iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115361

Ensembl Protein ID

ENSSSCP00000028760.1

UniProt Accession

A5GFW1; AURKA_PIG

Genbank Protein ID

CAN13135.1

Protein Name

Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A

Genbank Nucleotide ID

CR956640

Gene Name

AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000007493.3	ENSSSCT00000036639.1	ENSSSCP00000028760.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	88.83	0.00e+00	724.00	IUUC-Hsa-046968

Active Site

Position(s)	Description	Evidence
256	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10027}

Organism

Sus scrofa

Functional Description
(View)

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Necessary for proper cilia disassembly prior to mitosis (By similarity). Interacts with SIRT2 (By similarity).

Protein Sequence
(Fasta)

MDKCKENCIS GLKTTVPPGD GPKRVPVTQH FPAQHLPSAN SGQAQRVLCP SNSSQRLPSH 60
TQKLVSSHKP VQNLKQKQSQ ATSGPRPVSR PLSNTQQSEQ PQPAAPGNNP EKEAASKQKN 120

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Nucleotide Sequence
(Fasta)

GCAAGTGGGA GGTGTTGTGG GGAACAGTGT TTTTTAACTA CACACTGCCC CCTGGAGAAT 60
TACTGAGGCT AATGATAATA AGAAGAGCTA ACATTTATTG AGTTTTTTTT TTTTTACCAT 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0493--Microtubule
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR030616--Aur
IPR030611--AURKA
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0032133--C:chromosome passenger complex
GO:0005929--C:cilium
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005876--C:spindle microtubule
GO:0051233--C:spindle midzone
GO:0031616--C:spindle pole centrosome
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0004672--F:protein kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0051301--P:cell division
GO:0030030--P:cell projection organization
GO:0000212--P:meiotic spindle organization
GO:0007100--P:mitotic centrosome separation
GO:0007052--P:mitotic spindle organization
GO:1904146--P:positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:0045727--P:positive regulation of translation
GO:0032465--P:regulation of cytokinesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000930	Aegilops tauschii	61.64	4.00e-105	374.00
IUUC-Aml-001426	Ailuropoda melanoleuca	91.47	0.00e+00	728.00
IUUC-Atr-002453	Amborella trichopoda	63.14	2.00e-108	384.00
IUUC-Apl-003626	Anas platyrhynchos	70.62	4.00e-156	543.00
IUUC-Aca-004602	Anolis carolinensis	69.01	1.00e-148	518.00
IUUC-Aly-005878	Arabidopsis lyrata	63.27	8.00e-105	372.00
IUUC-Ath-007117	Arabidopsis thaliana	61.22	3.00e-105	374.00
IUUC-Acl-008199	Aspergillus clavatus	56.52	4.00e-87	314.00
IUUC-Afl-008419	Aspergillus flavus	59.22	5.00e-86	310.00
IUUC-Afu-008751	Aspergillus fumigatus	59.61	2.00e-86	312.00
IUUC-Ani-009181	Aspergillus nidulans	48.70	2.00e-90	325.00
IUUC-Ang-009787	Aspergillus niger	59.61	8.00e-87	313.00
IUUC-Aor-009980	Aspergillus oryzae	59.22	5.00e-86	310.00
IUUC-Ate-010286	Aspergillus terreus	57.30	3.00e-86	311.00
IUUC-Ame-010849	Astyanax mexicanus	60.61	3.00e-128	451.00
IUUC-Bgr-012110	Blumeria graminis	60.69	3.00e-87	315.00
IUUC-Bta-013474	Bos taurus	90.52	0.00e+00	750.00
IUUC-Bci-013756	Botrytis cinerea	55.85	5.00e-94	337.00
IUUC-Bdi-014257	Brachypodium distachyon	62.12	9.00e-107	379.00
IUUC-Bol-016310	Brassica oleracea	62.14	3.00e-103	367.00
IUUC-Bra-017438	Brassica rapa	61.89	3.00e-104	370.00
IUUC-Cel-018157	Caenorhabditis elegans	61.96	5.00e-102	363.00
IUUC-Cja-019282	Callithrix jacchus	88.06	0.00e+00	706.00
IUUC-Cfa-020162	Canis familiaris	89.92	0.00e+00	721.00
IUUC-Cpo-021764	Cavia porcellus	82.47	0.00e+00	652.00
IUUC-Cre-022827	Chlamydomonas reinhardtii	67.04	2.00e-107	381.00
IUUC-Csa-023694	Chlorocebus sabaeus	87.81	0.00e+00	663.00
IUUC-Cho-024350	Choloepus hoffmanni	96.94	5.00e-113	399.00
IUUC-Cin-025542	Ciona intestinalis	73.76	1.00e-119	421.00
IUUC-Csv-025873	Ciona savignyi	65.99	2.00e-119	421.00
IUUC-Cgl-026632	Colletotrichum gloeosporioides	50.15	7.00e-82	296.00
IUUC-Cne-026928	Cryptococcus neoformans	59.40	1.00e-93	336.00
IUUC-Cme-027336	Cyanidioschyzon merolae	72.08	4.00e-118	417.00
IUUC-Dre-028198	Danio rerio	62.47	5.00e-130	457.00
IUUC-Dno-029928	Dasypus novemcinctus	86.82	0.00e+00	648.00
IUUC-Dor-030238	Dipodomys ordii	78.22	0.00e+00	625.00
IUUC-Dse-031266	Dothistroma septosporum	52.46	2.00e-92	332.00
IUUC-Dme-032007	Drosophila melanogaster	61.60	1.00e-100	359.00
IUUC-Ete-032911	Echinops telfairi	66.93	7.00e-130	456.00
IUUC-Eca-033749	Equus caballus	90.86	0.00e+00	736.00
IUUC-Eeu-035170	Erinaceus europaeus	87.13	0.00e+00	708.00
IUUC-Fca-035498	Felis catus	92.05	0.00e+00	736.00
IUUC-Fal-037397	Ficedula albicollis	68.49	3.00e-150	524.00
IUUC-Fox-037747	Fusarium oxysporum	52.17	1.00e-90	325.00
IUUC-Fso-038429	Fusarium solani	55.22	4.00e-90	324.00
IUUC-Gmo-039378	Gadus morhua	59.90	2.00e-128	451.00
IUUC-Ggr-039939	Gaeumannomyces graminis	58.13	3.00e-94	338.00
IUUC-Gga-040187	Gallus gallus	70.98	5.00e-153	533.00
IUUC-Gac-042223	Gasterosteus aculeatus	61.27	1.00e-131	462.00
IUUC-Gma-042870	Glycine max	62.77	4.00e-99	353.00
IUUC-Ggo-045617	Gorilla gorilla	88.34	0.00e+00	721.00
IUUC-Hsa-046968	Homo sapiens	88.83	0.00e+00	724.00
IUUC-Hvu-047072	Hordeum vulgare	55.06	2.00e-82	298.00
IUUC-Itr-048233	Ictidomys tridecemlineatus	75.68	2.00e-171	594.00
IUUC-Kpa-049093	Komagataella pastoris	56.32	1.00e-76	279.00
IUUC-Lch-050346	Latimeria chalumnae	67.27	6.00e-147	513.00
IUUC-Lpe-051466	Leersia perrieri	66.05	8.00e-107	379.00
IUUC-Lma-053006	Leptosphaeria maculans	58.43	3.00e-89	321.00
IUUC-Laf-053422	Loxodonta africana	85.61	0.00e+00	691.00
IUUC-Mcc-055245	Macaca mulatta	87.63	0.00e+00	652.00
IUUC-Mor-056952	Magnaporthe oryzae	59.16	3.00e-90	325.00
IUUC-Mpo-057605	Magnaporthe poae	59.71	4.00e-95	341.00
IUUC-Mtr-057726	Medicago truncatula	62.90	3.00e-106	377.00
IUUC-Mla-059174	Melampsora laricipopulina	62.93	8.00e-98	350.00
IUUC-Mga-059562	Meleagris gallopavo	61.23	2.00e-119	421.00
IUUC-Mvi-060305	Microbotryum violaceum	61.60	2.00e-93	335.00
IUUC-Mmr-061588	Microcebus murinus	85.07	0.00e+00	704.00
IUUC-Mdo-061914	Monodelphis domestica	77.32	3.00e-174	603.00
IUUC-Mmu-063288	Mus musculus	82.13	0.00e+00	646.00
IUUC-Mac-064969	Musa acuminata	62.98	5.00e-106	376.00
IUUC-Mpu-066855	Mustela putorius furo	89.92	0.00e+00	717.00
IUUC-Mlu-068046	Myotis lucifugus	90.18	0.00e+00	716.00
IUUC-Nfi-068527	Neosartorya fischeri	60.00	2.00e-86	312.00
IUUC-Ncr-068678	Neurospora crassa	61.22	2.00e-92	332.00
IUUC-Nle-069848	Nomascus leucogenys	88.59	0.00e+00	721.00
IUUC-Opr-070589	Ochotona princeps	80.85	3.00e-180	624.00
IUUC-Ont-071733	Oreochromis niloticus	62.83	3.00e-125	441.00
IUUC-Oan-073399	Ornithorhynchus anatinus	86.99	3.00e-151	527.00
IUUC-Ocu-074063	Oryctolagus cuniculus	85.11	0.00e+00	697.00
IUUC-Oba-075264	Oryza barthii	63.01	4.00e-106	377.00
IUUC-Obr-076048	Oryza brachyantha	64.84	1.00e-105	375.00
IUUC-Ogl-077637	Oryza glaberrima	65.68	1.00e-105	375.00
IUUC-Ogu-078830	Oryza glumaepatula	63.01	3.00e-106	377.00
IUUC-Oin-079150	Oryza indica	63.01	2.00e-106	378.00
IUUC-Olo-080398	Oryza longistaminata	57.56	1.00e-81	295.00
IUUC-Ome-081544	Oryza meridionalis	54.61	3.00e-90	324.00
IUUC-Oni-082250	Oryza nivara	63.01	2.00e-106	378.00
IUUC-Opu-083638	Oryza punctata	63.36	5.00e-107	380.00
IUUC-Oru-084981	Oryza rufipogon	63.99	1.00e-106	378.00
IUUC-Osa-085961	Oryza sativa	63.99	1.00e-106	378.00
IUUC-Olu-087880	Ostreococcus lucimarinus	70.08	1.00e-112	399.00
IUUC-Oga-088891	Otolemur garnettii	86.75	0.00e+00	686.00
IUUC-Oar-090021	Ovis aries	90.27	0.00e+00	726.00
IUUC-Ptr-091458	Pan troglodytes	88.83	0.00e+00	724.00
IUUC-Pan-092546	Papio anubis	87.56	0.00e+00	661.00
IUUC-Psi-093280	Pelodiscus sinensis	73.75	4.00e-164	570.00
IUUC-Pma-094298	Petromyzon marinus	77.27	2.00e-120	424.00
IUUC-Pno-094847	Phaeosphaeria nodorum	49.71	5.00e-89	320.00
IUUC-Ppa-095855	Physcomitrella patens	61.59	2.00e-108	385.00
IUUC-Pfo-096428	Poecilia formosa	60.14	4.00e-132	464.00
IUUC-Pab-098696	Pongo abelii	88.12	0.00e+00	706.00
IUUC-Pop-099405	Populus trichocarpa	61.94	3.00e-106	377.00
IUUC-Pca-100740	Procavia capensis	80.40	0.00e+00	654.00
IUUC-Ppe-101854	Prunus persica	61.77	9.00e-107	379.00
IUUC-Pva-103212	Pteropus vampyrus	89.92	0.00e+00	709.00
IUUC-Pgr-103474	Puccinia graminis	59.72	3.00e-98	351.00
IUUC-Ptt-103933	Puccinia triticina	48.86	8.00e-62	230.00
IUUC-Pte-104089	Pyrenophora teres	57.65	3.00e-89	321.00
IUUC-Pyt-104555	Pyrenophora triticirepentis	57.65	3.00e-89	322.00
IUUC-Rno-105057	Rattus norvegicus	83.62	0.00e+00	662.00
IUUC-Sha-107137	Sarcophilus harrisii	79.84	5.00e-180	623.00
IUUC-Sja-107767	Schizosaccharomyces japonicus	59.34	1.00e-97	349.00
IUUC-Spo-108078	Schizosaccharomyces pombe	52.87	1.00e-102	366.00
IUUC-Smo-109288	Selaginella moellendorffii	65.81	3.00e-108	384.00
IUUC-Sit-110246	Setaria italica	63.86	9.00e-107	379.00
IUUC-Sly-111379	Solanum lycopersicum	64.06	5.00e-107	380.00
IUUC-Stu-112777	Solanum tuberosum	60.62	1.00e-106	379.00
IUUC-Sbi-114325	Sorghum bicolor	63.51	2.00e-106	378.00
IUUC-Sre-115203	Sporisorium reilianum	59.55	5.00e-81	294.00
IUUC-Tgu-116967	Taeniopygia guttata	72.53	6.00e-151	526.00
IUUC-Tru-117570	Takifugu rubripes	62.27	4.00e-136	477.00
IUUC-Tsy-119280	Tarsius syrichta	65.76	2.00e-133	468.00
IUUC-Tni-120721	Tetraodon nigroviridis	63.76	2.00e-134	471.00
IUUC-Tca-121494	Theobroma cacao	60.41	2.00e-105	374.00
IUUC-Tre-121869	Trichoderma reesei	58.11	5.00e-94	337.00
IUUC-Tvi-122510	Trichoderma virens	61.60	2.00e-91	328.00
IUUC-Tae-123071	Triticum aestivum	61.64	4.00e-105	374.00
IUUC-Tur-126240	Triticum urartu	61.64	1.00e-104	372.00
IUUC-Tme-126921	Tuber melanosporum	61.51	2.00e-95	342.00
IUUC-Tbe-127872	Tupaia belangeri	82.05	0.00e+00	627.00
IUUC-Ttr-129134	Tursiops truncatus	92.76	0.00e+00	709.00
IUUC-Uma-129412	Ustilago maydis	58.65	8.00e-80	290.00
IUUC-Vda-130003	Verticillium dahliae	52.00	1.00e-91	329.00
IUUC-Vvi-131272	Vitis vinifera	61.28	4.00e-106	377.00
IUUC-Xtr-132019	Xenopus tropicalis	66.92	8.00e-154	536.00
IUUC-Xma-134203	Xiphophorus maculatus	62.60	1.00e-133	469.00
IUUC-Yli-134503	Yarrowia lipolytica	54.23	6.00e-86	310.00
IUUC-Zma-135232	Zea mays	64.39	1.00e-104	372.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence