iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027655

Ensembl Protein ID

ENSDARP00000119160.1

UniProt Accession

A2CEX6; A2CEX6_DANRE

Genbank Protein ID

ENSDARP00000119160

Protein Name

Protein HIRA

Genbank Nucleotide ID

CR774200

Gene Name

hira

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000013434.9	ENSDART00000132164.1	ENSDARP00000119160.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-21	76.7	130	163

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtg 33
           Ht++v ++a+  +d  l+s+s D+ti +W+ r++
   Q: 130  HTGDVMDVAWspHDVWLASCSVDNTIVIWNARKF 163
           9**********655999*************7765 PP

Organism

Danio rerio

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

MKLLKPSWVN HNGKPIFSVD IHPDGTKFAT GGQGEDSGKV VIWNMAPVLR EEDEKNENIP 60
KLLCQMDNHL ACVNCVRWSN NGLYLASGGD DKLVMVWKRA AFIGPSTVFG SSSKLANVEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCATCCTTT GTTTCCAAGG GAACTTCGAG GAAGACGGCG AACTTCCGGC GTGACTTCAG 60
TTGCTGCAGC TTCACGCTCG CGCTCACGGA GTGATGAGAG AGAGGGAGAG AGAGAGACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0031935--P:regulation of chromatin silencing
GO:0006351--P:transcription, DNA-templated

KEGG

dre:568076

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001039	Aegilops tauschii	38.15	9.00e-85	308.00
IUUC-Aml-001723	Ailuropoda melanoleuca	68.84	0.00e+00	1292.00
IUUC-Atr-003132	Amborella trichopoda	35.45	8.00e-88	318.00
IUUC-Apl-003197	Anas platyrhynchos	70.91	0.00e+00	1362.00
IUUC-Aca-004733	Anolis carolinensis	69.40	0.00e+00	1364.00
IUUC-Aly-005446	Arabidopsis lyrata	39.74	5.00e-80	293.00
IUUC-Ath-007627	Arabidopsis thaliana	41.18	2.00e-83	304.00
IUUC-Ago-007766	Ashbya gossypii	29.81	2.00e-59	224.00
IUUC-Acl-008104	Aspergillus clavatus	32.86	1.00e-62	235.00
IUUC-Afl-008591	Aspergillus flavus	29.83	4.00e-62	233.00
IUUC-Afu-008781	Aspergillus fumigatus	33.17	1.00e-56	215.00
IUUC-Ani-009272	Aspergillus nidulans	32.17	2.00e-54	207.00
IUUC-Ang-009655	Aspergillus niger	34.34	1.00e-63	238.00
IUUC-Aor-010119	Aspergillus oryzae	29.59	1.00e-62	235.00
IUUC-Ate-010530	Aspergillus terreus	28.78	7.00e-56	212.00
IUUC-Ame-011147	Astyanax mexicanus	95.05	7.00e-56	207.00
IUUC-Bgr-012237	Blumeria graminis	33.33	2.00e-61	231.00
IUUC-Bta-013320	Bos taurus	67.87	0.00e+00	1310.00
IUUC-Bci-013795	Botrytis cinerea	30.75	4.00e-68	253.00
IUUC-Bdi-014075	Brachypodium distachyon	34.56	8.00e-88	318.00
IUUC-Bol-016440	Brassica oleracea	41.27	5.00e-85	309.00
IUUC-Bra-016651	Brassica rapa	40.56	4.00e-85	310.00
IUUC-Cel-018692	Caenorhabditis elegans	38.62	8.00e-76	278.00
IUUC-Cja-018987	Callithrix jacchus	67.69	0.00e+00	1209.00
IUUC-Cfa-020132	Canis familiaris	68.43	0.00e+00	1293.00
IUUC-Cpo-021484	Cavia porcellus	69.25	0.00e+00	1325.00
IUUC-Cre-022846	Chlamydomonas reinhardtii	34.29	4.00e-60	226.00
IUUC-Csa-023081	Chlorocebus sabaeus	68.75	0.00e+00	1301.00
IUUC-Cin-025182	Ciona intestinalis	52.82	1.00e-159	557.00
IUUC-Csv-026154	Ciona savignyi	57.11	4.00e-156	545.00
IUUC-Cgl-026655	Colletotrichum gloeosporioides	25.05	2.00e-90	327.00
IUUC-Cne-026891	Cryptococcus neoformans	40.81	1.00e-82	301.00
IUUC-Cme-027349	Cyanidioschyzon merolae	30.57	7.00e-52	199.00
IUUC-Dno-029557	Dasypus novemcinctus	62.68	0.00e+00	832.00
IUUC-Dor-030687	Dipodomys ordii	71.67	0.00e+00	667.00
IUUC-Dse-031334	Dothistroma septosporum	31.86	9.00e-65	242.00
IUUC-Dme-031746	Drosophila melanogaster	55.81	6.00e-161	561.00
IUUC-Ete-032384	Echinops telfairi	65.18	0.00e+00	1199.00
IUUC-Eca-033430	Equus caballus	68.28	0.00e+00	1280.00
IUUC-Fca-036121	Felis catus	68.53	0.00e+00	1294.00
IUUC-Fal-036817	Ficedula albicollis	70.91	0.00e+00	1371.00
IUUC-Fox-037906	Fusarium oxysporum	32.02	1.00e-66	248.00
IUUC-Fso-038409	Fusarium solani	30.59	1.00e-66	248.00
IUUC-Gmo-039151	Gadus morhua	92.45	0.00e+00	737.00
IUUC-Ggr-040016	Gaeumannomyces graminis	34.00	4.00e-68	253.00
IUUC-Gga-040936	Gallus gallus	71.47	0.00e+00	1420.00
IUUC-Gac-041405	Gasterosteus aculeatus	72.02	0.00e+00	1380.00
IUUC-Gma-044252	Glycine max	35.07	2.00e-86	314.00
IUUC-Ggo-045430	Gorilla gorilla	68.88	0.00e+00	1299.00
IUUC-Hsa-046442	Homo sapiens	69.14	0.00e+00	1308.00
IUUC-Hvu-047587	Hordeum vulgare	33.99	2.00e-75	278.00
IUUC-Itr-048910	Ictidomys tridecemlineatus	90.00	2.00e-162	564.00
IUUC-Kpa-049145	Komagataella pastoris	30.19	3.00e-61	230.00
IUUC-Lch-050474	Latimeria chalumnae	84.60	0.00e+00	814.00
IUUC-Lpe-051209	Leersia perrieri	34.76	3.00e-82	300.00
IUUC-Loc-052119	Lepisosteus oculatus	77.94	0.00e+00	1501.00
IUUC-Lma-053237	Leptosphaeria maculans	31.64	2.00e-66	248.00
IUUC-Laf-053718	Loxodonta africana	69.56	0.00e+00	1319.00
IUUC-Mcc-055621	Macaca mulatta	67.69	0.00e+00	1209.00
IUUC-Meu-055914	Macropus eugenii	61.73	0.00e+00	1159.00
IUUC-Mor-057090	Magnaporthe oryzae	34.34	3.00e-66	247.00
IUUC-Mpo-057364	Magnaporthe poae	34.24	3.00e-69	257.00
IUUC-Mtr-058691	Medicago truncatula	35.52	3.00e-87	317.00
IUUC-Mla-058914	Melampsora laricipopulina	42.47	3.00e-85	310.00
IUUC-Mga-060181	Meleagris gallopavo	70.63	0.00e+00	1377.00
IUUC-Mvi-060432	Microbotryum violaceum	38.11	2.00e-75	277.00
IUUC-Mmr-060871	Microcebus murinus	69.01	0.00e+00	1340.00
IUUC-Mdo-062301	Monodelphis domestica	68.88	0.00e+00	1335.00
IUUC-Mmu-063888	Mus musculus	68.76	0.00e+00	1316.00
IUUC-Mac-065137	Musa acuminata	35.59	2.00e-90	327.00
IUUC-Mpu-066732	Mustela putorius furo	68.88	0.00e+00	1306.00
IUUC-Mlu-067542	Myotis lucifugus	67.71	0.00e+00	1293.00
IUUC-Nfi-068396	Neosartorya fischeri	34.37	1.00e-56	215.00
IUUC-Ncr-068842	Neurospora crassa	31.19	1.00e-67	251.00
IUUC-Nle-070156	Nomascus leucogenys	69.24	0.00e+00	1315.00
IUUC-Opr-070808	Ochotona princeps	65.53	0.00e+00	996.00
IUUC-Ont-072105	Oreochromis niloticus	79.61	0.00e+00	1576.00
IUUC-Ocu-074962	Oryctolagus cuniculus	68.67	0.00e+00	1295.00
IUUC-Oba-075178	Oryza barthii	35.73	4.00e-89	323.00
IUUC-Obr-076399	Oryza brachyantha	35.63	4.00e-89	323.00
IUUC-Ogu-078797	Oryza glumaepatula	35.73	4.00e-89	323.00
IUUC-Oin-080085	Oryza indica	34.12	7.00e-76	279.00
IUUC-Olo-081048	Oryza longistaminata	39.09	2.00e-63	238.00
IUUC-Ome-081324	Oryza meridionalis	35.73	4.00e-89	323.00
IUUC-Oni-082548	Oryza nivara	35.73	4.00e-89	323.00
IUUC-Opu-084008	Oryza punctata	40.56	7.00e-88	318.00
IUUC-Oru-084339	Oryza rufipogon	35.73	4.00e-89	323.00
IUUC-Osa-085782	Oryza sativa	35.73	4.00e-89	323.00
IUUC-Ola-087302	Oryzias latipes	72.44	0.00e+00	1395.00
IUUC-Olu-087611	Ostreococcus lucimarinus	37.34	8.00e-92	332.00
IUUC-Oga-087935	Otolemur garnettii	67.98	0.00e+00	1264.00
IUUC-Oar-089229	Ovis aries	63.82	0.00e+00	757.00
IUUC-Ptr-090715	Pan troglodytes	69.04	0.00e+00	1307.00
IUUC-Pan-092318	Papio anubis	68.54	0.00e+00	1274.00
IUUC-Psi-094053	Pelodiscus sinensis	70.19	0.00e+00	1357.00
IUUC-Pno-094985	Phaeosphaeria nodorum	32.20	1.00e-57	218.00
IUUC-Ppa-095819	Physcomitrella patens	34.84	3.00e-85	310.00
IUUC-Pfo-096857	Poecilia formosa	76.04	0.00e+00	1492.00
IUUC-Pab-098047	Pongo abelii	68.95	0.00e+00	1305.00
IUUC-Pop-099587	Populus trichocarpa	41.58	2.00e-87	317.00
IUUC-Pca-100558	Procavia capensis	60.42	2.00e-127	450.00
IUUC-Ppe-101261	Prunus persica	36.66	4.00e-87	316.00
IUUC-Pva-102683	Pteropus vampyrus	68.45	0.00e+00	1327.00
IUUC-Pgr-103660	Puccinia graminis	40.61	1.00e-77	284.00
IUUC-Ptt-103900	Puccinia triticina	41.71	9.00e-79	288.00
IUUC-Pte-104209	Pyrenophora teres	35.03	5.00e-64	239.00
IUUC-Pyt-104802	Pyrenophora triticirepentis	34.77	2.00e-63	237.00
IUUC-Rno-105566	Rattus norvegicus	68.82	0.00e+00	1321.00
IUUC-Sce-106291	Saccharomyces cerevisiae	32.77	3.00e-62	233.00
IUUC-Sha-107514	Sarcophilus harrisii	65.34	0.00e+00	1218.00
IUUC-Sja-107833	Schizosaccharomyces japonicus	41.49	4.00e-79	289.00
IUUC-Spo-108162	Schizosaccharomyces pombe	39.68	4.00e-77	283.00
IUUC-Smo-109186	Selaginella moellendorffii	40.85	6.00e-89	322.00
IUUC-Sit-110730	Setaria italica	36.13	2.00e-88	321.00
IUUC-Sly-111547	Solanum lycopersicum	36.55	2.00e-88	320.00
IUUC-Stu-112705	Solanum tuberosum	36.55	2.00e-88	321.00
IUUC-Sar-113222	Sorex araneus	64.75	0.00e+00	1146.00
IUUC-Sbi-114272	Sorghum bicolor	36.76	8.00e-90	325.00
IUUC-Sre-115061	Sporisorium reilianum	34.58	6.00e-77	282.00
IUUC-Ssc-116364	Sus scrofa	68.74	0.00e+00	1345.00
IUUC-Tgu-116645	Taeniopygia guttata	71.20	0.00e+00	1386.00
IUUC-Tru-117590	Takifugu rubripes	76.62	0.00e+00	1502.00
IUUC-Tsy-119212	Tarsius syrichta	70.96	0.00e+00	788.00
IUUC-Tni-119915	Tetraodon nigroviridis	76.39	0.00e+00	1488.00
IUUC-Tca-121765	Theobroma cacao	36.16	1.00e-89	325.00
IUUC-Tre-121887	Trichoderma reesei	34.08	2.00e-60	228.00
IUUC-Tvi-122262	Trichoderma virens	33.58	3.00e-59	223.00
IUUC-Tae-124148	Triticum aestivum	42.93	2.00e-38	154.00
IUUC-Tur-126483	Triticum urartu	41.33	7.00e-89	322.00
IUUC-Tme-127202	Tuber melanosporum	30.14	4.00e-59	223.00
IUUC-Tbe-127350	Tupaia belangeri	69.73	7.00e-161	561.00
IUUC-Ttr-129077	Tursiops truncatus	65.15	0.00e+00	1271.00
IUUC-Uma-129465	Ustilago maydis	35.91	9.00e-79	288.00
IUUC-Vda-129844	Verticillium dahliae	24.34	5.00e-75	276.00
IUUC-Vvi-131397	Vitis vinifera	34.85	5.00e-89	322.00
IUUC-Xtr-132057	Xenopus tropicalis	67.32	0.00e+00	1288.00
IUUC-Xma-134139	Xiphophorus maculatus	78.49	0.00e+00	958.00
IUUC-Yli-134424	Yarrowia lipolytica	32.07	8.00e-64	239.00
IUUC-Zma-135506	Zea mays	35.73	7.00e-90	325.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence