98	352.00
IUUC-Ang-009720	Aspergillus niger	34.60	6.00e-112	397.00
IUUC-Aor-010111	Aspergillus oryzae	34.19	1.00e-119	423.00
IUUC-Ate-010531	Aspergillus terreus	32.26	6.00e-96	344.00
IUUC-Ame-011470	Astyanax mexicanus	41.78	0.00e+00	663.00
IUUC-Bgr-012183	Blumeria graminis	31.92	5.00e-108	384.00
IUUC-Bta-013179	Bos taurus	46.90	0.00e+00	746.00
IUUC-Bci-013858	Botrytis cinerea	34.18	4.00e-121	427.00
IUUC-Bdi-014904	Brachypodium distachyon	67.04	0.00e+00	1082.00
IUUC-Bol-015296	Brassica oleracea	71.45	0.00e+00	1189.00
IUUC-Bra-017939	Brassica rapa	71.82	0.00e+00	1195.00
IUUC-Cel-018625	Caenorhabditis elegans	34.03	4.00e-115	408.00
IUUC-Cja-019063	Callithrix jacchus	46.79	0.00e+00	738.00
IUUC-Cfa-020976	Canis familiaris	48.68	0.00e+00	760.00
IUUC-Cpo-022265	Cavia porcellus	48.32	0.00e+00	758.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.63	4.00e-115	407.00
IUUC-Csa-024078	Chlorocebus sabaeus	42.57	0.00e+00	669.00
IUUC-Cho-024522	Choloepus hoffmanni	35.04	1.00e-124	439.00
IUUC-Cin-025411	Ciona intestinalis	43.67	0.00e+00	629.00
IUUC-Csv-026347	Ciona savignyi	40.44	1.00e-171	596.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.45	2.00e-107	382.00
IUUC-Cne-026831	Cryptococcus neoformans	34.39	1.00e-115	409.00
IUUC-Cme-027335	Cyanidioschyzon merolae	33.45	1.00e-35	144.00
IUUC-Dre-027651	Danio rerio	41.62	0.00e+00	687.00
IUUC-Dno-029034	Dasypus novemcinctus	47.55	0.00e+00	752.00
IUUC-Dor-030130	Dipodomys ordii	38.24	6.00e-112	397.00
IUUC-Dse-031467	Dothistroma septosporum	35.77	8.00e-120	423.00
IUUC-Dme-032075	Drosophila melanogaster	43.65	0.00e+00	666.00
IUUC-Ete-032865	Echinops telfairi	44.82	0.00e+00	679.00
IUUC-Eca-034059	Equus caballus	47.50	0.00e+00	748.00
IUUC-Eeu-035304	Erinaceus europaeus	45.55	0.00e+00	677.00
IUUC-Fca-035515	Felis catus	47.49	0.00e+00	749.00
IUUC-Fal-037271	Ficedula albicollis	48.99	0.00e+00	732.00
IUUC-Fox-037745	Fusarium oxysporum	37.02	1.00e-122	433.00
IUUC-Fso-038158	Fusarium solani	36.63	1.00e-120	426.00
IUUC-Gmo-039071	Gadus morhua	43.90	0.00e+00	662.00
IUUC-Ggr-040098	Gaeumannomyces graminis	33.74	3.00e-113	402.00
IUUC-Gga-040635	Gallus gallus	47.51	0.00e+00	775.00
IUUC-Gac-042528	Gasterosteus aculeatus	43.57	0.00e+00	668.00
IUUC-Gma-043614	Glycine max	75.34	0.00e+00	1202.00
IUUC-Ggo-044602	Gorilla gorilla	47.60	0.00e+00	753.00
IUUC-Hsa-045959	Homo sapiens	47.60	0.00e+00	753.00
IUUC-Hvu-047563	Hordeum vulgare	66.67	0.00e+00	855.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	47.25	0.00e+00	749.00
IUUC-Kpa-049156	Komagataella pastoris	31.37	3.00e-105	375.00
IUUC-Lch-049648	Latimeria chalumnae	47.96	0.00e+00	761.00
IUUC-Lpe-051523	Leersia perrieri	64.91	0.00e+00	1075.00
IUUC-Loc-052072	Lepisosteus oculatus	42.94	0.00e+00	671.00
IUUC-Lma-053216	Leptosphaeria maculans	35.78	2.00e-113	403.00
IUUC-Laf-054327	Loxodonta africana	47.72	0.00e+00	756.00
IUUC-Mcc-055443	Macaca mulatta	47.72	0.00e+00	753.00
IUUC-Meu-056298	Macropus eugenii	50.26	4.00e-155	541.00
IUUC-Mor-057106	Magnaporthe oryzae	34.16	5.00e-119	421.00
IUUC-Mpo-057589	Magnaporthe poae	33.74	6.00e-116	410.00
IUUC-Mtr-058680	Medicago truncatula	74.88	0.00e+00	1225.00
IUUC-Mla-058903	Melampsora laricipopulina	32.89	3.00e-105	375.00
IUUC-Mga-059669	Meleagris gallopavo	47.37	0.00e+00	732.00
IUUC-Mvi-060476	Microbotryum violaceum	34.51	2.00e-106	379.00
IUUC-Mmr-060575	Microcebus murinus	47.25	0.00e+00	747.00
IUUC-Mdo-062183	Monodelphis domestica	47.68	0.00e+00	756.00
IUUC-Mmu-063592	Mus musculus	47.37	0.00e+00	754.00
IUUC-Mac-065446	Musa acuminata	65.33	0.00e+00	1124.00
IUUC-Mpu-066082	Mustela putorius furo	48.68	0.00e+00	759.00
IUUC-Mlu-067345	Myotis lucifugus	47.02	0.00e+00	738.00
IUUC-Nfi-068558	Neosartorya fischeri	34.63	3.00e-119	421.00
IUUC-Ncr-068960	Neurospora crassa	32.61	4.00e-106	378.00
IUUC-Nle-070173	Nomascus leucogenys	48.68	0.00e+00	760.00
IUUC-Opr-070556	Ochotona princeps	47.25	0.00e+00	763.00
IUUC-Ont-071502	Oreochromis niloticus	45.40	0.00e+00	672.00
IUUC-Oan-072959	Ornithorhynchus anatinus	52.79	2.00e-69	254.00
IUUC-Ocu-074861	Oryctolagus cuniculus	48.38	0.00e+00	768.00
IUUC-Oba-075109	Oryza barthii	65.59	0.00e+00	1083.00
IUUC-Obr-076292	Oryza brachyantha	67.25	0.00e+00	1072.00
IUUC-Ogl-077065	Oryza glaberrima	67.20	0.00e+00	1125.00
IUUC-Ogu-078776	Oryza glumaepatula	65.47	0.00e+00	1092.00
IUUC-Oin-080048	Oryza indica	66.96	0.00e+00	1112.00
IUUC-Olo-080711	Oryza longistaminata	64.15	0.00e+00	1000.00
IUUC-Ome-081506	Oryza meridionalis	65.45	0.00e+00	1011.00
IUUC-Oni-082320	Oryza nivara	63.77	0.00e+00	1074.00
IUUC-Opu-083801	Oryza punctata	66.34	0.00e+00	1064.00
IUUC-Oru-085139	Oryza rufipogon	63.65	0.00e+00	1069.00
IUUC-Osa-085713	Oryza sativa	67.33	0.00e+00	1130.00
IUUC-Ola-086951	Oryzias latipes	42.49	0.00e+00	647.00
IUUC-Olu-087822	Ostreococcus lucimarinus	39.55	4.00e-162	564.00
IUUC-Oga-088625	Otolemur garnettii	46.96	0.00e+00	743.00
IUUC-Oar-089995	Ovis aries	46.50	0.00e+00	736.00
IUUC-Ptr-090640	Pan troglodytes	46.90	0.00e+00	753.00
IUUC-Pan-091974	Papio anubis	47.37	0.00e+00	745.00
IUUC-Psi-093957	Pelodiscus sinensis	47.97	0.00e+00	789.00
IUUC-Pma-094242	Petromyzon marinus	51.16	9.00e-110	389.00
IUUC-Pno-094835	Phaeosphaeria nodorum	36.34	2.00e-108	385.00
IUUC-Ppa-095901	Physcomitrella patens	64.18	0.00e+00	1075.00
IUUC-Pfo-097148	Poecilia formosa	45.23	0.00e+00	674.00
IUUC-Pab-098068	Pongo abelii	43.27	0.00e+00	626.00
IUUC-Pop-098855	Populus trichocarpa	76.08	0.00e+00	1201.00
IUUC-Pca-100738	Procavia capensis	46.05	1.00e-146	513.00
IUUC-Ppe-101315	Prunus persica	76.67	0.00e+00	1240.00
IUUC-Pva-102154	Pteropus vampyrus	47.01	0.00e+00	738.00
IUUC-Pgr-103343	Puccinia graminis	33.63	1.00e-103	369.00
IUUC-Ptt-103928	Puccinia triticina	30.08	1.00e-98	353.00
IUUC-Pte-104306	Pyrenophora teres	34.18	2.00e-103	369.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	35.10	3.00e-110	392.00
IUUC-Rno-105801	Rattus norvegicus	47.49	0.00e+00	753.00
IUUC-Sce-106304	Saccharomyces cerevisiae	30.06	7.00e-63	234.00
IUUC-Sha-107635	Sarcophilus harrisii	48.20	0.00e+00	751.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.53	5.00e-93	334.00
IUUC-Spo-108144	Schizosaccharomyces pombe	34.42	6.00e-112	397.00
IUUC-Smo-108848	Selaginella moellendorffii	60.48	0.00e+00	962.00
IUUC-Sit-110728	Setaria italica	69.19	0.00e+00	1160.00
IUUC-Sar-113733	Sorex araneus	46.45	4.00e-99	355.00
IUUC-Sbi-114419	Sorghum bicolor	68.78	0.00e+00	1140.00
IUUC-Sre-115225	Sporisorium reilianum	32.87	1.00e-108	386.00
IUUC-Ssc-115686	Sus scrofa	47.02	0.00e+00	748.00
IUUC-Tgu-117346	Taeniopygia guttata	47.79	0.00e+00	762.00
IUUC-Tru-118350	Takifugu rubripes	42.31	0.00e+00	657.00
IUUC-Tsy-119278	Tarsius syrichta	38.95	5.00e-162	563.00
IUUC-Tni-120658	Tetraodon nigroviridis	42.66	0.00e+00	644.00
IUUC-Tca-121585	Theobroma cacao	75.84	0.00e+00	1208.00
IUUC-Tre-122043	Trichoderma reesei	35.97	3.00e-117	415.00
IUUC-Tvi-122303	Trichoderma virens	36.35	2.00e-119	422.00
IUUC-Tae-123798	Triticum aestivum	66.63	0.00e+00	1103.00
IUUC-Tur-126732	Triticum urartu	62.66	0.00e+00	1029.00
IUUC-Tme-126909	Tuber melanosporum	34.70	4.00e-106	378.00
IUUC-Tbe-127261	Tupaia belangeri	40.59	2.00e-119	422.00
IUUC-Ttr-128295	Tursiops truncatus	38.42	5.00e-161	560.00
IUUC-Uma-129599	Ustilago maydis	33.37	2.00e-115	409.00
IUUC-Vda-129688	Verticillium dahliae	34.65	1.00e-113	403.00
IUUC-Vpa-130170	Vicugna pacos	37.04	8.00e-146	510.00
IUUC-Vvi-131116	Vitis vinifera	77.97	0.00e+00	1233.00
IUUC-Xtr-131953	Xenopus tropicalis	46.39	0.00e+00	728.00
IUUC-Xma-133837	Xiphophorus maculatus	45.23	0.00e+00	674.00
IUUC-Yli-134510	Yarrowia lipolytica	34.19	3.00e-106	378.00
IUUC-Zma-135786	Zea mays	68.66	0.00e+00	1100.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence